| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jia Meng Pang, Po-Chen Chien, Ming-Chien Kao, Pei-Yun Chiu, Pin-Xu Chen, Yu-Ling Hsu, Chengyang Liu, Xiaowei Liang, Kai-Ti Li. MicroRNA-708 emerges as a potential candidate to target undruggable NRAS. PloS one. vol 18. issue 4. 2023-04-21. PMID:37083947. |
overexpression of mirna-708 successfully reduced nras protein levels in melanoma, leukemia, and lung cancer cell lines with nras mutations, resulting in suppressed cell proliferation, anchorage-independent growth, and promotion of reactive oxygen species-induced apoptosis. |
2023-04-21 |
2023-08-14 |
Not clear |
| Sowjanya Thatikonda, Venkatesh Pooladanda, Ramya Tokala, Nagula Shankaraiah, Chandraiah Godug. Niclosamide inhibits epithelial-mesenchymal transition with apoptosis induction in BRAF/ NRAS mutated metastatic melanoma cells. Toxicology in vitro : an international journal published in association with BIBRA. 2023-03-04. PMID:36870549. |
niclosamide inhibits epithelial-mesenchymal transition with apoptosis induction in braf/ nras mutated metastatic melanoma cells. |
2023-03-04 |
2023-08-14 |
Not clear |
| Retraction. Cancer medicine. 2022-09-09. PMID:36081336. |
retraction: 'effects of mir-145-5p through nras on the cell proliferation, apoptosis, migration, and invasion in melanoma by inhibiting mapk and pi3k/akt pathways,' sha liu, guozhen gao, dexiong yan, xiangjun chen, xingwei yao, shuzhong guo, guirong li, yu zhao, cancer medicine. |
2022-09-09 |
2023-08-14 |
Not clear |
| Retraction: Huang, L., Wang, L., Wang, L., Wu, Z., Jiang, F., Li, Q., & Wang, S. MicroRNA let-7b Inhibits Proliferation and Induces Apoptosis of Castration-Resistant Prostate Cancer Cells by Blocking the Ras/Rho Signaling Pathway via NRAS, Clin. Trans. Sci. https://ascpt.onlinelibrary.wiley.com/doi/full/10.1111/cts.12743. Clinical and translational science. vol 15. issue 2. 2022-02-14. PMID:35156320. |
retraction: huang, l., wang, l., wang, l., wu, z., jiang, f., li, q., & wang, s. microrna let-7b inhibits proliferation and induces apoptosis of castration-resistant prostate cancer cells by blocking the ras/rho signaling pathway via nras, clin. |
2022-02-14 |
2023-08-13 |
Not clear |
| Retracted: MicroRNA let-7b Inhibits Proliferation and Induces Apoptosis of Castration-Resistant Prostate Cancer Cells by Blocking the Ras/Rho Signaling Pathway via NRAS. Clinical and translational science. vol 14. issue 5. 2021-11-03. PMID:32043299. |
retracted: microrna let-7b inhibits proliferation and induces apoptosis of castration-resistant prostate cancer cells by blocking the ras/rho signaling pathway via nras. |
2021-11-03 |
2023-08-13 |
Not clear |
| Retracted: MicroRNA let-7b Inhibits Proliferation and Induces Apoptosis of Castration-Resistant Prostate Cancer Cells by Blocking the Ras/Rho Signaling Pathway via NRAS. Clinical and translational science. vol 14. issue 5. 2021-11-03. PMID:32043299. |
retraction: huang, l., wang, l., wang, l., wu, z., jiang, f., li, q., & wang, s. microrna let-7b inhibits proliferation and induces apoptosis of castration-resistant prostate cancer cells by blocking the ras/rho signaling pathway via nras, clin. |
2021-11-03 |
2023-08-13 |
Not clear |
| Joshua Miguel C Danac, Reynaldo L Garci. CircPVT1 attenuates negative regulation of NRAS by let-7 and drives cancer cells towards oncogenicity. Scientific reports. vol 11. issue 1. 2021-10-27. PMID:33907219. |
circpvt1 knockdown significantly reduced nras levels and attenuated cancer hallmark phenotypes such as proliferation, migration, resistance to apoptosis, cytoskeletal disorganization, and epithelial-mesenchymal transition. |
2021-10-27 |
2023-08-13 |
Not clear |
| David G Covel. Bioinformatic analysis linking genomic defects to chemosensitivity and mechanism of action. PloS one. vol 16. issue 4. 2021-09-13. PMID:33909629. |
the results of this analysis find a relatively small set of defective genes, inclusive of abl1, axl, braf, cdc25a, cdkn2a, igf1r, kras, mecom, mmp1, myc, notch1, nras, pik3cg, ptk2, rptor, sptbn1, stat2, tnks and zhx2, as possible candidates for roles in chemosensitivity for compound moas that target primarily, but not exclusively, kinases, nucleic acid synthesis, protein synthesis, apoptosis and tubulin. |
2021-09-13 |
2023-08-13 |
Not clear |
| Maedeh Yousefi, Maryam Koopaie, Roya Karimi, Farzad Mehrabipanah Kermani, Sajad Kolahdooz, Ahmadreza Shamshir. Effect of photodynamic therapy on expression of HRAS, NRAS and caspase 3 genes at mRNA levels, apoptosis of head and neck squamous cell carcinoma cell line. Photodiagnosis and photodynamic therapy. vol 33. 2021-05-14. PMID:33307231. |
effect of photodynamic therapy on expression of hras, nras and caspase 3 genes at mrna levels, apoptosis of head and neck squamous cell carcinoma cell line. |
2021-05-14 |
2023-08-13 |
Not clear |
| Maedeh Yousefi, Maryam Koopaie, Roya Karimi, Farzad Mehrabipanah Kermani, Sajad Kolahdooz, Ahmadreza Shamshir. Effect of photodynamic therapy on expression of HRAS, NRAS and caspase 3 genes at mRNA levels, apoptosis of head and neck squamous cell carcinoma cell line. Photodiagnosis and photodynamic therapy. vol 33. 2021-05-14. PMID:33307231. |
this study aimed to assess the effect of photodynamic therapy (pdt) on expression of casp3, nras and hras genes at mrna levels, and apoptosis of head and neck squamous cell carcinoma (hnscc) cell line. |
2021-05-14 |
2023-08-13 |
Not clear |
| Ryan Timothy D Yu, Reynaldo L Garci. NRAS mutant E132K identified in young-onset sporadic colorectal cancer and the canonical mutants G12D and Q61K affect distinct oncogenic phenotypes. Scientific reports. vol 10. issue 1. 2020-12-08. PMID:32620824. |
the novel nras mutant e132k and the canonical g12d and q61k mutants show resistance to apoptosis, cytoskeletal reorganization, and loss of adhesion. |
2020-12-08 |
2023-08-13 |
Not clear |
| Xiaoyan Liu, Yu Zhang, Su Wang, Guoying Liu, Liming Rua. Loss of miR-143 and miR-145 in condyloma acuminatum promotes cellular proliferation and inhibits apoptosis by targeting NRAS. Royal Society open science. vol 5. issue 8. 2020-09-30. PMID:30225000. |
loss of mir-143 and mir-145 in condyloma acuminatum promotes cellular proliferation and inhibits apoptosis by targeting nras. |
2020-09-30 |
2023-08-13 |
human |
| Xiaoyan Liu, Yu Zhang, Su Wang, Guoying Liu, Liming Rua. Loss of miR-143 and miR-145 in condyloma acuminatum promotes cellular proliferation and inhibits apoptosis by targeting NRAS. Royal Society open science. vol 5. issue 8. 2020-09-30. PMID:30225000. |
transduction of lv-pre-mir-143 or lv-pre-mir-145 to human papilloma virus (hpv)-infected siha cells led to reduced proliferation, greater apoptosis and inhibition of expression of nras, pi3 k p110 |
2020-09-30 |
2023-08-13 |
human |
| Krizelle Mae M Alcantara, Joshua Reginald P Malapit, Ryan Timothy D Yu, Jose Antonio Ma G Garrido, John Paul T Rigor, Arlou Kristina J Angeles, Eva Maria Cutiongco-de la Paz, Reynaldo L Garci. Non-Redundant and Overlapping Oncogenic Readouts of Non-Canonical and Novel Colorectal Cancer KRAS and NRAS Mutants. Cells. vol 8. issue 12. 2020-08-03. PMID:31816869. |
hct116 cells transfected with the novel nras a11v and the canonical nras g12d, but not the kras mutants, display enhanced resistance to apoptosis. |
2020-08-03 |
2023-08-13 |
mouse |
| Abdullah Al Emran, Brinda Reddy Chinna Chowdary, Farzana Ahmed, Heinz Hammerlindl, Antje Huefner, Nikolas K Haass, Wolfgang Schuehly, Helmut Schaide. Magnolol induces cell death through PI3K/Akt-mediated epigenetic modifications boosting treatment of BRAF- and NRAS-mutant melanoma. Cancer medicine. vol 8. issue 3. 2020-04-16. PMID:30793515. |
here, we show that magnolol, a constituent of magnolia officinalis, induced g1 arrest, apoptosis and cell death in braf- and nras-mutant melanoma cells at low concentration, with no effect in braf- and nras wild-type melanoma cells and human keratinocytes. |
2020-04-16 |
2023-08-13 |
human |
| Hanna Cho, Injae Shin, Eunhye Ju, Seunghye Choi, Wooyoung Hur, Haelee Kim, Eunmi Hong, Nam Doo Kim, Hwan Geun Choi, Nathanael S Gray, Taebo Si. First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia. Journal of medicinal chemistry. vol 61. issue 18. 2019-10-14. PMID:30153003. |
these substances strongly suppress proliferation of mutant nras expressing aml cells via apoptosis and akt/mtor signaling blockade. |
2019-10-14 |
2023-08-13 |
mouse |
| I S Abramov, M A Emelyanova, O O Ryabaya, G S Krasnov, A S Zasedatelev, T V Nasedkin. [Somatic Mutations Associated with Metastasis in Acral Melanoma]. Molekuliarnaia biologiia. vol 53. issue 4. 2019-10-04. PMID:31397438. |
somatic mutations were found in genes related to cell division, proliferation, and apoptosis (braf, nras, vav1, gata1, and gcm2); cell adhesion (ctnnd2 and itgb4); angiogenesis (vegfa); and the regulation of energy metabolism (bcs1l). |
2019-10-04 |
2023-08-13 |
Not clear |
| Sofía Jerez, Héctor Araya, Daniel Hevia, Carlos E Irarrázaval, Roman Thaler, Andre J van Wijnen, Mario Galind. Extracellular vesicles from osteosarcoma cell lines contain miRNAs associated with cell adhesion and apoptosis. Gene. vol 710. 2019-07-22. PMID:31176732. |
gene ontology analysis of predicted targets reveals that mirnas present in evs may regulate the metastatic potential of osteosarcoma cell lines by potentially inhibiting a network of genes (e.g., mapk1, nras, frs2, prcke, bcl2 and qki) involved in apoptosis and/or cell adhesion. |
2019-07-22 |
2023-08-13 |
human |
| Nadezda Dolgikh, Manuela Hugle, Meike Vogler, Simone Fuld. Cancer research. vol 78. issue 8. 2019-07-01. PMID:29437705. |
here, we report that coinhibition of nras or mek plus pi3kα triggers widespread apoptosis in |
2019-07-01 |
2023-08-13 |
Not clear |
| Michael K Kießling, Jan P Nicolay, Tabea Schlör, Claus-Detlev Klemke, Dorothee Süss, Peter H Krammer, Karsten Gülo. NRAS mutations in cutaneous T cell lymphoma (CTCL) sensitize tumors towards treatment with the multikinase inhibitor Sorafenib. Oncotarget. vol 8. issue 28. 2018-04-11. PMID:28537899. |
therapy of cutaneous t cell lymphoma (ctcl) is complicated by a distinct resistance of the malignant t cells towards apoptosis that can be caused by nras mutations in late-stage patients. |
2018-04-11 |
2023-08-13 |
Not clear |