| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anand Kumar Singh, Joanna Zajdel, Elahe Mirrasekhian, Nader Almoosawi, Isabell Frisch, Anna M Klawonn, Maarit Jaarola, Michael Fritz, David Engblo. Prostaglandin-mediated inhibition of serotonin signaling controls the affective component of inflammatory pain. The Journal of clinical investigation. vol 127. issue 4. 2017-09-12. PMID:28287401. |
further, mice lacking the prostaglandin e2 receptor ep3 selectively on serotonergic cells or selectively in the area of the dorsal raphe nucleus failed to form an aversion to formalin-induced pain, as did mice lacking the serotonin transporter. |
2017-09-12 |
2023-08-13 |
mouse |
| Catherine A Marcinkiewcz, Christopher M Mazzone, Giuseppe D'Agostino, Lindsay R Halladay, J Andrew Hardaway, Jeffrey F DiBerto, Montserrat Navarro, Nathan Burnham, Claudia Cristiano, Cayce E Dorrier, Gregory J Tipton, Charu Ramakrishnan, Tamas Kozicz, Karl Deisseroth, Todd E Thiele, Zoe A McElligott, Andrew Holmes, Lora K Heisler, Thomas L Kas. Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala. Nature. vol 537. issue 7618. 2017-03-14. PMID:27556938. |
however, the precise circuits have not yet been defined through which aversive states are orchestrated by 5-ht. |
2017-03-14 |
2023-08-13 |
Not clear |
| V P Nikitin, S V Solntseva, S A Kozyre. Dynamics of the Development of Amnesia Caused by Disruption of Memory Reconsolidation by Neurotransmitter Receptors Antagonists. Bulletin of experimental biology and medicine. vol 160. issue 5. 2017-01-09. PMID:27021109. |
disruption of reconsolidation of conditioned food aversion memory by antagonists of serotonin or nmda glutamate receptors led to the development of different types of amnesia that had similar strengthening gradient at the early stages, but differed by the possibility of memory formation during re-training at the late stage. |
2017-01-09 |
2023-08-13 |
Not clear |
| Ruey-Kuang Cheng, Seetha Krishnan, Suresh Jesuthasa. Activation and inhibition of tph2 serotonergic neurons operate in tandem to influence larval zebrafish preference for light over darkness. Scientific reports. vol 6. 2016-12-30. PMID:26868164. |
pharmacological inhibition of serotonin synthesis reduces dark avoidance, indicating an involvement of this neuromodulator. |
2016-12-30 |
2023-08-13 |
zebrafish |
| Marco Bocchio, Stephen B McHugh, David M Bannerman, Trevor Sharp, Marco Capogn. Serotonin, Amygdala and Fear: Assembling the Puzzle. Frontiers in neural circuits. vol 10. 2016-10-31. PMID:27092057. |
since 5-ht release increases in the basolateral amygdala (bla) during both fear memory acquisition and expression, we examine whether and how 5-ht neurons encode aversive stimuli and aversive cues. |
2016-10-31 |
2023-08-13 |
Not clear |
| N Ahmadi-Mahmoodabadi, M Nasehi, M Emam Ghoreishi, M-R Zarrindas. Synergistic effect between prelimbic 5-HT3 and CB1 receptors on memory consolidation deficit in adult male Sprague-Dawley rats: An isobologram analysis. Neuroscience. vol 317. 2016-10-24. PMID:26701293. |
the present study investigated the influence of bilateral post-training intra-prelimbic (pl) administrations of serotonergic 5-hydroxytryptamine type-3 (5-ht3) receptor agents on arachidonylcyclopropylamide (acpa) (cannabinoid cb1 receptor agonist)-induced amnesia, using the step-through inhibitory avoidance (ia) task to assess memory in adult male sprague-dawley rats. |
2016-10-24 |
2023-08-13 |
rat |
| E E Palmer, M Leffler, C Rogers, M Shaw, R Carroll, J Earl, N W Cheung, B Champion, H Hu, S A Haas, V M Kalscheuer, J Gecz, M Fiel. New insights into Brunner syndrome and potential for targeted therapy. Clinical genetics. vol 89. issue 1. 2016-10-13. PMID:25807999. |
cautious treatment with a serotonin reuptake inhibitor, dietary modifications and avoidance of medications contraindicated in patients on monoamine oxidase inhibitors can improve symptoms. |
2016-10-13 |
2023-08-13 |
Not clear |
| Masaki Iwai, Yoshikage Muroi, Ken-ichi Kinoshita, Toshiaki Ishi. Serotonin modulates the dehydration-induced changes in tolerance for bitter water. Physiology & behavior. vol 151. 2016-06-28. PMID:26325013. |
moreover, administration of paroxetine, a selective serotonin reuptake inhibitor, decreased the intake of quinine solution, but not water, in mice deprived of water for 48 h, indicating that paroxetine treatment restored the aversion to quinine. |
2016-06-28 |
2023-08-13 |
mouse |
| Felipe Corchs, David J Nutt, Dana A Hince, Simon J C Davies, Marcio Bernik, Sean D Hoo. Evidence for serotonin function as a neurochemical difference between fear and anxiety disorders in humans? Journal of psychopharmacology (Oxford, England). vol 29. issue 10. 2016-06-23. PMID:26187054. |
in accordance with this view, our results give support to a dissociation of the disorders traditionally grouped under fear and anxiety-related disorders in terms of different roles of serotonin in modulation of responses to aversive stimulation. |
2016-06-23 |
2023-08-13 |
Not clear |
| Stephen J Bonasera, A Katrin Schenk, Evan J Luxenberg, Xidao Wang, Allan Basbaum, Laurence H Tecot. Mice Lacking Serotonin 2C Receptors Have increased Affective Responses to Aversive Stimuli. PloS one. vol 10. issue 12. 2016-06-23. PMID:26630489. |
mice lacking serotonin 2c receptors have increased affective responses to aversive stimuli. |
2016-06-23 |
2023-08-13 |
mouse |
| Sudhakar Selvaraj, Elias Mouchlianitis, Paul Faulkner, Federico Turkheimer, Philip J Cowen, Jonathan P Roiser, Oliver Howe. Presynaptic Serotoninergic Regulation of Emotional Processing: A Multimodal Brain Imaging Study. Biological psychiatry. vol 78. issue 8. 2016-06-09. PMID:24882568. |
the amygdala is a central node in the brain network that processes aversive emotions and is extensively innervated by dorsal raphe nucleus (drn) serotonin (5-hydroxytryptamine [5-ht]) neurons. |
2016-06-09 |
2023-08-13 |
Not clear |
| Yi Li, Weixin Zhong, Daqing Wang, Qiru Feng, Zhixiang Liu, Jingfeng Zhou, Chunying Jia, Fei Hu, Jiawei Zeng, Qingchun Guo, Ling Fu, Minmin Lu. Serotonin neurons in the dorsal raphe nucleus encode reward signals. Nature communications. vol 7. 2016-06-09. PMID:26818705. |
rewards including sucrose, food, sex and social interaction rapidly activate 5-ht neurons, but aversive stimuli including quinine and footshock do not. |
2016-06-09 |
2023-08-13 |
mouse |
| Rafal Rygula, Hannah F Clarke, Rudolf N Cardinal, Gemma J Cockcroft, Jing Xia, Jeff W Dalley, Trevor W Robbins, Angela C Robert. Role of Central Serotonin in Anticipation of Rewarding and Punishing Outcomes: Effects of Selective Amygdala or Orbitofrontal 5-HT Depletion. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 9. 2016-05-10. PMID:24879752. |
understanding the role of serotonin (or 5-hydroxytryptamine, 5-ht) in aversive processing has been hampered by the contradictory findings, across studies, of increased sensitivity to punishment in terms of subsequent response choice but decreased sensitivity to punishment-induced response suppression following gross depletion of central 5-ht. |
2016-05-10 |
2023-08-13 |
monkey |
| Collin Challis, Olivier Berto. Top-Down Control of Serotonin Systems by the Prefrontal Cortex: A Path toward Restored Socioemotional Function in Depression. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25706226. |
additionally, adverse social experiences that result in permanent avoidance biases, such as social defeat, drive long-lasting plasticity in this microcircuit, potentiating the indirect inhibition of 5-ht output. |
2016-04-19 |
2023-08-13 |
Not clear |
| Collin Challis, Olivier Berto. Top-Down Control of Serotonin Systems by the Prefrontal Cortex: A Path toward Restored Socioemotional Function in Depression. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25706226. |
conversely, neuromodulation of the vmpfc via deep brain stimulation (dbs) attenuates avoidance biases by restoring the direct excitatory drive of 5-ht neurons and strengthening a key subset of forebrain 5-ht projections. |
2016-04-19 |
2023-08-13 |
Not clear |
| J Brandewiede, O Stork, M Schachne. NCAM deficiency in the mouse forebrain impairs innate and learned avoidance behaviours. Genes, brain, and behavior. vol 13. issue 5. 2016-03-24. PMID:24751161. |
our data suggest that genetically or environmentally induced changes of ncam expression in the late postnatal and mature forebrain determine avoidance behaviour and serotonin (5-ht)1a receptor signalling. |
2016-03-24 |
2023-08-13 |
mouse |
| Min Feng, Jun Gao, Nan Sui, Ming L. Effects of central activation of serotonin 5-HT2A/2C or dopamine D 2/3 receptors on the acute and repeated effects of clozapine in the conditioned avoidance response test. Psychopharmacology. vol 232. issue 7. 2016-02-29. PMID:25288514. |
effects of central activation of serotonin 5-ht2a/2c or dopamine d 2/3 receptors on the acute and repeated effects of clozapine in the conditioned avoidance response test. |
2016-02-29 |
2023-08-13 |
Not clear |
| K Helmbold, M Zvyagintsev, B Dahmen, S Bubenzer-Busch, T J Gaber, M J Crockett, M Klasen, C L Sánchez, A Eisert, K Konrad, U Habel, B Herpertz-Dahlmann, F D Zep. Effects of serotonin depletion on punishment processing in the orbitofrontal and anterior cingulate cortices of healthy women. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 6. 2016-02-16. PMID:25869157. |
diminished synthesis of the neurotransmitter serotonin (5-ht) has been linked to disrupted impulse control in aversive contexts. |
2016-02-16 |
2023-08-13 |
human |
| Michio Nomura, Masayuki Kaneko, Yasunobu Okuma, Jun Nomura, Ichiro Kusumi, Tsukasa Koyama, Yasuyuki Nomur. Involvement of serotonin transporter gene polymorphisms (5-HTT) in impulsive behavior in the japanese population. PloS one. vol 10. issue 3. 2016-01-28. PMID:25775400. |
the serotonergic pathway has been implicated in the pathogenesis of impulsivity, and sensitivity to aversive outcomes may be linked to serotonin (5-ht) levels. |
2016-01-28 |
2023-08-13 |
human |
| Michio Nomura, Masayuki Kaneko, Yasunobu Okuma, Jun Nomura, Ichiro Kusumi, Tsukasa Koyama, Yasuyuki Nomur. Involvement of serotonin transporter gene polymorphisms (5-HTT) in impulsive behavior in the japanese population. PloS one. vol 10. issue 3. 2016-01-28. PMID:25775400. |
polymorphisms in the gene that encodes the serotonin transporter (5-htt), which have differential effects on the level of serotonin transmission, display alternate responses to aversive stimuli. |
2016-01-28 |
2023-08-13 |
human |