All Relations between apoptosis and s6k

Publication Sentence Publish Date Extraction Date Species
Wenbin Lei, Tao Jia, Zhenzhong Su, Weiping Wen, Xiaolin Zh. Combined effect of rapamycin and cisplatin on survival of Hep-2 cells in vitro. Oncology research. vol 18. issue 2-3. 2010-01-28. PMID:20066897. inhibition of cell growth, apoptosis, and akt, mtor, s6k, and ercc1 protein levels were assessed. 2010-01-28 2023-08-12 Not clear
Helena Jernberg-Wiklund, Kenneth Nilsso. Control of apoptosis in human multiple myeloma by insulin-like growth factor I (IGF-I). Advances in cancer research. vol 97. 2009-10-14. PMID:17419944. testing the hypothesis that abrogating igf-ir-mediated signaling of survival should make mm cells more susceptible to apoptosis, our studies have so far provided proof-of-principle by the demonstration that inhibition of a signaling pathway stimulating survival renders cells susceptible to drug-induced apoptosis when the drug (dexamethasone) and inhibitor (rapamycin) converge on the same target, that is p70(s6k). 2009-10-14 2023-08-12 mouse
M A Scheper, R Chaisuparat, N G Nikitakis, J J Sau. Expression and alterations of the PTEN / AKT / mTOR pathway in ameloblastomas. Oral diseases. vol 14. issue 6. 2009-01-26. PMID:18826385. in carcinogenesis, loss of pten allows for overactivity of the phosphatidylinositol-3-kinase/protein kinase b (pi3k / akt) pathway inducing an upregulation of mammalian-target of rapamycin (mtor) and its downstream effector ribosomal-subunit-6 kinase (s6k); allowing for uncontrolled cell proliferation, apoptosis inhibition and cell cycle deregulation. 2009-01-26 2023-08-12 Not clear
Dario Barbone, Tsung-Ming Yang, Jeffrey R Morgan, Giovanni Gaudino, V Courtney Broaddu. Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids. The Journal of biological chemistry. vol 283. issue 19. 2008-06-17. PMID:18339627. rapamycin or s6k knockdown increased trail-induced caspase-8 cleavage in spheroids, suggesting initially that mtor inhibited apoptosis by actions at the death receptor pathway; however, isolation of the apoptotic pathways by means of bid knockdown ablated this effect showing that mtor actually controls a step distal to bid, probably at the level of the mitochondria. 2008-06-17 2023-08-12 human
Ying Cai, Qidi Wang, Zhidong Ling, Daniel Pipeleers, Paul McDermott, Mario Pende, Harry Heimberg, Mark Van de Casteel. Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR. Biochemical pharmacology. vol 75. issue 10. 2008-05-16. PMID:18377870. expression of a constitutively active form of the mtor target ribosomal protein s6 kinase (s6k) or of translation factor eif4e reduced apoptosis by glucose limitation, and co-expression of s6k and eif4e protected beta cells to the same extent as active akt. 2008-05-16 2023-08-12 Not clear
Vincent A Bielinski, Marc C Mumb. Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase. Experimental cell research. vol 313. issue 14. 2007-12-03. PMID:17570358. knockdown of the drosophila homolog of the pp2a/pp4/pp6 interaction protein alpha4/tap42 did not affect s6k phosphorylation, but did induce apoptosis. 2007-12-03 2023-08-12 drosophila_melanogaster
Markus J Riemenschneider, Rebecca A Betensky, Saskia M Pasedag, David N Loui. AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling. Cancer research. vol 66. issue 11. 2006-07-27. PMID:16740698. mtor activation results in subsequent activation of s6k and stat3, as well as suppression (i.e., phosphorylation) of 4e-bp1, leading to cell cycle progression and inhibition of apoptosis. 2006-07-27 2023-08-12 human
Jose R Bayascas, Nick R Leslie, Ramon Parsons, Stewart Fleming, Dario R Aless. Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice. Current biology : CB. vol 15. issue 20. 2006-06-26. PMID:16243031. knockout of pkbalpha in pten-deficient cells reduces aggressive growth and promotes apoptosis, whereas treatment of pten(+/-) mice with rapamycin, an inhibitor of the activation of s6k, reduces neoplasia. 2006-06-26 2023-08-12 mouse
Gudiseva Chandrasekher, Dasetty Sailaj. Phosphatidylinositol 3-kinase (PI-3K)/Akt but not PI-3K/p70 S6 kinase signaling mediates IGF-1-promoted lens epithelial cell survival. Investigative ophthalmology & visual science. vol 45. issue 10. 2004-11-06. PMID:15452065. to investigate the ability of insulin-like growth factor (igf)-1 to prevent apoptosis in lens epithelial cells and the involvement of phosphatidylinositol 3-kinase (pi-3k)/akt and pi-3k/p70 s6 kinase (p70 s6k) signaling in the cell-survival process. 2004-11-06 2023-08-12 Not clear
H Glantschnig, J E Fisher, G Wesolowski, G A Rodan, A A Reszk. M-CSF, TNFalpha and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase. Cell death and differentiation. vol 10. issue 10. 2004-06-07. PMID:14502240. inhibitors of these intermediates suppress cytokine activation of s6k and induce ocl apoptosis. 2004-06-07 2023-08-12 Not clear
W L Blalock, P M Navolanic, L S Steelman, J G Shelton, P W Moye, J T Lee, R A Franklin, A Mirza, M McMahon, M K White, J A McCubre. Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia. Leukemia. vol 17. issue 6. 2003-07-08. PMID:12764369. here we demonstrate the ability of deltamek1:er to activate the phosphatidylinositol 3-kinase (pi3k)/akt/p70 ribosomal s6 kinase (p70(s6k)) pathway and the importance of this pathway in mek1-mediated prevention of apoptosis. 2003-07-08 2023-08-12 human
Hidesuke Fukazawa, Kohji Noguchi, Yuko Murakami, Yoshimasa Uehar. Mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) inhibitors restore anoikis sensitivity in human breast cancer cell lines with a constitutively activated extracellular-regulated kinase (ERK) pathway. Molecular cancer therapeutics. vol 1. issue 5. 2003-06-16. PMID:12489846. the results indicate that concurrent inhibition of mek-erk and mtor-p70(s6k) pathways induces apoptosis in mda-mb231 and hbc4 cells when cells are deprived of anchorage but not when anchored. 2003-06-16 2023-08-12 human
Xiaolin Wan, Lee J Helma. Effect of insulin-like growth factor II on protecting myoblast cells against cisplatin-induced apoptosis through p70 S6 kinase pathway. Neoplasia (New York, N.Y.). vol 4. issue 5. 2003-02-20. PMID:12192598. blockade of p70 s6k activation by rapamycin abrogated the igf-ii-mediated protection of cells to cisplatin-induced apoptosis. 2003-02-20 2023-08-12 mouse
Xiaolin Wan, Lee J Helma. Effect of insulin-like growth factor II on protecting myoblast cells against cisplatin-induced apoptosis through p70 S6 kinase pathway. Neoplasia (New York, N.Y.). vol 4. issue 5. 2003-02-20. PMID:12192598. these data together suggest that igf-ii-associated protection to cisplatin-induced apoptosis is mediated through an activation of the p70 s6k pathway. 2003-02-20 2023-08-12 mouse
F Peiretti, S Lopez, P Deprez-Beauclair, B Bonardo, I Juhan-Vague, G Nalbon. Inhibition of p70(S6) kinase during transforming growth factor-beta 1/vitamin D(3)-induced monocyte differentiation of HL-60 cells allows tumor necrosis factor-alpha to stimulate plasminogen activator inhibitor-1 synthesis. The Journal of biological chemistry. vol 276. issue 34. 2001-09-20. PMID:11402043. in conclusion, these results indicate that inhibition of p70(s6k) phosphorylation during tgf/d3-induced monocyte differentiation of hl-60 cells is a determinant factor that allows tnf to exert its up-regulating effect on pai-1 synthesis while protecting cells from apoptosis. 2001-09-20 2023-08-12 human
S Bonatti, S Pigullo, M Simili, A Abbondandol. Induction of apoptosis and inhibition of signalling pathways by alkylated purines. Mutagenesis. vol 15. issue 4. 2000-11-03. PMID:10887217. at concentrations inducing apoptosis the three alkylpurines inhibited p70(s6k) activity, while they had the opposite effect on mapk. 2000-11-03 2023-08-12 Not clear
S Bonatti, S Pigullo, M Simili, A Abbondandol. Induction of apoptosis and inhibition of signalling pathways by alkylated purines. Mutagenesis. vol 15. issue 4. 2000-11-03. PMID:10887217. rapamycin, a specific inhibitor of the p70(s6k) pathway, did not induce apoptosis at doses inhibiting p70(s6k) activity, suggesting that p70(s6k) is not directly involved in apoptosis. 2000-11-03 2023-08-12 Not clear
S Bonatti, S Pigullo, M Simili, A Abbondandol. Induction of apoptosis and inhibition of signalling pathways by alkylated purines. Mutagenesis. vol 15. issue 4. 2000-11-03. PMID:10887217. as expected, and in line with results reported by others, wortmannin, an upstream inhibitor of the p70(s6k) pathway, did induce apoptosis. 2000-11-03 2023-08-12 Not clear
T Uchida, M G Myers, M F Whit. IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis. Molecular and cellular biology. vol 20. issue 1. 2000-01-10. PMID:10594015. thus, the activation of pkb/akt and bad phosphorylation might not be sufficient to inhibit the apoptosis of il-3-deprived 32d(ir) cells unless p85-associated pi 3-kinase or p70(s6k) are strongly activated. 2000-01-10 2023-08-12 human
J E Damen, J Krosl, D Morrison, S Pelech, G Krysta. The hyperresponsiveness of cells expressing truncated erythropoietin receptors is contingent on insulin-like growth factor-1 in fetal calf serum. Blood. vol 92. issue 2. 1998-08-06. PMID:9657741. in fact, long-term proliferation studies performed in the absence of serum show that even at saturating concentrations of epo, ba/f3 cells expressing these truncated receptors die via apoptosis, while cells bearing wt epors do not, and this programmed cell death correlates with an inability of epo-stimulated ba/f3 cells expressing truncated epors to induce the tyrosine phosphorylation of mapk and the activation of p70(s6k). 1998-08-06 2023-08-12 Not clear