| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tomoko Horisawa, Tadashi Ishibashi, Hiroyuki Nishikawa, Takeshi Enomoto, Satoko Toma, Takeo Ishiyama, Mutsuo Taij. The effects of selective antagonists of serotonin 5-HT7 and 5-HT1A receptors on MK-801-induced impairment of learning and memory in the passive avoidance and Morris water maze tests in rats: mechanistic implications for the beneficial effects of the novel atypical antipsychotic lurasidone. Behavioural brain research. vol 220. issue 1. 2011-07-15. PMID:21277905. |
we have previously reported that lurasidone, a novel atypical antipsychotic with potent serotonin 5-ht(7) antagonist and 5-ht(1a) partial agonist activities, is superior to other antipsychotics in improving the n-methyl-d-aspartate (nmda) receptor antagonist mk-801-induced learning and memory impairment in the passive avoidance (pa) and morris water maze (mwm) tests in rats. |
2011-07-15 |
2023-08-12 |
rat |
| Shin-ichi Kimura, Hiroko Togashi, Machiko Matsumoto, Taito Shiozawa, Junko Ishida, Satomi Kano, Atsuko Ohashi, Shyhei Ishikawa, Taku Yamaguchi, Mitsuhiro Yoshioka, Keiichi Shimamur. Serotonin(1A) receptor-mediated synaptic response in the rat medial prefrontal cortex is altered by early life stress: in vivo and in vitro electrophysiological studies. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 31. issue 1. 2011-06-21. PMID:21404951. |
the present study explored whether aversive stress exposure in the second and/or the third week (pnd 21-25, 3w-fs) affects the function of cortical 5-ht(1a) receptors, using in vivo and in vitro experiments. |
2011-06-21 |
2023-08-12 |
rat |
| Shin-ichi Kimura, Hiroko Togashi, Machiko Matsumoto, Taito Shiozawa, Junko Ishida, Satomi Kano, Atsuko Ohashi, Shyhei Ishikawa, Taku Yamaguchi, Mitsuhiro Yoshioka, Keiichi Shimamur. Serotonin(1A) receptor-mediated synaptic response in the rat medial prefrontal cortex is altered by early life stress: in vivo and in vitro electrophysiological studies. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 31. issue 1. 2011-06-21. PMID:21404951. |
thus, aversive stress exposure during the second postnatal period appears to cause persistent changes mediated via 5-ht(1a) receptors, presumably involving signal transduction regulating the development of synaptic connectivity underlying fear circuits. |
2011-06-21 |
2023-08-12 |
rat |
| F A Pamplona, K Henes, V Micale, C P Mauch, R N Takahashi, C T Wotja. Prolonged fear incubation leads to generalized avoidance behavior in mice. Journal of psychiatric research. vol 45. issue 3. 2011-06-14. PMID:20655545. |
we employed our recently established mouse model of ptsd (i) to study the emergence of avoidance behavior in the aftermath of a trauma, (ii) to disentangle the impact of context generalization vs. lack of motivation vs. novelty fear and (iii) to assess the therapeutic value of benzodiazepines and selective serotonin reuptake inhibitors (ssris). |
2011-06-14 |
2023-08-12 |
mouse |
| Nanna Hovelsø, Thomas Nicolaj Sager, Arne Mør. Combination of escitalopram and a 5-HT(₁A) receptor antagonist selectively decreases the extracellular levels of dopamine in the nucleus accumbens relative to striatum through 5-HT(₂C) receptor stimulation; suggestive of antipsychotic potential. Pharmacology, biochemistry, and behavior. vol 97. issue 3. 2011-04-11. PMID:20937301. |
the antipsychotic potential of the combined treatment with escitalopram, in therapeutic relevant doses, and the 5-ht(₁a) receptor antagonist, way-100635, has been evaluated by assessment of conditioned avoidance (car) behaviour and the use of microdialysis in freely moving rats. |
2011-04-11 |
2023-08-12 |
rat |
| E S da Silva, S C Poltronieri, J O G Nascimento, H Zangrossi, M B Vian. Facilitation of 5-HT(2A/2C)-mediated neurotransmission in the ventromedial hypothalamic nucleus decreases anxiety in the elevated T-maze. Behavioural brain research. vol 216. issue 2. 2011-03-22. PMID:20883726. |
these results suggest that 5-ht(2a/2c) receptors of the vmh are involved in the regulation of inhibitory avoidance and might be of relevance to the physiopathology of generalized anxiety. |
2011-03-22 |
2023-08-12 |
rat |
| J V Schweimer, M A Ungles. Phasic responses in dorsal raphe serotonin neurons to noxious stimuli. Neuroscience. vol 171. issue 4. 2011-03-10. PMID:20888395. |
serotonin is widely implicated in aversive processing. |
2011-03-10 |
2023-08-12 |
rat |
| J V Schweimer, M A Ungles. Phasic responses in dorsal raphe serotonin neurons to noxious stimuli. Neuroscience. vol 171. issue 4. 2011-03-10. PMID:20888395. |
it is not clear, however, whether serotonin neurons encode information about aversive stimuli. |
2011-03-10 |
2023-08-12 |
rat |
| J V Schweimer, M A Ungles. Phasic responses in dorsal raphe serotonin neurons to noxious stimuli. Neuroscience. vol 171. issue 4. 2011-03-10. PMID:20888395. |
these results suggest that discrete groups of serotonin neurons differentially code for aversive stimuli. |
2011-03-10 |
2023-08-12 |
rat |
| Qiong Wang, Li-Hua Sun, William Jia, Xin-Min Liu, Hai-Xia Dang, Wen-Li Mai, Ning Wang, Andre Steinmetz, Yu-Qin Wang, Chang-Jiang X. Comparison of ginsenosides Rg1 and Rb1 for their effects on improving scopolamine-induced learning and memory impairment in mice. Phytotherapy research : PTR. vol 24. issue 12. 2011-02-17. PMID:20564503. |
after 6 and 12 mg/kg of rg1 and rb1 intraperitoneal administration to mice for 7 days, their effects were assessed using the step-down passive avoidance (sd) and the morris water maze (mwm) tests, the acetylcholinesterase (ache) activity, acetylcholine (ach) content and serotonin (5-ht) level in the hippocampus were analysed after sd and mwm tests. |
2011-02-17 |
2023-08-12 |
mouse |
| Frederico G Graeff, Hélio Zangross. The dual role of serotonin in defense and the mode of action of antidepressants on generalized anxiety and panic disorders. Central nervous system agents in medicinal chemistry. vol 10. issue 3. 2011-01-07. PMID:20528764. |
the dual role of 5-ht in defense hypothesis assumes that 5-ht facilitates defensive responses to potential threat, like inhibitory avoidance, related to anxiety, whereas it inhibits defensive responses to proximal danger, like one-way escape, related to panic. |
2011-01-07 |
2023-08-12 |
human |
| Dina M Schardt, Susanne Erk, Corinna Nüsser, Markus M Nöthen, Sven Cichon, Marcella Rietschel, Jens Treutlein, Thomas Goschke, Henrik Walte. Volition diminishes genetically mediated amygdala hyperreactivity. NeuroImage. vol 53. issue 3. 2011-01-03. PMID:19969089. |
individuals carrying the short allele of a common polymorphism in the promoter region of the serotonin transporter gene (5-httlpr) exhibit heightened amygdala responses to passive stimulation with aversive emotional material. |
2011-01-03 |
2023-08-12 |
human |
| Olga A Kharchenko, Vera V Grinkevich, Olga V Vorobiova, Larisa N Grinkevic. Learning-induced lateralized activation of the MAPK/ERK cascade in identified neurons of the food-aversion network in the mollusk Helix lucorum. Neurobiology of learning and memory. vol 94. issue 2. 2010-12-13. PMID:20452447. |
in the mollusk helix lucorum, serotonin induces activation of mapk/erk in the central nervous system (cns) upon food aversion learning. |
2010-12-13 |
2023-08-12 |
Not clear |
| Molly J Crockett, Luke Clark, Marc D Hauser, Trevor W Robbin. Serotonin selectively influences moral judgment and behavior through effects on harm aversion. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 40. 2010-11-16. PMID:20876101. |
serotonin selectively influences moral judgment and behavior through effects on harm aversion. |
2010-11-16 |
2023-08-12 |
human |
| Molly J Crockett, Luke Clark, Marc D Hauser, Trevor W Robbin. Serotonin selectively influences moral judgment and behavior through effects on harm aversion. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 40. 2010-11-16. PMID:20876101. |
here, we show that the neurotransmitter serotonin directly alters both moral judgment and behavior through increasing subjects' aversion to personally harming others. |
2010-11-16 |
2023-08-12 |
human |
| Molly J Crockett, Luke Clark, Marc D Hauser, Trevor W Robbin. Serotonin selectively influences moral judgment and behavior through effects on harm aversion. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 40. 2010-11-16. PMID:20876101. |
together, these findings provide unique evidence that serotonin could promote prosocial behavior by enhancing harm aversion, a prosocial sentiment that directly affects both moral judgment and moral behavior. |
2010-11-16 |
2023-08-12 |
human |
| Alessandro Bartolomucci, Valeria Carola, Tiziana Pascucci, Stefano Puglisi-Allegra, Simona Cabib, Klaus-Peter Lesch, Stefano Parmigiani, Paola Palanza, Cornelius Gros. Increased vulnerability to psychosocial stress in heterozygous serotonin transporter knockout mice. Disease models & mechanisms. vol 3. issue 7-8. 2010-10-07. PMID:20371729. |
heterozygous 5-htt knockout mice exposed to high stress also showed significantly lower levels of serotonin turnover than wild-type littermates, selectively in the frontal cortex, which is a structure that is known to control fear and avoidance responses, and that is implicated in susceptibility to depression. |
2010-10-07 |
2023-08-12 |
mouse |
| Roger Luis Henschel Pobbe, Helio Zangross. The lateral habenula regulates defensive behaviors through changes in 5-HT-mediated neurotransmission in the dorsal periaqueductal gray matter. Neuroscience letters. vol 479. issue 2. 2010-09-27. PMID:20478359. |
while stimulation of 5-ht(1a) receptors selectively affects escape performance, 5-ht(2a/2c) receptors modulate both inhibitory avoidance and escape. |
2010-09-27 |
2023-08-12 |
rat |
| M S Man, J W Dalley, A C Robert. Opposing effects of 5,7-DHT infusions into the orbitofrontal cortex and amygdala on flexible responding. Cerebral cortex (New York, N.Y. : 1991). vol 20. issue 7. 2010-08-31. PMID:19903764. |
serotonin depletion can lead to exaggerated aversive processing and deficient response inhibition, effects that have been linked to serotonin's actions in the amygdala and orbitofrontal cortex (ofc), respectively. |
2010-08-31 |
2023-08-12 |
Not clear |
| Gareth Harris, Holly Mills, Rachel Wragg, Vera Hapiak, Michelle Castelletto, Amanda Korchnak, Richard W Komunieck. The monoaminergic modulation of sensory-mediated aversive responses in Caenorhabditis elegans requires glutamatergic/peptidergic cotransmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 23. 2010-08-24. PMID:20534837. |
food or serotonin sensitize the ashs and stimulate aversive responses through a pathway requiring the release of nlp-3-encoded neuropeptides from the ashs. |
2010-08-24 |
2023-08-12 |
caenorhabditis_elegans |