| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thi-Luu Ho, Chinmaya Mutalik, Lekshmi Rethi, Huynh-Ngoc Truc Nguyen, Pei-Ru Jheng, Chin-Chean Wong, Tzu-Sen Yang, Thi Thuy Nguyen, Bradley W Mansel, Chen-An Wang, Er-Yuan Chuan. Cancer-targeted fucoidan\\xe2\\x80\\x91iron oxide nanoparticles for synergistic chemotherapy/chemodynamic theranostics through amplification of P-selectin and oxidative stress. International journal of biological macromolecules vol issue 2023 36870633 |
moreover, fu-io nps induced efficient apoptosis of lung cancer cells, and thus offer significant anti-cancer functions by potential chemotherapeutic-cdt. |
2023-03-04 |
2023-03-06 |
Not clear |
| Liangliang Xiang, Yun Li, Xinyu Gu, Shujie Li, Junwei Li, Jinlong Li, Yongxiang Y. Nucleolin recognizing silica nanoparticles inhibit cell proliferation by activating the Bax/Bcl-2/caspase-3 signalling pathway to induce apoptosis in liver cancer. Frontiers in pharmacology vol 14 issue 2023 36843953 |
in addition, atp-msn (ict@fitc) nps can not only inhibit cell proliferation but also improve the level of ros while activating the bax/bcl-2/caspase-3 signalling pathway to induce apoptosis |
2023-02-27 |
2023-03-06 |
Not clear |
| Peter Tak\\xc3\\xa1\\xc4\\x8d, Radka Michalkov\\xc3\\xa1, Martina \\xc4\\x8ci\\xc5\\xbem\\xc3\\xa1rikov\\xc3\\xa1, Zdenka Bedlovi\\xc4\\x8dov\\xc3\\xa1, \\xc4\\xbdudmila Bal\\xc3\\xa1\\xc5\\xbeov\\xc3\\xa1, Gabriela Tak\\xc3\\xa1\\xc4\\x8dov\\xc3\\xa. The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future? Life (Basel, Switzerland) vol 13 issue 2 2023 36836823 |
it has been documented that, in cancer cells, nps promote reactive oxygen species (ros) production, induce cell cycle arrest and apoptosis, activate er (endoplasmic reticulum) stress, modulate various signaling pathways, etc. |
2023-02-25 |
2023-03-06 |
Not clear |
| Junyu Chen, Liucheng Mao, Yuming Jiang, Huihui Liu, Xiao Wang, Lingwei Meng, Qiuyao Du, Jing Han, Liuying He, Hongye Huang, Yawei Wang, Caiqiao Xiong, Yen Wei, Zongxiu Ni. Revealing the In Situ Behavior of Aggregation-Induced Emission Nanoparticles and Their Biometabolic Effects via Mass Spectrometry Imaging. ACS nano vol issue 2023 36802559 |
moreover, spatial-selective metabolic changes upon nps mediated photodynamic therapy was identified, which enables understanding of the nps induced apoptosis in the process of cancer therapy. |
2023-02-21 |
2023-03-06 |
Not clear |
| Nasrin Ziamajidi, Sajedeh Daei, Maryam Khajvand-Abedini, Roghayeh Abbasalipourkabir, Alireza Nouria. Vitamins A, C, and E Exert Anti-apoptotic Function in the Testis of Rats After Exposure to Zinc Oxide Nanoparticles. Chonnam medical journal vol 59 issue 1 2023 36794239 |
to this aim, a population of 54 healthy, male wistar rats were used in this work and then assigned into nine groups of 6 rats as g1: control 1 (water); g2: control 2 (olive oil); g3: va (1000 iu/kg), g4: vc (200 mg/kg), g5: ve (100 iu/kg), g6: zno nps exposed animals (200 mg/kg); and g7, 8 and 9: zno nps-exposed animals that were pre-treated with either va, c, or e. apoptosis rates were estimated by measuring the level of apoptotic regulatory markers including bcl-2-associated x (bax) and b-cell lymphoma protein 2 (bcl-2) using western blotting and qrt-pcr assays. |
2023-02-16 |
2023-03-06 |
rat |
| Sajmina Khatun, Monika Pebam, Chandra Lekha Putta, Aravind Kumar Renga. Camptothecin loaded casein nanosystem for tuning the therapeutic efficacy against highly metastatic triple-negative breast cancer cells. Biomaterials science vol issue 2023 36779378 |
enhanced uptake of ccs nps in zebrafish embryos and 4t1 cells, cancer cell toxicity of nearly 80-85%, sub-cellular mitochondrial localization, alterations of mitochondrial membrane potential, lysosomal localization, and reactive oxygen species generation that causes cancer cell apoptosis have been observed. |
2023-02-13 |
2023-03-06 |
zebrafish |
| Jingtong Zhao, Xupeng Mu, Xuejia Hou, Xiaowen Zhang, Ping Li, Jinlan Jian. Synergistic treatment of osteosarcoma with biomimetic nanoparticles transporting doxorubicin and siRNA. Frontiers in oncology vol 13 issue 2023 36756155 |
to make chemotherapy safer and more effective for osteosarcoma patients, biomimetic nanoparticles (nps) camouflaged by mesenchymal stem cell membranes (mscms) were synthesized to induce osteosarcoma cell apoptosis by co-delivering the anticancer drug doxorubicin hydrochloride(dox) and a small interfering rna (sirna). |
2023-02-09 |
2023-03-06 |
Not clear |
| Sitong Liu, Chen Zhang, Yuanyuan Zhou, Fang Zhang, Xiaohui Duan, Yang Liu, Xibang Zhao, Jie Liu, Xintao Shuai, Jiali Wang, Zhong Ca. MRI-visible mesoporous polydopamine nanoparticles with enhanced antioxidant capacity for osteoarthritis therapy. Biomaterials vol 295 issue 2023 36758340 |
a series of in vitro studies showed that the sustained release of dex from damm nps suppressed synovial inflammation and simultaneously inhibited toll-like receptor 3 (tlr-3) production in chondrocytes, contributing to prevention of chondrocyte apoptosis through the inflammatory factor-dependent tlr-3/nf-\xce\xbab signaling pathway via modulation of macrophage-chondrocyte crosstalk. |
2023-02-09 |
2023-03-06 |
mouse |
| Yi Yan, An Lu, Yun Dou, Zhen Zhang, Xiang-Yu Wang, Lin Zhai, Li-Ya Ai, Ming-Ze Du, Lin-Xia Jiang, Yuan-Jun Zhu, Yu-Jie Shi, Xiao-Yan Liu, Dong Jiang, Jian-Cheng Wan. Nanomedicines Reprogram Synovial Macrophages by Scavenging Nitric Oxide and Silencing CA9 in Progressive Osteoarthritis. Advanced science (Weinheim, Baden-Wurttemberg, Germany) vol issue 2023 36748885 |
in vitro experiments demonstrate that these nps can significantly scavenge intracellular no similar to the levels as those in the normal group and downregulate the expression levels of ca9 mrna (\xe2\x89\x8890%), thereby repolarizing the m1 macrophages into the m2 phenotype and increasing the expression levels of pro-chondrogenic tgf-\xce\xb21 mrna (\xe2\x89\x881.3-fold), and inhibiting chondrocyte apoptosis. |
2023-02-07 |
2023-03-06 |
rat |
| Jing Li, Yi-Fei Wang, Zi-Chun Shen, Qi Zou, Xiao-Fan Lin, Xiao-Yin Wan. Recent developments on natural polysaccharides as potential anti-gastric cancer substance: Structural feature and bioactivity. International journal of biological macromolecules vol issue 2023 36706878 |
nps exhibited anti-gc activities in cell and animal experiments as well as clinical trials, and the mechanisms might be anti-proliferation, inducing apoptosis, anti-metastasis and anti-invasion, inducing autophagy, boosting immunity, anti-angiogenesis, reducing drug resistance, anti-angiogenesis, improving antioxidant level and changing metabolites. |
2023-01-27 |
2023-01-31 |
human |
| Shenglong Xia, Zimo Liu, Jieru Cai, Huiming Ren, Qi Li, Hongfang Zhang, Jing Yue, Quan Zhou, Tianhua Zhou, Liangjing Wang, Xiangrui Liu, Xuefei Zho. Liver fibrosis therapy based on biomimetic nanoparticles which deplete activated hepatic stellate cells. Journal of controlled release : official journal of the Controlled Release Society vol issue 2023 36693527 |
non-coated nps loaded with atra) only showed the ability to induce apoptosis and decrease the \xce\xb1-sma expression in ahscs, respectively, tm-atra/nps induced both apoptosis and quiescence in ahscs, ultimately leading to improved fibrosis amelioration in both carbon tetrachloride-induced and methionine and choline deficient l-amino acid diet induced liver fibrosis mouse models. |
2023-01-24 |
2023-01-31 |
mouse |
| Chen Zhang, Wu Zhong, Ying Cao, Bohao Liu, Xiaojun Tao, Zhuan L. Sorafenib/2800Z Co-Loaded into Cholesterol and PEG Grafted Polylysine NPs for Liver Cancer Treatment. Pharmaceuticals (Basel, Switzerland) vol 16 issue 1 2023 36678616 |
in addition, s2@pspc nps inhibited the proliferation and induced apoptosis of liver cancer cells in vitro. |
2023-01-21 |
2023-01-30 |
Not clear |
| Afraa Ali Kadhim, Nahida R Abbas, Hussam H Kadhum, Salim Albukhaty, Majid S Jabir, Amel Muhson Naji, Sawsan S Hamzah, Mustafa K A Mohammed, Hassan Al-Karagol. Investigating the Effects of Biogenic Zinc Oxide Nanoparticles Produced Using Papaver somniferum Extract on Oxidative Stress, Cytotoxicity, and the Induction of Apoptosis in the THP-1 Cell Line. Biological trace element research vol issue 2023 36662347 |
this study investigated the effect of novel zinc oxide nanoparticles (zno nps) biosynthesized employing papaver somniferum leaf on oxidative stress, necrosis, and apoptosis in the leukemia cancer thp-1 cell. |
2023-01-20 |
2023-01-30 |
Not clear |
| Afraa Ali Kadhim, Nahida R Abbas, Hussam H Kadhum, Salim Albukhaty, Majid S Jabir, Amel Muhson Naji, Sawsan S Hamzah, Mustafa K A Mohammed, Hassan Al-Karagol. Investigating the Effects of Biogenic Zinc Oxide Nanoparticles Produced Using Papaver somniferum Extract on Oxidative Stress, Cytotoxicity, and the Induction of Apoptosis in the THP-1 Cell Line. Biological trace element research vol issue 2023 36662347 |
thp-1 cells were subjected to an mtt, an edu proliferation, a lactate dehydrogenase release tests, a reactive oxygen species (ros) induction experiment, a dapi staining detection assay, and a flow cytometric analysis for annexin v to measure the effects of zno nps on cancer cell growth inhibition, apoptosis, and necrosis. |
2023-01-20 |
2023-01-30 |
Not clear |
| Afraa Ali Kadhim, Nahida R Abbas, Hussam H Kadhum, Salim Albukhaty, Majid S Jabir, Amel Muhson Naji, Sawsan S Hamzah, Mustafa K A Mohammed, Hassan Al-Karagol. Investigating the Effects of Biogenic Zinc Oxide Nanoparticles Produced Using Papaver somniferum Extract on Oxidative Stress, Cytotoxicity, and the Induction of Apoptosis in the THP-1 Cell Line. Biological trace element research vol issue 2023 36662347 |
it was observed that zno nps triggered necrosis (cell death) and apoptosis in the cell line. |
2023-01-20 |
2023-01-30 |
Not clear |
| Yuanyuan He, Raimundo Fernandes de Ara\\xc3\\xbajo J\\xc3\\xbanior, R\\xc3\\xb4mulo S Cavalcante, Zhenfeng Yu, Timo Schomann, Zili Gu, Christina Eich, Luis J Cru. Effective breast cancer therapy based on palmitic acid-loaded PLGA nanoparticles. Biomaterials advances vol 145 issue 2023 36603405 |
at the molecular level, plga-pa nps reduced the expression of genes associated with multi-drug resistance and inhibition of apoptosis, and induced apoptosis via a caspase-3-independent pathway in breast cancer cells. |
2023-01-05 |
2023-01-30 |
mouse |
| Quan Sun, Hongqin Ma, Jiaxiong Zhang, Baiyang You, Xiaohui Gong, Xiaolin Zhou, Jin Chen, Guogang Zhang, Jia Huang, Qiong Huang, Yurong Yang, Kelong Ai, Yongping Ba. A Self-Sustaining Antioxidant Strategy for Effective Treatment of Myocardial Infarction. Advanced science (Weinheim, Baden-Wurttemberg, Germany) vol issue 2022 36567266 |
the therapeutic mechanism of ssse nps is intensively investigated through a series of experiments and mainly involved five critical aspects of myocardial repair: protecting mitochondria, reducing cardiomyocyte apoptosis and ferroptosis, reducing inflammation and fibrosis, and promoting angiogenesis. |
2022-12-25 |
2023-01-30 |
Not clear |
| Meimei Wang, Yu Feng, Zhenxiao Cao, Na Yu, Juan Wang, Xiaowei Wang, Dixiang Kang, Mingqin Su, Jian Hu, Hua D. Multiple generation exposure to ZnO nanoparticles induces loss of genomic integrity in Caenorhabditis elegans. Ecotoxicology and environmental safety vol 249 issue 2022 36508841 |
we observed that pristine zno nps elicit germ cell apoptosis to a greater extent than the 60-day aged zno nps. |
2022-12-12 |
2023-01-30 |
caenorhabditis_elegans |
| Han Wang, Yilan Wu, Xiaoyan Li. Crizotinib loaded polydopamine-polylactide-TPGS nanoparticles in targeted therapy for non-small cell lung cancer. Medical oncology (Northwood, London, England) vol 40 issue 1 2022 36459216 |
czt/pd-pt nps were synthesized and characterized, and their effects on pc-9 cell viability and apoptosis were determined. |
2022-12-02 |
2023-01-30 |
Not clear |
| Han Wang, Yilan Wu, Xiaoyan Li. Crizotinib loaded polydopamine-polylactide-TPGS nanoparticles in targeted therapy for non-small cell lung cancer. Medical oncology (Northwood, London, England) vol 40 issue 1 2022 36459216 |
tunel assay and western blot were respectively applied for the determination of cell apoptosis and apoptosis-related protein expression, while liver function-related index expression detection and liver histopathological detection were used to evaluate the hepatotoxicity of czt/pd-pt nps. |
2022-12-02 |
2023-01-30 |
Not clear |