Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Krishan Kumar, Shiv Govind Rawat, Manjit, Mohini Mishra, Priya, Ajay Kumar, Ruchi Chawl. Dual targeting pH responsive chitosan nanoparticles for enhanced active cellular internalization of gemcitabine in non-small cell lung cancer. International journal of biological macromolecules. 2023-07-31. PMID:37524283. |
in vitro cytotoxicity of nps quantified using cell based mtt, dapi and annexing-v/pi apoptosis assays showed superior antiproliferative activity of targeted nanoformulations (gmc-csn-sa-cxmab-nps ≫ gmc-csn-sa-nps, gmc-csn-cxmab-nps) over non-targeted nanoformulation (gmc-csn-nps) against a-549 cells. |
2023-07-31 |
2023-08-14 |
mouse |
Eunsol Lee, Eun Seong Le. Development of pH-Responsive Hyaluronic Acid-Conjugated Cyclodextrin Nanoparticles for Chemo-/CO-Gas Dual Therapy. Pharmaceutics. vol 15. issue 7. 2023-07-29. PMID:37514005. |
in vitro studies using mcf-7 tumor cells demonstrated that these nps were efficiently internalized by the cells expressing cd44 receptors and enhanced ptx/feco-mediated tumor cell apoptosis. |
2023-07-29 |
2023-08-14 |
Not clear |
Pu Yao, Xiaowen Wang, Qianmei Wang, Qing Dai, Yu Peng, Qian Yuan, Nan Mou, Shan Lv, Bangbi Weng, Yu Wang, Fengjun Su. Cyclic RGD-Functionalized pH/ROS Dual-Responsive Nanoparticle for Targeted Breast Cancer Therapy. Pharmaceutics. vol 15. issue 7. 2023-07-29. PMID:37514014. |
in vitro cellular assays verified that dtx/rgd nps could be effectively internalized by 4t1 cells, obviously inducing apoptosis, blocking the cell cycle of 4t1 cells and consequently, killing tumor cells. |
2023-07-29 |
2023-08-14 |
mouse |
Paola Trinidad Villalobos Gutiérrez, José Luis Muñoz Carrillo, Cuauhtémoc Sandoval Salazar, Juan Manuel Viveros Paredes, Oscar Gutiérrez Coronad. Functionalized Metal Nanoparticles in Cancer Therapy. Pharmaceutics. vol 15. issue 7. 2023-07-29. PMID:37514119. |
these nps can penetrate the cell and accumulate in the tumor tissue, resulting in a cytotoxic effect through the generation of ros, the induction of apoptosis, cell cycle arrest, dna fragmentation, and a photothermal effect. |
2023-07-29 |
2023-08-14 |
Not clear |
Fatemeh Ghorbanzadeh, Davoud Jafari-Gharabaghlou, Mohammad Reza Dashti, Mehrdad Hashemi, Nosratollah Zargham. Advanced nano-therapeutic delivery of metformin: potential anti-cancer effect against human colon cancer cells through inhibition of GPR75 expression. Medical oncology (Northwood, London, England). vol 40. issue 9. 2023-07-29. PMID:37515667. |
additionally, an apoptosis assay was conducted to assess the effect of free metf and metf-loaded nps on the programmed death of the caco2 cells, and the impact on the cell cycle was studied through a cell cycle test. |
2023-07-29 |
2023-08-14 |
human |
Ramsés Santacruz-Márquez, Jodi A Flaws, Luz Del Carmen Sánchez-Peña, Isabel Hernández-Ocho. Exposure to Zinc Oxide Nanoparticles Increases Estradiol Levels and Induces an Antioxidant Response in Antral Ovarian Follicles In Vitro. Toxics. vol 11. issue 7. 2023-07-28. PMID:37505567. |
antral follicles from cd-1 mice were cultured with zno nps (5, 10, and 15 µg/ml) for 96 h. zno np exposure did not affect apoptosis and cell cycle regulators at any of the tested concentrations. |
2023-07-28 |
2023-08-14 |
mouse |
Reza Malekzadeh, Tohid Mortezazadeh, Waleed K Abdulsahib, Behnaz Babaye Abdollahi, Michael R Hamblin, Behzad Mansoori, Fahad Alsaikhan, Bo Zen. Nanoarchitecture-based photothermal ablation of cancer: A systematic review. Environmental research. 2023-07-24. PMID:37487920. |
the presence of nps during ptt can increase the reactive generation of oxygen species, damage the dna and mitochondria, leading to cancer cell death mainly via apoptosis. |
2023-07-24 |
2023-08-14 |
Not clear |
Lihui Xuan, Zhao Ju, Magdalena Skonieczna, Ping-Kun Zhou, Ruixue Huan. Nanoparticles-induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models. MedComm. vol 4. issue 4. 2023-07-17. PMID:37457660. |
furthermore, we unravels the underlying mechanisms of nps including ros accumulation, mitochondrial damage, inflammatory reaction, apoptosis, dna damage, cell cycle, and epigenetic regulation. |
2023-07-17 |
2023-08-14 |
mouse |
Aifen Liu, Jingyan Hu, Tzu-Shao Yeh, Chengniu Wang, Jilong Tang, Xiaohong Huang, Bin Chen, Liexiang Huangfu, Weili Yu, Lei Zhan. Neuroprotective Strategies for Stroke by Natural Products: Advances and Perspectives. Current neuropharmacology. 2023-07-17. PMID:37458258. |
then we propose the comprehensive neuroprotective mechanism of nps in cerebral ischemic stroke, which involves complex cascade processes of oxidative stress, mitochondrial damage, apoptosis or ferroptosis-related cell death, inflammatory response, and disruption of the blood- brain barrier (bbb). |
2023-07-17 |
2023-08-14 |
Not clear |
Eda Argitekin, Esra Ersoz-Gulseven, Gulcin Cakan-Akdogan, Yasar Akdoga. Dopamine-Conjugated Bovine Serum Albumin Nanoparticles Containing pH-Responsive Catechol-V(III) Coordination for In Vitro and In Vivo Drug Delivery. Biomacromolecules. 2023-07-14. PMID:37450837. |
it was shown that d-bsa nps entered cancerous mcf-7 cells (66%) more efficiently than non-cancerous hek293t (33%) in 3 h. also, dox-loaded nps reduced cell viability of mcf-7 by 75% and induced apoptosis in a majority of cells after 24 h. biodegradability and lack of hemolytic activity were shown in vitro, whereas a lack of toxicity was shown in histological sections of zebrafish. |
2023-07-14 |
2023-08-14 |
cattle |
Suresh Mickymaray, Mohammed Saleh Al Aboody, Mostafa M Eraqi, Wardha A Alhoqail, Abdulaziz S Alothaim, Kaviya Suresh, Palanisamy Arulselva. Chitosan-encapsulated nickel oxide, tin dioxide, and farnesol nanoparticles: Antimicrobial and anticancer properties in breast cancer cells. International journal of biological macromolecules. 2023-07-14. PMID:37451381. |
the findings suggest that nps increased the number of reactive oxygen species (ros), changed the Δψm, and initiated apoptosis. |
2023-07-14 |
2023-08-14 |
Not clear |
Asif Mohd Itoo, Milan Paul, Balaram Ghosh, Swati Biswa. Polymeric graphene oxide nanoparticles loaded with doxorubicin for combined photothermal and chemotherapy in triple negative breast cancer. Biomaterials advances. vol 153. 2023-07-12. PMID:37437383. |
the results demonstrated that the dox@go(mpp) (1/0.5) nps treatment with laser (+l) (808 nm) was highly efficient in inducing apoptosis, cell cycle arrest (g2/m) phase, significant cytotoxicity, mitochondrial membrane depolarization, ros generation, and photothermal effect leading to a higher proportion of cell death than free dox, and dox@go(mpp) (1/0.5) nps (-l). |
2023-07-12 |
2023-08-14 |
mouse |
Abhishesh Kumar Mehata, Virendra Singh, Vikas, Nitesh Singh, Abhijit Mandal, Debabrata Dash, Biplob Koch, Madaswamy S Muth. Chitosan- ACS applied materials & interfaces. 2023-07-11. PMID:37433149. |
the nanoparticles (nps) were prepared by solvent evaporation using the ionic gelation method and characterized for particle size, zeta potential, polydispersity, surface morphology, surface chemistry, drug entrapment efficiency, cytotoxicity assay, cellular uptake, and apoptosis study. |
2023-07-11 |
2023-08-14 |
Not clear |
De-Ping Wang, Jian Zheng, Fang-Ying Jiang, Li-Fei Wu, Mei-Yue Wang, Yu-Lan Wang, Chuan-Yue Qin, Jun-Ya Ning, Ji-Min Cao, Xin Zho. Facile and green fabrication of tumor- and mitochondria-targeted AIEgen-protein nanoparticles for imaging-guided photodynamic cancer therapy. Acta biomaterialia. 2023-07-06. PMID:37414113. |
the nps also presented a mitochondria-targeting ability, and efficiently generated reactive oxygen species (ros) upon visible light irradiation, making them valuable for inducing efficient mitochondrial dysfunction and intrinsic apoptosis in cancer cells. |
2023-07-06 |
2023-08-14 |
human |
Yuanying Zhang, Nan Yang, Ziyi Dong, Jiahui Wu, Rui Liao, Yanling Zhang, Gege Zhang, Mengfei Ren, Feng Wang, Xiaochen Dong, Pingping Lian. Dual-Targeting Biomimetic Nanomaterials for Photo-/Chemo-/Antiangiogenic Synergistic Therapy. ACS applied materials & interfaces. 2023-07-03. PMID:37400422. |
the mbpp nps exhibit high biocompatibility, superb phototoxicity, excellent antiangiogenic ability, and double-trigging cancer cell apoptosis in vitro. |
2023-07-03 |
2023-08-14 |
Not clear |
Xia Cao, Tianwen Deng, Qin Zhu, Jianping Wang, Wenwan Shi, Qi Liu, Qintong Yu, Wenwen Deng, Jiangnan Yu, Qilong Wang, Gao Xiao, Ximing X. Photothermal Therapy Mediated Hybrid Membrane Derived Nano-formulation for Enhanced Cancer Therapy. AAPS PharmSciTech. vol 24. issue 6. 2023-06-28. PMID:37380936. |
compared to the normal section, pdt-mediated eg@emhm nps could induce an early stage of apoptosis of b16. |
2023-06-28 |
2023-08-14 |
Not clear |
Fan Zhao, Hongyan Yu, Liying Liang, Chen Wang, Dier Shi, Xiangyu Zhang, Yao Ying, Wei Cai, Wangchang Li, Juan Li, Jingwu Zheng, Liang Qiao, Shenglei Che, Jing Y. Redox Homeostasis Disruptors Based on Metal-Phenolic Network Nanoparticles for Chemo/Chemodynamic Synergistic Tumor Therapy Through Activating Apoptosis and Cuproptosis. Advanced healthcare materials. 2023-06-27. PMID:37369362. |
herein, metal-phenolic network nanoparticles (nps) self-assembled from copper ions and gallic acid (cu-ga) are developed to evoke apoptosis and cuproptosis for synergistic chemo/chemodynamic therapy. |
2023-06-27 |
2023-08-14 |
Not clear |
Kexin Zhang, Jiaxin Zhu, Ruyi Wang, Wanfang Zhu, Zhongtao Zhang, Liangping Gong, Feng Feng, Wenyuan Liu, Lingfei Han, Wei Q. Mitochondria-Anchoring Self-assembled Nanoparticles for Multi-Path Energy Depletion: A "Nano Bomb" in Chemo-co-Starvation Therapy. International journal of pharmaceutics. 2023-06-26. PMID:37364784. |
besides, apoptosis via mitochondria pathway and mitochondria fragmentation supported the hypothesis that nps eliminated mda-mb-231 cells by violently attacking mda-mb-231 cells and especially the mitochondria. |
2023-06-26 |
2023-08-14 |
Not clear |
Zhuoting Lu, Jingyu Li, Baohong Chen, Jiayu Feng, Qinglian Hu, Yuanxiang Jin, Zhengwei F. Mitochondria Targeted Nanoparticles Potentiate Tumor Chemo-Phototherapy by Toxic Oxidative Stress Mediated Oxeiptosis. Macromolecular bioscience. 2023-06-09. PMID:37295777. |
also, m-icg-ptx nps exhibited higher tumor growth inhibition ability by promoting cell apoptosis and oxeiptosis pathway, and high effective inhibition of primary tumor growth and tumor metastasis. |
2023-06-09 |
2023-08-14 |
Not clear |
Chenxi Zhu, Wenzong Zhou, Mingming Han, Ying Yang, Yiming Li, Qichen Jiang, Weiwei L. Dietary polystyrene nanoplastics exposure alters hepatic glycolipid metabolism, triggering inflammatory responses and apoptosis in Monopterus albus. The Science of the total environment. 2023-05-29. PMID:37247739. |
overexpression of the cytokines genes interleukin 1 (il1b) and interleukin-8 (il8), tumor necrosis factor alpha (tnf-α), activation of mapk signaling pathway, and increased gene expression of c-jun amino-terminal kinases (jnk) and p38 indicate that exposure to nps may lead to hepatopancreas apoptosis through oxidative stress and inflammation. |
2023-05-29 |
2023-08-14 |
cat |