| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shiho Kitaok. Microglia regulate neuronal and behavioral functions under physiological and pathological conditions. Journal of biochemistry. 2022-12-20. PMID:36539335. |
chronic stress activates microglia through toll-like receptor (tlr) 2 and tlr4 to release pro-inflammatory cytokines in the medial prefrontal cortex, thereby causing social avoidance. |
2022-12-20 |
2023-08-14 |
Not clear |
| Shiho Kitaok. Microglia regulate neuronal and behavioral functions under physiological and pathological conditions. Journal of biochemistry. 2022-12-20. PMID:36539335. |
moreover, microglia release inflammation-related molecules that suppress neuronal activity, thus leading to lipopolysaccharide-induced aversion. |
2022-12-20 |
2023-08-14 |
Not clear |
| Damon J DiSabato, Wenyuan Yin, Rebecca G Biltz, Natalie R Gallagher, Braedan Oliver, Daniel P Nemeth, Xiaoyu Liu, John F Sheridan, Ning Quan, Jonathan P Godbou. IL-1 Receptor-1 on Brain, behavior, & immunity - health. vol 26. 2022-11-17. PMID:36388133. |
social defeat in mice promotes the convergence of neuronal, central inflammatory (microglia), and peripheral immune (monocytes) pathways causing anxiety, social avoidance, and "stress-sensitization." |
2022-11-17 |
2023-08-14 |
mouse |
| Xiang-Ke Chen, Joseph Shiu-Kwong Kwan, Gordon Tin-Chun Wong, Zhen-Ni Yi, Alvin Chun-Hang Ma, Raymond Chuen-Chung Chan. Leukocyte invasion of the brain after peripheral trauma in zebrafish (Danio rerio). Experimental & molecular medicine. 2022-07-13. PMID:35831435. |
notably, myeloid cells in the brain that consist of microglia and invading macrophages were implicated in posttraumatic anxiety-like behaviors, such as hyperactivity (restlessness) and thigmotaxis (avoidance), while a reduction in systemic inflammation or myeloid cells can rescue these behaviors. |
2022-07-13 |
2023-08-14 |
zebrafish |
| Lucia Račková, Erika Cseke. Redox aspects of cytotoxicity and anti-neuroinflammatory profile of chloroquine and hydroxychloroquine in serum-starved BV-2 microglia. Toxicology and applied pharmacology. 2022-05-26. PMID:35618033. |
given the current demand for serum avoidance during pharmacological testing and modeling of some pathologies, we compared cytotoxicities of cq and hcq in both serum-deprived and -fed murine bv-2 microglia. |
2022-05-26 |
2023-08-13 |
human |
| Mai Sakai, Zhiqian Yu, Ryo Hirayama, Masa Nakasato, Yoshie Kikuchi, Chiaki Ono, Hiroshi Komatsu, Miharu Nakanishi, Hatsumi Yoshii, David Stellwagen, Tomoyuki Furuyashiki, Masaaki Komatsu, Hiroaki Tomit. Deficient Autophagy in Microglia Aggravates Repeated Social Defeat Stress-Induced Social Avoidance. Neural plasticity. vol 2022. 2022-02-28. PMID:35222638. |
in addition, the resilient mice exhibited enhanced autophagic flux in the prefrontal cortical microglia, and the autophagic deficiency in microglia aggravated rsd-induced social avoidance, indicating that microglial autophagy involves stress-induced behavioral changes. |
2022-02-28 |
2023-08-13 |
mouse |
| Mai Sakai, Zhiqian Yu, Ryo Hirayama, Masa Nakasato, Yoshie Kikuchi, Chiaki Ono, Hiroshi Komatsu, Miharu Nakanishi, Hatsumi Yoshii, David Stellwagen, Tomoyuki Furuyashiki, Masaaki Komatsu, Hiroaki Tomit. Deficient Autophagy in Microglia Aggravates Repeated Social Defeat Stress-Induced Social Avoidance. Neural plasticity. vol 2022. 2022-02-28. PMID:35222638. |
deficient autophagy in microglia aggravates repeated social defeat stress-induced social avoidance. |
2022-02-28 |
2023-08-13 |
mouse |
| Anna M Klawonn, Michael Fritz, Silvia Castany, Marco Pignatelli, Carla Canal, Fredrik Similä, Hugo A Tejeda, Julia Levinsson, Maarit Jaarola, Johan Jakobsson, Juan Hidalgo, Markus Heilig, Antonello Bonci, David Engblo. Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons. Immunity. vol 54. issue 2. 2021-09-07. PMID:33476547. |
activation of microglia in the dorsal striatum induced local cytokine expression and a negative affective state characterized by anhedonia and aversion, whereas inactivation of microglia blocked aversion induced by systemic inflammation. |
2021-09-07 |
2023-08-13 |
mouse |
| Anna M Klawonn, Michael Fritz, Silvia Castany, Marco Pignatelli, Carla Canal, Fredrik Similä, Hugo A Tejeda, Julia Levinsson, Maarit Jaarola, Johan Jakobsson, Juan Hidalgo, Markus Heilig, Antonello Bonci, David Engblo. Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons. Immunity. vol 54. issue 2. 2021-09-07. PMID:33476547. |
interleukin-6 signaling and cyclooxygenase-1 mediated prostaglandin synthesis in the microglia were critical for the inflammation-induced aversion. |
2021-09-07 |
2023-08-13 |
mouse |
| Jiayi Zhao, Wei Bi, Shu Xiao, Xin Lan, Xiaofeng Cheng, Jiawei Zhang, Daxiang Lu, Wei Wei, Yanping Wang, Hongmei Li, Yongmei Fu, Lihong Zh. Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice. Scientific reports. vol 9. issue 1. 2020-10-06. PMID:30962497. |
we found that lps treatment leads to sickness behavior and cognitive impairment in mice as shown in the morris water maze and passive avoidance test, and these effects were accompanied by microglia activation (labeled by ionized calcium binding adaptor molecule-1, iba-1) and neuronal cell loss (labeled by microtubule-associated protein 2, map-2) in the hippocampus. |
2020-10-06 |
2023-08-13 |
mouse |
| Teresa Joy, Muddanna S Rao, Sampath Madhyastha, Keshav Pa. Effect of N-Acetyl Cysteine on Intracerebroventricular Colchicine Induced Cognitive Deficits, Beta Amyloid Pathology, and Glial Cells. Neuroscience journal. vol 2019. 2020-10-01. PMID:31139638. |
cognitive function was evaluated in active avoidance test; beta amyloid protein, beta amyloid plaques, astrocytes, and microglia cells were quantified using immunohistochemistry in hippocampal and prefrontal cortices. |
2020-10-01 |
2023-08-13 |
human |
| Yancheng Wu, Yuhong Gong, Yongxin Luan, Yang Li, Juxiong Liu, Zitong Yue, Boyu Yuan, Jingxuan Sun, Changxin Xie, Lijuan Li, Junli Zhen, Xinxin Jin, Yan Zheng, Xiaomin Wang, Liwei Xie, Wei Wan. BHBA treatment improves cognitive function by targeting pleiotropic mechanisms in transgenic mouse model of Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 1. 2020-07-06. PMID:31914599. |
morris water maze test, nest construction, and passive avoidance experiments were performed to assess the therapeutic effects on ad prevention in vivo, and brain pathology of 5xfad mice including amyloid plaque deposition and microglia activation were assessed. |
2020-07-06 |
2023-08-13 |
mouse |
| Yancheng Wu, Yuhong Gong, Yongxin Luan, Yang Li, Juxiong Liu, Zitong Yue, Boyu Yuan, Jingxuan Sun, Changxin Xie, Lijuan Li, Junli Zhen, Xinxin Jin, Yan Zheng, Xiaomin Wang, Liwei Xie, Wei Wan. BHBA treatment improves cognitive function by targeting pleiotropic mechanisms in transgenic mouse model of Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 1. 2020-07-06. PMID:31914599. |
bhba improved cognitive function of 5xfad mice in morris water maze test, nesting construction and passive avoidance experiments, and attenuated aβ accumulation and microglia overactivation in the brain. |
2020-07-06 |
2023-08-13 |
mouse |
| Steven W Barge. Vascular consequences of passive Abeta immunization for Alzheimer's disease. Is avoidance of "malactivation" of microglia enough? Journal of neuroinflammation. vol 2. issue 1. 2019-11-20. PMID:15644140. |
is avoidance of "malactivation" of microglia enough? |
2019-11-20 |
2023-08-12 |
Not clear |
| Xiang Nie, Shiho Kitaoka, Kohei Tanaka, Eri Segi-Nishida, Yuki Imoto, Atsubumi Ogawa, Fumitake Nakano, Ayaka Tomohiro, Kazuki Nakayama, Masayuki Taniguchi, Yuko Mimori-Kiyosue, Akira Kakizuka, Shuh Narumiya, Tomoyuki Furuyashik. The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation. Neuron. vol 99. issue 3. 2019-08-01. PMID:30033154. |
transcriptome analyses revealed that r-sds induced il-1α and tnf-α in mpfc microglia in a tlr2/4-dependent manner, and antibody blockade of these cytokines in the mpfc suppressed r-sds-induced social avoidance. |
2019-08-01 |
2023-08-13 |
mouse |
| Mei Chen, Chang Luo, Jiawu Zhao, Gayathri Devarajan, Heping X. Immune regulation in the aging retina. Progress in retinal and eye research. vol 69. 2019-05-01. PMID:30352305. |
apart from the avoidance and tolerance strategies, the retina is also protected by its own defense system, i.e., microglia and the complement system. |
2019-05-01 |
2023-08-13 |
Not clear |
| Karol Ramirez, Daniel T Shea, Daniel B McKim, Brenda F Reader, John F Sherida. Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance. Brain, behavior, and immunity. vol 46. 2016-02-04. PMID:25701613. |
previously we showed that repeated social defeat (rsd) promoted microglia activation and social avoidance behavior that persisted for 24days after cessation of rsd. |
2016-02-04 |
2023-08-13 |
mouse |
| Iriana Galan-Arriero, Gerardo Avila-Martin, Agueda Ferrer-Donato, Julio Gomez-Soriano, Elisabeth Bravo-Esteban, Julian Taylo. Oral administration of the p38α MAPK inhibitor, UR13870, inhibits affective pain behavior after spinal cord injury. Pain. vol 155. issue 10. 2015-11-24. PMID:25180015. |
the effect of ur13870, a p38α mapk inhibitor, on microglia expression in the anterior cingulate cortex (acc) and spinal dorsal horn was addressed after t9 contusion spinal cord injury (sci) in the rat, in addition to behavioral testing of pain-related aversion and anxiety. |
2015-11-24 |
2023-08-13 |
rat |
| S Tanaka, H Kondo, K Kanda, T Ashino, T Nakamachi, K Sekikawa, Y Iwakura, S Shioda, S Numazawa, T Yoshid. Involvement of interleukin-1 in lipopolysaccaride-induced microglial activation and learning and memory deficits. Journal of neuroscience research. vol 89. issue 4. 2011-06-10. PMID:21290410. |
when subacute lipopolysaccharide treatment (20 μg/2 μl/injection, bilaterally for 5 consecutive days) was performed, long-term activation of microglia and learning and memory deficits as evaluated using a step-through passive avoidance test were observed in the wild-type mice. |
2011-06-10 |
2023-08-12 |
mouse |
| Selva Rivas-Arancibia, Rosalinda Guevara-Guzmán, Yolanda López-Vidal, Erika Rodríguez-Martínez, Margarete Zanardo-Gomes, Mariana Angoa-Pérez, Rita Raisman-Vozar. Oxidative stress caused by ozone exposure induces loss of brain repair in the hippocampus of adult rats. Toxicological sciences : an official journal of the Society of Toxicology. vol 113. issue 1. 2010-02-22. PMID:19833740. |
each group was then tested by (1) a spectrophotometer test to quantify lipid peroxidation (lpo) levels; (2) immunohistochemistry testing against doublecortin, neu-n, p53, microglia, and glial fibrillary acidic protein; (3) western blot tests for doublecortin and neu-n; and (4) a one-trial passive avoidance test. |
2010-02-22 |
2023-08-12 |
rat |