Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Wenbin Lei, Tao Jia, Zhenzhong Su, Weiping Wen, Xiaolin Zh. Combined effect of rapamycin and cisplatin on survival of Hep-2 cells in vitro. Oncology research. vol 18. issue 2-3. 2010-01-28. PMID:20066897. |
inhibition of cell growth, apoptosis, and akt, mtor, s6k, and ercc1 protein levels were assessed. |
2010-01-28 |
2023-08-12 |
Not clear |
Helena Jernberg-Wiklund, Kenneth Nilsso. Control of apoptosis in human multiple myeloma by insulin-like growth factor I (IGF-I). Advances in cancer research. vol 97. 2009-10-14. PMID:17419944. |
testing the hypothesis that abrogating igf-ir-mediated signaling of survival should make mm cells more susceptible to apoptosis, our studies have so far provided proof-of-principle by the demonstration that inhibition of a signaling pathway stimulating survival renders cells susceptible to drug-induced apoptosis when the drug (dexamethasone) and inhibitor (rapamycin) converge on the same target, that is p70(s6k). |
2009-10-14 |
2023-08-12 |
mouse |
M A Scheper, R Chaisuparat, N G Nikitakis, J J Sau. Expression and alterations of the PTEN / AKT / mTOR pathway in ameloblastomas. Oral diseases. vol 14. issue 6. 2009-01-26. PMID:18826385. |
in carcinogenesis, loss of pten allows for overactivity of the phosphatidylinositol-3-kinase/protein kinase b (pi3k / akt) pathway inducing an upregulation of mammalian-target of rapamycin (mtor) and its downstream effector ribosomal-subunit-6 kinase (s6k); allowing for uncontrolled cell proliferation, apoptosis inhibition and cell cycle deregulation. |
2009-01-26 |
2023-08-12 |
Not clear |
Dario Barbone, Tsung-Ming Yang, Jeffrey R Morgan, Giovanni Gaudino, V Courtney Broaddu. Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids. The Journal of biological chemistry. vol 283. issue 19. 2008-06-17. PMID:18339627. |
rapamycin or s6k knockdown increased trail-induced caspase-8 cleavage in spheroids, suggesting initially that mtor inhibited apoptosis by actions at the death receptor pathway; however, isolation of the apoptotic pathways by means of bid knockdown ablated this effect showing that mtor actually controls a step distal to bid, probably at the level of the mitochondria. |
2008-06-17 |
2023-08-12 |
human |
Ying Cai, Qidi Wang, Zhidong Ling, Daniel Pipeleers, Paul McDermott, Mario Pende, Harry Heimberg, Mark Van de Casteel. Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR. Biochemical pharmacology. vol 75. issue 10. 2008-05-16. PMID:18377870. |
expression of a constitutively active form of the mtor target ribosomal protein s6 kinase (s6k) or of translation factor eif4e reduced apoptosis by glucose limitation, and co-expression of s6k and eif4e protected beta cells to the same extent as active akt. |
2008-05-16 |
2023-08-12 |
Not clear |
Vincent A Bielinski, Marc C Mumb. Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase. Experimental cell research. vol 313. issue 14. 2007-12-03. PMID:17570358. |
knockdown of the drosophila homolog of the pp2a/pp4/pp6 interaction protein alpha4/tap42 did not affect s6k phosphorylation, but did induce apoptosis. |
2007-12-03 |
2023-08-12 |
drosophila_melanogaster |
Markus J Riemenschneider, Rebecca A Betensky, Saskia M Pasedag, David N Loui. AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling. Cancer research. vol 66. issue 11. 2006-07-27. PMID:16740698. |
mtor activation results in subsequent activation of s6k and stat3, as well as suppression (i.e., phosphorylation) of 4e-bp1, leading to cell cycle progression and inhibition of apoptosis. |
2006-07-27 |
2023-08-12 |
human |
Jose R Bayascas, Nick R Leslie, Ramon Parsons, Stewart Fleming, Dario R Aless. Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice. Current biology : CB. vol 15. issue 20. 2006-06-26. PMID:16243031. |
knockout of pkbalpha in pten-deficient cells reduces aggressive growth and promotes apoptosis, whereas treatment of pten(+/-) mice with rapamycin, an inhibitor of the activation of s6k, reduces neoplasia. |
2006-06-26 |
2023-08-12 |
mouse |
Gudiseva Chandrasekher, Dasetty Sailaj. Phosphatidylinositol 3-kinase (PI-3K)/Akt but not PI-3K/p70 S6 kinase signaling mediates IGF-1-promoted lens epithelial cell survival. Investigative ophthalmology & visual science. vol 45. issue 10. 2004-11-06. PMID:15452065. |
to investigate the ability of insulin-like growth factor (igf)-1 to prevent apoptosis in lens epithelial cells and the involvement of phosphatidylinositol 3-kinase (pi-3k)/akt and pi-3k/p70 s6 kinase (p70 s6k) signaling in the cell-survival process. |
2004-11-06 |
2023-08-12 |
Not clear |
H Glantschnig, J E Fisher, G Wesolowski, G A Rodan, A A Reszk. M-CSF, TNFalpha and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase. Cell death and differentiation. vol 10. issue 10. 2004-06-07. PMID:14502240. |
inhibitors of these intermediates suppress cytokine activation of s6k and induce ocl apoptosis. |
2004-06-07 |
2023-08-12 |
Not clear |
W L Blalock, P M Navolanic, L S Steelman, J G Shelton, P W Moye, J T Lee, R A Franklin, A Mirza, M McMahon, M K White, J A McCubre. Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia. Leukemia. vol 17. issue 6. 2003-07-08. PMID:12764369. |
here we demonstrate the ability of deltamek1:er to activate the phosphatidylinositol 3-kinase (pi3k)/akt/p70 ribosomal s6 kinase (p70(s6k)) pathway and the importance of this pathway in mek1-mediated prevention of apoptosis. |
2003-07-08 |
2023-08-12 |
human |
Hidesuke Fukazawa, Kohji Noguchi, Yuko Murakami, Yoshimasa Uehar. Mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) inhibitors restore anoikis sensitivity in human breast cancer cell lines with a constitutively activated extracellular-regulated kinase (ERK) pathway. Molecular cancer therapeutics. vol 1. issue 5. 2003-06-16. PMID:12489846. |
the results indicate that concurrent inhibition of mek-erk and mtor-p70(s6k) pathways induces apoptosis in mda-mb231 and hbc4 cells when cells are deprived of anchorage but not when anchored. |
2003-06-16 |
2023-08-12 |
human |
Xiaolin Wan, Lee J Helma. Effect of insulin-like growth factor II on protecting myoblast cells against cisplatin-induced apoptosis through p70 S6 kinase pathway. Neoplasia (New York, N.Y.). vol 4. issue 5. 2003-02-20. PMID:12192598. |
blockade of p70 s6k activation by rapamycin abrogated the igf-ii-mediated protection of cells to cisplatin-induced apoptosis. |
2003-02-20 |
2023-08-12 |
mouse |
Xiaolin Wan, Lee J Helma. Effect of insulin-like growth factor II on protecting myoblast cells against cisplatin-induced apoptosis through p70 S6 kinase pathway. Neoplasia (New York, N.Y.). vol 4. issue 5. 2003-02-20. PMID:12192598. |
these data together suggest that igf-ii-associated protection to cisplatin-induced apoptosis is mediated through an activation of the p70 s6k pathway. |
2003-02-20 |
2023-08-12 |
mouse |
F Peiretti, S Lopez, P Deprez-Beauclair, B Bonardo, I Juhan-Vague, G Nalbon. Inhibition of p70(S6) kinase during transforming growth factor-beta 1/vitamin D(3)-induced monocyte differentiation of HL-60 cells allows tumor necrosis factor-alpha to stimulate plasminogen activator inhibitor-1 synthesis. The Journal of biological chemistry. vol 276. issue 34. 2001-09-20. PMID:11402043. |
in conclusion, these results indicate that inhibition of p70(s6k) phosphorylation during tgf/d3-induced monocyte differentiation of hl-60 cells is a determinant factor that allows tnf to exert its up-regulating effect on pai-1 synthesis while protecting cells from apoptosis. |
2001-09-20 |
2023-08-12 |
human |
S Bonatti, S Pigullo, M Simili, A Abbondandol. Induction of apoptosis and inhibition of signalling pathways by alkylated purines. Mutagenesis. vol 15. issue 4. 2000-11-03. PMID:10887217. |
at concentrations inducing apoptosis the three alkylpurines inhibited p70(s6k) activity, while they had the opposite effect on mapk. |
2000-11-03 |
2023-08-12 |
Not clear |
S Bonatti, S Pigullo, M Simili, A Abbondandol. Induction of apoptosis and inhibition of signalling pathways by alkylated purines. Mutagenesis. vol 15. issue 4. 2000-11-03. PMID:10887217. |
rapamycin, a specific inhibitor of the p70(s6k) pathway, did not induce apoptosis at doses inhibiting p70(s6k) activity, suggesting that p70(s6k) is not directly involved in apoptosis. |
2000-11-03 |
2023-08-12 |
Not clear |
S Bonatti, S Pigullo, M Simili, A Abbondandol. Induction of apoptosis and inhibition of signalling pathways by alkylated purines. Mutagenesis. vol 15. issue 4. 2000-11-03. PMID:10887217. |
as expected, and in line with results reported by others, wortmannin, an upstream inhibitor of the p70(s6k) pathway, did induce apoptosis. |
2000-11-03 |
2023-08-12 |
Not clear |
T Uchida, M G Myers, M F Whit. IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis. Molecular and cellular biology. vol 20. issue 1. 2000-01-10. PMID:10594015. |
thus, the activation of pkb/akt and bad phosphorylation might not be sufficient to inhibit the apoptosis of il-3-deprived 32d(ir) cells unless p85-associated pi 3-kinase or p70(s6k) are strongly activated. |
2000-01-10 |
2023-08-12 |
human |
J E Damen, J Krosl, D Morrison, S Pelech, G Krysta. The hyperresponsiveness of cells expressing truncated erythropoietin receptors is contingent on insulin-like growth factor-1 in fetal calf serum. Blood. vol 92. issue 2. 1998-08-06. PMID:9657741. |
in fact, long-term proliferation studies performed in the absence of serum show that even at saturating concentrations of epo, ba/f3 cells expressing these truncated receptors die via apoptosis, while cells bearing wt epors do not, and this programmed cell death correlates with an inability of epo-stimulated ba/f3 cells expressing truncated epors to induce the tyrosine phosphorylation of mapk and the activation of p70(s6k). |
1998-08-06 |
2023-08-12 |
Not clear |