| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohamed S Abdel-Bakky, Hamdoon A Mohammed, Nesreen I Mahmoud, Elham Amin, Mansour Alsharidah, Osamah Al Rugaie, Mohamed G Ewee. Targeting the PI3K/pAKT/mTOR/NF-κB/FOXO3a signaling pathway for suppressing the development of hepatocellular carcinoma in rats: Role of the natural remedic Suaeda vermiculata forssk. Environmental toxicology. 2024-03-20. PMID:38506534. |
liver toxicity and tumor markers (hgfr, p-akt, pi3k, mtor, nf-κb, foxo3a), apoptosis markers, and histopathological changes were analyzed. |
2024-03-20 |
2024-03-23 |
rat |
| Wenqiu Mei, Bingyin Mei, Jing Chang, Yifei Liu, Yanhong Zhou, Ni Zhu, Meichun H. Role and regulation of FOXO3a: new insights into breast cancer therapy. Frontiers in pharmacology. vol 15. 2024-03-20. PMID:38505423. |
foxo3a plays a pivotal role in various cellular processes, including apoptosis, proliferation, cell cycle regulation, and drug resistance. |
2024-03-20 |
2024-03-23 |
Not clear |
| Statement of Retraction: Dexmedetomidine attenuates ischemia and reperfusion-induced cardiomyocyte injury through p53 and forkhead box O3a (FOXO3a)/p53-upregulated modulator of apoptosis (PUMA) signaling signaling. Bioengineered. vol 15. issue 1. 2024-02-20. PMID:38376902. |
statement of retraction: dexmedetomidine attenuates ischemia and reperfusion-induced cardiomyocyte injury through p53 and forkhead box o3a (foxo3a)/p53-upregulated modulator of apoptosis (puma) signaling signaling. |
2024-02-20 |
2024-02-22 |
Not clear |
| Rasha Abdelhady, Osama A Mohammed, Ahmed S Doghish, Rabab S Hamad, Mustafa Ahmed Abdel-Reheim, Mohannad Mohammad S Alamri, Muffarah Hamid Alharthi, Jaber Alfaifi, Masoud I E Adam, Abdullah Hassan Alhalafi, Nahid A Mohammed, Adamu Imam Isa, Sameh Abdel-Ghany, Mohammed A Attia, Elsayed A Elmorsy, Tohada M Al-Noshokaty, Yousra Nomier, Walaa A El-Dakroury, Sameh Sabe. Linagliptin, a DPP-4 inhibitor, activates AMPK/FOXO3a and suppresses NFκB to mitigate the debilitating effects of diethylnitrosamine exposure in rat liver: Novel mechanistic insights. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 4. 2024-02-14. PMID:38354025. |
foxo3a inactivation, driven by oncogenic stimuli, can lead to abnormal cell growth, suppression of apoptosis, and resistance to anticancer drugs. |
2024-02-14 |
2024-02-16 |
rat |
| Xinwan Wu, Yu Zhou, Hongjiao Xu, Xinyi Zhang, Liangfang Yao, Jinbao Li, Xiang L. PRMT6-FoxO3a attenuates apoptosis by upregulating Parkin expression in intestinal ischemia-reperfusion injury. Shock (Augusta, Ga.). 2024-02-07. PMID:38323918. |
this study aims to investigate the potential regulatory mechanisms involving protein arginine methyltransferase 6 (prmt6), forkhead box o3a (foxo3a), and parkin in iiri and elucidate their roles in mediating cell apoptosis. |
2024-02-07 |
2024-02-09 |
mouse |
| Xinwan Wu, Yu Zhou, Hongjiao Xu, Xinyi Zhang, Liangfang Yao, Jinbao Li, Xiang L. PRMT6-FoxO3a attenuates apoptosis by upregulating Parkin expression in intestinal ischemia-reperfusion injury. Shock (Augusta, Ga.). 2024-02-07. PMID:38323918. |
altogether, our results demonstrated that prmt6 upregulated the expression of parkin by regulating foxo3a methylation level, attenuating the apoptosis induced by iiri. |
2024-02-07 |
2024-02-09 |
mouse |
| Shajidan Abudureyimu, Chunhui He, Wei Xie, Zhuo Chen, Halisha Airikenjiang, Dilihumaer Abulaiti, Yan Cao, Haitang Qiu, Ying G. FOXO3a functions as a transcriptional and co-transcriptional splicing regulator in vascular endothelial cell lines. Gene. 2024-01-29. PMID:38286271. |
recent studies have indicated a connection between forkhead box o3a protein and coronary artery disease, yet the exact role of foxo3a in the regulation of metabolic processes and apoptosis in vascular endothelial cells is still unknown. |
2024-01-29 |
2024-02-01 |
human |
| Zhiqiang Dong, Zongming Guo, Hui Li, Dequan Han, Wei Xie, Shaoning Cui, Wei Zhang, Shuhong Huan. FOXO3a-interacting proteins' involvement in cancer: a review. Molecular biology reports. vol 51. issue 1. 2024-01-25. PMID:38270719. |
due to its role in apoptosis, differentiation, cell cycle arrest, and dna damage repair in stress responses (oxidative stress, hypoxia, chemotherapeutic drugs, and uv irradiation or radiotherapy), foxo3a is considered a key tumor suppressor that determines radiotherapeutic and chemotherapeutic responses in cancer cells. |
2024-01-25 |
2024-01-27 |
Not clear |
| Kuan-Ho Lin, Shang-Chuan Ng, Shang-Yeh Lu, Yueh-Min Lin, Shu-Hui Lin, Tzu-Cheng Su, Chih-Yang Huang, Wei-Wen Ku. Diallyl trisulfide (DATS) protects cardiac cells against advanced glycation end-product-induced apoptosis by enhancing FoxO3A-dependent upregulation of miRNA-210. The Journal of nutritional biochemistry. 2024-01-07. PMID:38185348. |
we investigated the dats-mediated attenuation mechanism of age-enhanced cardiac apoptosis by modulating mir-210 and its upstream transcriptional regulator, foxo3a. |
2024-01-07 |
2024-01-10 |
Not clear |
| Kuan-Ho Lin, Shang-Chuan Ng, Shang-Yeh Lu, Yueh-Min Lin, Shu-Hui Lin, Tzu-Cheng Su, Chih-Yang Huang, Wei-Wen Ku. Diallyl trisulfide (DATS) protects cardiac cells against advanced glycation end-product-induced apoptosis by enhancing FoxO3A-dependent upregulation of miRNA-210. The Journal of nutritional biochemistry. 2024-01-07. PMID:38185348. |
we also showed that foxo3a, upregulated by dats treatment, may bind to the mir-210 promoter to enhance its expression and downregulates jnk expression to attenuate age-induced cardiac apoptosis. |
2024-01-07 |
2024-01-10 |
Not clear |
| Kuan-Ho Lin, Shang-Chuan Ng, Shang-Yeh Lu, Yueh-Min Lin, Shu-Hui Lin, Tzu-Cheng Su, Chih-Yang Huang, Wei-Wen Ku. Diallyl trisulfide (DATS) protects cardiac cells against advanced glycation end-product-induced apoptosis by enhancing FoxO3A-dependent upregulation of miRNA-210. The Journal of nutritional biochemistry. 2024-01-07. PMID:38185348. |
oral administration of dats enhanced foxo3a expression in the heart and reduced diabetes-induced heart apoptosis. |
2024-01-07 |
2024-01-10 |
Not clear |
| Kuan-Ho Lin, Shang-Chuan Ng, Shang-Yeh Lu, Yueh-Min Lin, Shu-Hui Lin, Tzu-Cheng Su, Chih-Yang Huang, Wei-Wen Ku. Diallyl trisulfide (DATS) protects cardiac cells against advanced glycation end-product-induced apoptosis by enhancing FoxO3A-dependent upregulation of miRNA-210. The Journal of nutritional biochemistry. 2024-01-07. PMID:38185348. |
our findings indicate that dats mediates age-induced cardiac cell apoptosis attenuation by promoting foxo3a nuclear transactivation to enhance mir-210 expression and regulate jnk activation. |
2024-01-07 |
2024-01-10 |
Not clear |
| Suryaa Manoharan, Kunjkumar Prajapati, Ekambaram Peruma. Natural bioactive compounds and FOXO3a in cancer therapeutics: An update. Fitoterapia. 2024-01-03. PMID:38168566. |
foxo3a promotes its anticancer effects by upregulating the levels of its downstream targets, including bim, fasl, and bax, leading to apoptosis. |
2024-01-03 |
2024-01-06 |
Not clear |
| Jian-Heng Hao, Yue-Meng Zhao, Hai-Jun Wang, Yu-Xia Cao, Ying Lan, Lai-Xi J. [Mechanism of protective effect of resveratrol on poor ovarian response in mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114185. |
animal experiments showed that the model group had higher rate of estrous cycle disorders, lower number and poorer morphology of normally developed follicles at all levels, more atretic follicles, higher apoptosis of ovarian granulosa cells, lower number of retrieved oocytes, lower ovarian wet weight and ovarian index, higher serum levels of fsh and lh, lower levels of amh and e_2, higher expression levels of hif-1α, foxo3a and bax, and lower expression levels of pi3k, akt, and bcl-2 in the ovarian tissue than the normal group. |
2023-12-19 |
2023-12-23 |
mouse |
| Zhe Zhang, Qinghua Zhang, Yani Yu, Shan S. Epigallocatechin gallate inhibits ovarian cancer cell growth and induces cell apoptosis via activation of FOXO3A. In vitro cellular & developmental biology. Animal. 2023-12-01. PMID:38038884. |
epigallocatechin gallate inhibits ovarian cancer cell growth and induces cell apoptosis via activation of foxo3a. |
2023-12-01 |
2023-12-10 |
Not clear |
| Jun Chen, Yi Yang, Shuo Wang, Kaixin Zhan. Crocin improves lower extremity deep venous thrombosis by regulating the PIM1/FOXO3a axis. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 9. 2023-10-09. PMID:37807309. |
moreover, the knockdown of pim1 suppressed apoptosis and promoted angiogenesis in thrombin-huvecs treated with crocin, while overexpression of foxo3a reversed the effects. |
2023-10-09 |
2023-10-15 |
human |
| Shuangze Han, Xinfang Yu, Ruirui Wang, Xiaocong Wang, LuLu Liu, Qing Zhao, RongBo Xie, Ming Li, Zhong Su Zho. Tanshinone IIA inhibits cell viability and promotes PUMA-mediated apoptosis of oral squamous cell carcinoma. Journal of Cancer. vol 14. issue 13. 2023-09-06. PMID:37670974. |
moreover, tan iia inhibited akt activation from inducing foxo3a dephosphorylation and puma-mediated apoptosis. |
2023-09-06 |
2023-10-07 |
Not clear |
| Yusuke Urushihara, Takuma Hashimoto, Yohei Fujishima, Yoshio Hoso. AMPK/FOXO3a Pathway Increases Activity and/or Expression of ATM, DNA-PKcs, Src, EGFR, PDK1, and SOD2 and Induces Radioresistance under Nutrient Starvation. International journal of molecular sciences. vol 24. issue 16. 2023-08-26. PMID:37629008. |
knockdown of foxo3a increased the incidence of apoptosis after irradiation under nutrient starvation. |
2023-08-26 |
2023-09-07 |
Not clear |
| Lin Li, Weitong Qi, Yujiao Zhu, Mingming Yin, Chen Chen, Meng Wei, Zhenzhen Huang, Zhuhua Su, Jizong Jiang, Mingxue Zhang, Yihua Be. Danlou Tablet Protects Against Cardiac Remodeling and Dysfunction after Myocardial Ischemia/Reperfusion Injury through Activating AKT/FoxO3a Pathway. Journal of cardiovascular translational research. 2023-04-10. PMID:37036598. |
mechanistically, dan inhibited myocardial apoptosis through phosphorylating akt and foxo3a, thereby inhibiting downstream bim and puma expressions. |
2023-04-10 |
2023-08-14 |
human |
| Xun Chen, Qian Zhang, Tao Song, Wentao Zhang, Yan Yang, Ning Duan, Fei Con. Vitamin D deficiency triggers intrinsic apoptosis by impairing SPP1-dependent antiapoptotic signaling in chronic hematogenous osteomyelitis. Gene. 2023-04-06. PMID:37024063. |
foxo3a then upregulates the expression of the apoptotic genes bax (bcl2-associated x-protein), bid (bh3 interacting death domain), and bim (bcl2-interacting mediator of cell death), to induce apoptosis. |
2023-04-06 |
2023-08-14 |
mouse |