| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chi-Wen Wu, Chen Yin Ou, Ying Hao Yu, Yi Chun Yu, Bai Chuang Shyu, Andrew Chih Wei Huan. Involvement of the ventral tegmental area but not periaqueductal gray matter in the paradoxical rewarding and aversive effects of morphine. Behavioral neuroscience. vol 135. issue 6. 2021-12-07. PMID:34323519. |
the vta's involvement in morphine-induced cta aversion and cpp reward supports the paradoxical effect hypothesis of abused drugs. |
2021-12-07 |
2023-08-13 |
Not clear |
| Massimo Pierucci, Francis Delicata, Roberto Colangeli, Antonella Marino Gammazza, Alessandro Pitruzzella, Maurizio Casarrubea, Philippe De Deurwaerdère, Giuseppe Di Giovann. Nicotine modulation of the lateral habenula/ventral tegmental area circuit dynamics: An electrophysiological study in rats. Neuropharmacology. vol 202. 2021-11-26. PMID:34710468. |
recently, the lateral habenula (lhb), a structure that controls ventral tegmental area (vta) dopamine (da) function, has attracted attention as it is potentially involved in the aversive properties of drugs of abuse. |
2021-11-26 |
2023-08-13 |
rat |
| Dillon J McGovern, Abigail M Polter, David H Roo. Neurochemical Signaling of Reward and Aversion to Ventral Tegmental Area Glutamate Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 25. 2021-11-19. PMID:34001626. |
neurochemical signaling of reward and aversion to ventral tegmental area glutamate neurons. |
2021-11-19 |
2023-08-13 |
mouse |
| Dillon J McGovern, Abigail M Polter, David H Roo. Neurochemical Signaling of Reward and Aversion to Ventral Tegmental Area Glutamate Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 25. 2021-11-19. PMID:34001626. |
activity of glutamate inputs to vta glutamate neurons increased for both reward-predicting and aversion-predicting cues and aversive outcomes, but subpopulations of glutamate inputs were increased or decreased by reward. |
2021-11-19 |
2023-08-13 |
mouse |
| Feng He, Pei Zhang, Qian Zhang, Guangjian Qi, Hongwei Cai, Tongxia Li, Ming Li, Jiazhen Lu, Jiaen Lin, Jie Ming, Bo Tia. Dopaminergic Projection from Ventral Tegmental Area to Substantia Nigra Pars Reticulata Mediates Chronic Social Defeat Stress-Induced Hypolocomotion. Molecular neurobiology. vol 58. issue 11. 2021-11-18. PMID:34382160. |
in mdd, the midbrain ventral tegmental area (vta) dopamine (da) neurons are closely related to regulate the information processing of reward, motivation, cognition, and aversion. |
2021-11-18 |
2023-08-13 |
mouse |
| WojciechB Solecki, Michał Wilczkowski, Kamil Pradel, Karolina Karwowska, Michał Kielbinski, Gniewosz Drwięga, Katarzyna Zajda, Tomasz Blasiak, Zbigniew Soltys, Zenon Rajfur, Klaudia Szklarczyk, Ryszard Przewłock. Effects of brief inhibition of the ventral tegmental area dopamine neurons on the cocaine seeking during abstinence. Addiction biology. vol 25. issue 6. 2021-09-28. PMID:31478293. |
notably, vta pharmacological inactivation or dopamine receptor blockade in the forebrain may induce behavioral inhibition in general and acute aversive states in particular, thus reducing cocaine seeking indirectly. |
2021-09-28 |
2023-08-13 |
Not clear |
| Jicheng Li, Renfei Fan, Xiaofeng Liu, Xiangfeng Shen, Xin Liu, Hua Zha. The convergence of aversion and reward signals in individual neurons of the mice lateral habenula. Experimental neurology. vol 339. 2021-09-21. PMID:33549547. |
the lateral habenula (lhb) and ventral tegmental area (vta) are two structures closely connected, and they serve as aversion and reward junction of the brain, respectively. |
2021-09-21 |
2023-08-13 |
mouse |
| Jicheng Li, Renfei Fan, Xiaofeng Liu, Xiangfeng Shen, Xin Liu, Hua Zha. The convergence of aversion and reward signals in individual neurons of the mice lateral habenula. Experimental neurology. vol 339. 2021-09-21. PMID:33549547. |
using optogenetic combined with multi-channel recording of lhb / vta neuronal discharge, we found that most single neurons in the lhb/ vta respond to both aversion and reward stimuli. |
2021-09-21 |
2023-08-13 |
mouse |
| Jicheng Li, Renfei Fan, Xiaofeng Liu, Xiangfeng Shen, Xin Liu, Hua Zha. The convergence of aversion and reward signals in individual neurons of the mice lateral habenula. Experimental neurology. vol 339. 2021-09-21. PMID:33549547. |
furthermore, optogenetic activation or inhibition of glutamatergic neurons in lhb and their terminals in vta could induce aversive or reward behaviors. |
2021-09-21 |
2023-08-13 |
mouse |
| Jicheng Li, Renfei Fan, Xiaofeng Liu, Xiangfeng Shen, Xin Liu, Hua Zha. The convergence of aversion and reward signals in individual neurons of the mice lateral habenula. Experimental neurology. vol 339. 2021-09-21. PMID:33549547. |
these results indicate that identical neurons in the lhb and vta have different responses to reward and aversion stimuli. |
2021-09-21 |
2023-08-13 |
mouse |
| Jicheng Li, Renfei Fan, Xiaofeng Liu, Xiangfeng Shen, Xin Liu, Hua Zha. The convergence of aversion and reward signals in individual neurons of the mice lateral habenula. Experimental neurology. vol 339. 2021-09-21. PMID:33549547. |
the aversion behaviors induced by activating lhb glutamatergic neurons may be due to its inhibition on reward-activated neurons in vta. |
2021-09-21 |
2023-08-13 |
mouse |
| Jicheng Li, Renfei Fan, Xiaofeng Liu, Xiangfeng Shen, Xin Liu, Hua Zha. The convergence of aversion and reward signals in individual neurons of the mice lateral habenula. Experimental neurology. vol 339. 2021-09-21. PMID:33549547. |
this study suggests that interplay between the lhb and vta neurons may play a key role in regulating reward and aversion behaviors. |
2021-09-21 |
2023-08-13 |
mouse |
| Constance Y Peng, Philip Jean-Richard-Dit-Bressel, Sophia Gilchrist, John M Power, Gavan P McNall. Phasic inhibition of dopamine neurons is an instrumental punisher. Behavioral neuroscience. vol 135. issue 3. 2021-09-17. PMID:34264692. |
these effects of optogenetic inhibition of vta dopamine neurons on instrumental responding are formally similar to the effects of aversive events in instrumental preparations and show that optogenetic inhibition of vta dopamine neurons is sufficient to serve as an instrumental punisher. |
2021-09-17 |
2023-08-13 |
Not clear |
| Shaghayegh Navabpour, Ameneh Rezayof, Zahra Ghasemzade. Activation of VTA/CeA/mPFC cannabinoid CB1 receptors induced conditioned drug effects via interacting with hippocampal CAMKII-CREB-BDNF signaling pathway in rats. European journal of pharmacology. vol 909. 2021-09-10. PMID:34389313. |
the present study intended to investigate whether the activation of cannabinoid cb1 receptors of the ventral tegmental area (vta), the central amygdala (cea) and the medial prefrontal cortex (mpfc) could induce conditioned place preference or aversion (cpp or cpa) in adult male wistar rats. |
2021-09-10 |
2023-08-13 |
rat |
| Laura Maria Wade-Bohleber, Amelie Haugg, Sabrina Huber, Jutta Ernst, Simone Grimm, Dominique Recher, Andre Richter, Erich Seifritz, Heinz Boeker, Georg Northof. Anticipating control over aversive stimuli is mediated by the medial prefrontal cortex: An fMRI study with healthy adults. Human brain mapping. vol 42. issue 13. 2021-08-16. PMID:34105855. |
in a sample of 25 healthy adults, we observed increased neural activation in the medial prefrontal cortex (ventromedial prefrontal cortex and rostral anterior cingulate cortex), other brain areas relevant for reward anticipation (ventral striatum, brainstem [ventral tegmental area], midcingulate cortex), and the posterior cingulate cortex when they anticipated control over aversion compared with anticipating no control (1). |
2021-08-16 |
2023-08-13 |
Not clear |
| Anna I Dunigan, Andrew M Swanson, David P Olson, Aaron G Roseberr. Whole-brain efferent and afferent connectivity of mouse ventral tegmental area melanocortin-3 receptor neurons. The Journal of comparative neurology. vol 529. issue 6. 2021-08-13. PMID:32856297. |
vta mc3r neurons were broadly connected to neurons across the brain but were strongly connected to a discrete set of brain regions involved in the regulation of feeding, reward, and aversion. |
2021-08-13 |
2023-08-13 |
mouse |
| Hossein Masrouri, Maryam Azadi, Saeed Semnanian, Hossein Aziz. Maternal deprivation induces persistent adaptations in putative dopamine neurons in rat ventral tegmental area: in vivo electrophysiological study. Experimental brain research. vol 238. issue 10. 2021-07-28. PMID:32705295. |
early life aversive experiences can trigger persistent deficits in neuronal signaling within the mesolimbic pathway, most notably in the dopamine (da) neurons of the ventral tegmental area (vta). |
2021-07-28 |
2023-08-13 |
human |
| Shi-Hao Gao, Lin-Lin Shen, Hui-Zhong Wen, Yan-Dong Zhao, Peng-Hui Chen, Huai-Zhen Rua. The projections from the anterior cingulate cortex to the nucleus accumbens and ventral tegmental area contribute to neuropathic pain-evoked aversion in rats. Neurobiology of disease. vol 140. 2021-07-08. PMID:32251841. |
the projections from the anterior cingulate cortex to the nucleus accumbens and ventral tegmental area contribute to neuropathic pain-evoked aversion in rats. |
2021-07-08 |
2023-08-13 |
rat |
| Shi-Hao Gao, Lin-Lin Shen, Hui-Zhong Wen, Yan-Dong Zhao, Peng-Hui Chen, Huai-Zhen Rua. The projections from the anterior cingulate cortex to the nucleus accumbens and ventral tegmental area contribute to neuropathic pain-evoked aversion in rats. Neurobiology of disease. vol 140. 2021-07-08. PMID:32251841. |
taken together, our findings suggest that projections from the acc to the nac and vta mediate neuropathic pain-related aversive behavior. |
2021-07-08 |
2023-08-13 |
rat |
| Cecilia P Kramar, Fernando Castillo-Díaz, Eduardo D Gigante, Jorge H Medina, M Flavia Barban. The late consolidation of an aversive memory is promoted by VTA dopamine release in the dorsal hippocampus. The European journal of neuroscience. vol 53. issue 3. 2021-06-28. PMID:33617053. |
in addition and consistent with previous findings showing that late post-training infusions of dopaminergic agents into the hippocampus modulate the long-term storage of aversive memories, we found that the photostimulation of dopaminergic vta fibers in the dorsal hippocampus 11-12 hr after cpa training was enough to transform a short-lasting long-term memory into a long-lasting one. |
2021-06-28 |
2023-08-13 |
rat |