All Relations between feeding and 5-ht receptor 6

Publication Sentence Publish Date Extraction Date Species
Grace E Anderson, Alexandra Sharp, Wayne E Prat. Stimulation of nucleus accumbens 5-HT6 receptors increases both appetitive and consummatory motivation in an effort-based choice task. Neuroreport. vol 34. issue 2. 2023-01-06. PMID:36608167. activity of the serotonin 6(5-ht6) receptor impacts food intake and body weight in animal models and has also shown potential as a target for treatment of anhedonia, a symptom of major depressive disorder. 2023-01-06 2023-08-14 rat
Amanda Alves Marcelino da Silva, Mayara Matias Oliveira, Taisy Cinthia Ferro Cavalcante, Larissa Cavalcanti do Amaral Almeida, Paula Luiza Menezes Cruz, Sandra Lopes de Souz. Undernutrition during pregnancy and lactation increases the number of fos-cells in the reward system in response to a 5-HT6 receptor agonist in male adolescent rats. International journal of food sciences and nutrition. vol 69. issue 4. 2018-09-12. PMID:28958176. therefore, we aimed to evaluate the effect of a 5-ht6 receptor agonist on food intake and neuronal activation in areas of the reward system in adolescent rats subjected to perinatal protein undernutrition. 2018-09-12 2023-08-13 rat
Amanda Alves Marcelino da Silva, Mayara Matias Oliveira, Taisy Cinthia Ferro Cavalcante, Larissa Cavalcanti do Amaral Almeida, Paula Luiza Menezes Cruz, Sandra Lopes de Souz. Undernutrition during pregnancy and lactation increases the number of fos-cells in the reward system in response to a 5-HT6 receptor agonist in male adolescent rats. International journal of food sciences and nutrition. vol 69. issue 4. 2018-09-12. PMID:28958176. the involvement of the 5-ht6 receptor in motivational feeding behaviours was recently observed. 2018-09-12 2023-08-13 rat
Andrea Frassetto, Jiaping Zhang, Julie Z Lao, Amanda White, Joseph M Metzger, Tung M Fong, Richard Z Che. Reduced sensitivity to diet-induced obesity in mice carrying a mutant 5-HT6 receptor. Brain research. vol 1236. 2009-04-16. PMID:18755168. given the documented role of the serotonin systems in human feeding, our results provide an interesting piece of evidence supporting the development of 5-ht6 receptor antagonists for treating obesity. 2009-04-16 2023-08-12 mouse
Andrea Frassetto, Jiaping Zhang, Julie Z Lao, Amanda White, Joseph M Metzger, Tung M Fong, Richard Z Che. Reduced sensitivity to diet-induced obesity in mice carrying a mutant 5-HT6 receptor. Brain research. vol 1236. 2009-04-16. PMID:18755168. we investigated the feeding behavior of mice carrying a non-functional 5-hydroxytryptamine-6 receptor (5-ht6). 2009-04-16 2023-08-12 mouse
D J Heal, S L Smith, A Fisas, X Codony, H Buschman. Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders. Pharmacology & therapeutics. vol 117. issue 2. 2008-03-27. PMID:18068807. in animal models, 5-ht6 receptor ligands of all functional types have been shown to decrease food intake when given acutely and chronically, to evoke profound and sustained weight-loss in obese animals, and concomitantly to improve a number of cardio-metabolic risk factors. 2008-03-27 2023-08-12 Not clear
Remigiusz Zieb. [Obesity: a review of currently used antiobesity drugs and new compounds in clinical development]. Postepy higieny i medycyny doswiadczalnej (Online). vol 61. 2008-02-04. PMID:17971763. the new antiobesity drugs under clinical development include: 1) agents that affect neurotransmitters in the central nervous system, including noradrenaline and dopamine reuptake inhibitors (bupropion, radafaxine), selective 5ht2c receptor agonists (lorcaserin), and selective 5ht6 receptor antagonists, 2) agents that modulate the activity of neuropeptides influencing food intake, including leptin analogues, human ciliary neurotrophic factor (axokine), neuropeptide y antagonists, and melanine-concentrating hormone antagonists, 3) agents that affect the peripheral satiety signals and brain-gut axis, e.g. 2008-02-04 2023-08-12 human
Jason C G Halford, Joanne A Harrold, Emma J Boyland, Clare L Lawton, John E Blundel. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity. Drugs. vol 67. issue 1. 2007-03-21. PMID:17209663. in addition, 5-ht6 receptor antagonists such as prx-07034 and bvt74316 have been shown to potently reduce food intake and bodyweight gain in rodent models and have recently entered clinical trials. 2007-03-21 2023-08-12 Not clear
M L Woolley, J C Bentley, A J Sleight, C A Marsden, K C Fon. A role for 5-ht6 receptors in retention of spatial learning in the Morris water maze. Neuropharmacology. vol 41. issue 2. 2001-10-11. PMID:11489457. in addition, ao reduced both food consumption and body weight and the later effect was also seen following ro 04-6790, suggesting a role for the 5-ht6 receptor in the regulation of feeding. 2001-10-11 2023-08-12 rat