| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karl-Heinz Klempnaue. Transcription Factor MYB as Therapeutic Target: Current Developments. International journal of molecular sciences. vol 25. issue 6. 2024-03-28. PMID:38542205. |
the myb protein is a pivotal player in the cellular transcriptional network, influencing major important processes such as cell proliferation, differentiation, and apoptosis. |
2024-03-28 |
2024-03-30 |
Not clear |
| Ylenia Cicirò, Denise Ragusa, Paloma Tejera Nevado, Rossano Lattanzio, Gianluca Sala, Tessa DesRochers, Melissa Millard, Mattias K Andersson, Göran Stenman, Arturo Sal. The mitotic checkpoint kinase BUB1 is a direct and actionable target of MYB in adenoid cystic carcinoma. FEBS letters. 2023-12-19. PMID:38112379. |
using this new cell model, we identified bub1 as a targetable kinase directly controlled by myb, whose pharmacological inhibition caused myb-dependent synthetic lethality, growth arrest and apoptosis of patient-derived cells and organoids. |
2023-12-19 |
2023-12-23 |
Not clear |
| Chiami Moyama, Mitsugu Fujita, Hitoshi Okamoto, Hiromi Li, Susumu Nakat. Myb Repression Mediates Stat5b-knockdown-induced Apoptosis and Inhibits Proliferation of Glioblastoma Stem Cells. Cancer genomics & proteomics. vol 20. issue 2. 2023-03-04. PMID:36870690. |
myb repression mediates stat5b-knockdown-induced apoptosis and inhibits proliferation of glioblastoma stem cells. |
2023-03-04 |
2023-08-14 |
Not clear |
| Joaquim Carreras, Giovanna Roncador, Rifat Hamoud. Artificial Intelligence Predicted Overall Survival and Classified Mature B-Cell Neoplasms Based on Immuno-Oncology and Immune Checkpoint Panels. Cancers. vol 14. issue 21. 2022-11-11. PMID:36358737. |
oncogenes and tumor suppressor genes were highlighted (myc, bcl2, and tp53), along with immune microenvironment markers of tumor-associated macrophages (m2-like tams), t-cells and regulatory t lymphocytes (tregs) (cd68, cd163, marco, csf1r, csf1, pd-l1/cd274, sirpa, cd85a/lilrb3, cd47, il10, tnfrsf14/hvem, tnfaip8, ikaros, stat3, nfkb, mapk, pd-1/pdcd1, btla, and foxp3), apoptosis (bcl2, casp3, casp8, parp, and pathway-related mdm2, e2f1, cdk6, myb, and lmo2), and metabolism (eno3, gga3). |
2022-11-11 |
2023-08-14 |
Not clear |
| Shijie Lyu, Yaying Zhai, Xiaoting Zhu, Qiaoting Shi, Fuying Chen, Geyang Zhang, Zijing Zhang, Eryao Wan. Bta-miR-200b promotes endometrial epithelial cell apoptosis by targeting MYB in cattle. Theriogenology. vol 195. 2022-11-04. PMID:36332375. |
bta-mir-200b promotes endometrial epithelial cell apoptosis by targeting myb in cattle. |
2022-11-04 |
2023-08-14 |
cattle |
| Shijie Lyu, Yaying Zhai, Xiaoting Zhu, Qiaoting Shi, Fuying Chen, Geyang Zhang, Zijing Zhang, Eryao Wan. Bta-miR-200b promotes endometrial epithelial cell apoptosis by targeting MYB in cattle. Theriogenology. vol 195. 2022-11-04. PMID:36332375. |
overexpression of myb decreased the effect of bta-mir-200b on apoptosis of bovine endometrial epithelial cells. |
2022-11-04 |
2023-08-14 |
cattle |
| Shijie Lyu, Yaying Zhai, Xiaoting Zhu, Qiaoting Shi, Fuying Chen, Geyang Zhang, Zijing Zhang, Eryao Wan. Bta-miR-200b promotes endometrial epithelial cell apoptosis by targeting MYB in cattle. Theriogenology. vol 195. 2022-11-04. PMID:36332375. |
our findings suggest that bta-mir-200b can affect the apoptosis of endometrial epithelial cells in cattle by targeting the myb gene. |
2022-11-04 |
2023-08-14 |
cattle |
| Lívia Bassani Lins de Miranda, Keli Lima, Juan Luiz Coelho-Silva, Fabiola Traina, Susumu S Kobayashi, João Agostinho Machado-Net. NT157 exerts antineoplastic activity by targeting JNK and AXL signaling in lung cancer cells. Scientific reports. vol 12. issue 1. 2022-10-12. PMID:36224313. |
besides, nt157 decreased expression of oncogenes bcl2, ccnd1, myb, and myc and increased genes related to cellular stress and apoptosis, jun, bbc3, cdkn1a, cdkn1b, fos, and egr1 (p < 0.05), favoring a tumor-suppressive cell signaling network in the context of lung cancer. |
2022-10-12 |
2023-08-14 |
Not clear |
| Dingyu Hu, Wenjun Shao, Li Liu, Yanyan Wang, Shunling Yuan, Zhaoping Liu, Jing Liu, Ji Zhan. Intricate crosstalk between MYB and noncoding RNAs in cancer. Cancer cell international. vol 21. issue 1. 2021-12-12. PMID:34876130. |
this review focuses on the intricate crosstalk between oncogenic myb and ncrnas, which play a pivotal role in tumorigenesis, including proliferation, apoptosis, angiogenesis, metastasis, senescence and drug resistance. |
2021-12-12 |
2023-08-13 |
Not clear |
| Sumiko Takao, Lauren Forbes, Masahiro Uni, Shuyuan Cheng, Jose Mario Bello Pineda, Yusuke Tarumoto, Paolo Cifani, Gerard Minuesa, Celine Chen, Michael G Kharas, Robert K Bradley, Christopher R Vakoc, Richard P Koche, Alex Kentsi. Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia. eLife. vol 10. 2021-12-01. PMID:33527899. |
peptidomimetic remodeling of oncogenic myb complexes is accompanied by specific proteolysis and dynamic redistribution of cbp/p300 with alternative transcription factors such as runx1 to induce myeloid differentiation and apoptosis. |
2021-12-01 |
2023-08-13 |
human |
| Chengyan Xu, Zixia He, Chao Lin, Zhipeng She. MiR-30b-5p inhibits proliferation and promotes apoptosis of medulloblastoma cells via targeting MYB proto-oncogene like 2 (MYBL2). Journal of investigative medicine : the official publication of the American Federation for Clinical Research. vol 68. issue 6. 2021-09-27. PMID:32690599. |
mir-30b-5p inhibits proliferation and promotes apoptosis of medulloblastoma cells via targeting myb proto-oncogene like 2 (mybl2). |
2021-09-27 |
2023-08-13 |
human |
| Xue-Li Wang, Wen-Fang Wang, Jia-Ming Ha. [Effect of MiR-96 on Cell Invasion and Apoptosis in Pediatric Acute Myeloid Leukemia via Regulating MYB]. Zhongguo shi yan xue ye xue za zhi. vol 29. issue 2. 2021-04-06. PMID:33812412. |
[effect of mir-96 on cell invasion and apoptosis in pediatric acute myeloid leukemia via regulating myb]. |
2021-04-06 |
2023-08-13 |
Not clear |
| Xue-Li Wang, Wen-Fang Wang, Jia-Ming Ha. [Effect of MiR-96 on Cell Invasion and Apoptosis in Pediatric Acute Myeloid Leukemia via Regulating MYB]. Zhongguo shi yan xue ye xue za zhi. vol 29. issue 2. 2021-04-06. PMID:33812412. |
to analyze the relationship of the expression of transcription factor myb targeted regulation by mir-96 to cell invasion and apoptosis in pediatric acute myeloid leukemia (aml). |
2021-04-06 |
2023-08-13 |
Not clear |
| Reina Takeda, Shuhei Asada, Sung-Joon Park, Akihiko Yokoyama, Hans Jiro Becker, Akinori Kanai, Valeria Visconte, Courtney Hershberger, Yasutaka Hayashi, Taishi Yonezawa, Moe Tamura, Tsuyoshi Fukushima, Yosuke Tanaka, Tomofusa Fukuyama, Akiko Matsumoto, Satoshi Yamasaki, Kenta Nakai, Satoshi Yamazaki, Toshiya Inaba, Tatsuhiro Shibata, Daichi Inoue, Hiroaki Honda, Susumu Goyama, Jaroslaw P Maciejewski, Toshio Kitamur. HHEX promotes myeloid transformation in cooperation with mutant ASXL1. Blood. vol 136. issue 14. 2021-03-22. PMID:32492700. |
depletion of myb or etv5 induced apoptosis or differentiation in asxl1-mt-expressing leukemia cells, respectively. |
2021-03-22 |
2023-08-13 |
mouse |
| Maria V Yusenko, Amke Trentmann, Mattias K Andersson, Luca Abdel Ghani, Anke Jakobs, Mari-Francis Arteaga Paz, Jan-Henrik Mikesch, Jens Peter von Kries, Göran Stenman, Karl-Heinz Klempnaue. Monensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells. Cancer letters. vol 479. 2020-12-10. PMID:32014461. |
as a proof of principle, we show that monensin affects the expression of a significant number of myb-regulated genes in aml cells and causes down-regulation of myb expression, loss of cell viability, and induction of differentiation and apoptosis. |
2020-12-10 |
2023-08-13 |
human |
| Tianxiang Hu, Yating Chong, Baohuan Cai, Yun Liu, Sumin Lu, John K Cowel. DNA methyltransferase 1-mediated CpG methylation of the miR-150-5p promoter contributes to fibroblast growth factor receptor 1-driven leukemogenesis. The Journal of biological chemistry. vol 294. issue 48. 2020-06-09. PMID:31628193. |
one of the known targets of mir-150-5p is myb, and treatment of leukemic cells with the myb inhibitor mebendazole dose-dependently increased apoptosis and reduced cell viability. |
2020-06-09 |
2023-08-13 |
human |
| Mei-Hsin Cheng, Laura Andrejka, Paul J Vorster, Albert Hinman, Joseph S Lipsic. The Biology open. vol 6. issue 7. 2019-11-20. PMID:28522430. |
the the conserved multi-protein muvb core associates with the myb oncoproteins and with the rb-e2f-dp tumor suppressor proteins in complexes that regulate cell proliferation, differentiation, and apoptosis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Partha Mitra, Ren-Ming Yang, James Sutton, Robert G Ramsay, Thomas J Gond. CDK9 inhibitors selectively target estrogen receptor-positive breast cancer cells through combined inhibition of MYB and MCL-1 expression. Oncotarget. vol 7. issue 8. 2016-12-30. PMID:26812885. |
our previous studies showed that myb is required for proliferation of, and confers protection against apoptosis on, estrogen receptor-positive (er(+ve)) breast cancer cells, which are almost invariably also myb(+ve). |
2016-12-30 |
2023-08-13 |
Not clear |
| Partha Mitra, Ren-Ming Yang, James Sutton, Robert G Ramsay, Thomas J Gond. CDK9 inhibitors selectively target estrogen receptor-positive breast cancer cells through combined inhibition of MYB and MCL-1 expression. Oncotarget. vol 7. issue 8. 2016-12-30. PMID:26812885. |
importantly, ectopic myb expression conferred resistance to apoptosis induction, cell killing and g2/m accumulation. |
2016-12-30 |
2023-08-13 |
Not clear |
| Partha Mitra, Ren-Ming Yang, James Sutton, Robert G Ramsay, Thomas J Gond. CDK9 inhibitors selectively target estrogen receptor-positive breast cancer cells through combined inhibition of MYB and MCL-1 expression. Oncotarget. vol 7. issue 8. 2016-12-30. PMID:26812885. |
nevertheless, inhibition of bcl2 alone either by myb knockdown or by abt-199 treatment was insufficient for significant induction of apoptosis. |
2016-12-30 |
2023-08-13 |
Not clear |