| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gisella Vetere, Lina M Tran, Sara Moberg, Patrick E Steadman, Leonardo Restivo, Filomene G Morrison, Kerry J Ressler, Sheena A Josselyn, Paul W Franklan. Memory formation in the absence of experience. Nature neuroscience. vol 22. issue 6. 2019-07-05. PMID:31036944. |
here we replaced the odor cs with optogenetic stimulation of a specific olfactory glomerulus and the us with optogenetic stimulation of distinct inputs into the ventral tegmental area that mediate either aversion or reward. |
2019-07-05 |
2023-08-13 |
mouse |
| C Morel, S P Fernandez, F Pantouli, F J Meye, F Marti, S Tolu, S Parnaudeau, H Marie, F Tronche, U Maskos, M Moretti, C Gotti, M-H Han, A Bailey, M Mameli, J Barik, P Faur. Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells' activity. Molecular psychiatry. vol 23. issue 7. 2019-06-17. PMID:29155800. |
this interplay is underpinned by marked remodeling of nicotinic systems, causing increased ventral tegmental area (vta) da neurons' activity and stress-related behaviors, such as social aversion. |
2019-06-17 |
2023-08-13 |
Not clear |
| Lei Xiao, Michael F Priest, Yevgenia Kozorovitski. Oxytocin functions as a spatiotemporal filter for excitatory synaptic inputs to VTA dopamine neurons. eLife. vol 7. 2019-05-28. PMID:29676731. |
the experience of rewarding or aversive stimuli is encoded by distinct afferents to dopamine (da) neurons of the ventral tegmental area (vta). |
2019-05-28 |
2023-08-13 |
mouse |
| J A Gomez, J M Perkins, G M Beaudoin, N B Cook, S A Quraishi, E A Szoeke, K Thangamani, C W Tschumi, M J Wanat, A M Maroof, M J Beckstead, P A Rosenberg, C A Paladin. Ventral tegmental area astrocytes orchestrate avoidance and approach behavior. Nature communications. vol 10. issue 1. 2019-05-03. PMID:30926783. |
ventral tegmental area astrocytes orchestrate avoidance and approach behavior. |
2019-05-03 |
2023-08-13 |
Not clear |
| J A Gomez, J M Perkins, G M Beaudoin, N B Cook, S A Quraishi, E A Szoeke, K Thangamani, C W Tschumi, M J Wanat, A M Maroof, M J Beckstead, P A Rosenberg, C A Paladin. Ventral tegmental area astrocytes orchestrate avoidance and approach behavior. Nature communications. vol 10. issue 1. 2019-05-03. PMID:30926783. |
using genetic and optical dissection strategies we report that vta astrocytes tune glutamatergic signaling selectively on local inhibitory neurons to drive a functional circuit for learned avoidance. |
2019-05-03 |
2023-08-13 |
Not clear |
| J A Gomez, J M Perkins, G M Beaudoin, N B Cook, S A Quraishi, E A Szoeke, K Thangamani, C W Tschumi, M J Wanat, A M Maroof, M J Beckstead, P A Rosenberg, C A Paladin. Ventral tegmental area astrocytes orchestrate avoidance and approach behavior. Nature communications. vol 10. issue 1. 2019-05-03. PMID:30926783. |
in this circuit, astrocytes facilitate excitation of vta gaba neurons to increase inhibition of dopamine neurons, eliciting real-time and learned avoidance behavior that is sufficient to impede expression of preference for reward. |
2019-05-03 |
2023-08-13 |
Not clear |
| J A Gomez, J M Perkins, G M Beaudoin, N B Cook, S A Quraishi, E A Szoeke, K Thangamani, C W Tschumi, M J Wanat, A M Maroof, M J Beckstead, P A Rosenberg, C A Paladin. Ventral tegmental area astrocytes orchestrate avoidance and approach behavior. Nature communications. vol 10. issue 1. 2019-05-03. PMID:30926783. |
loss of one glutamate transporter (glt-1) from vta astrocytes selectively blocks these avoidance behaviors and spares preference for reward. |
2019-05-03 |
2023-08-13 |
Not clear |
| J A Gomez, J M Perkins, G M Beaudoin, N B Cook, S A Quraishi, E A Szoeke, K Thangamani, C W Tschumi, M J Wanat, A M Maroof, M J Beckstead, P A Rosenberg, C A Paladin. Ventral tegmental area astrocytes orchestrate avoidance and approach behavior. Nature communications. vol 10. issue 1. 2019-05-03. PMID:30926783. |
thus, vta astrocytes selectively regulate excitation of local gaba neurons to drive a distinct avoidance circuit that opposes approach behavior. |
2019-05-03 |
2023-08-13 |
Not clear |
| Daniel García-Pérez, Szilamer Ferenczi, Krisztina J Kovács, M Victoria Milané. Distinct regulation pattern of Egr-1, BDNF and Arc during morphine-withdrawal conditioned place aversion paradigm: Role of glucocorticoids. Behavioural brain research. vol 360. 2019-05-02. PMID:30550948. |
importantly, interconnected brain areas involved in aversive motivational processes, such as the ventral tegmental area (vta) and medial prefrontal cortex (mpfc), become activated when animals are confined to withdrawal-paired environments. |
2019-05-02 |
2023-08-13 |
rat |
| Daniel García-Pérez, Szilamer Ferenczi, Krisztina J Kovács, M Victoria Milané. Distinct regulation pattern of Egr-1, BDNF and Arc during morphine-withdrawal conditioned place aversion paradigm: Role of glucocorticoids. Behavioural brain research. vol 360. 2019-05-02. PMID:30550948. |
qpcr was employed to detect the expression of brain derived neurotrophic factor (bdnf) and the immediate early genes (ieg) early growth response 1 (egr-1) and activity-regulated cytoskeletal-associated protein (arc) mrnas in the vta and mpfc at different time points of the conditioned place aversion (cpa) paradigm: after the conditioning phase and after the test phase. |
2019-05-02 |
2023-08-13 |
rat |
| Eleanor J Paul, Eliza Kalk, Kyoko Tossell, Elaine E Irvine, Nicholas P Franks, William Wisden, Dominic J Withers, James Leiper, Mark A Ungles. nNOS-Expressing Neurons in the Ventral Tegmental Area and Substantia Nigra Pars Compacta. eNeuro. vol 5. issue 5. 2019-04-19. PMID:30456293. |
gaba neurons in the vta and snc play key roles in reward and aversion through their local inhibitory control of dopamine neuron activity and through long-range projections to several target regions including the nucleus accumbens. |
2019-04-19 |
2023-08-13 |
mouse |
| Shunpei Moriya, Akira Yamashita, Shigetaka Kawashima, Ryusei Nishi, Akihiro Yamanaka, Tomoyuki Kuwak. Acute Aversive Stimuli Rapidly Increase the Activity of Ventral Tegmental Area Dopamine Neurons in Awake Mice. Neuroscience. vol 386. 2019-03-11. PMID:29958943. |
our data clearly show that acute aversive stimuli rapidly increase the activity of vta dopamine neurons and thus suggest a salience-processing role. |
2019-03-11 |
2023-08-13 |
mouse |
| Ximena I Salinas-Hernández, Pascal Vogel, Sebastian Betz, Raffael Kalisch, Torfi Sigurdsson, Sevil Duvarc. Dopamine neurons drive fear extinction learning by signaling the omission of expected aversive outcomes. eLife. vol 7. 2019-03-11. PMID:30421719. |
here we show, using single-unit electrophysiology and cell-type specific fiber photometry, that dopamine neurons in the ventral tegmental area (vta) are activated by the omission of the aversive unconditioned stimulus (us) during fear extinction. |
2019-03-11 |
2023-08-13 |
Not clear |
| Chang You, Bertha Vandegrift, Mark S Brodi. Ethanol actions on the ventral tegmental area: novel potential targets on reward pathway neurons. Psychopharmacology. vol 235. issue 6. 2019-02-20. PMID:29549390. |
while primarily associated with rewarding and reinforcing stimuli, recent evidence indicates a role for the vta in aversion as well. |
2019-02-20 |
2023-08-13 |
Not clear |
| Chang You, Bertha Vandegrift, Mark S Brodi. Ethanol actions on the ventral tegmental area: novel potential targets on reward pathway neurons. Psychopharmacology. vol 235. issue 6. 2019-02-20. PMID:29549390. |
ethanol actions in the vta may trigger neuroadaptation resulting in reduction of the aversive responses to alcohol and a relative increase in the rewarding responses. |
2019-02-20 |
2023-08-13 |
Not clear |
| V I Maiorov, A N Serko. [Analyzing A- and 0-rhythms of Conditioned Avoidance Reflex in the Rat Brain With Granger Causality]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 66. issue 3. 2019-02-19. PMID:30695415. |
it has been shown by the method of frequency decomposition of conditional granger causality that under the execution of conditioned avoidance reflex θ-rhythm from the ventral hippocampus concurrently influences the ventral tegmental area and the series-connected basolateral amygdala and medial prefrontal cortex. |
2019-02-19 |
2023-08-13 |
rat |
| Severiano Risco, Cristina Mediavill. Orexin A in the ventral tegmental area enhances saccharin-induced conditioned flavor preference: The role of D1 receptors in central nucleus of amygdala. Behavioural brain research. vol 348. 2018-11-05. PMID:29684475. |
experiment 1 analyzes the effect of orexin administration (53 and 107 ng) in the ventral tegmental area (vta) on hedonic intake through acquisition of a flavor-taste preference and a flavor-taste aversion. |
2018-11-05 |
2023-08-13 |
Not clear |
| Siamak Beheshti, Neda Aslan. Local injection of d-lys-3-GHRP-6 in the rat amygdala, dentate gyrus or ventral tegmental area impairs memory consolidation. Neuropeptides. vol 67. 2018-08-16. PMID:29137815. |
in this study the effect of injection of a ghs-r1a selective antagonist (d-lys-3-ghrp-6) into the basolateral amygdala, dentate gyrus or ventral tegmental area was examined on memory consolidation in the passive avoidance task. |
2018-08-16 |
2023-08-13 |
rat |
| Junchol Park, Bita Moghadda. Risk of punishment influences discrete and coordinated encoding of reward-guided actions by prefrontal cortex and VTA neurons. eLife. vol 6. 2018-07-06. PMID:29058673. |
spike activity and local field potentials were recorded during task performance simultaneously from vta and mpfc, two reciprocally connected regions implicated in reward-seeking and aversive behaviors. |
2018-07-06 |
2023-08-13 |
rat |
| David H Root, Hui-Ling Wang, Bing Liu, David J Barker, László Mód, Péter Szocsics, Afonso C Silva, Zsófia Maglóczky, Marisela Morale. Glutamate neurons are intermixed with midbrain dopamine neurons in nonhuman primates and humans. Scientific reports. vol 6. 2018-04-19. PMID:27477243. |
the rodent ventral tegmental area (vta) and substantia nigra pars compacta (snc) contain dopamine neurons intermixed with glutamate neurons (expressing vesicular glutamate transporter 2; vglut2), which play roles in reward and aversion. |
2018-04-19 |
2023-08-13 |
human |