| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laia Alegre-Zurano, Alba García-Baos, Adriana Castro-Zavala, Mireia Medrano, Ines Gallego-Landin, Olga Valverd. The FAAH inhibitor URB597 reduces cocaine intake during conditioned punishment and mitigates cocaine seeking during withdrawal. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-27. PMID:37499453. |
the faah inhibitor urb597 reduces cocaine intake during conditioned punishment and mitigates cocaine seeking during withdrawal. |
2023-07-27 |
2023-08-14 |
mouse |
| Yolanda Paes-Colli, Priscila M P Trindade, Louise C Vitorino, Fabiana Piscitelli, Fabio Arturo Iannotti, Raquel M P Campos, Alinny R Isaac, Andrey Fabiano Lourenço de Aguiar, Silvana Allodi, Fernando G de Mello, Marcelo Einicker-Lamas, Raphael de Siqueira-Santos, Vincenzo Di Marzo, Bakhos A Tannous, Litia A Carvalho, Ricardo A De Melo Reis, Luzia S Sampai. Activation of cannabinoid type 1 receptor (CB1) modulates oligodendroglial process branching complexity in rat hippocampal cultures stimulated by olfactory ensheathing glia-conditioned medium. Frontiers in cellular neuroscience. vol 17. 2023-05-04. PMID:37138770. |
these cultures were also treated with urb597 10-9 m, a faah selective inhibitor, or jzl184 10-9 m, a magl selective inhibitor, which led to the increase in the concentrations of oea and 2-ag in the conditioned medium. |
2023-05-04 |
2023-08-14 |
rat |
| William G Warren, Eleni P Papagianni, Ed Hale, Rebecca A Brociek, Helen J Cassaday, Carl W Stevenso. Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats. Frontiers in pharmacology. vol 13. 2023-01-02. PMID:36588687. |
in two experiments using auditory fear conditioned rats, we examined the effects of the faah inhibitor urb597 and the magl inhibitor jzl184 administered systemically on 1) spontaneous fear recovery after delayed extinction, and 2) extinction resistance resulting from immediate extinction [the immediate extinction deficit (ied)]. |
2023-01-02 |
2023-08-14 |
rat |
| Erin M Rock, Cheryl L Limebeer, Lital Aliasi-Sinai, Linda A Parke. The ventral pallidum as a critical region for fatty acid amide hydrolase inhibition of nausea-induced conditioned gaping in male Sprague-Dawley rats. Neuropharmacology. vol 155. 2020-02-28. PMID:31145905. |
the ventral pallidum as a critical region for fatty acid amide hydrolase inhibition of nausea-induced conditioned gaping in male sprague-dawley rats. |
2020-02-28 |
2023-08-13 |
rat |
| Francisco J Pavon, Antonia Serrano, Nimish Sidhpura, Ilham Polis, David Stouffer, Fernando Rodriguez de Fonseca, Benjamin F Cravatt, Rémi Martin-Fardon, Loren H Parson. Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens. Addiction biology. vol 23. issue 2. 2019-09-17. PMID:28660730. |
we conducted a microdialysis study to characterize nicotine-induced changes in da and serotonin (5-ht) levels in the nac of faah knockout (ko) mice using a conditioned place preference-like paradigm with three nicotine doses (0.1, 1 and 10 mg/kg, s.c.). |
2019-09-17 |
2023-08-13 |
mouse |
| Francisco J Pavon, Antonia Serrano, Nimish Sidhpura, Ilham Polis, David Stouffer, Fernando Rodriguez de Fonseca, Benjamin F Cravatt, Rémi Martin-Fardon, Loren H Parson. Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens. Addiction biology. vol 23. issue 2. 2019-09-17. PMID:28660730. |
these observations in mice suggest that enhanced nicotine-induced nac da release might contribute to increased sensitivity to the conditioned rewarding effects of low-dose nicotine following faah inhibition, which has been previously reported. |
2019-09-17 |
2023-08-13 |
mouse |
| Francisco J Pavon, Antonia Serrano, Nimish Sidhpura, Ilham Polis, David Stouffer, Fernando Rodriguez de Fonseca, Benjamin F Cravatt, Rémi Martin-Fardon, Loren H Parson. Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens. Addiction biology. vol 23. issue 2. 2019-09-17. PMID:28660730. |
previous research has reported that both genetic deletion and pharmacological inhibition of faah enhance nicotine-induced conditioned place preference at low doses. |
2019-09-17 |
2023-08-13 |
mouse |
| Cheryl L Limebeer, Erin M Rock, Nirushan Puvanenthirarajah, Micah J Niphakis, Benjamin F Cravatt, Linda A Parke. Elevation of 2-AG by monoacylglycerol lipase inhibition in the visceral insular cortex interferes with anticipatory nausea in a rat model. Behavioral neuroscience. vol 130. issue 2. 2016-12-13. PMID:26974857. |
here we report that bilateral infusion of the magl inhibitor, mjn110 (but neither the faah inhibitor, pf3845, nor ondansetron) into the vic suppressed contextually elicited conditioned gaping, and this effect was reversed by coadministration of the cb1 antagonist, am251. |
2016-12-13 |
2023-08-13 |
rat |
| Thomas F Gamage, Bogna M Ignatowska-Jankowska, Pretal P Muldoon, Benjamin F Cravatt, M Imad Damaj, Aron H Lichtma. Differential effects of endocannabinoid catabolic inhibitors on morphine withdrawal in mice. Drug and alcohol dependence. vol 146. 2015-12-18. PMID:25479915. |
the present study investigated whether Δ(9)-tetrahydrocannabinol (thc), the magl inhibitor jzl184, the faah inhibitor pf-3845, or the dual faah/magl inhibitor sa-57 would reduce acquisition of morphine withdrawal-induced conditioned place avoidance (cpa) and jumping. |
2015-12-18 |
2023-08-13 |
mouse |
| Laurie A Manwell, Paul E Malle. Comparative effects of pulmonary and parenteral Δ⁹-tetrahydrocannabinol exposure on extinction of opiate-induced conditioned aversion in rats. Psychopharmacology. vol 232. issue 9. 2015-11-20. PMID:25395060. |
we demonstrated that the fatty acid amide hydrolase (faah) inhibitor urb597, which increases ecb levels, facilitates extinction of a naloxone-precipitated morphine withdrawal-induced conditioned place aversion (cpa). |
2015-11-20 |
2023-08-13 |
rat |
| Linda A Parker, Erin M Rock, Cheryl L Limebee. Regulation of nausea and vomiting by cannabinoids. British journal of pharmacology. vol 163. issue 7. 2012-01-18. PMID:21175589. |
cannabinoid agonists (Δ(9) -thc, hu-210) and the fatty acid amide hydrolase (faah) inhibitor, urb-597, suppress conditioned gaping reactions (nausea) in rats as they suppress vomiting in emetic species. |
2012-01-18 |
2023-08-12 |
mouse |
| Amanda L McCallum, Cheryl L Limebeer, Linda A Parke. Reducing endocannabinoid metabolism with the fatty acid amide hydrolase inhibitor, URB597, fails to modify reinstatement of morphine-induced conditioned floor preference and naloxone-precipitated morphine withdrawal-induced conditioned floor avoidance. Pharmacology, biochemistry, and behavior. vol 96. issue 4. 2010-12-23. PMID:20643159. |
the potential of the fatty acid amide hydrolase (faah) inhibitor, urb597, to modify drug prime-induced reinstatement of morphine-induced conditioned floor preference or naloxone-precipitated morphine withdrawal-induced conditioned floor avoidance was evaluated. |
2010-12-23 |
2023-08-12 |
rat |
| Amanda L McCallum, Cheryl L Limebeer, Linda A Parke. Reducing endocannabinoid metabolism with the fatty acid amide hydrolase inhibitor, URB597, fails to modify reinstatement of morphine-induced conditioned floor preference and naloxone-precipitated morphine withdrawal-induced conditioned floor avoidance. Pharmacology, biochemistry, and behavior. vol 96. issue 4. 2010-12-23. PMID:20643159. |
reducing endocannabinoid metabolism with the fatty acid amide hydrolase inhibitor, urb597, fails to modify reinstatement of morphine-induced conditioned floor preference and naloxone-precipitated morphine withdrawal-induced conditioned floor avoidance. |
2010-12-23 |
2023-08-12 |
rat |
| Antonio Luchicchi, Salvatore Lecca, Stefano Carta, Giuliano Pillolla, Anna L Muntoni, Sevil Yasar, Steven R Goldberg, Marco Pisti. Effects of fatty acid amide hydrolase inhibition on neuronal responses to nicotine, cocaine and morphine in the nucleus accumbens shell and ventral tegmental area: involvement of PPAR-alpha nuclear receptors. Addiction biology. vol 15. issue 3. 2010-11-02. PMID:20477753. |
we recently demonstrated that inhibition by urb597 of fatty acid amide hydrolase (faah), the main enzyme that degrades the endogenous cannabinoid n-acylethanolamine (nae) anandamide and the endogenous non-cannabinoid naes oleoylethanolamide and palmitoylethanolamide, blocks nicotine-induced excitation of ventral tegmental area (vta) dopamine (da) neurons and da release in the shell of the nucleus accumbens (shnac), as well as nicotine-induced drug self-administration, conditioned place preference and relapse in rats. |
2010-11-02 |
2023-08-12 |
rat |
| P Adamczyk, A C McCreary, E Przegalinski, P Mierzejewski, P Bienkowski, M Fili. The effects of fatty acid amide hydrolase inhibitors on maintenance of cocaine and food self-administration and on reinstatement of cocaine-seeking and food-taking behavior in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 60. issue 3. 2010-03-30. PMID:19826190. |
our results indicate that faah inhibitors could be potent modulators of motivational and conditioned aspects of goal-directed behaviors with less prominent effects on consumatory behaviors. |
2010-03-30 |
2023-08-12 |
rat |
| Laurie A Manwell, Elham Satvat, Stefan T Lang, Craig P Allen, Francesco Leri, Linda A Parke. FAAH inhibitor, URB-597, promotes extinction and CB(1) antagonist, SR141716, inhibits extinction of conditioned aversion produced by naloxone-precipitated morphine withdrawal, but not extinction of conditioned preference produced by morphine in rats. Pharmacology, biochemistry, and behavior. vol 94. issue 1. 2009-12-17. PMID:19698735. |
faah inhibitor, urb-597, promotes extinction and cb(1) antagonist, sr141716, inhibits extinction of conditioned aversion produced by naloxone-precipitated morphine withdrawal, but not extinction of conditioned preference produced by morphine in rats. |
2009-12-17 |
2023-08-12 |
rat |
| Maria Scherma, Julie Medalie, Walter Fratta, Subramanian K Vadivel, Alexandros Makriyannis, Daniele Piomelli, Eva Mikics, Jozsef Haller, Sevil Yasar, Gianluigi Tanda, Steven R Goldber. The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition. Neuropharmacology. vol 54. issue 1. 2008-04-18. PMID:17904589. |
however, when rats were pre-treated with the fatty acid amide hydrolase (faah) inhibitor urb597 (cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester; 0.3 mg/kg intraperitoneal), which blocks anandamide's metabolic degradation, anandamide produced dose-related conditioned place aversions. |
2008-04-18 |
2023-08-12 |
rat |