| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiong Lin, Tianxing Yu, Xiaohua Li, Xin Lin, Yong Fan, Liyu X. Umbilical cord mesenchymal stem cells inhibited inflammation of bronchial epithelial cells by regulating Hedgehog pathway. European journal of histochemistry : EJH. vol 67. issue 4. 2023-12-12. PMID:38085254. |
compared with the control group, bronchial epithelial cells treated with tgf-β1 showed significantly decreased proliferation, increased apoptosis, increased secretion of tnf-α and il-6, increased expression of α-sma, shh, gli1 and snail and decreased e-cadherin expression. |
2023-12-12 |
2023-12-17 |
human |
| Changle Zhao, Xiang Liu, Lei Liu, Jianeng Li, Xingyong Liu, Wenjing Tao, Deshou Wang, Jing We. Smoothened mediates medaka spermatogonia proliferation via Gli1-Rgcc-Cdk1 axis. Biology of reproduction. 2023-08-08. PMID:37552059. |
furthermore, gli1 transcriptionally upregulated the expression of rgcc, and rgcc overexpression rescued cell apoptosis caused by smo or gli1 inhibition. |
2023-08-08 |
2023-08-14 |
Not clear |
| Libangxi Liu, Yuyao Zhang, Jiawei Fu, Xuezheng Ai, Dan Long, Xue Leng, Yang Zhang, Bo Huang, Changqing Li, Yue Zhou, Chencheng Fen. Gli1 depletion induces oxidative stress and apoptosis of nucleus pulposus cells via Fos in intervertebral disc degeneration. Journal of orthopaedic translation. vol 40. 2023-07-17. PMID:37457313. |
gli1 depletion induces oxidative stress and apoptosis of nucleus pulposus cells via fos in intervertebral disc degeneration. |
2023-07-17 |
2023-08-14 |
Not clear |
| Rosalinda Mejía-Rodríguez, Daniel Romero-Trejo, Rosa O González, José Segovi. Combined treatments with AZD5363, AZD8542, curcumin or resveratrol induce death of human glioblastoma cells by suppressing the PI3K/AKT and SHH signaling pathways. Biochemistry and biophysics reports. vol 33. 2023-01-30. PMID:36714540. |
we found that the combined treatments with azd5363+azd8542+curcumin and azd8542+curcumin+resveratrol inhibit the pi3k/akt and shh survival pathways by decreasing the activity of akt, the reduction of the expression of smo, pp70s6k, ps6k, gli1, p21 and p27, and the activation of caspase-3 as a marker of apoptosis. |
2023-01-30 |
2023-08-14 |
human |
| Raphael Luís Rocha Nogueira, Taís Bacelar Sacramento de Araújo, Ludmila Faro Valverde, Viviane Aline Oliveira Silva, Bruno Raphael Ribeiro Cavalcante, Erik Aranha Rossi, Kyan James Allahdadi, Mitermayer Galvão Dos Reis, Thiago Almeida Pereira, Ricardo D Coletta, Daniel Pereira Bezerra, Bruno Solano de Freitas Souza, Rosane Borges Dias, Clarissa A Gurgel Roch. Arsenic Trioxide Triggers Apoptosis of Metastatic Oral Squamous Cells Carcinoma with Concomitant Downregulation of GLI1 in Hedgehog Signaling. Biomedicines. vol 10. issue 12. 2022-12-23. PMID:36552049. |
arsenic trioxide triggers apoptosis of metastatic oral squamous cells carcinoma with concomitant downregulation of gli1 in hedgehog signaling. |
2022-12-23 |
2023-08-14 |
Not clear |
| Urszula Smyczynska, Marcin Stanczak, Miljan Kuljanin, Aneta Włodarczyk, Ewelina Stoczynska-Fidelus, Joanna Taha, Bartłomiej Pawlik, Maciej Borowiec, Joseph D Mancias, Wojciech Mlynarski, Piotr Rieske, Wojciech Fendler, Agnieszka Zmysłowsk. Proteomic and Transcriptomic Landscapes of Alström and Bardet-Biedl Syndromes. Genes. vol 13. issue 12. 2022-12-23. PMID:36553637. |
furthermore, protein pathways associated with autophagy, apoptosis, cilium assembly and gli1 protein were upregulated in both ciliopathies. |
2022-12-23 |
2023-08-14 |
human |
| Yang Cai, Ming-Ming Zhang, Ming Wang, Zhuo-Hang Jiang, Zhi-Gang Ta. Bone Marrow-Derived Mesenchymal Stem Cell-Derived Exosomes Containing Gli1 Alleviate Microglial Activation and Neuronal Apoptosis In Vitro and in a Mouse Parkinson Disease Model by Direct Inhibition of Sp1 Signaling. Journal of neuropathology and experimental neurology. 2022-05-24. PMID:35609560. |
bone marrow-derived mesenchymal stem cell-derived exosomes containing gli1 alleviate microglial activation and neuronal apoptosis in vitro and in a mouse parkinson disease model by direct inhibition of sp1 signaling. |
2022-05-24 |
2023-08-13 |
mouse |
| Yang Cai, Ming-Ming Zhang, Ming Wang, Zhuo-Hang Jiang, Zhi-Gang Ta. Bone Marrow-Derived Mesenchymal Stem Cell-Derived Exosomes Containing Gli1 Alleviate Microglial Activation and Neuronal Apoptosis In Vitro and in a Mouse Parkinson Disease Model by Direct Inhibition of Sp1 Signaling. Journal of neuropathology and experimental neurology. 2022-05-24. PMID:35609560. |
thus, bmsc-derived exosomal gli1 alleviates inflammatory damage and neuronal apoptosis by inhibiting sp1 in vitro and in vivo. |
2022-05-24 |
2023-08-13 |
mouse |
| Haoji Gao, Weige Wang, Qinyu L. GANT61 suppresses cell survival, invasion and epithelial-mesenchymal transition through inactivating AKT/mTOR and JAK/STAT3 pathways in anaplastic thyroid carcinoma. Cancer biology & therapy. vol 23. issue 1. 2022-05-02. PMID:35491899. |
gant61 reduced gli1 expression, suppressed proliferation at several time settings, promoted apoptosis, inhibited invasion and increased e-cadherin while decreased vimentin and snail expressions (emt markers) in atc cells. |
2022-05-02 |
2023-08-13 |
Not clear |
| Ji Min Oh, Ramya Lakshmi Rajendran, Prakash Gangadaran, Chae Moon Hong, Ju Hye Jeong, Jaetae Lee, Byeong-Cheol Ah. Targeting GLI1 Transcription Factor for Restoring Iodine Avidity with Redifferentiation in Radioactive-Iodine Refractory Thyroid Cancers. Cancers. vol 14. issue 7. 2022-04-12. PMID:35406554. |
previous studies have demonstrated the effect of gli family zinc finger 1 (gli1) inhibition on tumor growth and apoptosis. |
2022-04-12 |
2023-08-13 |
Not clear |
| Hualin Chen, Donghong Yang, Yongcun Wang, Hua Tao, Yiping Luo, Aibing Wu, Shujun Li, Zhixiong Yang, Ming Che. Activation of the Hedgehog pathway mediates resistance to epidermal growth factor receptor inhibitors in non-small cell lung cancer. Journal of Cancer. vol 13. issue 3. 2022-02-14. PMID:35154464. |
shh stimulation promoted gli1 activation as well as cell motility in parental pc9 cells while suppressing gefitinib-induced apoptosis in gefitinib-resistant cells. |
2022-02-14 |
2023-08-13 |
Not clear |
| Chengliang Yang, Xiaoli Zheng, Ke Ye, Yanan Sun, Yufei Lu, Qingxia Fan, Hong G. miR-135a Inhibits the Invasion and Migration of Esophageal Cancer Stem Cells through the Hedgehog Signaling Pathway by Targeting Smo. Molecular therapy. Nucleic acids. vol 19. 2021-12-02. PMID:31981861. |
after that, the expression of mir-135a and hedgehog (hh) signaling pathway-related genes (smo, gli1, shh, and gli2) in tissues and cells was measured, accompanied by evaluation of cell viability, apoptosis, invasion, and migration. |
2021-12-02 |
2023-08-13 |
Not clear |
| Chengliang Yang, Xiaoli Zheng, Ke Ye, Yanan Sun, Yufei Lu, Qingxia Fan, Hong G. miR-135a Inhibits the Invasion and Migration of Esophageal Cancer Stem Cells through the Hedgehog Signaling Pathway by Targeting Smo. Molecular therapy. Nucleic acids. vol 19. 2021-12-02. PMID:31981861. |
in addition, overexpression of mir-135a or silencing of smo decreased the expression of gli1, gli2, and shh, thus inhibiting ec cell proliferation, migration, and invasion and promoting apoptosis. |
2021-12-02 |
2023-08-13 |
Not clear |
| Navin Viswakarma, Gautam Sondarva, Daniel R Principe, Rakesh Sathish Nair, Sandeep Kumar, Sunil Kumar Singh, Subhasis Das, Subhash C Sinha, Paul J Grippo, Sam Grimaldo, Pier Cristoforo Giulianotti, Basabi Rana, Ajay Ran. Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development. Cancer letters. vol 515. 2021-11-11. PMID:34052323. |
additionally, pharmacological inhibition of mlk3 by cep-1347 promoted apoptosis in pdac cell lines, reduced tumor burden, extended survival, and reduced gli1 expression in the pdx1-cre x lsl-kras |
2021-11-11 |
2023-08-13 |
human |
| Uri Rozovski, David M Harris, Ping Li, Zhiming Liu, Preetesh Jain, Taghi Manshouri, Ivo Veletic, Alessandra Ferrajoli, Prithviraj Bose, Phillip Thompson, Nitin Jain, Srdan Verstovsek, William Wierda, Michael J Keating, Zeev Estro. STAT3 induces the expression of GLI1 in chronic lymphocytic leukemia cells. Oncotarget. vol 12. issue 5. 2021-07-09. PMID:33747356. |
transfection with gli1-sirna significantly increased the spontaneous apoptosis rate of cll cells, suggesting that gli1 inhibitors might provide therapeutic benefit to patients with cll. |
2021-07-09 |
2023-08-13 |
Not clear |
| Prasuja Rokkam, Shailender Gugalavath, Deepak Kakara Gift Kumar, Rahul Kumar Vempati, Rama Rao Mall. Prognostic Role of Hedgehog-GLI1 Signaling Pathway in Aggressive and Metastatic Breast Cancers. Current drug metabolism. vol 21. issue 1. 2021-05-10. PMID:31969097. |
gli1 mediated hh pathway can induce apoptosis. |
2021-05-10 |
2023-08-13 |
human |
| Yanxi Wang, Fangfang Zhu, Yingxuan Zhang, Chunlin Chen, Yuling Lai, Jianhua Sun, Si Chen, Pin Qiu, Jie Gao, Gaopi Den. Shikonin suppresses trophoblast cell growth via regulation of GLI1, and p62 mediated caspase 8 activation. Reproductive toxicology (Elmsford, N.Y.). vol 95. 2021-04-28. PMID:32461113. |
moreover, shikonin suppressed gli1 expression, and gli1 overexpression attenuated shikonin-induced cell apoptosis. |
2021-04-28 |
2023-08-13 |
human |
| Yanxi Wang, Fangfang Zhu, Yingxuan Zhang, Chunlin Chen, Yuling Lai, Jianhua Sun, Si Chen, Pin Qiu, Jie Gao, Gaopi Den. Shikonin suppresses trophoblast cell growth via regulation of GLI1, and p62 mediated caspase 8 activation. Reproductive toxicology (Elmsford, N.Y.). vol 95. 2021-04-28. PMID:32461113. |
although silencing gli1 slightly promoted cell apoptosis, p62 overexpression enhanced gli1 silencing-induced cell apoptosis by activating caspase 8. |
2021-04-28 |
2023-08-13 |
human |
| Taís Bacelar Sacramento de Araújo, Leonardo de Oliveira Siquara da Rocha, Manuela Torres Andion Vidal, Paulo Lucas Cerqueira Coelho, Mitermayer Galvão Dos Reis, Bruno Solano de Freitas Souza, Milena Botelho Pereira Soares, Thiago Almeida Pereira, Ricardo Della Coletta, Daniel Pereira Bezerra, Rosane Borges Dias, Clarissa Araújo Gurgel Roch. GANT61 Reduces Hedgehog Molecule (GLI1) Expression and Promotes Apoptosis in Metastatic Oral Squamous Cell Carcinoma Cells. International journal of molecular sciences. vol 21. issue 17. 2021-03-01. PMID:32846867. |
gant61 reduces hedgehog molecule (gli1) expression and promotes apoptosis in metastatic oral squamous cell carcinoma cells. |
2021-03-01 |
2023-08-13 |
Not clear |
| Balaji Chandrasekaran, Nisha R Dahiya, Ashish Tyagi, Venkatesh Kolluru, Uttara Saran, Becca V Baby, J Christopher States, Ahmed Q Haddad, Murali K Ankem, Chendil Damodara. Chronic exposure to cadmium induces a malignant transformation of benign prostate epithelial cells. Oncogenesis. vol 9. issue 2. 2021-02-16. PMID:32066655. |
at the molecular level, zic2 interacts with the glioma-associated oncogene family (gli) zinc finger 1 (gli1), which activates prosurvival factors (nuclear factor nfκb, b-cell lymphoma-2 (bcl2), as well as an x-linked inhibitor of apoptosis protein (xiap)) signaling in cd-exposed bph1 cells. |
2021-02-16 |
2023-08-13 |
mouse |