| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rong-Xin Song, Ting-Ting Zhou, Shi-Yan Jia, Wen-Guang Li, Jun Wang, Bao-Dong Li, Yu-Dong Shan, Li-Min Zhang, Xiao-Ming L. Hydrogen sulfide mitigates memory impairments via the restoration of glutamatergic neurons in a mouse model of hemorrhage shock and resuscitation. Experimental neurology. 2024-03-21. PMID:38513970. |
the ventral tegmental area (vta) participates in both learned appetitive and aversive behaviors. |
2024-03-21 |
2024-03-24 |
mouse |
| Rong-Xin Song, Ting-Ting Zhou, Shi-Yan Jia, Wen-Guang Li, Jun Wang, Bao-Dong Li, Yu-Dong Shan, Li-Min Zhang, Xiao-Ming L. Hydrogen sulfide mitigates memory impairments via the restoration of glutamatergic neurons in a mouse model of hemorrhage shock and resuscitation. Experimental neurology. 2024-03-21. PMID:38513970. |
in addition to being prospective targets for the therapy of addiction, depression, and other stress-related diseases, vta glutamatergic neurons are becoming more widely acknowledged as powerful regulators of reward and aversion. |
2024-03-21 |
2024-03-24 |
mouse |
| Zachary A Grieb, Susan Lee, Maura C Stoehr, Benjamin W Horne, Alisa Norvelle, Emma K Shaughnessy, H Elliott Albers, Kim L Huhma. Sex-dependent regulation of social avoidance by oxytocin signaling in the ventral tegmental area. Behavioural brain research. 2024-01-25. PMID:38272188. |
sex-dependent regulation of social avoidance by oxytocin signaling in the ventral tegmental area. |
2024-01-25 |
2024-01-28 |
human |
| Gabriela Izowit, Magdalena Walczak, Gniewosz Drwięga, Wojciech Solecki, Tomasz Błasia. Brain state-dependent responses of midbrain dopaminergic neurons to footshock under urethane anaesthesia. The European journal of neuroscience. 2024-01-18. PMID:38233998. |
for a long time, it has been assumed that dopaminergic (da) neurons in both the ventral tegmental area (vta) and the substantia nigra pars compacta (snc) uniformly respond to rewarding and aversive stimuli by either increasing or decreasing their activity, respectively. |
2024-01-18 |
2024-01-20 |
rat |
| Gabriela Izowit, Magdalena Walczak, Gniewosz Drwięga, Wojciech Solecki, Tomasz Błasia. Brain state-dependent responses of midbrain dopaminergic neurons to footshock under urethane anaesthesia. The European journal of neuroscience. 2024-01-18. PMID:38233998. |
the identification of vta&snc da neurons that are excited by both rewarding and aversive stimuli has led to the categorisation of vta&snc da neurons into two subpopulations: one signalling the value and the other signalling the salience of the stimuli. |
2024-01-18 |
2024-01-20 |
rat |
| Gabriela Izowit, Magdalena Walczak, Gniewosz Drwięga, Wojciech Solecki, Tomasz Błasia. Brain state-dependent responses of midbrain dopaminergic neurons to footshock under urethane anaesthesia. The European journal of neuroscience. 2024-01-18. PMID:38233998. |
it has been shown that the general state of the brain can modulate the electrical activity of vta&snc da neurons, but it remains unknown whether this factor may also influence responses to aversive stimuli, such as a footshock (fs). |
2024-01-18 |
2024-01-20 |
rat |
| Gabriela Izowit, Magdalena Walczak, Gniewosz Drwięga, Wojciech Solecki, Tomasz Błasia. Brain state-dependent responses of midbrain dopaminergic neurons to footshock under urethane anaesthesia. The European journal of neuroscience. 2024-01-18. PMID:38233998. |
adding to the knowledge of aversion signalling by midbrain da neurons, we report that significant proportion of vta&snc da neurons can change their responses to an aversive stimulus in a brain state-dependent manner. |
2024-01-18 |
2024-01-20 |
rat |
| M Flavia Barbano, Shiliang Zhang, Emma Chen, Orlando Espinoza, Uzma Mohammad, Yocasta Alvarez-Bagnarol, Bing Liu, Suyun Hahn, Marisela Morale. Lateral hypothalamic glutamatergic inputs to VTA glutamatergic neurons mediate prioritization of innate defensive behavior over feeding. Nature communications. vol 15. issue 1. 2024-01-09. PMID:38195566. |
here, we demonstrated that lh-glutamatergic inputs to vta promoted active avoidance, long-term aversion, and escape attempts. |
2024-01-09 |
2024-01-13 |
mouse |
| Takashi Nagashima, Kaori Mikami, Suguru Tohyama, Ayumu Konno, Hirokazu Hirai, Ayako M Watab. State-dependent modulation of positive and negative affective valences by a parabrachial nucleus-to-ventral tegmental area pathway in mice. Frontiers in neural circuits. vol 17. 2023-12-14. PMID:38094239. |
inhibition of glutamic acid decarboxylase (gad) 65-expressing cells in the vta promotes avoidance behavior induced by photoactivation of the lpb-vta pathway. |
2023-12-14 |
2023-12-17 |
mouse |
| Shelley M Warlow, Sarthak M Singhal, Nick G Hollon, Lauren Faget, Dina S Dowlat, Vivien Zell, Avery C Hunker, Larry S Zweifel, Thomas S Hnask. Mesoaccumbal glutamate neurons drive reward via glutamate release but aversion via dopamine co-release. Neuron. 2023-12-12. PMID:38086374. |
optogenetic stimulation of vta glutamate neurons not only supports self-stimulation but can also induce avoidance behavior, even in the same assay. |
2023-12-12 |
2023-12-17 |
mouse |
| Shelley M Warlow, Sarthak M Singhal, Nick G Hollon, Lauren Faget, Dina S Dowlat, Vivien Zell, Avery C Hunker, Larry S Zweifel, Thomas S Hnask. Mesoaccumbal glutamate neurons drive reward via glutamate release but aversion via dopamine co-release. Neuron. 2023-12-12. PMID:38086374. |
here, we parsed the selective contribution of glutamate or dopamine co-release from vta glutamate neurons to reinforcement and avoidance. |
2023-12-12 |
2023-12-17 |
mouse |
| Shelley M Warlow, Sarthak M Singhal, Nick G Hollon, Lauren Faget, Dina S Dowlat, Vivien Zell, Avery C Hunker, Larry S Zweifel, Thomas S Hnask. Mesoaccumbal glutamate neurons drive reward via glutamate release but aversion via dopamine co-release. Neuron. 2023-12-12. PMID:38086374. |
our results demonstrate that glutamate release from vta glutamate neurons is positively reinforcing but that dopamine release from vta glutamate neurons can induce avoidance behavior. |
2023-12-12 |
2023-12-17 |
mouse |
| Jing Cai, Yanyan Jiang, Yuanzhong Xu, Zhiying Jiang, Claire Young, Hongli Li, Joshua Ortiz-Guzman, Yizhou Zhuo, Yulong Li, Yong Xu, Benjamin R Arenkiel, Qingchun Ton. An excitatory projection from the basal forebrain to the ventral tegmental area that underlies anorexia-like phenotypes. Neuron. 2023-12-06. PMID:38056455. |
notably, in vivo manipulation of bf terminals in the vta revealed that the glutamatergic bf → vta circuit reduces appetite, increases locomotion, and elicits avoidance. |
2023-12-06 |
2023-12-10 |
mouse |
| Ekaterina Martianova, Renata Sadretdinova, Alicia Pageau, Nikola Pausic, Tommy Doucet Gentiletti, Danahé Leblanc, Arturo Marroquin Rivera, Benoît Labonté, Christophe D Proul. Hypothalamic neuronal outputs transmit sensorimotor signals at the onset of locomotor initiation. iScience. vol 26. issue 11. 2023-12-01. PMID:38026162. |
the optogenetic activation of lh axon terminals in either of the drn, vta, or lhb was sufficient to increase motor initiation but had different effects on passive avoidance and sucrose consumption. |
2023-12-01 |
2023-12-10 |
mouse |
| Jen-Hui Tsou, Syun-Ruei Lee, Chia-Ying Chiang, Yi-Jie Yang, Fong-Yi Guo, Shih-Ying Ni, Hau-Jie Ya. Negative emotions recruit the parabrachial nucleus efferent to the VTA to disengage instrumental food seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-09-08. PMID:37684032. |
we further show that optogenetic activation of vta neurons functionally recruited by the pbn input results in aversion, dampens palatable feeding and disengages palatable food self-administration behavior. |
2023-09-08 |
2023-10-07 |
mouse |
| David J Barker, Shiliang Zhang, Huiling Wang, David J Estrin, Jorge Miranda-Barrientos, Bing Liu, Rucha J Kulkarni, Junia Lara de Deus, Marisela Morale. Lateral preoptic area glutamate neurons relay nociceptive information to the ventral tegmental area. Cell reports. vol 42. issue 9. 2023-08-26. PMID:37632750. |
these lpo glutamatergic neurons synapsing on vta neurons respond to nociceptive stimulation and conditioned stimuli predicting nociceptive stimulation and also mediate aversion. |
2023-08-26 |
2023-09-07 |
Not clear |
| Lauren Faget, Lucie Oriol, Wen-Chun Lee, Cody Sargent, Dhakshin Ramanathan, Thomas S Hnask. Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37502884. |
ventral pallidum gaba and glutamate neurons drive approach and avoidance through distinct modulation of vta cell types. |
2023-07-28 |
2023-08-14 |
human |
| Lauren Faget, Lucie Oriol, Wen-Chun Lee, Cody Sargent, Dhakshin Ramanathan, Thomas S Hnask. Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37502884. |
the ventral pallidum (vp) contains gaba and glutamate (glut) neurons projecting to ventral tegmental area (vta) whose stimulation drives approach and avoidance, respectively. |
2023-07-28 |
2023-08-14 |
human |
| Lauren Faget, Lucie Oriol, Wen-Chun Lee, Cody Sargent, Dhakshin Ramanathan, Thomas S Hnask. Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37502884. |
conversely, vp glut neurons activated vta gaba, as well as da and glut neurons, despite driving aversion. |
2023-07-28 |
2023-08-14 |
human |
| Lauren Faget, Lucie Oriol, Wen-Chun Lee, Cody Sargent, Dhakshin Ramanathan, Thomas S Hnask. Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37502884. |
these findings show how heterogeneous vp cell types can engage vta cell types to shape approach and avoidance behaviors. |
2023-07-28 |
2023-08-14 |
human |