| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aurélie Menigoz, Tariq Ahmed, Victor Sabanov, Koenraad Philippaert, Silvia Pinto, Sara Kerselaers, Andrei Segal, Marc Freichel, Thomas Voets, Bernd Nilius, Rudi Vennekens, Detlef Balschu. TRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons. Pflugers Archiv : European journal of physiology. vol 468. issue 4. 2016-12-13. PMID:26631168. |
taken together, our data are consistent with a novel model of ltp induction in ca1 hippocampal neurons, in which trpm4 is an essential player in a feed-forward loop that generates the post-synaptic membrane depolarization which is necessary to fully activate nmda receptors during the induction of ltp but which is dispensable for the induction of long-term depression (ltd). |
2016-12-13 |
2023-08-13 |
mouse |
| Sumangali Kailainathan, Thomas M Piers, Jee Hyun Yi, Seongmin Choi, Mark S Fahey, Eva Borger, Frank J Gunn-Moore, Laurie O'Neill, Michael Lever, Daniel J Whitcomb, Kwangwook Cho, Shelley J Alle. Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF). Pharmacological research. vol 104. 2016-12-13. PMID:26687096. |
as anticipated, exogenous application of probdnf val66 to rat hippocampal slices dysregulated synaptic plasticity, inhibiting long-term potentiation (ltp) and facilitating long-term depression (ltd). |
2016-12-13 |
2023-08-13 |
human |
| C Lemos, D Rial, F Q Gonçalves, J Pires, H B Silva, F C Matheus, A C da Silva, J M Marques, R J Rodrigues, I Jarak, R D Prediger, F Reis, R A Carvalho, F C Pereira, R A Cunh. High sucrose consumption induces memory impairment in rats associated with electrophysiological modifications but not with metabolic changes in the hippocampus. Neuroscience. vol 315. 2016-10-19. PMID:26704636. |
hsu rats also displayed no change of synaptic transmission and plasticity (long-term potentiation) in hippocampal schaffer fibers-ca1 pyramid synapses, but had decreased amplitude of long-term depression in the temporoammonic (ta) pathway. |
2016-10-19 |
2023-08-13 |
human |
| Somi Kim, TaeHyun Kim, Hye-Ryeon Lee, Eun-Hye Jang, Hyun-Hee Ryu, Minkyung Kang, So-Young Rah, Juyoun Yoo, Bolam Lee, Jae-Ick Kim, Chae Seok Lim, Sang Jeong Kim, Uh-Hyun Kim, Yong-Seok Lee, Bong-Kiun Kaan. Impaired learning and memory in CD38 null mutant mice. Molecular brain. vol 9. 2016-10-10. PMID:26856703. |
however, either long-term potentiation or long-term depression is not impaired in the hippocampus of cd38(-/-) mice. |
2016-10-10 |
2023-08-13 |
mouse |
| C Laurent, S Burnouf, B Ferry, V L Batalha, J E Coelho, Y Baqi, E Malik, E Mariciniak, S Parrot, A Van der Jeugd, E Faivre, V Flaten, C Ledent, R D'Hooge, N Sergeant, M Hamdane, S Humez, C E Müller, L V Lopes, L Buée, D Blu. A2A adenosine receptor deletion is protective in a mouse model of Tauopathy. Molecular psychiatry. vol 21. issue 1. 2016-09-16. PMID:25450226. |
we found that deleting a2ars protect from tau pathology-induced deficits in terms of spatial memory and hippocampal long-term depression. |
2016-09-16 |
2023-08-13 |
mouse |
| Hiroki Yasuda, Hideyuki Muka. Turning off of GluN2B subunits and turning on of CICR in hippocampal LTD induction after developmental GluN2 subunit switch. Hippocampus. vol 25. issue 11. 2016-08-29. PMID:25727316. |
here, we report that glun2b subunits mediate the induction of long-term depression (ltd) in the ca1 region of the hippocampus only until this period. |
2016-08-29 |
2023-08-13 |
rat |
| b' Jean-Christophe Delpech, Aurore Thomazeau, Charlotte Madore, Clementine Bosch-Bouju, Thomas Larrieu, Chloe Lacabanne, Julie Remus-Borel, Agn\\xc3\\xa8s Aubert, Corinne Joffre, Agn\\xc3\\xa8s Nadjar, Sophie Lay\\xc3\\xa. Dietary n-3 PUFAs Deficiency Increases Vulnerability to Inflammation-Induced Spatial Memory Impairment. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 12. 2016-08-02. PMID:25948102.' |
importantly, long-term depression (ltd), but not long-term potentiation (ltp) was impaired in the hippocampus of lps-treated n-3 pufa-deficient mice. |
2016-08-02 |
2023-08-13 |
mouse |
| Huili Han, Chunfang Dai, Zhifang Don. Single fluoxetine treatment before but not after stress prevents stress-induced hippocampal long-term depression and spatial memory retrieval impairment in rats. Scientific reports. vol 5. 2016-08-02. PMID:26218751. |
single fluoxetine treatment before but not after stress prevents stress-induced hippocampal long-term depression and spatial memory retrieval impairment in rats. |
2016-08-02 |
2023-08-13 |
rat |
| Sally M Till, Antonis Asiminas, Adam D Jackson, Danai Katsanevaki, Stephanie A Barnes, Emily K Osterweil, Mark F Bear, Sumantra Chattarji, Emma R Wood, David J A Wyllie, Peter C Kin. Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS. Human molecular genetics. vol 24. issue 21. 2016-08-02. PMID:26243794. |
using a new rat model of fragile x syndrome, we report that fmr1 knockout (ko) rats exhibit elevated basal protein synthesis and an increase in mglur-dependent long-term depression in ca1 of the hippocampus that is independent of new protein synthesis. |
2016-08-02 |
2023-08-13 |
mouse |
| Catherine H Choi, Brian P Schoenfeld, Aaron J Bell, Joseph Hinchey, Cory Rosenfelt, Michael J Gertner, Sean R Campbell, Danielle Emerson, Paul Hinchey, Maria Kollaros, Neal J Ferrick, Daniel B Chambers, Steven Langer, Steven Sust, Aatika Malik, Allison M Terlizzi, David A Liebelt, David Ferreiro, Ali Sharma, Eric Koenigsberg, Richard J Choi, Natalia Louneva, Steven E Arnold, Robert E Featherstone, Steven J Siegel, R Suzanne Zukin, Thomas V McDonald, Francois V Bolduc, Thomas A Jongens, Sean M J McBrid. Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models. Frontiers in behavioral neuroscience. vol 10. 2016-07-22. PMID:27445731. |
indeed, we have previously demonstrated that strategies that increase camp signaling can rescue short term memory in the fly model and restore dhpg induced mglur mediated long term depression (ltd) in the hippocampus to proper levels in the mouse model (mcbride et al., 2005; choi et al., 2011, 2015). |
2016-07-22 |
2023-08-13 |
mouse |
| Jun Li, Anping Chai, Lifang Wang, Yuanlin Ma, Zhiliu Wu, Hao Yu, Liwei Mei, Lin Lu, Chen Zhang, Weihua Yue, Lin Xu, Yi Rao, Dai Zhan. Synaptic P-Rex1 signaling regulates hippocampal long-term depression and autism-like social behavior. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 50. 2016-06-03. PMID:26621702. |
synaptic p-rex1 signaling regulates hippocampal long-term depression and autism-like social behavior. |
2016-06-03 |
2023-08-13 |
mouse |
| Jun Li, Anping Chai, Lifang Wang, Yuanlin Ma, Zhiliu Wu, Hao Yu, Liwei Mei, Lin Lu, Chen Zhang, Weihua Yue, Lin Xu, Yi Rao, Dai Zhan. Synaptic P-Rex1 signaling regulates hippocampal long-term depression and autism-like social behavior. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 50. 2016-06-03. PMID:26621702. |
genetic deletion or knockdown of p-rex1 in the ca1 region of the hippocampus in mice resulted in autism-like social behavior that was specifically linked to the defect of long-term depression (ltd) in the ca1 region through alteration of ampa receptor endocytosis mediated by the postsynaptic pp1α (protein phosphase 1α)-p-rex1-rac1 (ras-related c3 botulinum toxin substrate 1) signaling pathway. |
2016-06-03 |
2023-08-13 |
mouse |
| A Fole, M Martin, L Morales, N Del Olm. Effects of chronic cocaine treatment during adolescence in Lewis and Fischer-344 rats: Novel location recognition impairment and changes in synaptic plasticity in adulthood. Neurobiology of learning and memory. vol 123. 2016-05-26. PMID:26103137. |
long-term depression induced by the glutamate agonist nmda (ltd-nmda) is partially abolished in cocaine-treated animals in hippocampal slices from lew rats. |
2016-05-26 |
2023-08-13 |
rat |
| Gen Murakami, Yasushi Hojo, Mari Ogiue-Ikeda, Hideo Mukai, Pierre Chambon, Kohei Nakajima, Yuuki Ooishi, Tetsuya Kimoto, Suguru Kawat. Estrogen receptor KO mice study on rapid modulation of spines and long-term depression in the hippocampus. Brain research. vol 1621. 2016-05-23. PMID:25498865. |
estrogen receptor ko mice study on rapid modulation of spines and long-term depression in the hippocampus. |
2016-05-23 |
2023-08-13 |
mouse |
| Gen Murakami, Yasushi Hojo, Mari Ogiue-Ikeda, Hideo Mukai, Pierre Chambon, Kohei Nakajima, Yuuki Ooishi, Tetsuya Kimoto, Suguru Kawat. Estrogen receptor KO mice study on rapid modulation of spines and long-term depression in the hippocampus. Brain research. vol 1621. 2016-05-23. PMID:25498865. |
as another type of synaptic modulation, we observed that estradiol rapidly enhanced n-methyl-d-aspartate (nmda)-induced long-term depression (ltd) in ca1 of the wild type mouse hippocampus. |
2016-05-23 |
2023-08-13 |
mouse |
| Tine Pooters, Ann Van der Jeugd, Zsuzsanna Callaerts-Vegh, Rudi D'Hoog. Telencephalic neurocircuitry and synaptic plasticity in rodent spatial learning and memory. Brain research. vol 1621. 2016-05-23. PMID:25619550. |
two major forms of synaptic plasticity, namely long-term potentiation, a lasting increase in synaptic strength between simultaneously activated neurons, and long-term depression, a decrease in synaptic strength, have been found to occur in hippocampus, dorsal striatum and medial prefrontal cortex. |
2016-05-23 |
2023-08-13 |
human |
| Christopher M Norris, Pradoldej Sompol, Kelly N Roberts, Mubeen Ansari, Stephen W Schef. Pycnogenol protects CA3-CA1 synaptic function in a rat model of traumatic brain injury. Experimental neurology. vol 276. 2016-05-20. PMID:26607913. |
hippocampal slices from the injured (ipsilateral) and uninjured (contralateral) hemispheres were prepared at seven and fourteen days post-cci for electrophysiological analyses of ca3-ca1 synaptic function and induction of long-term depression (ltd). |
2016-05-20 |
2023-08-13 |
rat |
| Iwona A Cymerman, Agata Gozdz, Malgorzata Urbanska, Jacek Milek, Magdalena Dziembowska, Jacek Jaworsk. Structural Plasticity of Dendritic Spines Requires GSK3α and GSK3β. PloS one. vol 10. issue 7. 2016-05-13. PMID:26207897. |
we used latrunculin b, an actin polymerization inhibitor, and chemically induced long-term depression to trigger fast spine shape remodeling in cultured hippocampal neurons. |
2016-05-13 |
2023-08-13 |
Not clear |
| Felipe G Serrano, Cheril Tapia-Rojas, Francisco J Carvajal, Juan Hancke, Waldo Cerpa, Nibaldo C Inestros. Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice. Molecular neurodegeneration. vol 9. 2016-04-15. PMID:25524173. |
in the present study, we report that andrographolide (andro), which is a labdane diterpene extracted from andrographis paniculata, increases slope of field excitatory postsynaptic potentials (fepsp) in the ca1 region of hippocampal slices and inhibits long-term depression (ltd), protecting the long-term potentiation (ltp) against the damage induced by aβ oligomers in vitro, most likely by inhibiting glycogen synthase kinase-3β (gsk-3β). |
2016-04-15 |
2023-08-13 |
mouse |
| Kyungmin Lee, Yuki Kobayashi, Hyunhyo Seo, Ji-Hye Kwak, Akira Masuda, Chae-Seok Lim, Hye-Ryeon Lee, SukJae Joshua Kang, Pojeong Park, Su-Eon Sim, Naomi Kogo, Hiroaki Kawasaki, Bong-Kiun Kaang, Shigeyoshi Itohar. Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility. Molecular brain. vol 8. 2016-04-07. PMID:26104314. |
involvement of camp-guanine nucleotide exchange factor ii in hippocampal long-term depression and behavioral flexibility. |
2016-04-07 |
2023-08-13 |
mouse |