All Relations between apoptosis and dlc1

Publication Sentence Publish Date Extraction Date Species
Kate Hawkins, Meg Watt, Sébastien Gillotin, Maya Hanspal, Martin Helley, Jill Richardson, Nicola Corbett, Janet Brownlee. Disrupting the interaction between AMBRA1 and DLC1 prevents apoptosis while enhancing autophagy and mitophagy. Biology open. 2024-10-29. PMID:39469809. disrupting the interaction between ambra1 and dlc1 prevents apoptosis while enhancing autophagy and mitophagy. 2024-10-29 2024-10-31 mouse
Brajendra K Tripathi, Meghan F Anderman, Disha Bhargava, Luciarita Boccuzzi, Xiaolan Qian, Dunrui Wang, Marian E Durkin, Alex G Papageorge, Fernando J de Miguel, Katerina Politi, Kylie J Walters, James H Doroshow, Douglas R Low. Inhibition of cytoplasmic EZH2 induces antitumor activity through stabilization of the DLC1 tumor suppressor protein. Nature communications. vol 12. issue 1. 2021-12-06. PMID:34862367. these rational drug combinations induce potent tumor growth inhibition, with markers of apoptosis and senescence, that is highly dependent on dlc1 protein. 2021-12-06 2023-08-13 Not clear
Xueliang Zhou, Dechao Jiao, Mengmeng Dou, Weijie Zhang, Liying Lv, Jianjian Chen, Lifeng Li, Liuxing Wang, Xinwei Ha. Curcumin inhibits the growth of triple-negative breast cancer cells by silencing EZH2 and restoring DLC1 expression. Journal of cellular and molecular medicine. vol 24. issue 18. 2021-05-12. PMID:32725802. moreover, knockdown of ezh2 expression restored the expression of dlc1 and inhibited the migration, invasion and proliferation, promoted the apoptosis, and blocked the cell cycle of mda-mb-231 cells. 2021-05-12 2023-08-13 human
Xueliang Zhou, Dechao Jiao, Mengmeng Dou, Weijie Zhang, Liying Lv, Jianjian Chen, Lifeng Li, Liuxing Wang, Xinwei Ha. Curcumin inhibits the growth of triple-negative breast cancer cells by silencing EZH2 and restoring DLC1 expression. Journal of cellular and molecular medicine. vol 24. issue 18. 2021-05-12. PMID:32725802. finally, xenograft tumour models were used to demonstrate that curcumin restored dlc1 expression by inhibiting ezh2 and also inhibited the growth and promoted the apoptosis of tnbc cells. 2021-05-12 2023-08-13 human
Xueliang Zhou, Dechao Jiao, Mengmeng Dou, Weijie Zhang, Liying Lv, Jianjian Chen, Lifeng Li, Liuxing Wang, Xinwei Ha. Curcumin inhibits the growth of triple-negative breast cancer cells by silencing EZH2 and restoring DLC1 expression. Journal of cellular and molecular medicine. vol 24. issue 18. 2021-05-12. PMID:32725802. in conclusion, our results suggest that curcumin can inhibit the migration, invasion and proliferation, promote the apoptosis, block the cycle of tnbc cells and restore the expression of dlc1 by inhibiting the expression of ezh2. 2021-05-12 2023-08-13 human
Xueliang Zhou, Dechao Jiao, Mengmeng Dou, Weijie Zhang, Liying Lv, Jianjian Chen, Lifeng Li, Liuxing Wang, Xinwei Ha. Curcumin inhibits the growth of triple-negative breast cancer cells by silencing EZH2 and restoring DLC1 expression. Journal of cellular and molecular medicine. vol 24. issue 18. 2021-05-12. PMID:32725802. furthermore, we found that curcumin restored the expression of dlc1 by inhibiting ezh2; it also inhibited the migration, invasion and proliferation of mda-mb-231 cells, promoted their apoptosis and blocked the cell cycle. 2021-05-12 2023-08-13 human
Yang Zhang, Guorong L. A tumor suppressor DLC1: The functions and signal pathways. Journal of cellular physiology. vol 235. issue 6. 2021-03-09. PMID:31773748. in this review, we describe the characteristics and other members of the dlc1 family and delineate the signal pathways dlc1 involved in regulating cancer cell growth, colony formation, apoptosis, senescence, autophagy, migration and invasion. 2021-03-09 2023-08-13 human
Shuhua Ji, Zhaodi Zheng, Shan Liu, Guanghui Ren, Junying Gao, Yang Zhang, Guorong L. Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells. Experimental cell research. vol 370. issue 2. 2019-09-17. PMID:29964052. tumor suppressor gene dlc1 is shown to induce apoptosis, suppress migration and invasion in various cancer cells. 2019-09-17 2023-08-13 Not clear
Cailing Yang, Dapeng Wu, Jinling Jia, Dong Liu, Zhanguo Li, Chunxiao Zhang, Min Li, Yonghua Xi. DLC1 as a regulator of proliferation, invasion, cell cycle, and apoptosis in cutaneous squamous cell carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 34. issue 5. 2013-11-26. PMID:23625658. taken altogether, our data presented herein suggest that dlc1 plays a pivotal role in the development and progression of cutaneous scc, which may be in part achieved by regulating the signaling pathway related to proliferation, invasion, cell cycle, and apoptosis in cutaneous scc cells. 2013-11-26 2023-08-12 Not clear
Cailing Yang, Dapeng Wu, Jinling Jia, Dong Liu, Zhanguo Li, Chunxiao Zhang, Min Li, Yonghua Xi. DLC1 as a regulator of proliferation, invasion, cell cycle, and apoptosis in cutaneous squamous cell carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 34. issue 5. 2013-11-26. PMID:23625658. dlc1 as a regulator of proliferation, invasion, cell cycle, and apoptosis in cutaneous squamous cell carcinoma. 2013-11-26 2023-08-12 Not clear
Cailing Yang, Dapeng Wu, Jinling Jia, Dong Liu, Zhanguo Li, Chunxiao Zhang, Min Li, Yonghua Xi. DLC1 as a regulator of proliferation, invasion, cell cycle, and apoptosis in cutaneous squamous cell carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 34. issue 5. 2013-11-26. PMID:23625658. additionally, dlc1 overexpression induced apoptosis coupled with elevations of bax level and caspase-3 activity and decrease of bcl-2 level in a431 cells. 2013-11-26 2023-08-12 Not clear
T C Izidoro-Toledo, A C Borges, D D Araújo, D P S Leitão Mazzi, F O Nascimento Júnior, J F Sousa, C P Alves, A P B Paiva, D M Trindade, E V Patussi, P M Peixoto, K W Kinnally, E M Espreafic. A myosin-Va tail fragment sequesters dynein light chains leading to apoptosis in melanoma cells. Cell death & disease. vol 4. 2013-08-23. PMID:23519116. thus, we suggest that, mvaf induces apoptosis by sequestering dlc2 and dlc1, thereby unleashing the pair of sensitizer and activator bh3-only proteins bmf and bim. 2013-08-23 2023-08-12 mouse
Xiaoling Zhou, Xu-Yu Yang, Nicholas C Popesc. Synergistic antineoplastic effect of DLC1 tumor suppressor protein and histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), on prostate and liver cancer cells: perspectives for therapeutics. International journal of oncology. vol 36. issue 4. 2010-06-04. PMID:20198346. consistent with the oncosuppressive function of dlc1 in several cancers, including prostate and liver cancer, transduction of 22rv1 and 7703k cells with an ad-dlc1 expression vector resulted in alterations of cell morphology, induction of apoptosis, and inhibition of cell proliferation, migration, and anchorage-independent growth. 2010-06-04 2023-08-12 human
Ping-ping Wu, Yue-ling Jin, Yan-fang Shang, Zhi Jin, Peng Wu, Pei-lin Huan. Restoration of DLC1 gene inhibits proliferation and migration of human colon cancer HT29 cells. Annals of clinical and laboratory science. vol 39. issue 3. 2009-12-14. PMID:19667410. flow cytometry showed that dlc1 transfection into ht29 cells induced apoptosis and that the cell cycle was arrested at s-phase. 2009-12-14 2023-08-12 human
Xiaoling Zhou, Drazen B Zimonjic, Sang-Won Park, Xu-Yu Yang, Marian E Durkin, Nicholas C Popesc. DLC1 suppresses distant dissemination of human hepatocellular carcinoma cells in nude mice through reduction of RhoA GTPase activity, actin cytoskeletal disruption and down-regulation of genes involved in metastasis. International journal of oncology. vol 32. issue 6. 2008-07-30. PMID:18497990. we have previously demonstrated that restoration of dlc1 tumor suppressor gene expression in the dlc1-negative focus and 7703k human hepatocellular carcinoma (hcc) cell lines induced caspase-3 mediated apoptosis, reduced cell growth in vitro and tumorigenicity in vivo and diminished the ability to migrate through matrigel, a property suggestive of metastatic potential in vivo. 2008-07-30 2023-08-12 mouse
M Guan, V Tripathi, X Zhou, N C Popesc. Adenovirus-mediated restoration of expression of the tumor suppressor gene DLC1 inhibits the proliferation and tumorigenicity of aggressive, androgen-independent human prostate cancer cell lines: prospects for gene therapy. Cancer gene therapy. vol 15. issue 6. 2008-07-25. PMID:18369381. dlc1 induced apoptosis in c4-2-b2 cells, whereas it did not elicit such an effect in pc-3 cells. 2008-07-25 2023-08-12 mouse
Chunying Song, Wenyu Wen, Suresh K Rayala, Mingzhi Chen, Jianpeng Ma, Mingjie Zhang, Rakesh Kuma. Serine 88 phosphorylation of the 8-kDa dynein light chain 1 is a molecular switch for its dimerization status and functions. The Journal of biological chemistry. vol 283. issue 7. 2008-05-05. PMID:18084006. overexpression of a ser(88) phosphorylation-inactive dlc1 mutant in mammary epithelium cells and in a transgenic animal model caused apoptosis and accelerated mammary gland involution, respectively, with increased bim levels. 2008-05-05 2023-08-12 Not clear
Bao-Zhu Yuan, Amy M Jefferson, Lyndell Millecchia, Nicholas C Popescu, Steven H Reynold. Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells. Experimental cell research. vol 313. issue 18. 2007-12-12. PMID:17888903. subsequently, a fraction of cells exhibiting dlc1 protein nuclear translocation (pnt) underwent caspase 3-dependent apoptosis. 2007-12-12 2023-08-12 human
Bao-Zhu Yuan, Amy M Jefferson, Lyndell Millecchia, Nicholas C Popescu, Steven H Reynold. Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells. Experimental cell research. vol 313. issue 18. 2007-12-12. PMID:17888903. morphological changes and nuclear translocation of dlc1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells. 2007-12-12 2023-08-12 human
Bao-Zhu Yuan, Amy M Jefferson, Lyndell Millecchia, Nicholas C Popescu, Steven H Reynold. Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells. Experimental cell research. vol 313. issue 18. 2007-12-12. PMID:17888903. also, we found that dlc1 functions in the cytoplasm as an inhibitor of tumor cell proliferation and migration, but in the nucleus as an inducer of apoptosis. 2007-12-12 2023-08-12 human