| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiyu Tang, Greg R Markby, Andrew J MacNair, Keyi Tang, Michal Tkacz, Maciej Parys, Kanchan Phadwal, Vicky E MacRae, Brendan M Corcora. TGF-\\xce\\xb2-induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease. Cell proliferation vol issue 2023 36869852 |
selective knockdown of p70 s6k reverses cell transition by attenuating cell senescence, inhibiting apoptosis and improving autophagy. |
2023-03-04 |
2023-03-06 |
Not clear |
| Xueji Wu, Wei Xie, Wenxuan Xie, Wenyi Wei, Jianping Gu. Beyond controlling cell size: functional analyses of S6K in tumorigenesis. Cell death & disease vol 13 issue 7 2022 35879299 |
beyond controlling cell size, s6k simultaneously plays crucial roles in directing cell apoptosis, metabolism, and feedback regulation of its upstream signals. |
2022-07-25 |
2023-01-30 |
mouse |
| Nani Wang, Pingcui Xu, Renjie Wu, Xuping Wang, Yongjun Wang, Dan Shou, Yan Zhan. Timosaponin BII improved osteoporosis caused by hyperglycemia through promoting autophagy of osteoblasts via suppressing the mTOR/NF\\xce\\xbaB signaling pathway. Free radical biology & medicine vol 171 issue 2021 33992678 |
further studies showed that timosaponin bii suppressed the phosphorylation of mtor and s6k, as well as the downstream factors nf\xce\xbab and i\xce\xbab, consequently activating autophagy and decreasing apoptosis. |
2021-06-28 |
2023-01-26 |
rat |
| Er-Ying Hao, De-He Wang, Yi-Fan Chen, Rong-Yan Zhou, Hui Chen, Ren-Lu Huan. The relationship between the mTOR signaling pathway and ovarian aging in peak-phase and late-phase laying hens. Poultry science vol 100 issue 1 2021 33357698 |
treatment of chicken granulosa cells with the mtor agonist mhy1485 significantly enhanced granulocyte proliferation (p\xc2\xa0<\xc2\xa00.01) and inhibited apoptosis (p\xc2\xa0<\xc2\xa00.01) and significantly increased avtor, s6k, 4e-bp1, and pkc gene expression (p\xc2\xa0<\xc2\xa00.01). |
2021-04-19 |
2023-01-26 |
chicken |
| Ayako Nogami, Keigo Okada, Shinya Ishida, Hiroki Akiyama, Yoshihiro Umezawa, Osamu Miur. Inhibition of the STAT5/Pim Kinase Axis Enhances Cytotoxic Effects of Proteasome Inhibitors on FLT3-ITD-Positive AML Cells by Cooperatively Inhibiting the mTORC1/4EBP1/S6K/Mcl-1 Pathway. Translational oncology vol 12 issue 2 2020 30472492 |
genetic enhancement of the redd1 induction or pharmacological inhibition of stat5, pim kinases, mtorc1, or s6k by specific inhibitors, such as pimozide, azd1208, pim447, rapamycin, and pf-4708671, accelerated the downregulation of mtorc1/mcl-1 pathway to enhance bortezomib-induced apoptosis in flt3-itd-expressing cells, including primary aml cells, while overexpression of mcl-1 prevented induction of apoptosis. |
2020-10-01 |
2023-01-26 |
Not clear |
| Kanako Inaba, Katsutoshi Oda, Kazuhiro Aoki, Kenbun Sone, Yuji Ikeda, Aki Miyasaka, Tomoko Kashiyama, Tomohiko Fukuda, Chinami Makii, Takahide Arimoto, Osamu Wada-Hiraike, Kei Kawana, Tetsu Yano, Yutaka Osuga, Tomoyuki Fuji. Synergistic antitumor effects of combination PI3K/mTOR and MEK inhibition (SAR245409 and pimasertib) in mucinous ovarian carcinoma cells by fluorescence resonance energy transfer imaging. Oncotarget vol 7 issue 20 2018 27102436 |
however, s6k inhibition suppressed proliferation in a threshold manner in both cell lines, although apoptosis was only induced in oaw42 cells. |
2018-01-12 |
2023-01-25 |
Not clear |
| Jianwei Bai, Hua Han, Feng Wang, Liyu Su, Hongwei Ding, Xiyin Hu, Binli Hu, Hong Li, Wei Zheng, Yan L. Maternal linuron exposure alters testicular development in male offspring rats at the whole genome level. Toxicology vol 389 issue 2017 28705778 |
microarray analysis indicated that the expressions of testosterone synthesis-associated genes, i.e., star, p450scc, 3\xce\xb2-hsd, abp, cox7a2, pcna, p450c17and17\xce\xb2-hsd were significantly altered by linuron exposure, along with other genes involving in cell proliferation and apoptosis, such as c-myc, s6k, apaf1, and tsc1. |
2017-09-11 |
2023-01-26 |
rat |
| Kristen Fite, Lobna Elkhadragy, Julian Gomez-Cambroner. A Repertoire of MicroRNAs Regulates Cancer Cell Starvation by Targeting Phospholipase D in a Feedback Loop That Operates Maximally in Cancer Cells. Molecular and cellular biology vol 36 issue 7 2016 26787840 |
first, during initial starvation, an elevated pa (the product of pld enzymatic activity) activates mtor and s6k, known to inhibit apoptosis, and enhances cell migration especially in post-epithelial-to-mesenchymal transition (post-emt) cancer cells. |
2016-08-09 |
2023-01-25 |
Not clear |
| Qiao Pan, Xiaobo Xie, Yan Guo, Haichang Wan. Simvastatin promotes cardiac microvascular endothelial cells proliferation, migration and survival by phosphorylation of p70 S6K and FoxO3a. Cell biology international vol 38 issue 5 2015 24375611 |
the data suggest that simvastatin inhibits rapamycin-induced cmecs dysfunction and apoptosis, probably through activation of pi3k/akt/mtor/p70 s6k and mtor/foxo3a signalling pathway in a sequential manner and this pathway may be important in some of the pleiotropic effects of statins. |
2015-06-15 |
2023-01-25 |
rat |
| Theresa D Carr, John DiGiovanni, Christopher J Lynch, Lisa M Shant. Inhibition of mTOR suppresses UVB-induced keratinocyte proliferation and survival. Cancer prevention research (Philadelphia, Pa.) vol 5 issue 12 2013 23129577 |
in contrast, mtor deletion, which attenuated uvb-induced phosphorylation of both s6k and the mtorc2 target akt(ser473), significantly increased apoptosis both in vivo and in keratinocyte cultures, in addition to reducing hyperproliferation following uvb irradiation. |
2013-05-23 |
2023-01-25 |
mouse |
| Lorna W Harries, Alexander D Fellows, Luke C Pilling, Dena Hernandez, Andrew Singleton, Stefania Bandinelli, Jack Guralnik, Jonathan Powell, Luigi Ferrucci, David Melze. Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations. Mechanisms of ageing and development vol 133 issue 8 2012 22813852 |
genes involved in insulin signaling (pten, pi3k, pdk1), ribosomal biogenesis (s6k), lipid metabolism (srebf1), cellular apoptosis (sgk1), angiogenesis (vegfb), insulin production and sensitivity (foxo), cellular stress response (hif1a) and cytoskeletal remodeling (pkc) were inversely correlated with age, whereas genes relating to inhibition of ribosomal components (4ebp1) and inflammatory mediators (stat3) were positively associated with age in one or both datasets. |
2012-12-31 |
2023-01-25 |
human |
| Hideo Tomioka, Toru Mukohara, Yu Kataoka, Roudy Chiminch Ekyalongo, Yohei Funakoshi, Yasuo Imai, Naomi Kiyota, Yutaka Fujiwara, Hironobu Minam. Inhibition of the mTOR/S6K signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with HER2 amplification. International journal of oncology vol 41 issue 2 2012 22614071 |
trastuzumab decreased phosphorylation of s6k, showed synergistic effect with fluorouracil or doxorubicin, and increased fluorouracil-induced apoptosis in nci-n87 cells, but not in mkn-7 cells. |
2012-10-19 |
2023-01-25 |
Not clear |
| Hideo Tomioka, Toru Mukohara, Yu Kataoka, Roudy Chiminch Ekyalongo, Yohei Funakoshi, Yasuo Imai, Naomi Kiyota, Yutaka Fujiwara, Hironobu Minam. Inhibition of the mTOR/S6K signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with HER2 amplification. International journal of oncology vol 41 issue 2 2012 22614071 |
consistently, while the egfr/her2 inhibitor cl-387,785 inhibited cell growth of mkn-7, this growth inhibition did not accompany decrease in phosphorylation of s6k, and the compound did not enhance fluorouracil-induced apoptosis. |
2012-10-19 |
2023-01-25 |
Not clear |
| Changxuan Liu, Yan Bai, Yiliang Chen, Yu Wang, Yoann Sottejeau, Lijun Liu, Xiaomei Li, Jerry B Lingrel, Deepak Malhotra, Christopher J Cooper, Joseph I Shapiro, Zi-jian Xie, Jiang Tia. Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac dysfunction and myocyte apoptosis. The Journal of biological chemistry vol 287 issue 20 2012 22451662 |
mechanistically, it was found that in wt myocytes mbg activated the src/akt/mtor signaling pathway, which further increased phosphorylation of ribosome s6 kinase (s6k) and bad (bcl-2-associated death promoter) and protected cells from apoptosis. |
2012-07-13 |
2023-01-25 |
mouse |
| Soojeong Kang, Elie R Chemaly, Roger J Hajjar, Djamel Lebech. Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways. The Journal of biological chemistry vol 286 issue 21 2011 21478152 |
these data demonstrate that resistin induces cardiac hypertrophy and myocardial insulin resistance, possibly via the ampk/mtor/p70(s6k) and apoptosis signal-regulating kinase 1/jnk/irs1 pathways. |
2011-07-28 |
2023-01-25 |
rat |
| Rui Xu, Kenji Nakano, Hironori Iwasaki, Michiaki Kumagai, Rie Wakabayashi, Akio Yamasaki, Hiroyuki Suzuki, Ryuichi Mibu, Hideya Onishi, Mitsuo Katan. Dual blockade of phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer. Cancer letters vol 306 issue 2 2011 21429662 |
simultaneous blockade of pi3k and mapk pathways more suppressed the s6k activity and further increased the apoptosis. |
2011-07-12 |
2023-01-25 |
Not clear |
| Gemma Vilahur, Oriol Juan-Babot, Esther Pe\\xc3\\xb1a, Blanca O\\xc3\\xb1ate, Laura Casan\\xc3\\xad, Lina Badimo. Molecular and cellular mechanisms involved in cardiac remodeling after acute myocardial infarction. Journal of molecular and cellular cardiology vol 50 issue 3 2011 21219908 |
ischemic- (im) and non-ischemic myocardium (nim) was obtained for molecular analysis of: 1) apoptosis (p-bcl2, bax, p-p53, active-caspase-3); 2) the tlr-4-myd88-dependent and independent pathways; 3) akt/mtor/p70(s6k) axis activation; and, 4) fibrosis (tgf-\xce\xb2, collagen1-a1/a3). |
2011-06-09 |
2023-01-25 |
Not clear |
| Ying-Wei Lin, Zanna M Beharry, Elizabeth G Hill, Jin H Song, Wenxue Wang, Zuping Xia, Zhenhua Zhang, Peter D Aplan, Jon C Aster, Charles D Smith, Andrew S Kraf. A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood vol 115 issue 4 2010 19965690 |
incubation of pre-t-lbl cells with smi-4a induced g1 phase cell-cycle arrest secondary to a dose-dependent induction of p27(kip1), apoptosis through the mitochondrial pathway, and inhibition of the mammalian target of rapamycin c1 (mtorc1) pathway based on decreases in phospho-p70 s6k and phospho-4e-bp1, 2 substrates of this enzyme. |
2010-03-12 |
2023-01-25 |
mouse |
| Wenbin Lei, Tao Jia, Zhenzhong Su, Weiping Wen, Xiaolin Zh. Combined effect of rapamycin and cisplatin on survival of Hep-2 cells in vitro. Oncology research vol 18 issue 2-3 2010 20066897 |
inhibition of cell growth, apoptosis, and akt, mtor, s6k, and ercc1 protein levels were assessed. |
2010-01-28 |
2023-01-25 |
Not clear |
| Helena Jernberg-Wiklund, Kenneth Nilsso. Control of apoptosis in human multiple myeloma by insulin-like growth factor I (IGF-I). Advances in cancer research vol 97 issue 2009 17419944 |
testing the hypothesis that abrogating igf-ir-mediated signaling of survival should make mm cells more susceptible to apoptosis, our studies have so far provided proof-of-principle by the demonstration that inhibition of a signaling pathway stimulating survival renders cells susceptible to drug-induced apoptosis when the drug (dexamethasone) and inhibitor (rapamycin) converge on the same target, that is p70(s6k). |
2009-10-14 |
2023-01-24 |
human |