| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elena Beltramo, Aurora Mazzeo, Massimo Port. Release of Pro-Inflammatory/Angiogenic Factors by Retinal Microvascular Cells Is Mediated by Extracellular Vesicles Derived from M1-Activated Microglia. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203187. |
m1-derived evs showed increased content of mir-21, mir-155, ccl2, mmp2, and mmp9, and enhanced apoptosis, proliferation, migration, and ros production in hrps and hrecs. |
2024-01-11 |
2024-01-13 |
human |
| Min Chen, Shanjiao Huang, Shuoyun Weng, Junting Weng, Rongjie Guo, Bingbing Shi, Danjuan Li. Songorine ameliorates LPS-induced sepsis cardiomyopathy by Wnt/β-catenin signaling pathway-mediated mitochondrial biosynthesis. Naunyn-Schmiedeberg's archives of pharmacology. 2023-12-22. PMID:38133657. |
sgr also blocked the inflammatory factors and reversed pgc-1α, β-catenin, and mmp2 in vitro, while sgr alleviated the myocardial cell apoptosis via flow cytometry. |
2023-12-22 |
2023-12-24 |
mouse |
| X Liu, Y Yang, H Cai, Y Zhang, F Fan, X Li, S L. [Aumolertinib inhibits proliferation, invasion and migration and promotes apoptosis of neuroblastoma cells by downregulating MMP2 and MMP9 expression]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 43. issue 9. 2023-10-10. PMID:37814863. |
[aumolertinib inhibits proliferation, invasion and migration and promotes apoptosis of neuroblastoma cells by downregulating mmp2 and mmp9 expression]. |
2023-10-10 |
2023-10-15 |
Not clear |
| Qian Zhang, Guoyang Sun, Yuna Huang, Shanshan Cui, Tingshen Li, Lianbo Zhao, Kui Lu, Peng Yu, Yongmin Zhang, Herve Galons, Nassima Oumata, Yuou Ten. Synthesis and mechanism of action of new purine derivatives against triple negative breast cancer. European journal of medicinal chemistry. vol 261. 2023-09-14. PMID:37708799. |
the results in vitro indicated that compounds 3g and 3j can induce mda-mb-231 cells apoptosis, and inhibit its migration and angiogenesis through influencing protein expression such as bcl-2, bax, bcl-xl, p38, mmp2, mmp9, akt and egfr. |
2023-09-14 |
2023-10-07 |
Not clear |
| Fereshteh Omidi, Shahrzad Shahbazi, Somayeh Reiisi, Sara Azhdari, Mohammad Reza Karimzade. Glycyrrhizic acid enhances the anticancer activity of cisplatin in the human ovarian cancer cell line. Toxicology in vitro : an international journal published in association with BIBRA. 2023-09-02. PMID:37659683. |
qpcr was used to study the effects of individual and combined treatments with gl and cisplatin on the expression levels of migration genes (mmp2 and mmp9), and some apoptosis pathway genes (caspase-3, -8, -9, and bcl2). |
2023-09-02 |
2023-09-07 |
human |
| Jiyang Wang, Min Deng, Jiaona Yang, Xiaojuan Zhou, Peng Yang, Yan Li, Guimin Zhan. FOXN4 affects myocardial ischemia-reperfusion injury through HIF-1α/MMP2-mediated ferroptosis of cardiomyocytes. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 6. 2023-08-22. PMID:37605566. |
the expressions of foxn4 and mmp2 were measured by quantitative reverse transcriptase polymerase chain reaction, apoptosis was detected by flow cytometry, and cell viability was detected by examining edu incorporation into dna. |
2023-08-22 |
2023-09-07 |
Not clear |
| Yi Zhao, Fang Hu, Qizhi Wan. Cortactin contributes to the tumorigenesis of gastric cancer by activating ERK/MMP pathway. Heliyon. vol 9. issue 7. 2023-08-04. PMID:37539204. |
overexpression of cortactin inhibited apoptosis and enhanced cellular proliferation and mobility in ags cells, while those activities were reversed by the knockdown of mmp2 or mmp9. |
2023-08-04 |
2023-08-14 |
mouse |
| Yi Zhao, Fang Hu, Qizhi Wan. Cortactin contributes to the tumorigenesis of gastric cancer by activating ERK/MMP pathway. Heliyon. vol 9. issue 7. 2023-08-04. PMID:37539204. |
conversely, the deletion of cortactin induced apoptosis and suppressed cell growth and metastasis in sgc7901 cells, whereas those behaviors were inhibited by overexpression of mmp2 or mmp9. |
2023-08-04 |
2023-08-14 |
mouse |
| Liang-Hsuan Chien, Jeng-Shyan Deng, Wen-Ping Jiang, Ya-Ni Chou, Jaung-Geng Lin, Guan-Jhong Huan. Evaluation of lung protection of Sanghuangporus sanghuang through TLR4/NF-κB/MAPK, keap1/Nrf2/HO-1, CaMKK/AMPK/Sirt1, and TGF-β/SMAD3 signaling pathways mediating apoptosis and autophagy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-01. PMID:37392658. |
western blot analysis of ss showed that it reduces inflammatory factors (tweak, inos, and cox-2), mapk (jnk, p-erk, and p-38), fibrosis-related molecules (tgf-β, smad3, fibronectin, collagen, α-sma, mmp2, and mmp9), apoptosis (p53, p21, and bax), and autophagy (beclin-1, lc3a/b-i/ii, and p62), and notably increases caspase 3, bcl-2, and antioxidant (catalase, gpx3, and sod-1) levels. |
2023-07-01 |
2023-08-14 |
mouse |
| Kun Lei, Quanwei Wei, Ying Cheng, Zhe Wang, Haoze Wu, Fang Zhao, Wei Ding, Fangxiong Sh. OONO-/MMP2/MMP9 pathway-mediated apoptosis of porcine granulosa cells is associated with DNA damage. Reproduction (Cambridge, England). 2023-02-06. PMID:36745011. |
we created a model of oono--induced apoptosis in granulosa cells and discovered that oono- could boost the expression of mmp2 and mmp9, and increase the expression of pro-apoptotic proteins and dna damage. |
2023-02-06 |
2023-08-14 |
Not clear |
| Fenqian Yuan, Jingkang Yong, Xueming Liu, Yifeng Wan. Selinexor assists vorinostat in inhibiting HDAC activity via promoting the accumulation of maspin in the nucleus of oral tongue squamous cell carcinoma cells. Cytotechnology. vol 75. issue 1. 2023-01-30. PMID:36713062. |
in vitro, both vorinostat and selinexor effectively inhibited cell viability, invasion, and migration, promoted cell apoptosis, down-regulated hdac1, matrix metalloproteinase 2 (mmp2), and b cell leukemia/lymphoma 2 (bcl-2), and up-regulated nuclear maspin and cleaved caspase 3. |
2023-01-30 |
2023-08-14 |
mouse |
| Yi-Kai Wang, Shi-Jie Li, Lu-Lu Zhou, Duan Li, Li-Wei Gu. GALNT3 protects against vascular calcification by reducing oxidative stress and apoptosis of smooth muscle cells. European journal of pharmacology. vol 939. 2022-12-16. PMID:36473594. |
moreover, overexpression of galnt3 significantly down-regulated the expression of the oxidative stress markers nox2 and nox4, up-regulated total antioxidant capacity, decreased the expression of pro-inflammatory factors il-1β, tnf-α and il-8, matrix metalloproteinases mmp2 and mmp9, as well as reduced the apoptosis of cells in phosphate induced hasmcs. |
2022-12-16 |
2023-08-14 |
mouse |
| Guiyue Cai, Ruitao Zou, Huizhi Yang, Jiahao Xie, Xiaoxuan Chen, Chunchan Zheng, Sujun Luo, Na Wei, Shuang Liu, Rongyi Che. Circ_0084043-miR-134-5p axis regulates PCDH9 to suppress melanoma. Frontiers in oncology. vol 12. 2022-11-17. PMID:36387162. |
ectopic expression or knock down (kd) of pcdh9 with a lentivirus vector, we explored its effects on the proliferation, invasion, and apoptosis of melanoma and verified its regulatory effect on ras-related c3 botulinum toxin substrate 1 (rac1), proline-rich tyrosine kinase 2 (pyk2), cyclin d1, matrix metalloproteinase 2 (mmp2), and mmp9. |
2022-11-17 |
2023-08-14 |
human |
| Hossam El-Sheikh Ali, Kirsten Scoggin, Harutaka Murase, Jamie Norris, Bruno Menarim, Pouya Dini, Barry Bal. Transcriptomic and histochemical analysis reveal the complex regulatory networks in equine Chorioallantois during spontaneous term labor. Biology of reproduction. 2022-08-01. PMID:35913756. |
also, tl was associated with the upregulation of matrix metalloproteinase (mmp1, mmp2, mmp3, and mmp9) with subsequent extracellular matrix degradation and apoptosis, as reflected by upregulation of several apoptosis-related genes (atf3, atf4, fas, fos, and birc3). |
2022-08-01 |
2023-08-14 |
Not clear |
| Zhang Yang, Wang Yaling, Liu Tao, Rao Mingyue, Li Yongju. Cardioprotective effect of NRG-4 gene expression on spontaneous hypertension rats and its mechanism through mediating the activation of ErbB signaling pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 1. 2022-07-09. PMID:35809324. |
while shrna group showed decreased expressions of nrg-4, erbb2, erbb4, mmp2, tgfβ1, α-sma and bcl-2, while increased caspase3 and bax expressions, as well as promoted cell proliferation and cell apoptosis when compared with the shrna nc group (p<0.05); while compared with pcdna3.1(-) nc group, pcdna3.1(-) group had highly increased expressions of nrg-4, erbb2, erbb4, mmp2, tgfβ1, α-sma and bcl-2, while decreased caspase3 and bax expressions, inhibited cell proliferation and cell apoptosis (all p<0.05). |
2022-07-09 |
2023-08-14 |
rat |
| Hongjie Chen, Ziyi Wang, Ninggang Yang, Jun Zhang, Zhong Lian. Decorin inhibits proliferation and metastasis in human bladder cancer cells by upregulating P21. Medicine. vol 101. issue 26. 2022-07-01. PMID:35777025. |
in addition, decorin blocked the g1/s phase by upregulating p21 protein and inhibiting the expression of tgf-β1 and mmp2, promoting the occurrence of apoptosis and inhibiting the proliferation of human bc t24 cells. |
2022-07-01 |
2023-08-14 |
human |
| Hongjie Chen, Ziyi Wang, Ninggang Yang, Jun Zhang, Zhong Lian. Decorin inhibits proliferation and metastasis in human bladder cancer cells by upregulating P21. Medicine. vol 101. issue 26. 2022-07-01. PMID:35777025. |
decorin regulated the expression of tgf-β1 and mmp2 through p21 protein, promoted apoptosis and adhesion, and inhibited the proliferation and metastasis of bc cells. |
2022-07-01 |
2023-08-14 |
human |
| Xin Zhang, Xuebing Zhou, Ming Gao, You Lyu, Ying Wang, Chunyu Yang, Yingshi Piao, Xiangshan Re. [Cordycepin inhibits the proliferation and migration of human gastric cancer cells by suppressing lipid metabolism via AMPK and MAPK activation]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 6. 2022-06-22. PMID:35732609. |
the proliferation ability of mgc-803 and hgc-27 cells was detected by mtt assay and edu assay; the colony formation ability of cells was detected by colony formation assay; both wound healing assay and cell migration assay were applied to detect the cell migration ability of mgc-803 and hgc-27 cells; the chromatin agglutination was detected by hoechst 33342 staining; the apoptosis of gastric cancer cells was detected by annexin v-fitc/pi double labeling combined with flow cytometry; western blot was used to measure the protein expression levels of lipid metabolism-related proteins including sterol regulatory element binding transcription factor 1 (srebf1), fatty acid synthase (fasn), and acetyl coa carboxylase 1 (acc1), epithelial-mesenchymal transition (emt)-related proteins including e-cadherin, vimentin, snail, slug, matrix metalloproteinase 2 (mmp2), mmp9, ampk, and phosphorylated ampk (p-ampk), mapk signaling pathway-related proteins including jnk, phosphorylated jnk (p-jnk), p38 mapk, and p-p38 mapk, and apoptosis-related proteins including cleaved caspase-9 (c-caspase-9), c-caspase-3, and cleaved poly (adp-ribose) polymerase (c-parp). |
2022-06-22 |
2023-08-14 |
human |
| Kai-Ling E Coleman, Hind Al Khashali, Ravel Ray, Sarah Atali, Sadaf Dorandish, Jeffrey Guthrie, Deborah Heyl, Hedeel G Evan. Differences in the Levels of ProBDNF and Mature BDNF in A549 and H1299 Human Lung Cancer Cell Media. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556645. |
downregulation of either mmp2 or mmp9 by sirna showed that mmp9 sirna treatment of either a549 or h1299 cells resulted in decreased cell viability and increased apoptosis, an effect diminished upon the same treatment with media immunodepleted of probdnf, suggesting that mmp9 plays a role in regulating the cytotoxic effects induced by probdnf in lung cancer cells. |
2022-05-13 |
2023-08-13 |
human |
| Atiye Saeedi Sadr, Hassan Ehteram, Elahe Seyed Hosseini, Marziyeh Alizadeh Zarei, Hassan Alizadeh Bafrani, Hamed Haddad Kashan. The Effect of Irisin on Proliferation, Apoptosis, and Expression of Metastasis Markers in Prostate Cancer Cell Lines. Oncology and therapy. 2022-04-25. PMID:35467303. |
the aim of this study was to investigate the effect of irisin on expression of metastatic markers mmp2 and mmp9 and induced apoptosis in human prostate cancer cells. |
2022-04-25 |
2023-08-13 |
human |