All Relations between long term depression and \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

Publication Sentence Publish Date Extraction Date Species
Sarah C Simmons, William J Flerlage, Ludovic D Langlois, Ryan D Shepard, Christopher Bouslog, Emily H Thomas, Kaitlyn M Gouty, Jennifer L Sanderson, Shawn Gouty, Brian M Cox, Mark L Dell'Acqua, Fereshteh S Nugen. AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula. Communications biology. vol 7. issue 1. 2024-03-21. PMID:38509283. using whole cell patch clamp recordings in lhb of male wildtype and Δpka knockin mice (with deficiency in akap-anchoring of pka), here we show that the genetic disruption of pka anchoring to akap150 significantly reduces ampa receptor-mediated glutamatergic transmission and prevents the induction of presynaptic endocannabinoid-mediated long-term depression in lhb neurons. 2024-03-21 2024-03-23 mouse
Naoya Atarashi, Misaki Morishita, Shinji Matsud. Activation of innate immune receptor TLR9 by mitochondrial DNA plays essential roles in the chemical long-term depression of hippocampal neurons. The Journal of biological chemistry. 2024-02-14. PMID:38354781. although long-term depression (ltd), a form of synaptic plasticity, is caused by the activity-dependent reduction of cell surface α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (ampa)--type glutamate receptors (ampa receptors) at postsynaptic sites, its regulation by neuronal activity is not completely understood. 2024-02-14 2024-02-17 Not clear
S C Simmons, W J Flerlage, L D Langlois, R D Shepard, C Bouslog, E H Thomas, K M Gouty, J L Sanderson, S Gouty, B M Cox, M L Dell'Acqua, F S Nugen. AKAP150-anchored PKA regulation of synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the lateral habenula. bioRxiv : the preprint server for biology. 2023-12-18. PMID:38106086. using whole cell patch clamp recordings in lhb of male wildtype (wt) and Δpka knockin mice (with deficiency in akap-anchoring of pka), we found that the genetic disruption of pka anchoring to akap150 significantly reduced ampa receptor (ampar)-mediated glutamatergic transmission and prevented the induction of presynaptic endocannabinoid (ecb)-mediated long-term depression (ltd) in lhb neurons. 2023-12-18 2023-12-21 mouse
Sumasri Guntupalli, Pojeong Park, Dae Hee Han, Lingrui Zhang, Xuan Ling Hilary Yong, Mitchell Ringuet, Daniel G Blackmore, Dhanisha J Jhaveri, Frank Koentgen, Jocelyn Widagdo, Bong-Kiun Kaang, Victor Anggon. Ubiquitination of the GluA1 subunit of AMPA receptors is required for synaptic plasticity, memory and cognitive flexibility. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-07-07. PMID:37419688. activity-dependent changes in the number of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (ampa)-type glutamate receptors (ampars) at the synapse underpin the expression of long-term potentiation (ltp) and long-term depression (ltd), cellular correlates of learning and memory. 2023-07-07 2023-08-14 mouse
Jian-Ming Li, Lawrence W C Chan, Xianyu Li, Ruinian Hu, Sijun Yan. A high fat diet in glutamate 3-/Y mice causes changes in behavior that resemble human intellectual disability. Physiology & behavior. 2022-12-08. PMID:36476780. ionotropic ampa mediate the majority of excitatory synaptic transmission in the central nervous system and are essential for the induction and maintenances of long-term potentiation (ltp) and long-term depression (ltd), two cellular models of learning and memory underlie many the symptoms of id. 2022-12-08 2023-08-14 mouse
Huiqin Zhang, Xuefan Jiang, Lina Ma, Wei Wei, Zehui Li, Surui Chang, Jiayu Wen, Jiahui Sun, Hao L. Role of Aβ in Alzheimer's-related synaptic dysfunction. Frontiers in cell and developmental biology. vol 10. 2022-09-12. PMID:36092715. aβ disrupts glutamate receptors, such as nmda and ampa receptors, which mediates calcium dyshomeostasis and damages synapse plasticity characterized by long-term potentiation (ltp) suppression and long-term depression (ltd) enhancement. 2022-09-12 2023-08-14 Not clear
Hongxu Zhou, Yacong Xie, Weiqing Fang, Yonglan Du, Jinqi Zhou, Lijun Du, Bin Zhan. The Down-regulation of Tyrosine Phosphatase SHP2 Activity Is Involved in the Removal of Surface AMPA Receptors in Long Term Depression. Neuroscience letters. 2022-04-19. PMID:35439551. the down-regulation of tyrosine phosphatase shp2 activity is involved in the removal of surface ampa receptors in long term depression. 2022-04-19 2023-08-13 Not clear
Shinji Matsuda, Michisuke Yuzak. Subunit-dependent and subunit-independent rules of AMPA receptor trafficking during chemical long-term depression in hippocampal neurons. The Journal of biological chemistry. vol 297. issue 2. 2021-11-03. PMID:34252460. subunit-dependent and subunit-independent rules of ampa receptor trafficking during chemical long-term depression in hippocampal neurons. 2021-11-03 2023-08-13 Not clear
Jennifer L Sanderson, Ronald K Freund, Jessica A Gorski, Mark L Dell'Acqu. β-Amyloid disruption of LTP/LTD balance is mediated by AKAP150-anchored PKA and Calcineurin regulation of Ca Cell reports. vol 37. issue 1. 2021-10-23. PMID:34610314. β-amyloid disruption of ltp/ltd balance is mediated by akap150-anchored pka and calcineurin regulation of ca regulated insertion and removal of postsynaptic ampa glutamate receptors (ampars) mediates hippocampal long-term potentiation (ltp) and long-term depression (ltd) synaptic plasticity underlying learning and memory. 2021-10-23 2023-08-13 Not clear
Alejandra M Pacchioni, Peter W Kaliva. The Role of AMPAR Trafficking Mediated by Neuronal Pentraxins in Cocaine-induced Neuroadaptations. Molecular and cellular pharmacology. vol 1. issue 2. 2021-10-20. PMID:20336176. narp and np1 cluster ampa receptors, while npr contributes to removing ampa receptors during mglur-dependent long-term depression. 2021-10-20 2023-08-12 mouse
Anna Brachet, Argentina Lario, Alba Fernández-Rodrigo, Frank F Heisler, Yolanda Gutiérrez, Clara Lobo, Matthias Kneussel, José A Esteba. A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression. Cell reports. vol 36. issue 5. 2021-08-04. PMID:34348158. a kinesin 1-protrudin complex mediates ampa receptor synaptic removal during long-term depression. 2021-08-04 2023-08-13 Not clear
Daniela Lichtman, Eyal Bergmann, Alexandra Kavushansky, Nadav Cohen, Nina S Levy, Andrew P Levy, Itamar Kah. Structural and functional brain-wide alterations in A350V Iqsec2 mutant mice displaying autistic-like behavior. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33753721. iqsec2 is a postsynaptic density protein, localized on excitatory synapses as part of the nmda receptor complex and is suggested to play a role in ampa receptor trafficking and mediation of long-term depression. 2021-06-28 2023-08-13 mouse
Hiroki Yasuda, Hikaru Yamamoto, Kenji Hanamura, Mona Mehruba, Toshio Kawamata, Hiromi Morisaki, Masaaki Miyamoto, Shinji Takada, Tomoaki Shirao, Yoshitaka Ono, Hideyuki Muka. PKN1 promotes synapse maturation by inhibiting mGluR-dependent silencing through neuronal glutamate transporter activation. Communications biology. vol 3. issue 1. 2021-06-25. PMID:33244074. knocking out pkn1a, the dominant pkn1 subtype in the brain, unmasked abnormal input-nonspecific mglur-dependent long-term depression (mglur-ltd) and ampa receptor (ampar) silencing in the developing hippocampus. 2021-06-25 2023-08-13 mouse
Jang Hyuk Cho, Dong Gyu Le. Translocation of AMPA Receptors in the Dorsal Horn of the Spinal Cord Corresponding to Long-term Depression Following Pulsed Radiofrequency Stimulation at the Dorsal Root Ganglion. Pain medicine (Malden, Mass.). vol 21. issue 9. 2021-05-14. PMID:31794026. translocation of ampa receptors in the dorsal horn of the spinal cord corresponding to long-term depression following pulsed radiofrequency stimulation at the dorsal root ganglion. 2021-05-14 2023-08-13 Not clear
Miseon Kang, Jihyun Noh, Jun-Mo Chun. NMDA receptor-dependent long-term depression in the lateral habenula: implications in physiology and depression. Scientific reports. vol 10. issue 1. 2021-04-08. PMID:33087756. despite the emphasis on the pathological importance of nmda receptor (nmdar)-dependent long-term depression (ltd) and the involvement of calcium permeable ampa receptor (cp-ampar) as major ca 2021-04-08 2023-08-13 Not clear
Elena Coccia, Laura Planells-Ferrer, Raquel Badillos-Rodríguez, Marta Pascual, Miguel F Segura, Rita Fernández-Hernández, Joaquin López-Soriano, Eloi Garí, Eduardo Soriano, Bruna Barneda-Zahonero, Rana S Moubarak, M Jose Pérez-García, Joan X Comell. SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L. Cell death & disease. vol 11. issue 2. 2021-02-16. PMID:32015347. this interaction also modulates non-apoptotic functions of caspases, such as the endocytosis of ampa receptor (ampar) in hippocampal long-term depression (ltd). 2021-02-16 2023-08-13 Not clear
Rodrigo Bainy Leal, Mark William Lopes, Douglas Affonso Formolo, Cristiane Ribeiro de Carvalho, Alexandre Ademar Hoeller, Alexandra Latini, Daniel Santos Sousa, Peter Wolf, Rui Daniel Prediger, Zuner Assis Bortolotto, Marcelo Neves Linhares, Kátia Lin, Roger Wal. Amygdala levels of the GluA1 subunit of glutamate receptors and its phosphorylation state at serine 845 in the anterior hippocampus are biomarkers of ictal fear but not anxiety. Molecular psychiatry. vol 25. issue 3. 2021-01-14. PMID:29880883. synaptic transmission efficacy can be bi-directionally modified through potentiation (long-term potentiation (ltp)) or depression (long-term depression (ltd)) as well as the phosphorylation state of ser831 and ser845 sites at the glua1 subunit of the glutamate ampa receptors, which has been characterized as a critical event for this synaptic plasticity. 2021-01-14 2023-08-13 human
Thiago M Pinto, Maria J Schilstra, Antonio C Roque, Volker Steube. Binding of Filamentous Actin to CaMKII as Potential Regulation Mechanism of Bidirectional Synaptic Plasticity by β CaMKII in Cerebellar Purkinje Cells. Scientific reports. vol 10. issue 1. 2020-12-17. PMID:32488204. we present the first model of ampa receptor phosphorylation that simulates the induction of long-term depression (ltd) and potentiation (ltp) at the pf-pc synapse. 2020-12-17 2023-08-13 Not clear
Masahiro Fukaya, Takeyuki Sugawara, Yoshinobu Hara, Makoto Itakura, Masahiko Watanabe, Hiroyuki Sakagam. BRAG2a Mediates mGluR-Dependent AMPA Receptor Internalization at Excitatory Postsynapses through the Interaction with PSD-95 and Endophilin 3. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 22. 2020-10-22. PMID:32341099. brag2 regulates arf6-dependent endocytosis of ampa receptors (ampars) through the direct interaction during the hippocampal long-term depression. 2020-10-22 2023-08-13 mouse
Shinji Matsuda, Wataru Kakegawa, Michisuke Yuzak. PhotonSABER: new tool shedding light on endocytosis and learning mechanisms Communicative & integrative biology. vol 12. issue 1. 2020-10-01. PMID:31143361. photonsaber: new tool shedding light on endocytosis and learning mechanisms in the central nervous system, activity-dependent endocytosis of postsynaptic ampa-type glutamate receptors (ampa receptors) is thought to mediate long-term depression (ltd), which is a synaptic plasticity model in various neuronal circuits. 2020-10-01 2023-08-13 Not clear