| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| José Javier Miguel-Hidalgo, Ian A Paul, Valerie Wanzo, Pradeep K Banerje. Memantine prevents cognitive impairment and reduces Bcl-2 and caspase 8 immunoreactivity in rats injected with amyloid β1-40. European journal of pharmacology. vol 692. issue 1-3. 2013-05-29. PMID:22824463. |
two days after treatment initiation, the animals were bilaterally injected with aβ(1-40) into the ca1/dg region of the hippocampus, subjected to active avoidance testing for 7 days, and sacrificed for immunohistochemical examination of four caspases (3, 6, 8, and 9) and three proteins of the bcl-2 family (bcl-2, bax, and bad). |
2013-05-29 |
2023-08-12 |
rat |
| A Wisłowska-Stanek, M Lehner, A Skórzewska, P Maciejak, J Szyndler, D Turzyńska, A Sobolewska, A Płaźni. Corticosterone modulates fear responses and the expression of glucocorticoid receptors in the brain of high-anxiety rats. Neuroscience letters. vol 533. 2013-05-23. PMID:23178190. |
immunocytochemical analysis revealed that the second exposure to contextual aversive stimuli resulted in higher levels of grs expression in cingulate cortex area 1 (cg1), the secondary motor cortex (m2) of the prefrontal cortex and the dentate gyrus of the hippocampus (dg) in lr rats compared with hr rats. |
2013-05-23 |
2023-08-12 |
rat |
| James L Searcy, Jeremiah T Phelps, Tristano Pancani, Inga Kadish, Jelena Popovic, Katie L Anderson, Tina L Beckett, Michael P Murphy, Kuey-Chu Chen, Eric M Blalock, Philip W Landfield, Nada M Porter, Olivier Thibaul. Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 30. issue 4. 2013-05-15. PMID:22495349. |
after four months, pio-treated animals showed multiple beneficial effects, including improved learning on the active avoidance task, reduced serum cholesterol, decreased hippocampal amyloid-β and tau deposits, and enhanced short- and long-term plasticity. |
2013-05-15 |
2023-08-12 |
mouse |
| Todd Charlton Sackto. Memory maintenance by PKMζ--an evolutionary perspective. Molecular brain. vol 5. 2013-05-15. PMID:22986281. |
furthermore, blocking pkmζ activity by pharmacological or dominant negative inhibitors disrupts previously stored long-term memories in a variety of neural circuits, including spatial and trace memories in the hippocampus, aversive memories in the basolateral amygdala, appetitive memories in the nucleus accumbens, habit memory in the dorsal lateral striatum, and elementary associations, extinction, and skilled sensorimotor memories in the neocortex. |
2013-05-15 |
2023-08-12 |
aplysia |
| Tatiana Barichello, Ana Lucia B Santos, Geovana D Savi, Jaqueline S Generoso, Paola Otaran, Cleonice M Michelon, Amanda V Steckert, Francielle Mina, Clarissa M Comim, Felipe Dal-Pizzol, João Queved. Antioxidant treatment prevents cognitive impairment and oxidative damage in pneumococcal meningitis survivor rats. Metabolic brain disease. vol 27. issue 4. 2013-05-03. PMID:22592569. |
ten days after meningitis, the animals underwent inhibitory avoidance and habituation to an open field tasks and, immediately after, were assessed for oxidative damage in the hippocampus and cortex. |
2013-05-03 |
2023-08-12 |
rat |
| Cynthia Katche, Andrea Goldin, Carolina Gonzalez, Pedro Bekinschtein, Jorge H Medin. Maintenance of long-term memory storage is dependent on late posttraining Egr-1 expression. Neurobiology of learning and memory. vol 98. issue 3. 2013-04-30. PMID:22906840. |
here we show that dorsal hippocampal egr-1 protein expression is upregulated between 12 and 24 h after strong inhibitory avoidance (ia) training in rats. |
2013-04-30 |
2023-08-12 |
rat |
| Amy A Arguello, Xiaojing Ye, Ozlem Bozdagi, Gabriella Pollonini, Sophie Tronel, Dhananjay Bambah-Mukku, George W Huntley, Daniela Platano, Cristina M Alberin. CCAAT enhancer binding protein δ plays an essential role in memory consolidation and reconsolidation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 8. 2013-04-24. PMID:23426691. |
in rats, the consolidation of inhibitory avoidance (ia) memory requires gene expression in both the hippocampus and amygdala, two brain regions that process contextual/spatial and emotional information, respectively; ia reconsolidation requires de novo gene expression in the amygdala. |
2013-04-24 |
2023-08-12 |
rat |
| Alline Cristina Campos, Fabricio Araújo Moreira, Felipe Villela Gomes, Elaine Aparecida Del Bel, Francisco Silveira Guimarãe. Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1607. 2013-04-08. PMID:23108553. |
other effects, such as anti-compulsive, increased extinction and impaired reconsolidation of aversive memories, and facilitation of adult hippocampal neurogenesis could depend on potentiation of anandamide-mediated neurotransmission. |
2013-04-08 |
2023-08-12 |
Not clear |
| Joseane Jiménez Rojas, Bruna Ferrary Deniz, Patrícia Maidana Miguel, Ramiro Diaz, Erica do Espírito-Santo Hermel, Matilde Achaval, Carlos Alexandre Netto, Lenir Orlandi Pereir. Effects of daily environmental enrichment on behavior and dendritic spine density in hippocampus following neonatal hypoxia-ischemia in the rat. Experimental neurology. vol 241. 2013-04-08. PMID:23219882. |
the aim of this study was to investigate behavioral performance in the open field and rota-rod apparatuses, in object recognition and inhibitory avoidance tasks, as well as dendritic spine density in the hippocampus, in rats undergoing hi and exposed to ee. |
2013-04-08 |
2023-08-12 |
rat |
| Eleonora Napoli, Catherine Ross-Inta, Sarah Wong, Connie Hung, Yasuko Fujisawa, Danielle Sakaguchi, James Angelastro, Alicja Omanska-Klusek, Robert Schoenfeld, Cecilia Giuliv. Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53. PloS one. vol 7. issue 8. 2013-03-22. PMID:22900024. |
at 8-13 weeks of age, pten haplo-insufficient mice did not show significant behavioral abnormalities or changes in mitochondrial outcomes, but by 20-29 weeks, they displayed aberrant social behavior (social avoidance, failure to recognize familiar mouse, and repetitive self-grooming), macrocephaly, increased oxidative stress, decreased cytochrome c oxidase (cco) activity (50%) and increased mtdna deletions in cerebellum and hippocampus. |
2013-03-22 |
2023-08-12 |
mouse |
| Iva Prokopova, Stepan Bahnik, Vanessa Doulames, Karel Vales, Tomas Petrasek, Jan Svoboda, Ales Stuchli. Synergistic effects of dopamine D2-like receptor antagonist sulpiride and β-blocker propranolol on learning in the carousel maze, a dry-land spatial navigation task. Pharmacology, biochemistry, and behavior. vol 102. issue 1. 2013-03-14. PMID:22525744. |
the task involves avoidance of a stable sector on a rotating arena and is highly dependent upon the hippocampus. |
2013-03-14 |
2023-08-12 |
human |
| C-S Lin, D M Niddam, M-L Hsu, J-C Hsie. Pain catastrophizing is associated with dental pain in a stressful context. Journal of dental research. vol 92. issue 2. 2013-03-12. PMID:23232145. |
brain activation at the right posterior hippocampus, a region critically related to associative learning of aversive stimuli and context, was correlated with the individual catastrophizing level. |
2013-03-12 |
2023-08-12 |
human |
| Cássia Sallaberry, Fernanda Nunes, Marcelo S Costa, Gabriela T Fioreze, Ana Paula Ardais, Paulo Henrique S Botton, Bruno Klaudat, Thomás Forte, Diogo O Souza, Elaine Elisabetsky, Lisiane O Porciúncul. Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats. Neuropharmacology. vol 64. 2013-02-11. PMID:22841916. |
chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal bdnf immunocontent in middle-aged rats. |
2013-02-11 |
2023-08-12 |
rat |
| Cássia Sallaberry, Fernanda Nunes, Marcelo S Costa, Gabriela T Fioreze, Ana Paula Ardais, Paulo Henrique S Botton, Bruno Klaudat, Thomás Forte, Diogo O Souza, Elaine Elisabetsky, Lisiane O Porciúncul. Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats. Neuropharmacology. vol 64. 2013-02-11. PMID:22841916. |
caffeine treatment substantially reduced i) age-related impairments in the two types of memory in an inhibitory avoidance paradigm, and ii) parallel increases in hippocampal bdnf levels. |
2013-02-11 |
2023-08-12 |
rat |
| Dillon Y Chen, Dhananjay Bambah-Mukku, Gabriella Pollonini, Cristina M Alberin. Glucocorticoid receptors recruit the CaMKIIα-BDNF-CREB pathways to mediate memory consolidation. Nature neuroscience. vol 15. issue 12. 2013-01-29. PMID:23160045. |
we found that the hippocampal glucocorticoid receptors that are critically engaged during the formation of long-term inhibitory avoidance memory in rats were coupled to the activation of camkiiα, trkb, erk, akt, plcγ and creb, as well as a to a substantial induction of arc and synaptic glua1. |
2013-01-29 |
2023-08-12 |
rat |
| M S Costa, A P Ardais, G T Fioreze, S Mioranzza, P H S Botton, D O Souza, J B T Rocha, L O Porciúncul. The impact of the frequency of moderate exercise on memory and brain-derived neurotrophic factor signaling in young adult and middle-aged rats. Neuroscience. vol 222. 2013-01-24. PMID:22796076. |
aversive and recognition memory were assessed as well as the immunocontent of probdnf, bdnf and tyrosine kinase receptor type b (trkb) in the hippocampus. |
2013-01-24 |
2023-08-12 |
rat |
| Melissa E Wang, Ellen G Wann, Robin K Yuan, Manuel M Ramos Álvarez, Squire M Stead, Isabel A Muzzi. Long-term stabilization of place cell remapping produced by a fearful experience. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 45. 2013-01-23. PMID:23136419. |
physiological evidence supporting the role of the hippocampus in contextual fear indicates that pyramidal cells in this region, which fire in specific locations as an animal moves through an environment, shift their preferred firing locations shortly after the presentation of an aversive stimulus (moita et al., 2004). |
2013-01-23 |
2023-08-12 |
mouse |
| Nesha S Burghardt, Eun Hye Park, René Hen, André A Fento. Adult-born hippocampal neurons promote cognitive flexibility in mice. Hippocampus. vol 22. issue 9. 2013-01-17. PMID:22431384. |
we evaluated a proposed role for adult hippocampal neurogenesis in cognitive flexibility using variants of the active place avoidance task and two independent methods of ablating adult-born neurons, focal x-irradiation of the hippocampus, and genetic ablation of glial fibrillary acidic protein positive neural progenitor cells, in mice. |
2013-01-17 |
2023-08-12 |
mouse |
| Therese M Eriksson, Sarah Holst, Tiberiu L Stan, Torben Hager, Benita Sjögren, Sven Öve Ogren, Per Svenningsson, Oliver Stied. 5-HT1A and 5-HT7 receptor crosstalk in the regulation of emotional memory: implications for effects of selective serotonin reuptake inhibitors. Neuropharmacology. vol 63. issue 6. 2013-01-10. PMID:22801295. |
dorsohippocampal infusion of 8-oh-dpat impaired passive avoidance retention through hippocampal 5-ht(1a)r activation, while 5-ht(7)rs appear to facilitate memory processes in a broader cortico-limbic network and not the hippocampus alone. |
2013-01-10 |
2023-08-12 |
mouse |
| Farzaneh Rostami, Shahrbanoo Oryan, Abolhassan Ahmadiani, Leila Dargah. Morphine preconditioning protects against LPS-induced neuroinflammation and memory deficit. Journal of molecular neuroscience : MN. vol 48. issue 1. 2013-01-09. PMID:22388653. |
four hours after lps, rats were subjected to passive avoidance testing and then for the assessments of inflammatory and apoptotic cell death mediators in the hippocampus. |
2013-01-09 |
2023-08-12 |
rat |