| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Jackson, G Ramsay, N V Sharkov, E Lium, A L Katze. The role of transcriptional activation in the function of the Drosophila myb gene. Blood cells, molecules & diseases. vol 27. issue 2. 2001-12-04. PMID:11500058. |
vertebrate myb genes encode dna-binding proteins that regulate transcription and have been implicated in regulation of cell proliferation, differentiation, and apoptosis. |
2001-12-04 |
2023-08-12 |
drosophila_melanogaster |
| A Lauder, A Castellanos, K Westo. c-Myb transcription is activated by protein kinase B (PKB) following interleukin 2 stimulation of Tcells and is required for PKB-mediated protection from apoptosis. Molecular and cellular biology. vol 21. issue 17. 2001-09-20. PMID:11486019. |
we show that myb is required to protect activated peripheral t cells from bcl-2-independent apoptosis and that overexpression of oncogenic v-myb is antiapoptotic. |
2001-09-20 |
2023-08-12 |
Not clear |
| A Lauder, A Castellanos, K Westo. c-Myb transcription is activated by protein kinase B (PKB) following interleukin 2 stimulation of Tcells and is required for PKB-mediated protection from apoptosis. Molecular and cellular biology. vol 21. issue 17. 2001-09-20. PMID:11486019. |
overexpression of a myb dominant-negative transgene abrogates pkb-mediated protection from apoptosis. |
2001-09-20 |
2023-08-12 |
Not clear |
| M Arsura, C S Hofmann, J Golay, M Introna, G E Sonenshei. A-myb rescues murine B-cell lymphomas from IgM-receptor-mediated apoptosis through c-myc transcriptional regulation. Blood. vol 96. issue 3. 2000-08-24. PMID:10910917. |
a-myb is a member of the myb family of transcription factors, which regulates proliferation, differentiation, and apoptosis of hematopoietic cells. |
2000-08-24 |
2023-08-12 |
mouse |
| J R White, K Westo. Myb is required for self-renewal in a model system of early hematopoiesis. Oncogene. vol 19. issue 9. 2000-04-05. PMID:10713708. |
however when endogenous myb activity was inhibited with an inducible dominant interfering protein, self-renewal was replaced by apoptosis and differentiation. |
2000-04-05 |
2023-08-12 |
Not clear |
| I H Oh, E P Redd. The myb gene family in cell growth, differentiation and apoptosis. Oncogene. vol 18. issue 19. 1999-06-25. PMID:10378697. |
the myb gene family in cell growth, differentiation and apoptosis. |
1999-06-25 |
2023-08-12 |
mouse |
| E Grassilli, P Salomoni, D Perrotti, C Franceschi, B Calabrett. Resistance to apoptosis in CTLL-2 cells overexpressing B-Myb is associated with B-Myb-dependent bcl-2 induction. Cancer research. vol 59. issue 10. 1999-06-17. PMID:10344757. |
to investigate the role of myb proteins in the regulation of apoptosis, we studied the apoptotic response of interleukin 2-dependent ctll-2 cells stably transfected with b-myb. |
1999-06-17 |
2023-08-12 |
Not clear |
| D A Lieberman. Normal development, oncogenesis and programmed cell death. Oncogene. vol 17. issue 10. 1998-10-28. PMID:9771961. |
invited speakers included: dr andrei v gudkov (university of illinois) who started the symposium talking about 'new cellular factors modulating the tumor suppressor function of p53'; dr yuri lazebnik (cold spring harbor laboratories) spoke about 'caspases considered as enemies within'; dr e premkumar reddy (fels institute, temple university) talked about recent exciting findings in his laboratory regarding 'jak-stats dedicated signaling pathways'; dr michael greenberg (harvard university) spoke about 'signal transduction pathways that regulate differentiation and survival in the developing nervous system'; dr richard kolesnick's (memorial sloan-kettering cancer center) talk has been focused at 'stress signals for apoptosis, including ceramide and c-jun kinase/stress-activated protein kinase'; dr barbara hoffman (fels institute, temple university) described research, conducted in collaboration with dr dan a liebermann, aimed at deciphering the roles of 'myc, myb, and e2f as negative regulators of terminal differentiation', using hematopoietic cells as model system. |
1998-10-28 |
2023-08-12 |
rat |
| K Westo. Myb proteins in life, death and differentiation. Current opinion in genetics & development. vol 8. issue 1. 1998-05-21. PMID:9529609. |
regulation of myb proteins by phosphorylation and intermolecular cooperation has recently been demonstrated, together with a new role for the proteins, in the control of apoptosis. |
1998-05-21 |
2023-08-12 |
Not clear |
| A Hogg, S Schirm, H Nakagoshi, P Bartley, S Ishii, J M Bishop, T J Gond. Inactivation of a c-Myb/estrogen receptor fusion protein in transformed primary cells leads to granulocyte/macrophage differentiation and down regulation of c-kit but not c-myc or cdc2. Oncogene. vol 15. issue 24. 1998-01-15. PMID:9416832. |
while bcl-2 expression was reduced by 50% in ermyb cells grown in the absence of beta-estradiol, there was no increase in dna laddering, suggesting that myb was not protecting ermyb cells from apoptosis. |
1998-01-15 |
2023-08-12 |
Not clear |
| P Salomoni, D Perrotti, R Martinez, C Franceschi, B Calabrett. Resistance to apoptosis in CTLL-2 cells constitutively expressing c-Myb is associated with induction of BCL-2 expression and Myb-dependent regulation of bcl-2 promoter activity. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 7. 1997-05-08. PMID:9096387. |
to further investigate the role of c-myb in t cell proliferation and survival, interleukin (il) 2-dependent ctll-2 cells were transfected with a constitutively active c-myb or with a c-myb antisense construct able to down-regulate endogenous myb levels, and the transfectants were assessed for proliferation and survival in low concentrations of il-2 and for susceptibility to dexamethasone-induced apoptosis. |
1997-05-08 |
2023-08-12 |
Not clear |
| D Taylor, P Badiani, K Westo. A dominant interfering Myb mutant causes apoptosis in T cells. Genes & development. vol 10. issue 21. 1997-01-14. PMID:8946914. |
a dominant interfering myb mutant causes apoptosis in t cells. |
1997-01-14 |
2023-08-12 |
mouse |
| G Patel, R Tantravahi, I H Oh, E P Redd. Transcriptional activation potential of normal and tumor-associated myb isoforms does not correlate with their ability to block GCSF-induced terminal differentiation of murine myeloid precursor cells. Oncogene. vol 13. issue 6. 1996-11-08. PMID:8808694. |
the myb gene has been shown to be an important regulator of hematopoietic cell proliferation, differentiation and apoptosis. |
1996-11-08 |
2023-08-12 |
Not clear |
| A Sala, I Casella, L Grasso, T Bellon, J C Reed, T Miyashita, C Peschl. Apoptotic response to oncogenic stimuli: cooperative and antagonistic interactions between c-myb and the growth suppressor p53. Cancer research. vol 56. issue 9. 1996-06-12. PMID:8616838. |
these results might contribute to the elucidation of the mechanisms underlying p53-dependent pathways of oncogene-induced apoptosis and provide a further example of dna-binding independent myb activity. |
1996-06-12 |
2023-08-12 |
human |
| M Selvakumaran, H K Lin, R T Sjin, J C Reed, D A Liebermann, B Hoffma. The novel primary response gene MyD118 and the proto-oncogenes myb, myc, and bcl-2 modulate transforming growth factor beta 1-induced apoptosis of myeloid leukemia cells. Molecular and cellular biology. vol 14. issue 4. 1994-04-28. PMID:8139540. |
the novel primary response gene myd118 and the proto-oncogenes myb, myc, and bcl-2 modulate transforming growth factor beta 1-induced apoptosis of myeloid leukemia cells. |
1994-04-28 |
2023-08-12 |
Not clear |