| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Chen, Yuan Gao, Shu-Ting Bao, Ying-Di Wang, Tao Jia, Cui Yin, Cheng Xiao, Chunyi Zho. Insula-amygdala and insula-thalamus pathways are involved in comorbid chronic pain and depression-like behavior in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-03-07. PMID:38453468. |
optogenetic activation of pic neurons induced hyperalgesia and conditioned place aversion in naïve mice, whereas inhibition of these neurons led to analgesia, conditioned place preference (cpp), and antidepressant effect in both naïve and sni mice. |
2024-03-07 |
2024-03-10 |
mouse |
| George Kenefati, Mika M Rockholt, Deborah Ok, Michael McCartin, Qiaosheng Zhang, Guanghao Sun, Julia Maslinski, Aaron Wang, Baldwin Chen, Erich P Voigt, Zhe Sage Chen, Jing Wang, Lisa V Doa. Changes in alpha, theta, and gamma oscillations in distinct cortical areas are associated with altered acute pain responses in chronic low back pain patients. Frontiers in neuroscience. vol 17. 2023-10-30. PMID:37901433. |
while animal studies have indicated that the cingulate and prefrontal cortices are involved in this generalized hyperalgesia, the mechanisms distinguishing increased sensitivity at the site of injury from a generalized site-nonspecific enhancement in the aversive response to nociceptive inputs are not well known. |
2023-10-30 |
2023-11-08 |
Not clear |
| Ketan Prafull Jaltare, Laetitia Vanderijst, Kai Karos, Diana M Tort. The impact of the social context on the development of secondary hyperalgesia: an experimental study. Pain. 2023-07-11. PMID:37433188. |
increasing attachment avoidance was associated with both a smaller width of hyperalgesia and a smaller increase in the sensitivity on the stimulated arm. |
2023-07-11 |
2023-08-14 |
human |
| Ketan Prafull Jaltare, Laetitia Vanderijst, Kai Karos, Diana M Tort. The impact of the social context on the development of secondary hyperalgesia: an experimental study. Pain. 2023-07-11. PMID:37433188. |
for the first time, we show that social support can attenuate the development of secondary hyperalgesia and that attachment avoidance may be associated with an attenuated development of secondary hyperalgesia. |
2023-07-11 |
2023-08-14 |
human |
| Liangbiao Wang, Xiaojing Su, Jinjin Yan, Qiaofeng Wu, Xiang Xu, Xinyue Wang, Xiaoqing Liu, Xiaoyuan Song, Zhi Zhang, Wei Hu, Xinfeng Liu, Yan Zhan. Involvement of Mrgprd-expressing nociceptors-recruited spinal mechanisms in nerve injury-induced mechanical allodynia. iScience. vol 26. issue 5. 2023-05-30. PMID:37250305. |
here, we showed that von frey-evoked static allodynia and aversion, along with mechanical hyperalgesia after spared nerve injury (sni) were reduced by ablation of |
2023-05-30 |
2023-08-14 |
Not clear |
| Valeria Mussetto, Hannah Luise Teuchmann, Bernhard Heinke, Lidia Trofimova, Jürgen Sandkühler, Ruth Drdla-Schutting, Roni Hogr. Opioids induce bidirectional synaptic plasticity in a brainstem pain centre in the rat. The journal of pain. 2023-05-07. PMID:37150382. |
unravelling opioid-induced adaptations in parabrachial function might facilitate the identification of new therapeutic measures for addressing adverse effects of opioid discontinuation such as hyperalgesia and aversion. |
2023-05-07 |
2023-08-14 |
rat |
| Nathan M Sharfman, Leslie K Kelley, Maria E Secci, Nicholas W Gilpi. Melanocortin-4 receptor signaling in the central amygdala mediates chronic inflammatory pain effects on nociception. Neuropharmacology. 2022-03-19. PMID:35304172. |
first, we report that cfa produces long-lasting hyperalgesia in adult male and female wistar rats, and long-lasting pain avoidance in male wistar rats. |
2022-03-19 |
2023-08-13 |
rat |
| Razieh Kooshki, Mehdi Abbasnejad, Saeed Esmaeili-Mahani, Maryam Raoof, Vahid Sheiban. Activation orexin 1 receptors in the ventrolateral periaqueductal gray matter attenuate nitroglycerin-induced migraine attacks and calcitonin gene related peptide up-regulation in trigeminal nucleus caudalis of rats. Neuropharmacology. vol 178. 2021-08-12. PMID:32745488. |
light-dark chamber and hot plate tests were used for assessing light aversion and thermal hyperalgesia, respectively. |
2021-08-12 |
2023-08-13 |
human |
| Razieh Kooshki, Mehdi Abbasnejad, Saeed Esmaeili-Mahani, Maryam Raoof, Vahid Sheiban. Activation orexin 1 receptors in the ventrolateral periaqueductal gray matter attenuate nitroglycerin-induced migraine attacks and calcitonin gene related peptide up-regulation in trigeminal nucleus caudalis of rats. Neuropharmacology. vol 178. 2021-08-12. PMID:32745488. |
furthermore, ntg-induced light aversion and thermal hyperalgesia were attenuated by orxa at doses of 50 and 100 pm. |
2021-08-12 |
2023-08-13 |
human |
| M Pagliusi, I J M Bonet, A F Brandão, S F Magalhães, C H Tambeli, C A Parada, C R Sartor. Therapeutic and Preventive Effect of Voluntary Running Wheel Exercise on Social Defeat Stress (SDS)-induced Depressive-like Behavior and Chronic Pain in Mice. Neuroscience. vol 428. 2021-04-07. PMID:31927101. |
our results showed that the voluntary running wheel exercise was more effective than fluoxetine reversing the sds-induced persistent hyperalgesia and both, fluoxetine and voluntary running wheel exercise, was effective reversing sds-induced social avoidance. |
2021-04-07 |
2023-08-13 |
mouse |
| M Pagliusi, I J M Bonet, A F Brandão, S F Magalhães, C H Tambeli, C A Parada, C R Sartor. Therapeutic and Preventive Effect of Voluntary Running Wheel Exercise on Social Defeat Stress (SDS)-induced Depressive-like Behavior and Chronic Pain in Mice. Neuroscience. vol 428. 2021-04-07. PMID:31927101. |
also, voluntary running wheel exercise is an effective tool preventing both hyperalgesia and social avoidance induced by sds. |
2021-04-07 |
2023-08-13 |
mouse |
| Marcus M Weera, Allyson L Schreiber, Elizabeth M Avegno, Nicholas W Gilpi. The role of central amygdala corticotropin-releasing factor in predator odor stress-induced avoidance behavior and escalated alcohol drinking in rats. Neuropharmacology. vol 166. 2021-04-02. PMID:32028150. |
we also showed previously that systemic antagonism of corticotropin-releasing factor-1 receptors (crfr1) reduced escalation of operant alcohol sa in rats not indexed for avoidance, that corticotropin-releasing factor (crf) infusions into the central amygdala (cea) produced conditioned place avoidance in stress-naïve rats, and that intra-cea infusion of a crfr1 antagonist reduced hyperalgesia in avoiders. |
2021-04-02 |
2023-08-13 |
rat |
| Roger Lopez-Bellido, Michael J Galk. An Improved Assay and Tools for Measuring Mechanical Nociception in Drosophila Larvae. Journal of visualized experiments : JoVE. issue 164. 2020-12-25. PMID:33191934. |
using mechanical probes that are normally innocuous or probes that typically elicit an aversive behavior, we found that drosophila larvae develop mechanical hypersensitization (both allodynia and hyperalgesia) after tissue damage. |
2020-12-25 |
2023-08-13 |
drosophila_melanogaster |
| Li Sun, Rui Liu, Fang Guo, Man-Qing Wen, Xiao-Lin Ma, Kai-Yuan Li, Hao Sun, Ceng-Lin Xu, Yuan-Yuan Li, Meng-Yin Wu, Zheng-Gang Zhu, Xin-Jian Li, Yan-Qin Yu, Zhong Chen, Xiang-Yao Li, Shumin Dua. Parabrachial nucleus circuit governs neuropathic pain-like behavior. Nature communications. vol 11. issue 1. 2020-12-11. PMID:33239627. |
however, it is unclear whether the lpbn actively processes neuropathic pain characterized by persistent hyperalgesia with aversive emotional responses. |
2020-12-11 |
2023-08-13 |
mouse |
| Ryan B Griggs, Don E Laird, Renee R Donahue, Weisi Fu, Bradley K Taylo. Methylglyoxal Requires AC1 and TRPA1 to Produce Pain and Spinal Neuron Activation. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:29270106. |
methylglyoxal produced conditioned place avoidance (cpa) (a measure of affective pain), dose-dependent licking and lifting nociceptive behaviors, hyperalgesia to heat and mechanical stimulation, and p-erk in the spinal cord dorsal horn. |
2020-10-01 |
2023-08-13 |
mouse |
| Yuanyuan Wu, Xinmiao Yao, Yongliang Jiang, Xiaofen He, Xiaomei Shao, Junying Du, Zui Shen, Qiaoying He, Jianqiao Fan. Pain aversion and anxiety-like behavior occur at different times during the course of chronic inflammatory pain in rats. Journal of pain research. vol 10. 2020-09-29. PMID:29158690. |
therefore, although the negative effect (including pain aversion and anxiety) is always associated with hyperalgesia, the manifestations of negative effect may follow different time courses, which may influence the progress of primary disease. |
2020-09-29 |
2023-08-13 |
rat |
| Chang-Qing Yang, Xiao-Shu Guo, Ji-Li, Zi-Bai Wei, Li Zhao, Gan-Ting Zhao, Shu-Ting Shen. Rifaximin Improves Visceral Hyperalgesia via TRPV1 by Modulating Intestinal Flora in the Water Avoidance Stressed Rat. Gastroenterology research and practice. vol 2020. 2020-09-28. PMID:32765600. |
rifaximin improves visceral hyperalgesia via trpv1 by modulating intestinal flora in the water avoidance stressed rat. |
2020-09-28 |
2023-08-13 |
rat |
| Franciane Bobinski, Juliana Maia Teixeira, Kathleen Anne Sluka, Adair Roberto Soares Santo. Interleukin-4 mediates the analgesia produced by low-intensity exercise in mice with neuropathic pain. Pain. vol 159. issue 3. 2019-04-01. PMID:29140923. |
we show that 2 weeks of treadmill exercise improves neuropathic pain behaviors in mice: mechanical hyperalgesia, escape and avoidance behavior, and spontaneous locomotor activity. |
2019-04-01 |
2023-08-13 |
mouse |
| Amy L Creekmore, Shuangsong Hong, Shengtao Zhu, Jing Xue, John W Wile. Chronic stress-associated visceral hyperalgesia correlates with severity of intestinal barrier dysfunction. Pain. vol 159. issue 9. 2019-02-25. PMID:29912860. |
in humans, chronic psychological stress is associated with increased intestinal paracellular permeability and visceral hyperalgesia, which is recapitulated in the chronic intermittent water avoidance stress (was) rat model. |
2019-02-25 |
2023-08-13 |
rat |
| Deniz Bagdas, Yasmin Alkhlaif, Asti Jackson, F Ivy Carroll, Joseph W Ditre, M Imad Dama. New insights on the effects of varenicline on nicotine reward, withdrawal and hyperalgesia in mice. Neuropharmacology. vol 138. 2019-02-13. PMID:29860196. |
moreover, the effects of varenicline on nicotine withdrawal-induced hyperalgesia and aversion are unknown. |
2019-02-13 |
2023-08-13 |
mouse |