| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helen C S. The technological transformation of patient-driven human immunology research. Immunologic research. vol 43. issue 1-3. 2009-06-09. PMID:18818883. |
studies of patients with autoimmune lymphoproliferative syndrome (alps) or caspase-8 deficiency state (ceds) demonstrated the ability of gene expression microarray analyses and small interfering rnas (sirna) to establish the physiologically important roles of nras, caspase-10, and caspase-8 for normal lymphocyte apoptosis and activation. |
2009-06-09 |
2023-08-12 |
human |
| Won-Il Kim, Ilze Matise, Miechaleen D Diers, David A Largaespad. RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia. Blood. vol 113. issue 5. 2009-02-27. PMID:18952898. |
conditional repression of nras(g12v) expression greatly reduced peripheral white blood cell (wbc) counts in leukemia recipient mice and induced apoptosis in the transplanted aml cells correlated with reduced ras/erk signaling. |
2009-02-27 |
2023-08-12 |
mouse |
| Won-Il Kim, Ilze Matise, Miechaleen D Diers, David A Largaespad. RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia. Blood. vol 113. issue 5. 2009-02-27. PMID:18952898. |
we conclude that, in aml induced by an mll-af9 transgene, nras(g12v) expression contributes to acute leukemia maintenance by suppressing apoptosis and reducing differentiation of leukemia cells. |
2009-02-27 |
2023-08-12 |
mouse |
| João B Oliveira, Nicolas Bidère, Julie E Niemela, Lixin Zheng, Keiko Sakai, Cynthia P Nix, Robert L Danner, Jennifer Barb, Peter J Munson, Jennifer M Puck, Janet Dale, Stephen E Straus, Thomas A Fleisher, Michael J Lenard. NRAS mutation causes a human autoimmune lymphoproliferative syndrome. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 21. 2007-08-01. PMID:17517660. |
we show here that the salient features of alps as well as a predisposition to hematological malignancies can be caused by a heterozygous germline gly13asp activating mutation of the nras oncogene that does not impair cd95-mediated apoptosis. |
2007-08-01 |
2023-08-12 |
human |
| João B Oliveira, Nicolas Bidère, Julie E Niemela, Lixin Zheng, Keiko Sakai, Cynthia P Nix, Robert L Danner, Jennifer Barb, Peter J Munson, Jennifer M Puck, Janet Dale, Stephen E Straus, Thomas A Fleisher, Michael J Lenard. NRAS mutation causes a human autoimmune lymphoproliferative syndrome. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 21. 2007-08-01. PMID:17517660. |
the increase in active, gtp-bound nras augments raf/mek/erk signaling, which markedly decreases the proapoptotic protein bim and attenuates intrinsic, nonreceptor-mediated mitochondrial apoptosis. |
2007-08-01 |
2023-08-12 |
human |
| Malihe Eskandarpour, Shahryar Kiaii, Chaoyong Zhu, Juan Castro, Andrew J Sakko, Johan Hansso. Suppression of oncogenic NRAS by RNA interference induces apoptosis of human melanoma cells. International journal of cancer. vol 115. issue 1. 2005-05-31. PMID:15688405. |
suppression of oncogenic nras by rna interference induces apoptosis of human melanoma cells. |
2005-05-31 |
2023-08-12 |
human |
| Malihe Eskandarpour, Shahryar Kiaii, Chaoyong Zhu, Juan Castro, Andrew J Sakko, Johan Hansso. Suppression of oncogenic NRAS by RNA interference induces apoptosis of human melanoma cells. International journal of cancer. vol 115. issue 1. 2005-05-31. PMID:15688405. |
suppression of oncogenic nras in these cell lines resulted in increased apoptosis. |
2005-05-31 |
2023-08-12 |
human |
| Malihe Eskandarpour, Shahryar Kiaii, Chaoyong Zhu, Juan Castro, Andrew J Sakko, Johan Hansso. Suppression of oncogenic NRAS by RNA interference induces apoptosis of human melanoma cells. International journal of cancer. vol 115. issue 1. 2005-05-31. PMID:15688405. |
in contrast, rna interference directed at wild-type (wt) nras had no significant effect on apoptosis of 224 cells or 2 human melanoma cell lines (a375 and 397) containing wt nras but a codon 600 gtg (valine) to gag (glutamate) mutation in braf. |
2005-05-31 |
2023-08-12 |
human |
| Malihe Eskandarpour, Shahryar Kiaii, Chaoyong Zhu, Juan Castro, Andrew J Sakko, Johan Hansso. Suppression of oncogenic NRAS by RNA interference induces apoptosis of human melanoma cells. International journal of cancer. vol 115. issue 1. 2005-05-31. PMID:15688405. |
these data suggest that oncogenic nras is important for avoidance of apoptosis in melanomas that harbor the codon 61 nras mutation and emphasizes oncogenic nras as a therapeutic target in patients with tumors that harbor this mutation. |
2005-05-31 |
2023-08-12 |
human |