All Relations between learning and memory and microglial cell

Publication Sentence Publish Date Extraction Date Species
Bao-Wen Zhang, Ying Li, Xian-Juan Ko. [Resistance exercise regulates hippocampal microglia polarization through TREM2/NF-κB/STAT3 signal pathway to improve cognitive dysfunction in T2DM mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 76. issue 5. 2024-10-29. PMID:39468808. however, the 8-week re improved the spatial learning and memory of db/db mice, alleviated the damage of hippocampal neurons, promoted the polarization of m2 microglia, and inhibited the neuroinflammation. 2024-10-29 2024-10-31 mouse
Xianxie Zhang, Huiting Zhang, Zuoxu Liu, Tianke Huang, Ru Yi, Zengchun Ma, Yue Ga. Salidroside improves blood-brain barrier integrity and cognitive function in hypobaric hypoxia mice by inhibiting microglia activation through GSK3β. Phytotherapy research : PTR. 2024-10-04. PMID:39364585. this study demonstrates that salidroside can inhibit the activation of microglia by inducing gsk3β phosphorylation, achieve neuroprotective effects and alleviate learning and memory dysfunction in hypobaric hypoxia mice. 2024-10-04 2024-10-07 mouse
Mauricio Rangel-Gomez, Cristina M Alberini, Benjamin Deneen, Gabrielle T Drummond, Tiina Manninen, Mriganka Sur, Aleksandra Vicenti. Neuron-Glial Interactions: Implications for Plasticity, Behavior, and Cognition. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 44. issue 40. 2024-10-02. PMID:39358030. microglia, another type of glial cell, also extend beyond their supportive roles, contributing to learning and memory processes, with microglial reductions impacting these functions in a developmentally dependent manner. 2024-10-02 2024-10-05 Not clear
Haley A Vecchiarelli, Luana Tenorio Lopes, Rosa C Paolicelli, Beth Stevens, Hiroaki Wake, Marie-Ève Trembla. Synapse Regulation. Advances in neurobiology. vol 37. 2024-08-29. PMID:39207693. in this chapter, we will describe how surveillant microglia interact with synaptic elements and modulate the number, maturation, function, and plasticity of synapses in the healthy developing, mature, and aging brain, with consequences on neuronal activity, learning and memory, and the behavioral outcome. 2024-08-29 2024-09-04 Not clear
Eva Šimončičová, Keelin Henderson Pekarik, Haley A Vecchiarelli, Clotilde Lauro, Laura Maggi, Marie-Ève Trembla. Adult Neurogenesis, Learning and Memory. Advances in neurobiology. vol 37. 2024-08-29. PMID:39207695. following the introduction to neurogenesis, this chapter details the role that microglia play in regulating neurogenesis in adulthood, specifically as it relates to learning and memory, as well as factors involved in modulation of microglia. 2024-08-29 2024-09-04 Not clear
Andrew Pearson, Milica Koprivica, Max Eisenbaum, Camila Ortiz, Mackenzie Browning, Tessa Vincennie, Cooper Tinsley, Michael Mullan, Fiona Crawford, Joseph Oj. PPARγ activation ameliorates cognitive impairment and chronic microglial activation in the aftermath of r-mTBI. Journal of neuroinflammation. vol 21. issue 1. 2024-08-03. PMID:39097742. we revealed that pioglitazone treatment attenuated spatial learning and memory impairments at 6 months post-injury and reduced the expression of reactive microglia and astrocyte markers in the cortex, hippocampus, and corpus callosum. 2024-08-03 2024-08-06 mouse
Zsolt Gáll, Ágnes Csüdör, István-Gábor Sável, Krisztina Kelemen, Melinda Kolcsá. Cholecalciferol Supplementation Impacts Behavior and Hippocampal Neuroglial Reorganization in Vitamin D-Deficient Rats. Nutrients. vol 16. issue 14. 2024-07-27. PMID:39064769. an immunohistochemical analysis of the brain regions involved in learning and memory was performed by quantifying the neurons, astrocytes, and microglia labelled with anti-neuronal nuclei (neun), glial fibrillary acidic protein (gfap), and ionized calcium-binding adaptor molecule 1 (iba-1) antibodies, respectively. 2024-07-27 2024-07-29 rat
Weipeng Wei, Denglei Ma, Lihong Gu, Yali Li, Li Zhang, Lin Li, Lan Zhan. Epimedium flavonoids improve cerebral white matter lesions by inhibiting neuroinflammation and activating neurotrophic factor signal pathways in spontaneously hypertensive rats. International immunopharmacology. vol 139. 2024-07-17. PMID:39018691. the results revealed that ef could significantly improve the learning and memory impairments in shr, alleviate the injury and demyelination of wm nerve fibers, promote the differentiation of oligodendrocyte precursor cells (opcs) into mature ols, inhibit the activation of microglia and astrocytes, inhibit the expression of p38 mapk/nf-κb p65/nlrp3 and inflammatory cytokines, and increase the expression of tight-junction related proteins zo-1, occludin, and claudin-5. 2024-07-17 2024-07-20 rat
Yujia Liu, Xue Han, Yan Su, Yiming Zhou, Minhui Xu, Jiyan Xu, Zhengliang Ma, Xiaoping Gu, Tianjiao Xi. Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice. Neural regeneration research. 2024-07-12. PMID:38993135. recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via m2 microglia polarization in postoperative cognitive dysfunction mice. 2024-07-12 2024-07-14 mouse
Jing Bian, Chunxu Liu, Xiang Li, Xiaoye Qin, Feng Wang, Lina Xuan, Weimin Zhan. Electroacupuncture improves the learning and memory abilities of rats with PSCI by attenuating the TLR4/NF-κB/NLRP3 signaling pathway on the hippocampal microglia. Neuroreport. 2024-06-27. PMID:38935074. electroacupuncture improves the learning and memory abilities of rats with psci by attenuating the tlr4/nf-κb/nlrp3 signaling pathway on the hippocampal microglia. 2024-06-27 2024-06-29 rat
Jing Bian, Chunxu Liu, Xiang Li, Xiaoye Qin, Feng Wang, Lina Xuan, Weimin Zhan. Electroacupuncture improves the learning and memory abilities of rats with PSCI by attenuating the TLR4/NF-κB/NLRP3 signaling pathway on the hippocampal microglia. Neuroreport. 2024-06-27. PMID:38935074. this study aims to investigate how electroacupuncture regulates the learning and memory abilities of poststroke cognitive impairment (psci) rats through the tlr4/nf-κb/nlrp3 signaling pathway on the hippocampal microglia. 2024-06-27 2024-06-29 rat
Yihang Xing, Haoyuan Shi, Xi Gao, Xinyu Zhu, Dingwen Zhang, Li Fang, Ji Wang, Chunlei Liu, Dan Wu, Xiyan Wang, Weihong Mi. Walnut-Derived Peptides Alleviate Learning and Memory Impairments in a Mice Model via Inhibition of Microglia Phagocytose Synapses. Journal of agricultural and food chemistry. 2024-06-10. PMID:38853533. walnut-derived peptides alleviate learning and memory impairments in a mice model via inhibition of microglia phagocytose synapses. 2024-06-10 2024-06-14 mouse
Yihang Xing, Haoyuan Shi, Xi Gao, Xinyu Zhu, Dingwen Zhang, Li Fang, Ji Wang, Chunlei Liu, Dan Wu, Xiyan Wang, Weihong Mi. Walnut-Derived Peptides Alleviate Learning and Memory Impairments in a Mice Model via Inhibition of Microglia Phagocytose Synapses. Journal of agricultural and food chemistry. 2024-06-10. PMID:38853533. these data suggested that tw-7 improved the learning and memory capability of lps-induced cognitively impaired mice through a mechanism associated with the classical complement pathway-mediated microglia phagocytose synapse. 2024-06-10 2024-06-14 mouse
Andrew R Gomez, Hyae Ran Byun, Shaogen Wu, Akm Ghulam Mohammad, Jasmine Ikbariyeh, Jaelin Chen, Alek Muro, Lin Li, Ken E Bernstein, Richard Ainsworth, Warren G Tourtellott. Angiotensin Converting Enzyme (ACE) expression in microglia reduces amyloid β deposition and neurodegeneration by increasing SYK signaling and endolysosomal trafficking. bioRxiv : the preprint server for biology. 2024-05-07. PMID:38712251. using novel mice engineered to express ace in microglia and cns associated macrophages (cams), we find that ace expression in microglia reduces aβ plaque load, preserves vulnerable neurons and excitatory synapses, and greatly reduces learning and memory abnormalities in the 5xfad amyloid mouse model of alzheimer's disease (ad). 2024-05-07 2024-05-27 mouse
Masen Leigh Boucher, Grace Conley, Nicholas Morriss, Sara Ospina-Mora, Jianhua Qiu, Rebekah Mannix, William Meeha. Time-Dependent Long-Term Effect of Memantine Following Repetitive Mild Traumatic Brain Injury. Journal of neurotrauma. 2024-04-26. PMID:38666723. we observed chronic changes in behavior (anxiety-like behavior, motor coordination, spatial learning and memory), as well as neuroinflammation (microglia, astrocytes) and tau phosphorylation (t231). 2024-04-26 2024-04-28 Not clear
Bingxue Zhang, Li Deng, Xiaodan Liu, Yao Hu, Wenyi Wang, Minghua Li, Ting Xu, Li Pang, Meifen L. Transcranial direct current stimulation combined with swimming exercise improves the learning and memory abilities of vascular dementia rats by regulating microglia through miR-223-3p/PRMT8. Neurological research. 2024-04-02. PMID:38563325. transcranial direct current stimulation combined with swimming exercise improves the learning and memory abilities of vascular dementia rats by regulating microglia through mir-223-3p/prmt8. 2024-04-02 2024-04-04 rat
Qingquan Li, Xiaokui Gan, Ming Zhang, Guangmin Zhang, Yingbin Li, Liang Ga. Erianin promotes endogenous neurogenesis in traumatic brain injury rats. Scientific reports. vol 14. issue 1. 2024-02-19. PMID:38374284. additionally, there was an increase in neuronal regeneration in the cortex and hippocampus, inhibition of pro-inflammatory microglial cell transformation in the cortex, improvement in learning and memory function in tbi rats, and simultaneous inhibition of the activation of the erk1/c-jun signal pathway. 2024-02-19 2024-02-22 rat
Chaohong Li, Zhen Zhao, Jiahao Jin, Chenlu Zhao, Baosheng Zhao, Yuzhen Li. NLRP3-GSDMD-dependent IL-1β secretion from microglia mediates learning and memory impairment in a chronic intermittent hypoxia-induced mouse model. Neuroscience. 2023-12-28. PMID:38154620. nlrp3-gsdmd-dependent il-1β secretion from microglia mediates learning and memory impairment in a chronic intermittent hypoxia-induced mouse model. 2023-12-28 2023-12-31 mouse
Yu-Han Xie, Lin Jiang, Yi Zhang, Yu-Hui Deng, Hao Yang, Qi He, Yu-Ning Zhou, Chun-Ni Zhou, Yan-Min Luo, Xin Liang, Jin Wang, Du-Juan Huang, Lin Zhu, Yong Tang, Feng-Lei Cha. Antagonizing LINGO-1 reduces activated microglia and alleviates dendritic spine loss in the hippocampus of APP/PS1 transgenic mice. Neuroscience letters. 2023-12-24. PMID:38142924. the anti-lingo-1 antibody significantly reversed these changes in ad, indicating that the anti-lingo-1 antibody can improve hippocampus-dependent learning and memory abilities and effectively rescue dendritic spines in the hippocampus of ad mice and that microglia might participate in this progression in ad. 2023-12-24 2023-12-27 mouse
Hao Han, Yawei Zhao, Junda Du, Sushan Wang, Xuehan Yang, Weijie Li, Jiayi Song, Siwei Zhang, Ziyi Zhang, Yongfei Tan, Grant M Hatch, Ming Zhang, Li Che. Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia. Immunity & ageing : I & A. vol 20. issue 1. 2023-11-18. PMID:37978517. in this study, we investigated the effect of an exercise-induced metabolite, lactate, on the microglia phenotype and its association with learning and memory. 2023-11-18 2023-11-20 mouse