| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura Soumoy, Aline Genbauffe, Lena Mouchart, Alexandra Sperone, Anne Trelcat, Léa Mukeba-Harchies, Mathilde Wells, Bertrand Blankert, Ahmad Najem, Ghanem Ghanem, Sven Saussez, Fabrice Journ. ATP1A1 is a promising new target for melanoma treatment and can be inhibited by its physiological ligand bufalin to restore targeted therapy efficacy. Cancer cell international. vol 24. issue 1. 2024-01-04. PMID:38178183. |
in vitro, bufalin induced apoptosis in melanoma cell lines by acting on atp1a1 (sirna experiments) and, in vivo, significantly impeded melanoma growth using a nude mouse xenograft model with continuous bufalin delivery via an osmotic pump. |
2024-01-04 |
2024-01-07 |
mouse |
| Laura Soumoy, Aline Genbauffe, Lena Mouchart, Alexandra Sperone, Anne Trelcat, Léa Mukeba-Harchies, Mathilde Wells, Bertrand Blankert, Ahmad Najem, Ghanem Ghanem, Sven Saussez, Fabrice Journ. ATP1A1 is a promising new target for melanoma treatment and can be inhibited by its physiological ligand bufalin to restore targeted therapy efficacy. Cancer cell international. vol 24. issue 1. 2024-01-04. PMID:38178183. |
by targeting atp1a1, bufalin inhibited cell proliferation, induced apoptosis in vitro, and effectively suppressed tumor development in mice. |
2024-01-04 |
2024-01-07 |
mouse |
| Yang Li, Xiuli Lu, Zhihao Yu, Haozhen Wang, Bing Ga. Meta-data analysis of kidney stone disease highlights ATP1A1 involvement in renal crystal formation. Redox biology. vol 61. 2023-03-05. PMID:36871182. |
however, the overexpression of atp1a1 or treatment with pnaktide, a specific inhibitor of the atp1a1/src complex, inhibited the atp1a1/src signal system and alleviated oxidative stress, inflammatory responses, apoptosis, crystal-cell adhesion, and stone formation. |
2023-03-05 |
2023-08-14 |
Not clear |
| Islam M Saadeldin, Fariba Moulavi, Ayman Abdel-Aziz Swelum, Sokhangouy Saiede Khorshid, Hossini-Fahraji Hamid, Sayyed Morteza Hossein. Vitrification of camel oocytes transiently impacts mitochondrial functions without affecting the developmental potential after intracytoplasmic sperm injection and parthenogenetic activation. Environmental science and pollution research international. vol 27. issue 35. 2020-11-25. PMID:33029771. |
at the molecular level, vitrification reduced mrna expression of many genes, including those related to mitochondrial function (tfam, mt-co1, mfn1, atp1a1, nrf1), pluripotency (sox2 and pou5f1), and apoptosis (p53 and bax). |
2020-11-25 |
2023-08-13 |
Not clear |
| Liping Zhuang, Litao Xu, Peng Wang, Yan Jiang, Pan Yong, Chenyue Zhang, Haibin Zhang, Zhiqiang Meng, Peiying Yan. Na+/K+-ATPase α1 subunit, a novel therapeutic target for hepatocellular carcinoma. Oncotarget. vol 6. issue 29. 2016-08-02. PMID:26334094. |
downregulation of atp1a1 expression resulted in cell-cycle arrest at g2/m phase and apoptosis in hepg2 cells as well as decreased migration in hep3b cells. |
2016-08-02 |
2023-08-13 |
human |
| Pål A Olsvik, Robin Ørnsrud, Bjørn Tore Lunestad, Nils Steine, Børge Nilsen Fredrikse. Transcriptional responses in Atlantic salmon (Salmo salar) exposed to deltamethrin, alone or in combination with azamethiphos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 162. 2014-12-16. PMID:24674905. |
significant responses for casp3b, bclx, igfbp1b and atp1a1 (na-k-atpase a1b) by some of the treatments suggest that the pharmaceutical drugs may affect apoptosis, growth and ion regulation mechanisms. |
2014-12-16 |
2023-08-12 |
cat |
| Y X Liu, C H Xu, T Y Gao, Y Su. Polymorphisms of the ATP1A1 gene associated with mastitis in dairy cattle. Genetics and molecular research : GMR. vol 11. issue 1. 2012-08-22. PMID:22535401. |
since sodium-potassium adenosine triphosphatase (na(+), k(+)-atpase) is critical for maintaining the homeostasis of these two ions, and is involved in cell apoptosis and pathogenesis, we presumed that polymorphism of the atp1a1 gene, which encodes the bovine na(+), k(+)-atpase α1 subunit could be associated with mastitis. |
2012-08-22 |
2023-08-12 |
cattle |