| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhiqiao Dang, Haijie Li, Shishan Xue, Baowei Shao, Yansong Ning, Guohai Su, Fengquan Zhang, Wenqian Yu, Shuai Len. Histone deacetylase 9-mediated phenotypic transformation of vascular smooth muscle cells is a potential target for treating aortic aneurysm/dissection. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 173. 2024-03-09. PMID:38460370. |
furthermore, hdac9 triggered the transformation of vsmcs from a systolic to synthetic phenotype, increasing their proliferation and migration abilities and suppressing their apoptosis. |
2024-03-09 |
2024-03-12 |
mouse |
| Min Liu, Yang Zhang, Ping Zhan, Wenjuan Sun, Chuanqiao Dong, Xiaohan Liu, Yujie Yang, Xiaojie Wang, Yusheng Xie, Chengjiang Gao, Huili Hu, Benkang Shi, Ziying Wang, Chun Guo, Fan Y. Histone deacetylase 9 exacerbates podocyte injury in hyperhomocysteinemia through epigenetic repression of Klotho. Pharmacological research. 2023-11-23. PMID:37995896. |
in vitro, gene silencing of hdac9 attenuated podocyte injury by inhibiting apoptosis, reducing oxidative stress and maintaining the expressions of podocyte slit diaphragm proteins. |
2023-11-23 |
2023-11-29 |
mouse |
| Totan Das, Samima Khatun, Tarun Jha, Shovanlal Gaye. HDAC9 as a Privileged Target: Reviewing its Role in Different Diseases and Structure-activity Relationships (SARs) of its Inhibitors. Mini reviews in medicinal chemistry. 2023-10-11. PMID:37818566. |
hdac9 inhibit cell proliferation by repairing dna, arresting the cell cycle, inducing apoptosis, and altering genetic expression. |
2023-10-11 |
2023-10-15 |
human |
| Jingwei Sun, Langfeng Zhang, Quanjiang Cheng, Yajun W. Aberrant expression and regulatory role of histone deacetylase 9 in vascular endothelial cell injury in intracranial aneurysm. Biomolecules & biomedicine. 2023-08-13. PMID:37573538. |
silencing of hdac9 inhibited apoptosis and increased viability, proliferation, and migration of vecs, whereas overexpression of hdac9 exerted the opposite functions. |
2023-08-13 |
2023-08-16 |
Not clear |
| Mengru Zhang, Jianjun Wang, Jinfang Li, Fanxin Kong, Songjun Li. miR-101-3p improves neuronal morphology and attenuates neuronal apoptosis in ischemic stroke in young mice by downregulating HDAC9. Translational neuroscience. vol 14. issue 1. 2023-05-30. PMID:37250142. |
mir-101-3p improves neuronal morphology and attenuates neuronal apoptosis in ischemic stroke in young mice by downregulating hdac9. |
2023-05-30 |
2023-08-14 |
mouse |
| Long Yang, Chunxue Wu, Ying Cui, Shimin Don. Knockdown of HDAC9 attenuates sepsis-induced myocardial injury and inflammatory response. Experimental animals. 2023-03-17. PMID:36927982. |
in addition, hdac9 silencing alleviated release of inflammatory cytokines (tnf-α, il-6 and il-1β) and cardiomyocyte apoptosis in vivo and in vitro. |
2023-03-17 |
2023-08-14 |
rat |
| Yongjie Xu, Haizhi Li, Gang Chen, Liying Zhu, Hairong Lin, Changyudong Huang, Sijia Wei, Tingting Yang, Wen Qian, Xing Li, Shuyun Zhao, Wei Pa. Radix polygoni multiflori protects against hippocampal neuronal apoptosis in diabetic encephalopathy by inhibiting the HDAC4/JNK pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076547. |
though the histone deacetylase 4 (hdac4), hdac5, hdac7, and hdac9 form class iia of the hdac superfamily have been found participating in multiple neurodegenerative diseases, while jnk signaling pathway activation was hypothesized as a key cause leading to cell apoptosis, the correlation between hdac4 and jnk signaling pathway remains unknown. |
2022-09-09 |
2023-08-14 |
rat |
| Jun Shen, Qiu Han, Wangjun Li, Xiaochang Chen, Jingmin Lu, Jinyu Zheng, Shouru Xu. miR-383-5p Regulated by the Transcription Factor CTCF Affects Neuronal Impairment in Cerebral Ischemia by Mediating Deacetylase HDAC9 Activity. Molecular neurobiology. 2022-08-04. PMID:35927544. |
in the ogd model and the mcao model, we confirmed that elevation of hdac9 regulated by the ctcf/mir-383-5p/hdac9 pathway mediated apoptosis induced by endoplasmic reticulum stress, while reduction of hdac9 alleviated apoptosis and the symptoms of cerebral infarction in mcao rats. |
2022-08-04 |
2023-08-14 |
rat |
| Jinpeng Zhong, Bin Cheng, Li Yang, Guanlan Li, Yunzhong Yuan, Gang Luo, Zhiping Shu, Hong Jian. LncRNA ZEB1-AS1 knockdown alleviates oxidative low-density lipoprotein-induced endothelial cell injury via the miR-590-5p/HDAC9 axis. Central-European journal of immunology. vol 46. issue 3. 2021-11-13. PMID:34764804. |
furthermore, hdac9 reversed the influence of mir-590-5p on propagation and apoptosis of ox-ldl-induced endothelial cells. |
2021-11-13 |
2023-08-13 |
Not clear |
| Weisheng Wang, Zhiming Liu, Xuegang Zhang, Junning Liu, Junqing Gui, Maorong Cui, Yong L. miR-211-5p is down-regulated and a prognostic marker in bladder cancer. The journal of gene medicine. vol 22. issue 12. 2021-08-31. PMID:32893379. |
in the present study, we aimed to determine whether mir-211-5p serves as a post-transcriptional regulator in bladder cancer (bca) cell proliferation and apoptosis by targeting hdac9. |
2021-08-31 |
2023-08-13 |
Not clear |
| Yuejing Jiang, Xiaoji Cong, Shangwen Jiang, Ying Dong, Lei Zhao, Yi Zang, Minjia Tan, Jia L. Phosphoproteomics Reveals AMPK Substrate Network in Response to DNA Damage and Histone Acetylation. Genomics, proteomics & bioinformatics. 2021-02-19. PMID:33607295. |
together with these findings, we discover that ampk promotes apoptosis by phosphorylating apoptosis-stimulating of p53 protein 2 (aspp2) in irradiation (ir)-dependent way and regulates histone acetylation by phosphorylating histone deacetylase 9 (hdac9) in ir-independent way. |
2021-02-19 |
2023-08-13 |
Not clear |
| Kai Xiong, Hejun Zhang, Yang Du, Jie Tian, Shigang Din. Identification of HDAC9 as a viable therapeutic target for the treatment of gastric cancer. Experimental & molecular medicine. vol 51. issue 8. 2020-05-29. PMID:31451695. |
moreover, hdac9 sirna suppressed gc tumor growth and enhanced the antitumor efficacy of cisplatin in gc treatment by inhibiting the proliferation and inducing the apoptosis of gc cells in vitro and in vivo. |
2020-05-29 |
2023-08-13 |
mouse |
| Kai Xiong, Hejun Zhang, Yang Du, Jie Tian, Shigang Din. Identification of HDAC9 as a viable therapeutic target for the treatment of gastric cancer. Experimental & molecular medicine. vol 51. issue 8. 2020-05-29. PMID:31451695. |
further experiments confirmed that knockdown of hdac9 inhibits cell growth, reduces colony formation, and induces apoptosis and cell cycle arrest. |
2020-05-29 |
2023-08-13 |
mouse |
| Zhiqiang Ma, Dong Liu, Shouyin Di, Zhipei Zhang, Weimiao Li, Jiao Zhang, Liqun Xu, Kai Guo, Yifang Zhu, Xiaofei Li, Jing Han, Xiaolong Ya. Histone deacetylase 9 downregulation decreases tumor growth and promotes apoptosis in non-small cell lung cancer after melatonin treatment. Journal of pineal research. vol 67. issue 2. 2020-01-09. PMID:31090223. |
hdac9 knockdown significantly reduced nsclc cell growth and induced apoptosis both in vivo and in vitro. |
2020-01-09 |
2023-08-13 |
Not clear |
| Gang Xu, Na Li, Yan Zhang, Jinbiao Zhang, Rui Xu, Yanling W. MicroRNA-383-5p inhibits the progression of gastric carcinoma via targeting HDAC9 expression. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 52. issue 8. 2019-09-03. PMID:31365693. |
hdac9 knockout or mir-383-5p mimics led to growth inhibition and increased apoptosis in ags and sgc-7901 cells. |
2019-09-03 |
2023-08-13 |
Not clear |
| Feng Liu, Ming Zong, Xiaofei Wen, Xuezhu Li, Jun Wang, Yi Wang, Wei Jiang, Xiaojun Li, Zhongliang Guo, Hualin Q. Silencing of Histone Deacetylase 9 Expression in Podocytes Attenuates Kidney Injury in Diabetic Nephropathy. Scientific reports. vol 6. 2018-06-04. PMID:27633396. |
moreover, in diabetic db/db mice, silencing of hdac9 attenuated the glomerulosclerosis, inflammatory cytokine release, podocyte apoptosis and renal injury. |
2018-06-04 |
2023-08-13 |
mouse |
| Feng Liu, Ming Zong, Xiaofei Wen, Xuezhu Li, Jun Wang, Yi Wang, Wei Jiang, Xiaojun Li, Zhongliang Guo, Hualin Q. Silencing of Histone Deacetylase 9 Expression in Podocytes Attenuates Kidney Injury in Diabetic Nephropathy. Scientific reports. vol 6. 2018-06-04. PMID:27633396. |
secondly, knockdown of hdac9 in mouse podocytes significantly suppressed hg-induced reactive oxygen species (ros) generation, cell apoptosis and inflammation through jak2/stat3 pathway and reduced the podocytes injury by decreasing the expression levels of nephrin and podocin. |
2018-06-04 |
2023-08-13 |
mouse |
| Xu Han, Xiang Han, Zheng Wang, Junjun Shen, Qiang Don. HDAC9 regulates ox-LDL-induced endothelial cell apoptosis by participating in inflammatory reactions. Frontiers in bioscience (Landmark edition). vol 21. 2017-12-19. PMID:27100479. |
depletion of hdac9 by its specific shrna significantly antagonized ox-ldl-induced cell apoptosis and suppressed the expression of ox-ldl-induced inflammatory factors, such as tnf-alpha and mcp1. |
2017-12-19 |
2023-08-13 |
Not clear |
| Xu Han, Xiang Han, Zheng Wang, Junjun Shen, Qiang Don. HDAC9 regulates ox-LDL-induced endothelial cell apoptosis by participating in inflammatory reactions. Frontiers in bioscience (Landmark edition). vol 21. 2017-12-19. PMID:27100479. |
hdac9 regulates ox-ldl-induced endothelial cell apoptosis by participating in inflammatory reactions. |
2017-12-19 |
2023-08-13 |
Not clear |
| Xu Han, Xiang Han, Zheng Wang, Junjun Shen, Qiang Don. HDAC9 regulates ox-LDL-induced endothelial cell apoptosis by participating in inflammatory reactions. Frontiers in bioscience (Landmark edition). vol 21. 2017-12-19. PMID:27100479. |
these data suggest that hdac9 is an important epigenetic factor regulating ox-ldl-induced endothelial cell apoptosis and inflammatory factor expression. |
2017-12-19 |
2023-08-13 |
Not clear |