Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Lingyan Chen, Dejian Chen, Yiming Pan, Yimei Mo, Biyu Lai, Huiguang Chen, Da-Wei Zhang, Xiao-Dan Xi. Inhibition of mitochondrial OMA1 ameliorates osteosarcoma tumorigenesis. Cell death & disease. vol 15. issue 11. 2024-11-02. PMID:39487118. |
specifically, oma1 deficiency reduces the amount of cytosolic p53 and p53-associated cytosolic parkin but increases mitochondrial p53, which may lead to enhanced apoptosis. |
2024-11-02 |
2024-11-05 |
mouse |
Qian Su, Huizhen Sun, Ling Mei, Ying Yan, Huimin Ji, Le Chang, Lunan Wan. Ribosomal proteins in hepatocellular carcinoma: mysterious but promising. Cell & bioscience. vol 14. issue 1. 2024-11-02. PMID:39487553. |
in addition to regulating related signaling pathways such as the p53 pathway, rps also act in proliferation and metastasis by influencing cell cycle, apoptosis, angiogenesis, and epithelial-to-mesenchymal transition in hcc. |
2024-11-02 |
2024-11-05 |
Not clear |
Xingnan Zhang, Chenhao Hu, Shengqiao Sun, Chao Guo, Yakun Bu, Zicong Wang, Zewei Liu, Xiaoli Zhang, Dezhi Li, Song Li. TSPO deficiency promotes the progression of malignant peripheral sheath tumors by regulating the G2/M phase of the cell cycle via CDK1. Scientific reports. vol 14. issue 1. 2024-11-01. PMID:39482412. |
in addition, tspo depletion suppressed cell apoptosis by downregulating the expression of caspase-3, caspase-8, hsp60, p27, p53, and bcl-2 and suppressed the cell cycle by upregulating cdk1, cdk2, ccnb1 and ccna2. |
2024-11-01 |
2024-11-03 |
Not clear |
Xin Yi, Huabin Cao, Jianzhao Liao, Wenlan Yu, Guoliang Hu, Zhaoxin Tang, Fan Yan. Metabolomics analysis reveals the effects of high dietary copper on mitochondria-mediated autophagy and apoptosis in spleen of broiler chicken. Avian pathology : journal of the W.V.P.A. 2024-11-01. PMID:39483061. |
meanwhile, high dose of cu promoted the splenocytes apoptosis by ascend the levels of p53, bak-1, bax, cyt c and caspase-3 and descend the level of bcl-2. |
2024-11-01 |
2024-11-03 |
chicken |
Brian Ball, Wenbin Xiao, Gautam Borthakur, Le Xuan Truong Nguyen, Melissa Valerio, Avanthika Venkatachalam, Guido Marcucci, Anthony Stein, Dung Luong Thai, David Cook, Kyle Chan, Sonali Persaud, Ross Levine, Omar Abdel-Wahab, Yinon Ben-Neriah, Eytan Stei. Phase I First-in-Human Dose Escalation Study of the oral Casein Kinase 1α and Cyclin Dependent Kinase 7/9 inhibitor BTX-A51 in advanced MDS and AML. Research square. 2024-11-01. PMID:39483885. |
btx-a51, a first-in-class oral small molecule inhibitor of casein kinase 1α (ck1α) and cyclin dependent kinase (cdk) 7 and 9, induces apoptosis of leukemic cells by activating p53 and inhibiting expression of |
2024-11-01 |
2024-11-03 |
Not clear |
Jiarui Song, Qiuxia Cui, Jidong Ga. Roles of lncRNAs related to the p53 network in breast cancer progression. Frontiers in oncology. vol 14. 2024-10-31. PMID:39479021. |
the p53 is a crucial tumor suppressor and transcription factor that participates in apoptosis and senescence. |
2024-10-31 |
2024-11-02 |
Not clear |
Qamar A Alshammari, Saud O Alshammari, Abdulkarim Alshammari, Moaddey Alfarhan, Fahad Hassan Baal. Unraveling the mechanisms of glioblastoma's resistance: investigating the influence of tumor suppressor p53 and non-coding RNAs. Naunyn-Schmiedeberg's archives of pharmacology. 2024-10-30. PMID:39476245. |
the present article details the functional aspects of p53 as a cellular stress response protein, including its roles in apoptosis, cell cycle regulation, and dna repair in glioblastoma (gb), along with the disruption of p53 and its involvement in chemoresistance (cr). |
2024-10-30 |
2024-11-02 |
Not clear |
Yuexiao Sun, Yang Zhou, Dongli Xie, Xuejiao Wang, Ya Wang, Yunxia Liang, Xiaogang Lu. Preclinical Evaluation of Protective Effects of Terpenoids Against Nanomaterial-Induced Toxicity: A Meta-Analysis. Journal of applied toxicology : JAT. 2024-10-30. PMID:39477689. |
the meta-analysis by stata 15.0 showed that terpenoid supplementation significantly improved cell viability and altered oxidative stress (decreased ros, no, mda, and toc and increased sod, cat, gpx, gsh, gsh-px, and tac)-, inflammation (decreased il-6, il-1β, tnf-α, nf-κb, monocytes, and increased il-10)-, apoptosis (reduced bax, caspase-3, caspase-9, p53, and elevated bcl-2)-, genotoxic (reduced tail length, % tail dna, tail moment, dna fragmentation, chromosomal aberration, and mnpces)-, liver function (reduced alt, ast, and alp)-, renal function (reduced creatinine, urea, and uric acid)-, reproductive function (increased sperm count, testosterone, johnsen's score, and number of progeny)-, lipid profile (lower cholesterol, tg, ldl, and higher hdl)-, and carcinogenesis (downregulated afp and cea)-related biomarkers induced by nanomaterials. |
2024-10-30 |
2024-11-02 |
cat |
Jing Li, Xia Huang, Lei Luo, Jialin Sun, Qie Guo, Xue Yang, Chuanzhou Zhang, Beibei N. The role of p53 in male infertility. Frontiers in endocrinology. vol 15. 2024-10-29. PMID:39469578. |
the tumor suppressor p53 is a transcription factor involved in a variety of crucial cellular functions, including cell cycle arrest, dna repair and apoptosis. |
2024-10-29 |
2024-10-31 |
Not clear |
Jing Li, Xia Huang, Lei Luo, Jialin Sun, Qie Guo, Xue Yang, Chuanzhou Zhang, Beibei N. The role of p53 in male infertility. Frontiers in endocrinology. vol 15. 2024-10-29. PMID:39469578. |
the representative functions of p53 in spermatogenesis include the proliferation of spermatogonial stem cells (sscs), spermatogonial differentiation, spontaneous apoptosis, and dna damage repair. |
2024-10-29 |
2024-10-31 |
Not clear |
Shuo Wang, Jinhui Xu, Xingchen Wang, Mingdi Wang, Huiliang Xue, Ming Wu, Chao Fan, Lei Chen, Laixiang X. cba-miR-222-3p involved in photoperiod-induced apoptosis in testes of striped hamsters by targeting TRAF7. Integrative zoology. 2024-10-28. PMID:39466916. |
in addition, the expression of traf7 decreased in the testes, which injected mirna agomir, leading to inhibition of apoptosis, and the expression of key genes (mekk3, p38, p53) in the downstream mapk signaling pathway of traf7 was suppressed. |
2024-10-28 |
2024-10-31 |
Not clear |
Nicholas Dale D Talubo, Po-Wei Tsai, Lemmuel L Tay. Comprehensive RNA-Seq Gene Co-Expression Analysis Reveals Consistent Molecular Pathways in Hepatocellular Carcinoma across Diverse Risk Factors. Biology. vol 13. issue 10. 2024-10-26. PMID:39452074. |
g1/g2 exhibited the involvement of pathways related to metabolism and the pi3k/akt pathway, which regulates cell proliferation and related pathways, whereas g3/g4 showed the activation of cell adhesion genes and the p53 signaling pathway, which regulates apoptosis, cell cycle arrest, and similar processes. |
2024-10-26 |
2024-10-28 |
Not clear |
Shunze Jia, Xinpeng Wen, Minwei Zhu, Xudong F. The pluripotent-to-totipotent state transition in mESCs activates the intrinsic apoptotic pathway through DUX-induced DNA replication stress. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-10-26. PMID:39460804. |
this rs further activates p53 and pmaip1, ultimately leading to caspase-9/7-dependent intrinsic apoptosis. |
2024-10-26 |
2024-10-29 |
mouse |
Carla Martins, Lara M Carvalho, Inês Moutinho Cabral, Leonor Saúde, Kristian Dreij, Pedro M Cost. A mechanistic study on the interaction effects between legacy and pollutants of emerging concern: A case study with B[a]P and diclofenac. Environmental pollution (Barking, Essex : 1987). 2024-10-25. PMID:39454814. |
the formation of oedemas in the heart cavity and yolk sac can be an adverse outcome (ao) resulting from exposure to dfc isolated or combined, whose potential key events (kes) may involve cell cycle arrest and apoptosis via p53 and mapk pathways. |
2024-10-25 |
2024-10-29 |
zebrafish |
Maria Lina Tornesell. TP53 mutations in cancer: Molecular features and therapeutic opportunities (Review). International journal of molecular medicine. vol 55. issue 1. 2024-10-25. PMID:39450536. |
the tumour suppressor factor p53 plays an essential role in regulating numerous cellular processes, including the cell cycle, dna repair, apoptosis, autophagy, cell metabolism and immune response. |
2024-10-25 |
2024-10-28 |
human |
Jiayan Fang, Mengqi Zou, Mei Yang, Yejia Cui, Rong Pu, Yufeng Yan. TAF15 inhibits p53 nucleus translocation and promotes HCC cell 5-FU resistance via post-transcriptional regulation of UBE2N. Journal of physiology and biochemistry. 2024-10-24. PMID:39446246. |
ube2n inhibited the translocation of p53 protein into the cell nucleus to increase 5-fu resistance, as reflected by an increased ic50 value, an increase in cell viability, and a reduction in cell apoptosis. |
2024-10-24 |
2024-10-26 |
Not clear |
Yuhui Du, Guoqing Wang, Bin Liu, Meng Guo, Xi Yan, Ming Dou, Fangfang Yu, Yue Ba, Guoyu Zho. Naringin alleviates fluoride-induced neurological impairment: A focus on the regulation of energy metabolism mediated by mitochondrial permeability transition pore. The Science of the total environment. 2024-10-24. PMID:39447898. |
after inhibiting the expression of p53 with pifithrin-α and p53-sirna, the decreased apoptosis rates and mptp opening, increased mmp, and decreased protein expressions of p53, cytoc, and cleaved caspase 3 were observed in naf-treated pc12 cells. |
2024-10-24 |
2024-10-28 |
rat |
Zuleyha Demirci, Zeynep Islek, Halime Ilhan Siginc, Fikrettin Sahin, Mehmet H Ucisik, Zeynep Busra Bola. Curcumin-loaded emulsome nanoparticles induces apoptosis through p53 signaling pathway in pancreatic cancer cell line PANC-1. Toxicology in vitro : an international journal published in association with BIBRA. 2024-10-23. PMID:39442639. |
curcumin-loaded emulsome nanoparticles induces apoptosis through p53 signaling pathway in pancreatic cancer cell line panc-1. |
2024-10-23 |
2024-10-26 |
Not clear |
Zuleyha Demirci, Zeynep Islek, Halime Ilhan Siginc, Fikrettin Sahin, Mehmet H Ucisik, Zeynep Busra Bola. Curcumin-loaded emulsome nanoparticles induces apoptosis through p53 signaling pathway in pancreatic cancer cell line PANC-1. Toxicology in vitro : an international journal published in association with BIBRA. 2024-10-23. PMID:39442639. |
curcumin has anticancer properties promoting apoptosis through the p53 pathway. |
2024-10-23 |
2024-10-26 |
Not clear |
Aftab Hossain Khan, Ambalika Basak, Afreen Zaman, Prasanta Kumar Da. Inherently targeted estradiol-derived carbon dots for selective killing of ER (+) breast cancer cells Journal of materials chemistry. B. 2024-10-22. PMID:39435655. |
reactivation of p53 can lead to cell cycle arrest as well as apoptosis. |
2024-10-22 |
2024-10-24 |
Not clear |