| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Soraya Seedat, Dan J. Stein, Robin A. Emsle. Open trial of citalopram in adults with post-traumatic stress disorder. The international journal of neuropsychopharmacology. vol 3. issue 2. 2019-11-20. PMID:11343590. |
citalopram, an ssri with highly potent and selective serotonin reuptake inhibition, may be a useful agent for treating the intrusive, avoidance, and arousal symptoms that characterize ptsd. |
2019-11-20 |
2023-08-12 |
human |
| Sonia Verma, Pavitra Ranawat, Neha Sharma, Bimla Nehr. Ginkgo biloba attenuates aluminum lactate-induced neurotoxicity in reproductive senescent female rats: behavioral, biochemical, and histopathological study. Environmental science and pollution research international. vol 26. issue 26. 2019-11-19. PMID:31321719. |
based on the above results, gbe prevented the neuronal loss in the hippocampus and cortex, hence caused significant improvement in the learning and memory of the animals in terms of ache activity, serotonin levels, morris water maze, and active and passive avoidance tests. |
2019-11-19 |
2023-08-13 |
rat |
| Luobing Liu, Li Wang, Chengqi Cao, Xing Cao, Ye Zhu, Ping Liu, Shu Luo, Jianxin Zhan. Serotonin transporter 5-HTTLPR genotype is associated with intrusion and avoidance symptoms of DSM-5 posttraumatic stress disorder (PTSD) in Chinese earthquake survivors. Anxiety, stress, and coping. vol 31. issue 3. 2019-09-13. PMID:29280387. |
serotonin transporter 5-httlpr genotype is associated with intrusion and avoidance symptoms of dsm-5 posttraumatic stress disorder (ptsd) in chinese earthquake survivors. |
2019-09-13 |
2023-08-13 |
Not clear |
| Tuhin S Chakraborty, Christi M Gendron, Yang Lyu, Allyson S Munneke, Madeline N DeMarco, Zachary W Hoisington, Scott D Pletche. Sensory perception of dead conspecifics induces aversive cues and modulates lifespan through serotonin in Drosophila. Nature communications. vol 10. issue 1. 2019-06-17. PMID:31147540. |
sensory perception of dead conspecifics induces aversive cues and modulates lifespan through serotonin in drosophila. |
2019-06-17 |
2023-08-13 |
drosophila_melanogaster |
| Jing Ren, Drew Friedmann, Jing Xiong, Cindy D Liu, Brielle R Ferguson, Tanya Weerakkody, Katherine E DeLoach, Chen Ran, Albert Pun, Yanwen Sun, Brandon Weissbourd, Rachael L Neve, John Huguenard, Mark A Horowitz, Liqun Lu. Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems. Cell. vol 175. issue 2. 2019-06-14. PMID:30146164. |
further, amygdala- and frontal-cortex-projecting dr serotonin neurons have largely complementary whole-brain collateralization patterns, receive biased inputs from presynaptic partners, and exhibit opposite responses to aversive stimuli. |
2019-06-14 |
2023-08-13 |
Not clear |
| Charlotte S Auth, Magdalena T Weidner, Sandy Popp, Tatyana Strekalova, Angelika G Schmitt-Böhrer, Daniel LA van den Hove, Klaus-Peter Lesch, Jonas Waide. Differential anxiety-related behaviours and brain activation in Tph2-deficient female mice exposed to adverse early environment. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 28. issue 11. 2019-05-29. PMID:30146458. |
taken together, our findings suggest that ms promotes active responses to aversive stimuli, dependent on the availability of brain 5-ht. |
2019-05-29 |
2023-08-13 |
mouse |
| Adam K Klein, Erin M Purvis, Kathy Ayala, Lisette Collins, Jacob T Krug, Matthew S Mayes, Aaron Ettenber. Activation of 5-HT Behavioural brain research. vol 357-358. 2019-03-29. PMID:29660439. |
activation of 5-ht recent work has implicated the lateral habenula (lhb) in the production of anxiogenic and aversive states. |
2019-03-29 |
2023-08-13 |
rat |
| Xiaqing Wang, Meng Sun, Lu Gan, Weihai Che. MK212, a 5-hydroxytryptamine 2C receptor agonist, inhibits conditioned avoidance responses independent of blocking endogenous dopamine release in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 89. 2019-03-25. PMID:30145182. |
mk212, a 5-hydroxytryptamine 2c receptor agonist, inhibits conditioned avoidance responses independent of blocking endogenous dopamine release in rats. |
2019-03-25 |
2023-08-13 |
rat |
| Caroline A Browne, Edgardo Falcon, Shivon A Robinson, Olivier Berton, Irwin Luck. Reversal of Stress-Induced Social Interaction Deficits by Buprenorphine. The international journal of neuropsychopharmacology. vol 21. issue 2. 2019-03-08. PMID:29020387. |
the avoidance of other rodents can be reversed by 28 days of treatment with selective serotonin reuptake inhibitors, the only pharmaceutical class approved by the u.s. food and drug administration for treating post-traumatic stress disorder. |
2019-03-08 |
2023-08-13 |
Not clear |
| Alex Morris, Michael Green, Hayley Martin, Katie Crossland, William T Swaney, Sally M Williamson, Robbie Ra. A nematode that can manipulate the behaviour of slugs. Behavioural processes. vol 151. 2018-09-10. PMID:29499346. |
these findings suggest that a possible mechanism by which p. hermaphrodita is able to manipulate parasite avoidance behaviour in host slugs is by manipulating serotonergic signalling in the brain, and that increased serotonin levels are potentially associated with a reduction in parasite avoidance. |
2018-09-10 |
2023-08-13 |
Not clear |
| Francesco Ballestriero, Jadranka Nappi, Giuseppina Zampi, Paolo Bazzicalupo, Elia Di Schiavi, Suhelen Ega. Caenorhabditis elegans employs innate and learned aversion in response to bacterial toxic metabolites tambjamine and violacein. Scientific reports. vol 6. 2018-05-18. PMID:27384057. |
the learned avoidance of violacein is specific, reversible, is mediated via the nematode olfactory apparatus (aversive olfactory learning) and is reduced in the absence of the neurotransmitter serotonin. |
2018-05-18 |
2023-08-13 |
caenorhabditis_elegans |
| Sofi da Cunha-Bang, Liv Vadskjær Hjordt, Vibeke Høyrup Dam, Dea Siggaard Stenbæk, Dorte Sestoft, Gitte M Knudse. Anterior cingulate serotonin 1B receptor binding is associated with emotional response inhibition. Journal of psychiatric research. vol 92. 2018-03-27. PMID:28502766. |
serotonin has a well-established role in emotional processing and is a key neurotransmitter in impulsive aggression, presumably by facilitating response inhibition and regulating subcortical reactivity to aversive stimuli. |
2018-03-27 |
2023-08-13 |
Not clear |
| Pieter Schipper, Marloes J A G Henckens, Bart Borghans, Marlies Hiemstra, Tamas Kozicz, Judith R Homber. Prior fear conditioning does not impede enhanced active avoidance in serotonin transporter knockout rats. Behavioural brain research. vol 326. 2018-03-07. PMID:28286283. |
prior fear conditioning does not impede enhanced active avoidance in serotonin transporter knockout rats. |
2018-03-07 |
2023-08-13 |
rat |
| Minmin Luo, Yi Li, Weixin Zhon. Do dorsal raphe 5-HT neurons encode "beneficialness"? Neurobiology of learning and memory. vol 135. 2018-02-09. PMID:27544850. |
however, experimental data so far support several seeming irreconcilable theories, suggesting that 5-ht neurons mediate behavioral inhibition, aversive processing, or reward signaling. |
2018-02-09 |
2023-08-13 |
Not clear |
| Chandni Sheth, Teri M Furlong, Kristen A Keefe, Sharif A Tah. The lateral hypothalamus to lateral habenula projection, but not the ventral pallidum to lateral habenula projection, regulates voluntary ethanol consumption. Behavioural brain research. vol 328. 2018-02-07. PMID:28432009. |
the lateral habenula (lhb) is an epithalamic brain region implicated in aversive processing via negative modulation of midbrain dopamine (da) and serotonin (5-ht) systems. |
2018-02-07 |
2023-08-13 |
Not clear |
| Andreas Heinz, Florian Schlagenhauf, Anne Beck, Carolin Wackerhage. Dimensional psychiatry: mental disorders as dysfunctions of basic learning mechanisms. Journal of neural transmission (Vienna, Austria : 1996). vol 123. issue 8. 2018-01-26. PMID:27145766. |
with respect to negative mood states, it has been shown that both reduced functional activation of the ventral striatum elicited by reward-predicting stimuli and stress-associated activation of the hypothalamic-pituitary-adrenal axis in interaction with reduced serotonin transporter availability and increased amygdala activation by aversive cues contribute to clinical depression; altogether these observations support the notion that basic learning mechanisms, such as pavlovian and instrumental conditioning and pavlovian-to-instrumental transfer, represent a basic dimension of mental disorders that can be mechanistically characterized using computational modeling and associated with specific clinical syndromes across established nosological boundaries. |
2018-01-26 |
2023-08-13 |
Not clear |
| Hailan H. Reward and Aversion. Annual review of neuroscience. vol 39. 2018-01-03. PMID:27145915. |
recent progress is pushing the boundaries of knowledge on two major fronts in research on reward and aversion: first, new layers of complexity have been reported on the functions of dopamine (da) and serotonin (5-ht) neuromodulatory systems in reward and aversion. |
2018-01-03 |
2023-08-13 |
Not clear |
| Giuseppe Musumeci, Paola Castrogiovanni, Marta Anna Szychlinska, Rosa Imbesi, Carla Loreto, Sergio Castorina, Salvatore Giunt. Protective effects of high Tryptophan diet on aging-induced passive avoidance impairment and hippocampal apoptosis. Brain research bulletin. vol 128. 2017-11-21. PMID:27889579. |
considering that loss or reduction in 5-ht neurotransmission may contribute to age-related cognitive decline, here we have investigated the effect of such diet on passive avoidance (pa) behavior, cell death, pro- and anti- apoptotic molecules (bax, bcl-2 and caspase-3) and an important transcription factor involved in synaptic plasticity and memory (creb). |
2017-11-21 |
2023-08-13 |
rat |
| J K Siemann, C L Muller, C G Forsberg, R D Blakely, J Veenstra-VanderWeele, M T Wallac. An autism-associated serotonin transporter variant disrupts multisensory processing. Translational psychiatry. vol 7. issue 3. 2017-11-16. PMID:28323282. |
a gain-of-function coding variant in the serotonin transporter (sert) associates with sensory aversion in humans, and when expressed in mice produces traits associated with asd, including disruptions in social and communicative function and repetitive behaviors. |
2017-11-16 |
2023-08-13 |
mouse |
| Marit Sijbrandij, Annet Kleiboer, Jonathan I Bisson, Corrado Barbui, Pim Cuijper. Pharmacological prevention of post-traumatic stress disorder and acute stress disorder: a systematic review and meta-analysis. The lancet. Psychiatry. vol 2. issue 5. 2017-10-03. PMID:26360285. |
this is the first systematic review to examine the effects of pharmacotherapies (eg, β blockers, hydrocortisone, and selective serotonin re-uptake inhibitors) given within the first month after a traumatic or aversive event to prevent ptsd or asd compared with no pharmacotherapy or placebo control. |
2017-10-03 |
2023-08-13 |
Not clear |