| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fang Che. Inhibiting Pink1/Parkin-mediated mitophagy enhances the anticancer effects of quercetin in hepatocellular carcinomaf. Biochemical and biophysical research communications. vol 712-713. 2024-04-23. PMID:38653003. |
in vivo experiments using hep3b xenograft models revealed that the combination of quercetin with the mitophagy inhibitor hydroxychloroquine or sirt1 knockdown significantly enhanced the anticancer effects of quercetin, as evidenced by reduced tumor size and weight, increased necrosis and apoptosis, and decreased proliferation in tumor tissues. |
2024-04-23 |
2024-04-26 |
Not clear |
| Feilan Xuan, Yuefang Ren, Jiali Lu, Weimei Zhou, Ruiying Jin, Aixue Chen, Yongju Y. CPEB1 induces autophagy and promotes apoptosis in ovarian granulosa cells of polycystic ovary syndrome. Molecular reproduction and development. vol 91. issue 4. 2024-04-15. PMID:38616716. |
in vitro, cpeb1 overexpression inhibited cell viability and sirtuin-1 (sirt1), activated tumor necrosis factor-α, and interleukin-6 levels, as well as apoptosis and autophagy; however, cpeb1 knockdown had the opposite effect. |
2024-04-15 |
2024-04-17 |
rat |
| Xing-Nian Zhou, Quan Zhang, Hong Peng, Yu-Jie Qin, Yu-Hong Liu, Lu Wang, Ming-Liang Cheng, Xin-Hua Luo, Hong L. Silent information regulator sirtuin 1 ameliorates acute liver failure World journal of gastroenterology. vol 30. issue 11. 2024-04-15. PMID:38617450. |
the silent information regulator sirtuin 1 (sirt1)-mediated deacetylation affects multiple biological processes, including cellular senescence, apoptosis, sugar and lipid metabolism, oxidative stress, and inflammation. |
2024-04-15 |
2024-04-17 |
Not clear |
| Mohammad Hasan Maleki, Sara Abdizadeh Javazm, Sanaz Dastghaib, Anahita Panji, Mohammad Hojjati Far, Hajar Mahmoodi, Morvarid Siri, Sayed Mohammad Shafie. The effect of quercetin on adipogenesis, lipolysis, and apoptosis in 3T3-L1 adipocytes: The role of SIRT1 pathways. Obesity science & practice. vol 10. issue 2. 2024-04-15. PMID:38618521. |
the effect of quercetin on adipogenesis, lipolysis, and apoptosis in 3t3-l1 adipocytes: the role of sirt1 pathways. |
2024-04-15 |
2024-04-17 |
Not clear |
| Cheng Tian, Rongrong Huang, Ming Xian. SIRT1: Harnessing multiple pathways to hinder NAFLD. Pharmacological research. 2024-03-25. PMID:38527697. |
mechanically, sirt1 alleviates nafld by reestablishing autophagy, enhancing mitochondrial function, suppressing oxidative stress, and coordinating lipid metabolism, as well as reducing hepatocyte apoptosis and inflammation. |
2024-03-25 |
2024-03-28 |
Not clear |
| Yongchun Zheng, Xueyan Chen, Chuanbo Ding, Xinglong Liu, Lihua Chi, Shuai Zhan. Abscisic acid ameliorates d-galactose -induced aging in mice by modulating AMPK-SIRT1-p53 pathway and intestinal flora. Heliyon. vol 10. issue 6. 2024-03-25. PMID:38524603. |
in addition, aba regulated the b-cell-lymphoma-2 (bcl-2) family and phosphatidylinositol 3-kinase/protein kinase b (pi3k/akt) signaling pathway, while further regulating the acetylation of p53 protein by modulating the ampk pathway and activating sirt1 protein, thereby inhibiting the apoptosis of brain neurons and thus regulating the aging process. |
2024-03-25 |
2024-03-27 |
mouse |
| Hui-Yin Chan, Thamil Selvee Ramasamy, Felicia Fei-Lei Chung, Sin-Yeang Teo. Role of sirtuin 1 (SIRT1) in regulation of autophagy and nuclear factor-kappa Beta (NF-ĸβ) pathways in sorafenib-resistant hepatocellular carcinoma (HCC). Cell biochemistry and biophysics. 2024-03-11. PMID:38466472. |
sirtuin 1 (sirt1), is a nicotinamide adenosine dinucleotide (nad)-dependent histone deacetylases that regulates various metabolic and oncogenic events such as cell survival, apoptosis, autophagy, tumourigenesis, metastasis and drug resistance in various cancers, but its role in hcc, particularly in sorafenib resistance is underexplored. |
2024-03-11 |
2024-03-14 |
Not clear |
| Mohammadjavad Sotoudeheian, Seyed-Mohamad-Sadegh Mirahmadi, Mohammad Pirhayati, Navid Farahmandian, Reza Azarbad, Hamidreza Pazoki Toroud. Targeting SIRT1 by Scopoletin to Inhibit XBB.1.5 COVID-19 Life Cycle. Current reviews in clinical and experimental pharmacology. 2024-03-05. PMID:38441021. |
the silent information regulator 1 (sirt1) pathway, linked to autophagy, protects cells via foxo3, inhibits apoptosis, and modulates sirt1 in type-ii epithelial cells. |
2024-03-05 |
2024-03-07 |
Not clear |
| Sara A Mahmoud, Abeer Elkhoely, Elsayed K El-Sayed, Amany A E Ahme. Enhanced upregulation of SIRT1 via pioglitazone and ligustrazine confers protection against ethanol-induced gastric ulcer in rats. Naunyn-Schmiedeberg's archives of pharmacology. 2024-03-05. PMID:38441571. |
our study was the first to show that piog, ligu, and (piog+ligu) ameliorated oxidative stress, inflammation, and apoptosis and accelerated the autophagic process via the upregulation of the upstream sirt1 protein. |
2024-03-05 |
2024-03-07 |
rat |
| Gholamreza Taheripak, Niusha Sabeti, Naba Najar, Zahrasadat Razavi, Saber Saharkhiz, Iraj Alipourfar. SIRT1 activation attenuates palmitate induced apoptosis in C Molecular biology reports. vol 51. issue 1. 2024-02-24. PMID:38400872. |
sirt1 activation attenuates palmitate induced apoptosis in c type 2 diabetes is characterized by insulin resistance, which manifests mainly in skeletal muscles. |
2024-02-24 |
2024-02-27 |
Not clear |
| Gholamreza Taheripak, Niusha Sabeti, Naba Najar, Zahrasadat Razavi, Saber Saharkhiz, Iraj Alipourfar. SIRT1 activation attenuates palmitate induced apoptosis in C Molecular biology reports. vol 51. issue 1. 2024-02-24. PMID:38400872. |
however, the molecular underpinnings of sirt1's function in palmitate fatty acid-induced apoptosis still need to be better understood. |
2024-02-24 |
2024-02-27 |
Not clear |
| Yan Wang, Jialiang Lin, Zihao Yu, Jinbo Cheng, Jianhua Cheng, Weikang Cu. Rigid-flexible nanocarriers loaded with active peptides for antioxidant and anti-inflammatory applications in skin. Colloids and surfaces. B, Biointerfaces. vol 236. 2024-02-23. PMID:38394858. |
furthermore, cellular experiments showed that this system mainly regulates nrf2, sirt1, and peg2/cox-2-related signaling pathways, thus effectively counteracting cellular inflammation, senescence, and apoptosis from oxidative damage. |
2024-02-23 |
2024-02-26 |
Not clear |
| Jing Wang, Yiqiong Yang, Yang Xu, Zhipeng Xu, Xiaozhi Zhao, Ruipeng Jia, Yutian Da. Long noncoding RNA XIST inhibition promotes Leydig cell apoptosis by acting as a competing endogenous RNA for microRNA-145a-5p that targets SIRT1 in late-onset hypogonadism. Cell and tissue research. 2024-02-14. PMID:38353742. |
long noncoding rna xist inhibition promotes leydig cell apoptosis by acting as a competing endogenous rna for microrna-145a-5p that targets sirt1 in late-onset hypogonadism. |
2024-02-14 |
2024-02-16 |
Not clear |
| Yazhong Ma, Xiaotong Wang, Xin Li, Xi Chen, Zhifeng Teng, Xuekun Wang, Jie Yang, Guoyun Li. COP-22 Alleviates D-Galactose-Induced Brain Aging by Attenuating Oxidative Stress, Inflammation, and Apoptosis in Mice. Molecular neurobiology. 2024-02-12. PMID:38347285. |
we found that cop-22 could effectively protect against brain injury (sirt1, p53, p21, and p16) by inhibiting oxidative stress (nrf2 and ho-1), inflammation (il-6 and tnf-α), and apoptosis (bax and caspase-3) in d-gal-induced aging mice. |
2024-02-12 |
2024-02-15 |
mouse |
| Yuxun Shi, Dan Ye, Kaixuan Cui, Xue Bai, Matthew Fan, Yanlin Feng, Chenyang Hu, Yue Xu, Jingjing Huan. Melatonin ameliorates retinal ganglion cell senescence and apoptosis in a SIRT1-dependent manner in an optic nerve injury model. Biochimica et biophysica acta. Molecular basis of disease. 2024-02-07. PMID:38325588. |
thus, this study aimed to examine the effects of melatonin on rgc senescence and apoptosis after onc and investigate the involvement of sirt1 in this process. |
2024-02-07 |
2024-02-10 |
mouse |
| Zhaoyang Sun, Anhui Jiao, Yuhan Zhao, Tiancang Han, Hongbo Zhang, Qingshan Ga. Isoliquiritin can cause mitochondrial dysfunction and regulate Nrf2 to affect the development of mouse oocytes. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-02-04. PMID:38311047. |
its upstream and downstream foxo3 gpx1, cat, sod2, sirt1 gene also appear different degree of significant change (p < 0.05), in which the lower expression of nadp + (p < 0.05) illustrates the mitochondrial atp synthesis electronic chain were suppressed, it also has the reason, by inhibiting electron chain and atp synthesis, ilg leads to oocyte apoptosis and initiation of autophagy, reducing oocyte and its subsequent developmental potential. |
2024-02-04 |
2024-02-07 |
mouse |
| Yoon-Young Kang, Dong-Young Kim, Sang-Yong Lee, Hee-Joong Kim, Taehawn Kim, Jeong A Cho, Taewon Lee, Eun Young Cho. Innate Immune Training Initiates Efferocytosis to Protect against Lung Injury. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-01-27. PMID:38279580. |
elevated epithelial sirt1 expression is associated with decreased epithelial cell apoptosis after lung injury, attenuating tissue damage. |
2024-01-27 |
2024-01-29 |
mouse |
| He Hu, Weichao Xu, Yan Li, Zhicheng Wang, Siyue Wang, Yansheng Liu, Minan Bai, Yingying Lou, Qian Yan. SIRT1 regulates endoplasmic reticulum stress-related organ damage. Acta histochemica. vol 126. issue 1. 2024-01-18. PMID:38237370. |
increasing evidence suggests that sirt1 plays a positive role in various ers-induced organ damage via multiple mechanisms, including inhibiting cellular apoptosis and promoting autophagy. |
2024-01-18 |
2024-01-21 |
Not clear |
| Samira Barangi, Soghra Mehri, Zahra Moosavi, Fatemeh Yarmohammadi, A Wallace Hayes, Gholamreza Karim. Melatonin attenuates liver injury in arsenic-treated rats: The potential role of the Nrf2/HO-1, apoptosis, and miR-34a/Sirt1/autophagy pathways. Journal of biochemical and molecular toxicology. vol 38. issue 1. 2024-01-17. PMID:38229313. |
the liver tissue was removed and then histological alterations, oxidative stress markers, antioxidant capacity, the levels of nrf2 and ho-1, apoptosis (bcl-2, survivin, mcl1, bax, and caspase-3), and autophagy (sirt1, beclin-1, and lc3 ii/i ratio) proteins, as well as the expression level of mir-34a, were evaluated on this tissue. |
2024-01-17 |
2024-01-19 |
rat |
| Xiaodong Wang, Jin Yan, Xiaolong Ni, Sipin Hu, Mingwan Zhang, Yin Yin. Phloretin targets SIRT1 to alleviate oxidative stress, apoptosis, and inflammation in deep venous thrombosis. Toxicological research. vol 40. issue 1. 2024-01-15. PMID:38223667. |
phloretin targets sirt1 to alleviate oxidative stress, apoptosis, and inflammation in deep venous thrombosis. |
2024-01-15 |
2024-01-17 |
human |