| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming Li, Tao Sun, Alexa Mea. Clozapine, but not olanzapine, disrupts conditioned avoidance response in rats by antagonizing 5-HT2A/2C receptors. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 4. 2012-07-30. PMID:21986871. |
these results confirmed our previous findings and suggest that clozapine, but not olanzapine, acts on through 5-ht(2a/2c) receptors to achieve its acute avoidance disruptive effect and likely its therapeutic effects. |
2012-07-30 |
2023-08-12 |
rat |
| Steven J Shabel, Christophe D Proulx, Anthony Trias, Ryan T Murphy, Roberto Malino. Input to the lateral habenula from the basal ganglia is excitatory, aversive, and suppressed by serotonin. Neuron. vol 74. issue 3. 2012-07-12. PMID:22578499. |
input to the lateral habenula from the basal ganglia is excitatory, aversive, and suppressed by serotonin. |
2012-07-12 |
2023-08-12 |
Not clear |
| Julie Espallergues, Sarah L Teegarden, Avin Veerakumar, Janette Boulden, Collin Challis, Jeanine Jochems, Michael Chan, Tess Petersen, Evan Deneris, Patrick Matthias, Chang-Gyu Hahn, Irwin Lucki, Sheryl G Beck, Olivier Berto. HDAC6 regulates glucocorticoid receptor signaling in serotonin pathways with critical impact on stress resilience. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 13. 2012-05-18. PMID:22457490. |
serotonin-selective depletion of hdac6 also blocked the expression of social avoidance in mice exposed to chronic social defeat and concurrently prevented the electrophysiological and morphological changes induced, in serotonin neurons, by this murine model of traumatic stress. |
2012-05-18 |
2023-08-12 |
mouse |
| Alisa R Kosheleff, Millie Grimes, Steve J O'Dell, John F Marshall, Alicia Izquierd. Work aversion and associated changes in dopamine and serotonin transporter after methamphetamine exposure in rats. Psychopharmacology. vol 219. issue 2. 2012-05-01. PMID:21643674. |
work aversion and associated changes in dopamine and serotonin transporter after methamphetamine exposure in rats. |
2012-05-01 |
2023-08-12 |
rat |
| Oliver J Robinson, Roshan Cools, Barbara J Sahakia. Tryptophan depletion disinhibits punishment but not reward prediction: implications for resilience. Psychopharmacology. vol 219. issue 2. 2012-05-01. PMID:21769566. |
this provided evidence for a valence-specific role of serotonin (which declines under depleted tryptophan) in aversive processing. |
2012-05-01 |
2023-08-12 |
Not clear |
| M J Crockett, L Clark, L D Smillie, T W Robbin. The effects of acute tryptophan depletion on costly information sampling: impulsivity or aversive processing? Psychopharmacology. vol 219. issue 2. 2012-05-01. PMID:22094531. |
the neurotransmitter serotonin (5-ht) has been implicated in both aversive processing and impulsivity. |
2012-05-01 |
2023-08-12 |
Not clear |
| Ross A McDevitt, John F Neumaie. Regulation of dorsal raphe nucleus function by serotonin autoreceptors: a behavioral perspective. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21620956. |
experiments targeting 5-ht autoreceptors in awake, behaving animals have generally shown that increasing autoreceptor feedback is anxiolytic and rewarding, while enhanced 5-ht function is aversive and anxiogenic; however, the role of serotonergic activity in behavioral models of helplessness is more complex. |
2012-02-22 |
2023-08-12 |
Not clear |
| D C de Paula, A S Torricelli, M R Lopreato, J O G Nascimento, M B Vian. 5-HT(2A) receptor activation in the dorsolateral septum facilitates inhibitory avoidance in the elevated T-maze. Behavioural brain research. vol 226. issue 1. 2012-02-09. PMID:21907244. |
5-ht(2a) receptor activation in the dorsolateral septum facilitates inhibitory avoidance in the elevated t-maze. |
2012-02-09 |
2023-08-12 |
rat |
| D C de Paula, A S Torricelli, M R Lopreato, J O G Nascimento, M B Vian. 5-HT(2A) receptor activation in the dorsolateral septum facilitates inhibitory avoidance in the elevated T-maze. Behavioural brain research. vol 226. issue 1. 2012-02-09. PMID:21907244. |
we evaluated the effects of intra-dorsolateral septum (dls) injections of the preferential 5-ht(2a) receptor agonist doi (8 and 16nmol), the 5-ht(2c) selective agonist mk-212 (0.1 and 1nmol) and the preferential 5-ht(2a) antagonist ketanserin (10 and 20nmol) in rats exposed to the elevated t-maze (etm), a model which allows the measurement of two defensive responses: inhibitory avoidance and escape. |
2012-02-09 |
2023-08-12 |
rat |
| D C de Paula, A S Torricelli, M R Lopreato, J O G Nascimento, M B Vian. 5-HT(2A) receptor activation in the dorsolateral septum facilitates inhibitory avoidance in the elevated T-maze. Behavioural brain research. vol 226. issue 1. 2012-02-09. PMID:21907244. |
the data suggests that dls 5-ht(2a) receptors are involved in the control of inhibitory avoidance and that a failure in this mechanism may be of importance to the physiopathology of generalized anxiety. |
2012-02-09 |
2023-08-12 |
rat |
| Elizabeth J P O'Nions, Raymond J Dolan, Jonathan P Roise. Serotonin transporter genotype modulates subgenual response to fearful faces using an incidental task. Journal of cognitive neuroscience. vol 23. issue 11. 2012-02-08. PMID:21568644. |
the findings are discussed in relation to the role of sgacc and serotonin in moderating responses to aversive stimuli [dayan, p., & huys, q. j., serotonin, inhibition, and negative mood. |
2012-02-08 |
2023-08-12 |
human |
| Koilmani Emmanuvel Rajan, Hemant K Singh, Arunagiri Parkavi, Prisila Dulcy Charle. Attenuation of 1-(m-chlorophenyl)-biguanide induced hippocampus-dependent memory impairment by a standardised extract of Bacopa monniera (BESEB CDRI-08). Neurochemical research. vol 36. issue 11. 2012-01-27. PMID:21735137. |
furthermore, 5ht(3a) receptor agonist 1-(m-chlorophenyl)-biguanide (mcpbg) impaired learning in the passive avoidance task followed by reduction of 5ht(3a) receptor expression, 5ht and ach levels. |
2012-01-27 |
2023-08-12 |
rat |
| O Johnson, J Becnel, C D Nichol. Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster. Neuroscience. vol 192. 2012-01-18. PMID:21749913. |
although many neurotransmitters including acetylcholine, dopamine, glutamate, and gaba have previously been demonstrated to be involved in aversive olfactory learning and memory, the role of serotonin has not been well defined. |
2012-01-18 |
2023-08-12 |
drosophila_melanogaster |
| Gareth Harris, Amanda Korchnak, Philip Summers, Vera Hapiak, Wen Jing Law, Andrew M Stein, Patricia Komuniecki, Richard Komunieck. Dissecting the serotonergic food signal stimulating sensory-mediated aversive behavior in C. elegans. PloS one. vol 6. issue 7. 2011-12-08. PMID:21814562. |
nsm 5-ht activates ser-5 on the ashs and ser-1 on the ria interneurons and stimulates aversive responses, suggesting that food-dependent serotonergic stimulation involves local changes in 5-ht levels mediated by extrasynaptic 5-ht receptors. |
2011-12-08 |
2023-08-12 |
caenorhabditis_elegans |
| Paula Shimene de Melo Yamashita, Valquiria Camin de Bortoli, Helio Zangross. 5-HT2C receptor regulation of defensive responses in the rat dorsal periaqueductal gray. Neuropharmacology. vol 60. issue 2-3. 2011-11-22. PMID:20850460. |
our results showed that intra-dpag microinjection of the endogenous agonist 5-ht (20 nmol) or the 5-ht2c receptor agonists mk-212 (1 and 10 nmol) and ro-600175 (40 nmol) significantly increased inhibitory avoidance acquisition in rats tested in the elevated t-maze, suggesting an anxiogenic effect. |
2011-11-22 |
2023-08-12 |
rat |
| Robert D Roger. The roles of dopamine and serotonin in decision making: evidence from pharmacological experiments in humans. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 1. 2011-11-10. PMID:20881944. |
finally, i suggest that the role played by serotonin in the regulation of cognitive biases, and representation of context in learning, point toward a role in the cortically mediated cognitive appraisal of reinforcers when selecting between actions, potentially accounting for its influence upon the processing salient aversive outcomes and social choice. |
2011-11-10 |
2023-08-12 |
human |
| Y-Lan Boureau, Peter Daya. Opponency revisited: competition and cooperation between dopamine and serotonin. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 1. 2011-11-10. PMID:20881948. |
there is ample evidence for the role of dopamine in the appetitive half of this spectrum, but little agreement about the existence, nature, or role of putative aversive opponents such as serotonin. |
2011-11-10 |
2023-08-12 |
Not clear |
| Geraldine A Wrigh. The role of dopamine and serotonin in conditioned food aversion learning in the honeybee. Communicative & integrative biology. vol 4. issue 3. 2011-11-10. PMID:21980568. |
the role of dopamine and serotonin in conditioned food aversion learning in the honeybee. |
2011-11-10 |
2023-08-12 |
Not clear |
| Frederico G Graef. [Serotonin, periaqueductal gray matter and panic disorder]. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). vol 25 Suppl 2. 2011-08-15. PMID:14978586. |
results obtained with conflict tests in experimental animals indicate that 5-ht enhances anxiety, whereas results with aversive stimulation of the dorsal pag point to an anxiolytic role of 5-ht. |
2011-08-15 |
2023-08-12 |
human |
| Tomoko Horisawa, Tadashi Ishibashi, Hiroyuki Nishikawa, Takeshi Enomoto, Satoko Toma, Takeo Ishiyama, Mutsuo Taij. The effects of selective antagonists of serotonin 5-HT7 and 5-HT1A receptors on MK-801-induced impairment of learning and memory in the passive avoidance and Morris water maze tests in rats: mechanistic implications for the beneficial effects of the novel atypical antipsychotic lurasidone. Behavioural brain research. vol 220. issue 1. 2011-07-15. PMID:21277905. |
the effects of selective antagonists of serotonin 5-ht7 and 5-ht1a receptors on mk-801-induced impairment of learning and memory in the passive avoidance and morris water maze tests in rats: mechanistic implications for the beneficial effects of the novel atypical antipsychotic lurasidone. |
2011-07-15 |
2023-08-12 |
rat |