| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Collin Challis, Janette Boulden, Avin Veerakumar, Julie Espallergues, Fair M Vassoler, R Christopher Pierce, Sheryl G Beck, Olivier Berto. Raphe GABAergic neurons mediate the acquisition of avoidance after social defeat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 35. 2013-10-28. PMID:23986235. |
serotonin (5-ht) modulates neural responses to socioaffective cues and can bias approach or avoidance behavioral decisions, yet the cellular mechanisms underlying its contribution to the regulation of social experiences remain poorly understood. |
2013-10-28 |
2023-08-12 |
mouse |
| Collin Challis, Janette Boulden, Avin Veerakumar, Julie Espallergues, Fair M Vassoler, R Christopher Pierce, Sheryl G Beck, Olivier Berto. Raphe GABAergic neurons mediate the acquisition of avoidance after social defeat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 35. 2013-10-28. PMID:23986235. |
we tested this hypothesis using whole-cell recording techniques in genetically identified drn gaba and 5-ht neurons in mice exposed to social defeat, a model that induces long-lasting avoidance behaviors in a subset of mice responsive to serotonergic antidepressants. |
2013-10-28 |
2023-08-12 |
mouse |
| Collin Challis, Janette Boulden, Avin Veerakumar, Julie Espallergues, Fair M Vassoler, R Christopher Pierce, Sheryl G Beck, Olivier Berto. Raphe GABAergic neurons mediate the acquisition of avoidance after social defeat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 35. 2013-10-28. PMID:23986235. |
furthermore, optogenetic silencing of drn gaba neurons disinhibited neighboring 5-ht neurons and prevented the acquisition of social avoidance in mice exposed to a social threat, but did not affect a previously acquired avoidance phenotype. |
2013-10-28 |
2023-08-12 |
mouse |
| Collin Challis, Janette Boulden, Avin Veerakumar, Julie Espallergues, Fair M Vassoler, R Christopher Pierce, Sheryl G Beck, Olivier Berto. Raphe GABAergic neurons mediate the acquisition of avoidance after social defeat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 35. 2013-10-28. PMID:23986235. |
we provide the first characterization of gaba neurons in the drn that monosynaptically inhibit 5-ht neurons and reveal their key role in neuroplastic processes underlying the development of social avoidance. |
2013-10-28 |
2023-08-12 |
mouse |
| Hong-Mei Wang, Li-Wei Wang, Xin-Min Liu, Chang-Lu Li, Shu-Ping Xu, Ahsana-Dar Faroo. Neuroprotective effects of forsythiaside on learning and memory deficits in senescence-accelerated mouse prone (SAMP8) mice. Pharmacology, biochemistry, and behavior. vol 105. 2013-10-23. PMID:23290932. |
forsythiaside (60, 120 and 240mg/kg) was orally administered to aged (8months old) samp8 mice for 45days followed by evaluating cognitive impairment (morris water maze and step-through passive avoidance), inflammation (interleukin-1β (il-1β) and interleukin-6 (il-6) levels), oxidative stress (glutathione peroxidase (gsh-px) and total superoxide dismutase (t-sod) activities; malondialdehyde (mda) and nitric oxide (no) contents) and neurotransmitter such as norepinephrine (ne), dopamine (da), 5-hydroxytryptamine (5-ht), glutamate (glu) gamma-aminobutyric acid (gaba) and acetyl choline (ach). |
2013-10-23 |
2023-08-12 |
mouse |
| Maria A Briscione, Katherine M Serafine, Andrew P Merluzzi, Kenner C Rice, Anthony L Rile. The effects of the 5-HT3 receptor antagonist tropisetron on cocaine-induced conditioned taste aversions. Pharmacology, biochemistry, and behavior. vol 105. 2013-10-23. PMID:23415734. |
cocaine induced dose-dependent taste aversions that were not blocked by tropisetron, suggesting that cocaine's aversive effects are not mediated by 5-ht, at least at this specific receptor subtype. |
2013-10-23 |
2023-08-12 |
rat |
| Kae Nakamur. The role of the dorsal raphé nucleus in reward-seeking behavior. Frontiers in integrative neuroscience. vol 7. 2013-08-29. PMID:23986662. |
anatomical and physiological evidence also revealed that the dorsal raphé nucleus (drn), a major source of serotonin, and the dopamine system receive common inputs from brain regions associated with appetitive and aversive information processing. |
2013-08-29 |
2023-08-12 |
Not clear |
| Tanel Visnapuu, Sirli Raud, Maarja Loomets, Riin Reimets, Silva Sütt, Hendrik Luuk, Mario Plaas, Sulev Kõks, Vallo Volke, Aet Alttoa, Jaanus Harro, Eero Vasa. Wfs1-deficient mice display altered function of serotonergic system and increased behavioral response to antidepressants. Frontiers in neuroscience. vol 7. 2013-08-05. PMID:23914152. |
we found that this aversive challenge caused a significant increase in the levels of 5-ht and 5-hydroxyindoleacetic acid (5-hiaa), a metabolite of 5-ht, in the ventral and dorsal striatum of wild-type mice, but not in their homozygous littermates. |
2013-08-05 |
2023-08-12 |
mouse |
| Walter H Kaye, Christina E Wierenga, Ursula F Bailer, Alan N Simmons, Amanda Bischoff-Greth. Nothing tastes as good as skinny feels: the neurobiology of anorexia nervosa. Trends in neurosciences. vol 36. issue 2. 2013-07-31. PMID:23333342. |
restricted eating may be a means of reducing negative mood caused by skewed interactions between serotonin aversive or inhibitory and dopamine reward systems. |
2013-07-31 |
2023-08-12 |
Not clear |
| Narattaphol Charoenphandhu, Amporn Nuntapornsak, Kannikar Wongdee, Nateetip Krishnamra, Jantarima Charoenphandh. Upregulated mRNA levels of SERT, NET, MAOB, and BDNF in various brain regions of ovariectomized rats exposed to chronic aversive stimuli. Molecular and cellular biochemistry. vol 375. issue 1-2. 2013-07-26. PMID:23208077. |
herein, we used quantitative real-time pcr to quantify the mrna levels of serotonin reuptake transporter (sert), norepinephrine transporter (net), monoamine oxidase-b (maob), tryptophan hydroxylase (tph), and tyrosine hydroxylase (th) in various brain regions of ovariectomized (ovx) rats which had been exposed for 4 weeks to chronic aversive stimuli (cas), such as water deprivation, cage tilt, and illumination. |
2013-07-26 |
2023-08-12 |
rat |
| Hidehiko Takahash. Monoamines and assessment of risks. Current opinion in neurobiology. vol 22. issue 6. 2013-05-22. PMID:22749131. |
circumstantial evidence suggests that dopamine tone might be related to distortion of subjective reward probability and noradrenaline and serotonin tone might influence aversive emotional reaction to potential loss. |
2013-05-22 |
2023-08-12 |
Not clear |
| Kari B Schroeder, Richard McElreath, Daniel Nettl. Variants at serotonin transporter and 2A receptor genes predict cooperative behavior differentially according to presence of punishment. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 10. 2013-05-02. PMID:23431136. |
functional serotonin gene variants have been associated with variation in the processing of aversive stimuli and widely studied as risk factors for psychiatric disorders. |
2013-05-02 |
2023-08-12 |
human |
| Abigail G Schindler, Daniel I Messinger, Jeffrey S Smith, Haripriya Shankar, Richard M Gustin, Selena S Schattauer, Julia C Lemos, Nicholas W Chavkin, Catherine E Hagan, John F Neumaier, Charles Chavki. Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 49. 2013-04-11. PMID:23223282. |
stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake. |
2013-04-11 |
2023-08-12 |
mouse |
| Abigail G Schindler, Daniel I Messinger, Jeffrey S Smith, Haripriya Shankar, Richard M Gustin, Selena S Schattauer, Julia C Lemos, Nicholas W Chavkin, Catherine E Hagan, John F Neumaier, Charles Chavki. Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 49. 2013-04-11. PMID:23223282. |
activation of the dynorphin/κ-opioid receptor (kor) system by repeated stress exposure or agonist treatment produces place aversion, social avoidance, and reinstatement of extinguished cocaine place preference behaviors by stimulation of p38α mapk, which subsequently causes the translocation of the serotonin transporter (sert, slc6a4) to the synaptic terminals of serotonergic neurons. |
2013-04-11 |
2023-08-12 |
mouse |
| Arihiro Osanai, Dong-Liang Hu, Akio Nakan. Caenorhabditis elegans avoids staphylococcal superantigenic toxins via 5-hydroxytryptamine-dependent pathway. Canadian journal of microbiology. vol 58. issue 11. 2013-04-08. PMID:23145824. |
when mutants of c. elegans deficient in toll/interleukin-1 receptor (tir-1) and 5-hydroxytryptamine (5-ht) biosynthesis were used, avoidance behavior was attenuated. |
2013-04-08 |
2023-08-12 |
caenorhabditis_elegans |
| Arihiro Osanai, Dong-Liang Hu, Akio Nakan. Caenorhabditis elegans avoids staphylococcal superantigenic toxins via 5-hydroxytryptamine-dependent pathway. Canadian journal of microbiology. vol 58. issue 11. 2013-04-08. PMID:23145824. |
in the 5-ht biosynthesis deficient mutant nematodes, the avoidance activity was recovered when exogenous 5-ht was added. |
2013-04-08 |
2023-08-12 |
caenorhabditis_elegans |
| Arihiro Osanai, Dong-Liang Hu, Akio Nakan. Caenorhabditis elegans avoids staphylococcal superantigenic toxins via 5-hydroxytryptamine-dependent pathway. Canadian journal of microbiology. vol 58. issue 11. 2013-04-08. PMID:23145824. |
these results suggest that c. elegans avoids s. aureus by recognizing secretory molecules including tsst-1 and sec and this avoidance is dependent on tir and production of 5-ht. |
2013-04-08 |
2023-08-12 |
caenorhabditis_elegans |
| Yuqi Qin, Xiaodong Zhang, Yun Zhan. A neuronal signaling pathway of CaMKII and Gqα regulates experience-dependent transcription of tph-1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 3. 2013-04-01. PMID:23325232. |
training with pathogenic bacteria induces a learned aversion to the smell of the pathogen, a behavioral plasticity that depends on the serotonin signal from adf neurons. |
2013-04-01 |
2023-08-12 |
caenorhabditis_elegans |
| Jeffrey L Krichma. A neurorobotic platform to test the influence of neuromodulatory signaling on anxious and curious behavior. Frontiers in neurorobotics. vol 7. 2013-02-07. PMID:23386829. |
whereas changes in the overall level of dopamine (da) have an effect on the organism's reward or curiosity-seeking behavior, changes in the level of serotonin (5-ht) can affect its level of anxiety or harm aversion. |
2013-02-07 |
2023-08-12 |
Not clear |
| Lourens J P Nonkes, Inge P G van Bussel, Michel M M Verheij, Judith R Homber. The interplay between brain 5-hydroxytryptamine levels and cocaine addiction. Behavioural pharmacology. vol 22. issue 8. 2013-02-05. PMID:22015806. |
in addition, the contribution of 5-ht to the rewarding, aversive, discriminative and subjective, as well as the motivational and reinforcing effects of cocaine is discussed. |
2013-02-05 |
2023-08-12 |
Not clear |