| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tyron Jensen, Jeffrey G Edward. Calcineurin is required for TRPV1-induced long-term depression of hippocampal interneurons. Neuroscience letters. vol 510. issue 2. 2012-06-25. PMID:22260796. |
calcineurin is required for trpv1-induced long-term depression of hippocampal interneurons. |
2012-06-25 |
2023-08-12 |
rat |
| Tyron Jensen, Jeffrey G Edward. Calcineurin is required for TRPV1-induced long-term depression of hippocampal interneurons. Neuroscience letters. vol 510. issue 2. 2012-06-25. PMID:22260796. |
transient receptor potential vanilloid 1 (trpv1) mediates a novel form of presynaptic long-term depression (ltd) in hippocampal interneurons. |
2012-06-25 |
2023-08-12 |
rat |
| Ashok Kumar, Asha Rani, Olga Tchigranova, Wei-Hua Lee, Thomas C Foste. Influence of late-life exposure to environmental enrichment or exercise on hippocampal function and CA1 senescent physiology. Neurobiology of aging. vol 33. issue 4. 2012-06-15. PMID:21820213. |
an examination of senescent hippocampal physiology revealed that enrichment and exercise reversed age-related changes in long-term depression (ltd) and long-term potentiation (ltp). |
2012-06-15 |
2023-08-12 |
rat |
| Yu-Feng Xie, Jillian C Belrose, Gang Lei, Michael Tymianski, Yasuo Mori, John F Macdonald, Michael F Jackso. Dependence of NMDA/GSK-3β mediated metaplasticity on TRPM2 channels at hippocampal CA3-CA1 synapses. Molecular brain. vol 4. 2012-06-05. PMID:22188973. |
using hippocampal cultures and slices from trpm2 null mice we demonstrate that the loss of these channels selectively impairs nmdar-dependent long-term depression (ltd) while sparing long-term potentiation. |
2012-06-05 |
2023-08-12 |
mouse |
| Theodore C Duma. Postnatal alterations in induction threshold and expression magnitude of long-term potentiation and long-term depression at hippocampal synapses. Hippocampus. vol 22. issue 2. 2012-05-14. PMID:21069779. |
postnatal alterations in induction threshold and expression magnitude of long-term potentiation and long-term depression at hippocampal synapses. |
2012-05-14 |
2023-08-12 |
mouse |
| Jeffrey G Edwards, Helen E Gibson, Tyron Jensen, Fereshteh Nugent, Curtis Walther, Jacob Blickenstaff, Julie A Kaue. A novel non-CB1/TRPV1 endocannabinoid-mediated mechanism depresses excitatory synapses on hippocampal CA1 interneurons. Hippocampus. vol 22. issue 2. 2012-05-14. PMID:21069781. |
we recently identified that trpv1 is required for long-term depression at excitatory synapses on ca1 hippocampal stratum radiatum interneurons. |
2012-05-14 |
2023-08-12 |
rat |
| Kristofor D Carlson, Nicholas Giordan. Interplay of the magnitude and time-course of postsynaptic Ca2+ concentration in producing spike timing-dependent plasticity. Journal of computational neuroscience. vol 30. issue 3. 2012-05-04. PMID:21120688. |
studies of neurons in the hippocampus and in other regions have found that when presynaptic activity occurs within a narrow time window, typically 10 or 20 ms, before postsynaptic activity, long-term potentiation (ltp) is induced, while if presynaptic activity occurs within a similar time window after postsynaptic activity, long-term depression (ltd) results. |
2012-05-04 |
2023-08-12 |
Not clear |
| Meredith J Noetzel, Jerri M Rook, Paige N Vinson, Hyekyung P Cho, Emily Days, Y Zhou, Alice L Rodriguez, Hilde Lavreysen, Shaun R Stauffer, Colleen M Niswender, Zixiu Xiang, J Scott Daniels, Carrie K Jones, Craig W Lindsley, C David Weaver, P Jeffrey Con. Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function. Molecular pharmacology. vol 81. issue 2. 2012-05-04. PMID:22021324. |
furthermore, ago-pams have no agonist activity in the native systems tested, including cortical astrocytes and subthalamic nucleus neurons and in measures of long-term depression at the hippocampal schaffer collateral-ca1 synapse. |
2012-05-04 |
2023-08-12 |
human |
| Ger J A Ramakers, David Wolfer, Georg Rosenberger, Kerstin Kuchenbecker, Hans-Jürgen Kreienkamp, Janine Prange-Kiel, Gabriele Rune, Karin Richter, Kristina Langnaese, Sophie Masneuf, Michael R Bösl, Klaus-Dieter Fischer, Harm J Krugers, Hans-Peter Lipp, Elly van Galen, Kerstin Kutsch. Dysregulation of Rho GTPases in the αPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits. Human molecular genetics. vol 21. issue 2. 2012-04-26. PMID:21989057. |
early-phase long-term potentiation was reduced and long-term depression was increased in the ca1 hippocampal area of αpix/arhgef6-deficient animals. |
2012-04-26 |
2023-08-12 |
mouse |
| Kotaro Ikarashi, Hiroki Fujiwara, Yoshihiko Yamazaki, Jun-Ichi Goto, Kenya Kaneko, Hiroshi Kato, Satoshi Fujii, Hiroshi Sasaki, Satoshi Fukumoto, Keiko Furukawa, Hatsue Waki, Koichi Furukaw. Impaired hippocampal long-term potentiation and failure of learning in β1,4-N-acetylgalactosaminyltransferase gene transgenic mice. Glycobiology. vol 21. issue 10. 2012-04-23. PMID:21733970. |
in the present study, three types of synaptic plasticity, long-term potentiation (ltp), long-term depression (ltd) and reversal of ltp (depotentiation, dp), in the field excitatory post-synaptic potential in ca1 hippocampal neurons and learning behavior were examined in β1,4-n-acetylgalactosaminyltransferase (β1,4 galnac-t; gm2/gd2 synthase) gene transgenic (tg) mice, which showed a marked decrease in b-pathway gangliosides (gq1b, gt1b and gd1b) in the brain and isolated hippocampus compared with wild-type (wt) mice. |
2012-04-23 |
2023-08-12 |
mouse |
| Crystal G Pontrello, Min-Yu Sun, Alice Lin, Todd A Fiacco, Kathryn A DeFea, Iryna M Ethel. Cofilin under control of β-arrestin-2 in NMDA-dependent dendritic spine plasticity, long-term depression (LTD), and learning. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 7. 2012-04-20. PMID:22308427. |
β-arrestin-2-deficient mice exhibit normal hippocampal long-term potentiation, but significantly impaired nmda-dependent long-term depression and spatial learning deficits. |
2012-04-20 |
2023-08-12 |
mouse |
| Jing Han, Philip Kesner, Mathilde Metna-Laurent, Tingting Duan, Lin Xu, Francois Georges, Muriel Koehl, Djoher Nora Abrous, Juan Mendizabal-Zubiaga, Pedro Grandes, Qingsong Liu, Guang Bai, Wei Wang, Lize Xiong, Wei Ren, Giovanni Marsicano, Xia Zhan. Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD. Cell. vol 148. issue 5. 2012-04-20. PMID:22385967. |
here, we demonstrate that the impairment of spatial working memory (swm) and in vivo long-term depression (ltd) of synaptic strength at hippocampal ca3-ca1 synapses, induced by an acute exposure of exogenous cannabinoids, is fully abolished in conditional mutant mice lacking type-1 cannabinoid receptors (cb(1)r) in brain astroglial cells but is conserved in mice lacking cb(1)r in glutamatergic or gabaergic neurons. |
2012-04-20 |
2023-08-12 |
mouse |
| Kris Rutten, Tanya L Wallace, Melissa Works, Jos Prickaerts, Arjan Blokland, Thomas J Novak, Luca Santarelli, Dinah L Misne. Enhanced long-term depression and impaired reversal learning in phosphodiesterase 4B-knockout (PDE4B-/-) mice. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21458469. |
electrophysiological recordings from hippocampal slice preparations of mice deficient in the pde4b gene (pde4b(-/-)) showed that knockout animals displayed markedly enhanced basal postsynaptic responses to stimulation and long-term depression as compared to wild-type littermates. |
2012-04-17 |
2023-08-12 |
mouse |
| Yasuyuki Ishikawa, Hideki Tamura, Sadao Shiosak. Diversity of neuropsin (KLK8)-dependent synaptic associativity in the hippocampal pyramidal neuron. The Journal of physiology. vol 589. issue Pt 14. 2012-04-16. PMID:21646406. |
hippocampal early (e-) long-term potentiation (ltp) and long-term depression (ltd) elicited by a weak stimulus normally fades within 90 min. |
2012-04-16 |
2023-08-12 |
Not clear |
| Ramakrishna Tadavarty, Padmesh S Rajput, Jennifer M Wong, Ujendra Kumar, Bhagavatula R Sastr. Sleep-deprivation induces changes in GABA(B) and mGlu receptor expression and has consequences for synaptic long-term depression. PloS one. vol 6. issue 9. 2012-04-13. PMID:21980366. |
long term depression (ltd) in the ca1 region of the hippocampus, induced with a 20-hz, 30 s tetanus to schaffer collaterals, is enhanced in sleep-deprived (sd) rats. |
2012-04-13 |
2023-08-12 |
rat |
| J I Addae, T W Ston. The serine protease subtilisin suppresses epileptiform activity in rat hippocampal slices and neocortex in vivo. Neuroscience. vol 199. 2012-04-06. PMID:22033457. |
serine proteases of the s8a family and those belonging to the subtilase group generate a long-lasting inhibition of hippocampal evoked potentials, which shows little recovery and resembles long-term depression. |
2012-04-06 |
2023-08-12 |
rat |
| Jocelyn C Mauna, Takeaki Miyamae, Benjamin Pulli, Edda Thiel. Protein phosphatases 1 and 2A are both required for long-term depression and associated dephosphorylation of cAMP response element binding protein in hippocampal area CA1 in vivo. Hippocampus. vol 21. issue 10. 2012-04-02. PMID:20824729. |
protein phosphatases 1 and 2a are both required for long-term depression and associated dephosphorylation of camp response element binding protein in hippocampal area ca1 in vivo. |
2012-04-02 |
2023-08-12 |
Not clear |
| Jocelyn C Mauna, Takeaki Miyamae, Benjamin Pulli, Edda Thiel. Protein phosphatases 1 and 2A are both required for long-term depression and associated dephosphorylation of cAMP response element binding protein in hippocampal area CA1 in vivo. Hippocampus. vol 21. issue 10. 2012-04-02. PMID:20824729. |
both protein phosphatases can target the transcription factor camp response element binding protein (creb), whose phosphorylation at ser133, we previously found, was downregulated during long-term depression (ltd) of glutamatergic transmission in area ca1 of the adult hippocampus in vivo. |
2012-04-02 |
2023-08-12 |
Not clear |
| Ismael Valladolid-Acebes, Beatriz Merino, Antonio Principato, Alberto Fole, Coral Barbas, María P Lorenzo, Antonia García, Nuria Del Olmo, Mariano Ruiz-Gayo, Victoria Can. High-fat diets induce changes in hippocampal glutamate metabolism and neurotransmission. American journal of physiology. Endocrinology and metabolism. vol 302. issue 4. 2012-03-30. PMID:22114023. |
in addition, hf diet hippocampus displayed diminished basal synaptic transmission and hindered nmda-induced long-term depression (nmda-ltd). |
2012-03-30 |
2023-08-12 |
mouse |
| Thomas E Bartlett, Jie Lu, Yu Tian Wan. Slice orientation and muscarinic acetylcholine receptor activation determine the involvement of N-methyl D-aspartate receptor subunit GluN2B in hippocampal area CA1 long-term depression. Molecular brain. vol 4. 2012-03-19. PMID:22082088. |
slice orientation and muscarinic acetylcholine receptor activation determine the involvement of n-methyl d-aspartate receptor subunit glun2b in hippocampal area ca1 long-term depression. |
2012-03-19 |
2023-08-12 |
Not clear |