| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fei Wang, Hao Zhang, Xiru Liu, Yuanyuan Dou, Hui Yan. MEOX2 mediates cisplatin resistance in ovarian cancer via E2F target and DNA repair pathways. Journal of ovarian research. vol 18. issue 1. 2025-03-22. PMID:40119426. |
further gene silencing experiments revealed that silencing meox2 markedly enhanced cisplatin resistance in resistant cells and significantly reduced cisplatin-induced early apoptosis, although it had no notable effect on cell proliferation. |
2025-03-22 |
2025-03-25 |
Not clear |
| Ruiyang Zhang, Feifei Hou, Jianguo Gan, Lishen Zhang, Dan Yang, Fan Yang, Xiaoqiang Xia, Qianming Chen, Ce Bian, Xiaodong Fen. Metformin-induced E6/E7 inhibition prevents HPV-positive cancer progression through p53 reactivation. Anti-cancer drugs. 2025-03-18. PMID:40100964. |
cell counting kit-8, ethynyl-2'-deoxyuridine, and terminal-deoxynucleotidyl transferase-mediated nick end labeling assays were conducted to evaluate the effects of metformin on cell viability, proliferation, and apoptosis. |
2025-03-18 |
2025-03-21 |
human |
| Fangfang Di, Yan Yan, Lihua Yao, Zhongxiao Zhang, Liwen Song, Jin Qiu, Runjie Zhan. Unveiling ODP4: A breakthrough in PCOS treatment via BAT transplantation. Biochemical pharmacology. 2025-03-16. PMID:40090595. |
we validated the impact of bat transplantation and found that an overexpressed ovary derived peptide 4 (odp4) in bat transplantation rats could potentiate the inhibitory effect of dehydroepiandrosterone (dhea) on granulosa cell (gc) development, yield a stimulatory effect on cell apoptosis and regulate ovulation genes and hormone synthesis. |
2025-03-16 |
2025-03-19 |
rat |
| Hongli Yin, Tianyi Liu, Di Wu, Xiaolu Li, Gen Li, Weiwei Song, Xiaodong Wang, Shan Xin, Yisu Liu, Jian Pa. Exploring FAM13A-N-Myc interactions to uncover potential targets in MYCN-amplified neuroblastoma: a study of protein interactions and molecular dynamics simulations. BMC cancer. vol 25. issue 1. 2025-03-15. PMID:40087586. |
cell functional experiments, including those on cell proliferation, apoptosis, and cell cycle, also indicate that fam13a is a potential risk factor. |
2025-03-15 |
2025-03-18 |
Not clear |
| Chenlu Li, Haolong Luo, Mengyuan Chen, Fuxing Lin, Xiangmei Ren, Yefei Huang, Li Zho. Bisphenol AF induces cell cycle arrest and apoptosis in TM3 Leydig cells via the p53 signaling pathway. Reproductive toxicology (Elmsford, N.Y.). 2025-03-15. PMID:40089166. |
to comprehensively understand the male reproductive toxicity of bpaf, tm3 leydig cells were used to investigate the effects of bpaf on cell proliferation, apoptosis, and cell cycle arrest. |
2025-03-15 |
2025-03-18 |
Not clear |
| Razmik Mirzayan. Anastasis and Other Apoptosis-Related Prosurvival Pathways Call for a Paradigm Shift in Oncology: Significance of Deintensification in Treating Solid Tumors. International journal of molecular sciences. vol 26. issue 5. 2025-03-13. PMID:40076508. |
the nomenclature committee on cell death and numerous other pioneering cancer/p53 biologists use the terms "apoptosis" and "cell death" interchangeably, disregard the mind-numbing complexity and heterogeneity that exists within a tumor (intratumor heterogeneity), disregard the contribution of polyploid giant cancer cells (pgccs; the root causes of therapy resistance and relapse) to this heterogeneity, and then propose novel apoptosis-stimulating anticancer strategies. |
2025-03-13 |
2025-03-15 |
Not clear |
| Muhammet Oner, Yu-Chiao Cheng, Shiuan-Woei Soong, Pang-Ting Cheng, Yan-Hsiung Wang, Shun-Fa Yang, Stella Chin-Shaw Tsai, Ho Li. Dinaciclib Interrupts Cell Cycle and Induces Apoptosis in Oral Squamous Cell Carcinoma: Mechanistic Insights and Therapeutic Potential. International journal of molecular sciences. vol 26. issue 5. 2025-03-13. PMID:40076816. |
this study investigated dinaciclib's effects on cell proliferation, cell cycle progression, and apoptosis in the oscc cell lines ca9-22, oecm-1, and hsc-3. |
2025-03-13 |
2025-03-15 |
Not clear |
| Marine Devinat, Jessica Thevenard-Devy, Fatiha Ghilane, Jerome Devy, Lise Chazee, Christine Terryn, Laurent Duca, Emmanuelle Devarenne-Charpentier, Hassan El Btaour. Xanthohumol Sensitizes Melanoma Cells to Vemurafenib by Lowering Membrane Cholesterol and Increasing Membrane Fluidity. International journal of molecular sciences. vol 26. issue 5. 2025-03-13. PMID:40076912. |
we measured the xn effect on cell viability and apoptosis. |
2025-03-13 |
2025-03-15 |
Not clear |
| Yuepeng An, Qing Zhang, Jiusi Zhao, Nan Zhen. Tangeretin regulates oxidative stress in cutaneous melanoma cells via the Nrf2 signaling pathway. Archives of dermatological research. vol 317. issue 1. 2025-03-12. PMID:40072600. |
the effects of tangeretin on cell proliferation, migration, invasion, and apoptosis were assessed using mtt, wound healing, transwell invasion, and flow cytometry assays, respectively. |
2025-03-12 |
2025-03-15 |
human |
| Shanshan Zhang, Xinfeng Zou, Xiaona Feng, Shuai Shi, Yanyun Zheng, Qun Li, Yanqun W. Exosomes derived from hypoxic mesenchymal stem cell ameliorate premature ovarian insufficiency by reducing mitochondrial oxidative stress. Scientific reports. vol 15. issue 1. 2025-03-11. PMID:40065033. |
in addition, ctx-treated kgn cell lines were used to investigate the effects of nexos and hexos on cell proliferation, apoptosis, oxidative stress and mitochondrial membrane potential.the results indicated that hucmscs-exos transplantation substantially improved body weight, ovarian weight coefficient, estrous cycles, ovarian morphology, ovulation count, and sex hormone levels in poi rats. |
2025-03-11 |
2025-03-13 |
human |
| Yi Liu, Yina Wang, Adili Salai, Yueying Yang, Yang Wan. Induction of miR-224 by Reactive Oxygen Species Regulates RASSF6 and Thus Modulates Malignant Behaviors and Chemosensitivity in Esophageal Squamous Cell Carcinoma. Journal of biochemical and molecular toxicology. vol 39. issue 3. 2025-03-11. PMID:40067291. |
the expression of mir-224 and hif-1α in esophageal cancer cells under hypoxic induction and their relationship with ros was studied using rt-qpcr and western blot assays; cell viability and apoptosis under hypoxia, as well as the effects of mir-224 on cell proliferation and drug resistance, were investigated using cck8, annexin v-fitc/pi, h2dcfda staining and western blot assays. |
2025-03-11 |
2025-03-14 |
Not clear |
| Cuifang Lu, Bin Yang, Ying Liu, Wenbo Liu, Jie Yan, Chenggong Guo, Tingyu Song, Xiaofei Wan. Carvacrol Regulates the Expression of SLC25A6 by Inhibiting VDAC1 to Improve Mitochondrial Function and Reduce LPS-Induced Inflammatory Injury in HMEC-1 Cells. ACS omega. vol 10. issue 8. 2025-03-10. PMID:40060777. |
the results show that carvacrol significantly reduced lps-induced expression of il-1β, il-6, il-18, and tnf-α and alleviated the effects of lps on cell proliferation and apoptosis of hmec-1. |
2025-03-10 |
2025-03-12 |
human |
| Guilherme Augusto Sousa Alcântara, Mariane Cristina do Nascimento, Livia Bassani Lins de Miranda, Bruna Oliveira de Almeida, Keli Lima, Eduardo Magalhães Rego, Leticia Veras Costa-Lotufo, João Agostinho Machado-Net. Eribulin exerts multitarget antineoplastic activity in glioma cells. Pharmacological reports : PR. 2025-03-08. PMID:40056292. |
this study investigates the cellular and molecular effects of eribulin in glioma models, focusing on its impact on cell cycle progression, apoptosis, mitochondrial function, and migration. |
2025-03-08 |
2025-03-11 |
Not clear |
| Jikuan Zhu, Xudong Zhang, Tianping Luo, Cailin Xue, Jiadeng Chao, Jun Li, Bei Zhu, Lei Jin, Chunfu Zhu, Xihu Qi. tRF-Pro-CGG Suppresses Cell Proliferation and Promotes Apoptosis in Pancreatic Cancer. Digestive diseases and sciences. 2025-03-08. PMID:40056302. |
this study aimed to investigate the role of trna-derived rna fragment trf-pro-cgg in pancreatic cancer (pc), focusing on its expression levels in pc tissues and cell lines, and its effects on cell proliferation, clonality, migration, invasion, and apoptosis. |
2025-03-08 |
2025-03-11 |
Not clear |
| Xu-Li Wang, Jia Me. LncRNA TUSC7 Inhibits Cell Proliferation in Chronic Lymphocytic Leukemia by Modulating the miR-211-5p/SLC37A3 Axis. The Kaohsiung journal of medical sciences. 2025-03-08. PMID:40056063. |
further rescue experiments demonstrated that silencing slc37a3 or upregulating mir-211-5p reversed the effects of tusc7 elevation on cell proliferation and apoptosis. |
2025-03-08 |
2025-03-12 |
Not clear |
| Xiaosong Li, Yifen Shen, Jianhua Lang, Jianzhong Wu, Zhenhai Qian, Genhai Shen, Yihang She. CD39 Contributes to the Ability of Cell Invasion in Heterogeneity of Colorectal Cancer. Journal of cellular and molecular medicine. vol 29. issue 5. 2025-03-07. PMID:40052646. |
overall, our study uncovered distinct gene signatures amongst different heterogeneities of colorectal cells and revealed the effect of cd39 on cell invasion and apoptosis, as well as determined the epigenetic role in regulating cd39 transcription. |
2025-03-07 |
2025-03-09 |
Not clear |
| A S Kucheryavenko, E A Muzyko, V N Perfilova, K D Kaplanov, M Yu Frolo. The role of the PPM1D gene in tumor pathogenesis. Biomeditsinskaia khimiia. vol 71. issue 1. 2025-03-06. PMID:40045720. |
amplification, overexpression, or mutations of the ppm1d gene have a significant impact on cell responses to stress factors and genetic instability as well as impairments of processes of double-strand break repair, nucleotide excision repair, base excision repair, cell cycle, and apoptosis. |
2025-03-06 |
2025-03-08 |
Not clear |
| Haribalan Perumalsamy, Johan Sukweenadhi, Anuj Ranjan, Akhilesh Dubey, Manohar Mahadev, Mohamed Farouk Elsadek, Saeedah Musaed Almutairi, Daewon Sohn, Sri Renukadevi Balusam. Structural isomers of carene persuade apoptotic cell death by inhibiting cell cycle in breast cancer cells: An in silico and in vitro approach. Tissue & cell. vol 93. 2025-03-04. PMID:39765134. |
for the first time, our study provides a comprehensive examination of the anti-cancer effects of structural isomers of carene in breast cancer cells, specifically focusing on cell cycle inhibition and the induction of apoptosis. |
2025-03-04 |
2025-03-06 |
Not clear |
| Fuqun Wei, PeiShu Huang, Bing Zhang, Rui Guo, Xiang You, Zhong Wu Chen, YiPing Che. Machine learning analysis identified NNMT as a potential therapeutic target for hepatocellular carcinoma based on PCD-related genes. Scientific reports. vol 15. issue 1. 2025-03-03. PMID:40032894. |
the model was validated across multiple cohorts to evaluate its predictive accuracy for clinical outcomes, immune infiltration, and therapeutic response, and further validation of the relationship between nnmt overexpression and clinical prognosis using tumor tissue microarray data, and in vitro experiments to confirm the impact of nnmt overexpression on cell proliferation and apoptosis. |
2025-03-03 |
2025-03-06 |
Not clear |
| Jinkui Sun, Xiang Chen, Yong Ruan, Jiali Xu, Houqiang X. MEF2A promoter methylation negatively regulates mRNA transcription and affects myoblast physiological function in cattle. Genomics. 2025-03-02. PMID:40024578. |
the effects on cell cycle progression, apoptosis, and other growth parameters were assessed using flow cytometry, elisa, and qrt-pcr. |
2025-03-02 |
2025-03-05 |
cattle |