| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiangping Deng, Timothy Searl, Samuel Ohlander, Danuta Dynda, Daniel A Harrington, Kevin T McVary, Carol A Podlase. BMP4 and GREM1 are targets of SHH signaling and downstream regulators of collagen in the penis. The journal of sexual medicine. 2024-03-07. PMID:38451311. |
cavernous nerve (cn) injury, caused by prostatectomy and diabetes, initiates a remodeling process (smooth muscle apoptosis and increased collagen) in the corpora cavernosa of the penis of patients and animal models that is an underlying cause of erectile dysfunction (ed), and the sonic hedgehog (shh) pathway plays an essential role in the response of the penis to denervation, as collagen increases with shh inhibition and decreases with shh treatment. |
2024-03-07 |
2024-03-09 |
Not clear |
| Qiong Lin, Tianxing Yu, Xiaohua Li, Xin Lin, Yong Fan, Liyu X. Umbilical cord mesenchymal stem cells inhibited inflammation of bronchial epithelial cells by regulating Hedgehog pathway. European journal of histochemistry : EJH. vol 67. issue 4. 2023-12-12. PMID:38085254. |
compared with the control group, bronchial epithelial cells treated with tgf-β1 showed significantly decreased proliferation, increased apoptosis, increased secretion of tnf-α and il-6, increased expression of α-sma, shh, gli1 and snail and decreased e-cadherin expression. |
2023-12-12 |
2023-12-17 |
human |
| Zhang Xinling, Sun Zhongyang, Chen Yujie, Lin Zhiyu, Zhao Zhenmin, Zhao Hongy. Coexpression analysis of angiogenesis, proliferation, apoptosis, autophagy and SHH pathway genes involved in skin expansion. Archives of biochemistry and biophysics. 2023-11-09. PMID:37944780. |
coexpression analysis of angiogenesis, proliferation, apoptosis, autophagy and shh pathway genes involved in skin expansion. |
2023-11-09 |
2023-11-20 |
mouse |
| Zhang Xinling, Sun Zhongyang, Chen Yujie, Lin Zhiyu, Zhao Zhenmin, Zhao Hongy. Coexpression analysis of angiogenesis, proliferation, apoptosis, autophagy and SHH pathway genes involved in skin expansion. Archives of biochemistry and biophysics. 2023-11-09. PMID:37944780. |
furthermore, we identified that shh signaling genes formed a coexpression regulatory network with cellular proliferation, apoptosis, autophagy and angiogenesis-related genes in the expanded skin. |
2023-11-09 |
2023-11-20 |
mouse |
| Cuicui Liu, Tianfeng Yang, Cheng Cheng, Jian Huo, Xiuhong Peng, Yanmin Zhan. Dauricine attenuates Oct4/sonic hedgehog co-activated stemness and induces reactive oxygen species-mediated mitochondrial apoptosis via AKT/β-catenin signaling in human neuroblastoma and glioblastoma stem-like cells. Phytotherapy research : PTR. 2023-10-11. PMID:37821355. |
we identified that shh effectively improved oct4-mediated generation of stemness in sh-sy5y and t98-g cells, and oct4 and shh co-activation promoted cell growth, the resistance of apoptosis. |
2023-10-11 |
2023-10-15 |
human |
| Wen Liu, Yinan Fu, Meng Wang, Junhong Zhao, Julin Chen, Yongxin Wang, Hu Qi. A preliminary study on the mechanism of VASH2 in childhood medulloblastoma. Scientific reports. vol 13. issue 1. 2023-10-11. PMID:37821528. |
we used vasopressin 2 (vash2) as a research target and overexpressed and knocked down vash2 in shh medulloblastoma cell lines daoy by lentiviral vectors in vitro, respectively, to investigate its role in shh medulloblastoma cell lines daoy cell proliferation, apoptosis, migration, invasion and biological roles in the cell cycle. |
2023-10-11 |
2023-10-15 |
Not clear |
| Yong He, Hong-Hong Liu, Xue-Lin Zhou, Ting-Ting He, Ao-Zhe Zhang, Xin Wang, Shi-Zhang Wei, Hao-Tian Li, Li-Sheng Chen, Lei Chang, Yan-Ling Zhao, Man-Yi Jin. Rutaecarpine Ameliorates Murine N-Methyl-N'-Nitro-N-Nitrosoguanidine-Induced Chronic Atrophic Gastritis by Sonic Hedgehog Pathway. Molecules (Basel, Switzerland). vol 28. issue 17. 2023-09-09. PMID:37687125. |
the qrt-pcr and wb analyses indicated that the protective effect of rut is related to the upregulation of the shh pathway and downregulation of the downstream of apoptosis to improve gastric cellular survival. |
2023-09-09 |
2023-10-07 |
rat |
| Binhao Chen, Weifeng Ji. A comprehensive review of stroke-related signaling pathways and treatment in western medicine and traditional Chinese medicine. Frontiers in neuroscience. vol 17. 2023-06-23. PMID:37351420. |
the involvement of multiple signaling pathways, including sonic hedgehog (shh), nuclear factor erythroid 2-related factor 2 (nrf2)/antioxidant response element (are), hypoxia-inducible factor-1α (hif-1α), pi3k/akt, jak/stat, and ampk in pathophysiological mechanisms such as oxidative stress and apoptosis, highlights the complexity of stroke. |
2023-06-23 |
2023-08-14 |
Not clear |
| Daniela Giovannini, Cinzia De Angelis, Maria Denise Astorino, Emiliano Fratini, Evaristo Cisbani, Giulia Bazzano, Alessandro Ampollini, Massimo Piccinini, Enrico Nichelatti, Emiliano Trinca, Paolo Nenzi, Mariateresa Mancuso, Luigi Picardi, Carmela Marino, Concetta Ronsivalle, Simonetta Pazzagli. In Vivo Radiobiological Investigations with the TOP-IMPLART Proton Beam on a Medulloblastoma Mouse Model. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175984. |
mice bearing sonic-hedgehog (shh)-dependent mb in the flank were irradiated with protons to test whether irradiation could be restricted to a specific depth in the tumor tissue and to compare apoptosis induced by the same dose of protons or photons. |
2023-05-14 |
2023-08-14 |
mouse |
| Elina Pokharel, Yam P Aryal, Tae-Young Kim, Anna Kim, Jae-Kwang Jung, Seo-Young An, Tae-Yub Kwon, Bong-Ki Min, Hitoshi Yamamoto, Sung-Won Cho, Wern-Joo Sohn, Chang-Hyeon An, Youngkyun Lee, Do-Yeon Kim, Jung-Hong Ha, Jae-Young Ki. The role of O-GlcNAcylation mediated by OGT during tooth development. Journal of cellular physiology. 2023-04-26. PMID:37098720. |
overall, inhibition of ogt resulted in altered cellular physiology, including proliferation, apoptosis, and epithelial rearrangements, with significant changes in the expression patterns of β-catenin, fibroblast growth factor 4 (fgf4), and sonic hedgehog (shh). |
2023-04-26 |
2023-08-14 |
mouse |
| Rosalinda Mejía-Rodríguez, Daniel Romero-Trejo, Rosa O González, José Segovi. Combined treatments with AZD5363, AZD8542, curcumin or resveratrol induce death of human glioblastoma cells by suppressing the PI3K/AKT and SHH signaling pathways. Biochemistry and biophysics reports. vol 33. 2023-01-30. PMID:36714540. |
we found that the combined treatments with azd5363+azd8542+curcumin and azd8542+curcumin+resveratrol inhibit the pi3k/akt and shh survival pathways by decreasing the activity of akt, the reduction of the expression of smo, pp70s6k, ps6k, gli1, p21 and p27, and the activation of caspase-3 as a marker of apoptosis. |
2023-01-30 |
2023-08-14 |
human |
| Anran Xu, Yuanyuan Fan, Song Liu, Lianbing Sheng, Yanyan Sun, Huijun Yan. GIMAP7 induces oxidative stress and apoptosis of ovarian granulosa cells in polycystic ovary syndrome by inhibiting sonic hedgehog signalling pathway. Journal of ovarian research. vol 15. issue 1. 2022-12-29. PMID:36581994. |
this study proved that gimap7 promotes oxidative stress and apoptosis in ovarian granulosa cells in pcos by inhibiting the shh signalling pathway. |
2022-12-29 |
2023-08-14 |
human |
| Ria Gupta, Sidharth Mehan, Swesha Chhabra, Aditi Giri, Kajal Sherawa. Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder. Neurotoxicity research. 2022-10-22. PMID:36272053. |
shh signaling dysregulation leads to decreased target gene transcription, which contributes to increased neuronal excitation, apoptosis, and neurodegeneration, eventually leading to neurological deficits. |
2022-10-22 |
2023-08-14 |
Not clear |
| Hualin Chen, Donghong Yang, Yongcun Wang, Hua Tao, Yiping Luo, Aibing Wu, Shujun Li, Zhixiong Yang, Ming Che. Activation of the Hedgehog pathway mediates resistance to epidermal growth factor receptor inhibitors in non-small cell lung cancer. Journal of Cancer. vol 13. issue 3. 2022-02-14. PMID:35154464. |
shh stimulation promoted gli1 activation as well as cell motility in parental pc9 cells while suppressing gefitinib-induced apoptosis in gefitinib-resistant cells. |
2022-02-14 |
2023-08-13 |
Not clear |
| Bo Meng, Fang-Yuan Liu, Ming-Ming Liu, Liang-Chen Yu, Wen-Ting Zhang, Meng-Yuan Zhou, Si-Yu Liu, Rong Li, Li Ca. AMSP-30 m as a novel HIF-1α inhibitor attenuates the development and severity of adjuvant-induced arthritis in rats: Impacts on synovial apoptosis, synovial angiogenesis and sonic hedgehog signaling pathway. International immunopharmacology. vol 103. 2021-12-21. PMID:34933161. |
the influences of amsp-30 m on synovial apoptosis, angiogenesis and sonic hedgehog (shh) pathway were examined. |
2021-12-21 |
2023-08-13 |
rat |
| Anna Junga, Ivo Siņicins, Aigars Pētersons, Māra Pilman. Evaluation of PGP 9.5, NGFR, TGFβ1, FGFR1, MMP-2, AT2R2, SHH, and TUNEL in Primary Obstructive Megaureter Tissue. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2021-12-17. PMID:34915763. |
apoptosis, appearance of mmp-2, fgfr1, and shh prevailed, but tgfβ1 positive cell number was lower in patients. |
2021-12-17 |
2023-08-13 |
Not clear |
| Chengliang Yang, Xiaoli Zheng, Ke Ye, Yanan Sun, Yufei Lu, Qingxia Fan, Hong G. miR-135a Inhibits the Invasion and Migration of Esophageal Cancer Stem Cells through the Hedgehog Signaling Pathway by Targeting Smo. Molecular therapy. Nucleic acids. vol 19. 2021-12-02. PMID:31981861. |
after that, the expression of mir-135a and hedgehog (hh) signaling pathway-related genes (smo, gli1, shh, and gli2) in tissues and cells was measured, accompanied by evaluation of cell viability, apoptosis, invasion, and migration. |
2021-12-02 |
2023-08-13 |
Not clear |
| Chengliang Yang, Xiaoli Zheng, Ke Ye, Yanan Sun, Yufei Lu, Qingxia Fan, Hong G. miR-135a Inhibits the Invasion and Migration of Esophageal Cancer Stem Cells through the Hedgehog Signaling Pathway by Targeting Smo. Molecular therapy. Nucleic acids. vol 19. 2021-12-02. PMID:31981861. |
in addition, overexpression of mir-135a or silencing of smo decreased the expression of gli1, gli2, and shh, thus inhibiting ec cell proliferation, migration, and invasion and promoting apoptosis. |
2021-12-02 |
2023-08-13 |
Not clear |
| Sumei Li, Jingxiang Wang, Yurong Lu, Yuqing Zhao, Richard A Prinz, Xiulong X. Inhibition of the sonic hedgehog pathway activates TGF-β-activated kinase (TAK1) to induce autophagy and suppress apoptosis in thyroid tumor cells. Cell death & disease. vol 12. issue 5. 2021-10-14. PMID:33966040. |
the objective of this study was to determine whether autophagy was induced by inhibition of the shh pathway and could negatively regulate gant61-induced apoptosis. |
2021-10-14 |
2023-08-13 |
Not clear |
| Sumei Li, Jingxiang Wang, Yurong Lu, Yuqing Zhao, Richard A Prinz, Xiulong X. Inhibition of the sonic hedgehog pathway activates TGF-β-activated kinase (TAK1) to induce autophagy and suppress apoptosis in thyroid tumor cells. Cell death & disease. vol 12. issue 5. 2021-10-14. PMID:33966040. |
our study has shown that inhibition of the shh pathway induces autophagy by activating tak1, whereas autophagy in turn suppresses gant61-induced apoptosis. |
2021-10-14 |
2023-08-13 |
Not clear |