| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer L Sanderson, Ronald K Freund, Jessica A Gorski, Mark L Dell'Acqu. β-Amyloid disruption of LTP/LTD balance is mediated by AKAP150-anchored PKA and Calcineurin regulation of Ca Cell reports. vol 37. issue 1. 2021-10-23. PMID:34610314. |
β-amyloid disruption of ltp/ltd balance is mediated by akap150-anchored pka and calcineurin regulation of ca regulated insertion and removal of postsynaptic ampa glutamate receptors (ampars) mediates hippocampal long-term potentiation (ltp) and long-term depression (ltd) synaptic plasticity underlying learning and memory. |
2021-10-23 |
2023-08-13 |
Not clear |
| Haorui Zhang, Youssif Ben Zablah, Haiwang Zhang, Zhengping Ji. Rho Signaling in Synaptic Plasticity, Memory, and Brain Disorders. Frontiers in cell and developmental biology. vol 9. 2021-10-22. PMID:34671600. |
in this paper, we will review recent studies on the roles of rho proteins in the regulation of hippocampal long-term potentiation (ltp) and long-term depression (ltd), the most extensively studied forms of synaptic plasticity widely regarded as cellular mechanisms for learning and memory. |
2021-10-22 |
2023-08-13 |
Not clear |
| Fernanda Mansur, Juan Marcos Alarcon, Emily E Stackpole, Ruijia Wang, Joel D Richte. Noncanonical cytoplasmic poly(A) polymerases regulate RNA levels, alternative RNA processing, and synaptic plasticity but not hippocampal-dependent behaviours. RNA biology. vol 18. issue 7. 2021-10-13. PMID:32954964. |
to test whether a related enzyme, gld4, compensates for the lack of gld2, we separately or simultaneously depleted both proteins from hippocampal area ca1 and again found little change in animal behaviour, but observed a deficit in ltp as well as an increase in long-term depression (ltd), two forms of protein synthesis-dependent synaptic plasticity. |
2021-10-13 |
2023-08-13 |
mouse |
| Machhindra Garad, Elke Edelmann, Volkmar Leßman. Long-term depression at hippocampal mossy fiber-CA3 synapses involves BDNF but is not mediated by p75NTR signaling. Scientific reports. vol 11. issue 1. 2021-10-13. PMID:33879805. |
long-term depression at hippocampal mossy fiber-ca3 synapses involves bdnf but is not mediated by p75ntr signaling. |
2021-10-13 |
2023-08-13 |
Not clear |
| Gabriele Di Cicco, Emanuela Marzano, Luisa Iacovelli, Roberta Celli, Gilles van Luijtelaar, Ferdinando Nicoletti, Richard T Ngomba, Mark J Wal. Group I metabotropic glutamate receptor-mediated long term depression is disrupted in the hippocampus of WAG/Rij rats modelling absence epilepsy. Neuropharmacology. vol 196. 2021-10-01. PMID:34197893. |
group i metabotropic glutamate receptor-mediated long term depression is disrupted in the hippocampus of wag/rij rats modelling absence epilepsy. |
2021-10-01 |
2023-08-13 |
rat |
| Qianqian Cao, Yuan Wei, Jialin Deng, Junfeng Li, Yanhua Huang, Yuke Li, Ji-Chun Zhang, Zili Zhang, Song Li. NRG1 accelerates the forgetting of fear memories and facilitates the induction of long-term depression in adult mice. Psychopharmacology. vol 238. issue 9. 2021-09-28. PMID:34189597. |
forgetting of fear memory is a current medical therapy for posttraumatic stress disorder (ptsd), and hippocampal long-term depression (ltd) may be the underlying mechanism. |
2021-09-28 |
2023-08-13 |
mouse |
| Manivannan Subramaniyan, Sumithrra Manivannan, Vikas Chelur, Theodoros Tsetsenis, Evan Jiang, John A Dan. Fear conditioning potentiates the hippocampal CA1 commissural pathway in vivo and increases awake phase sleep. Hippocampus. vol 31. issue 10. 2021-09-21. PMID:34418215. |
candidate memory mechanisms for cfc are long-term potentiation (ltp) and long-term depression (ltd), but there is little direct evidence of them operating in the hippocampus in vivo following cfc. |
2021-09-21 |
2023-08-13 |
mouse |
| Shane Wiebe, Xiang Qi Meng, Sung-Hoon Kim, Xu Zhang, Jean-Claude Lacaille, Argel Aguilar-Valles, Nahum Sonenber. The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior. Molecular autism. vol 11. issue 1. 2021-09-02. PMID:33225984. |
the eif4e homolog 4ehp (eif4e2) regulates hippocampal long-term depression and impacts social behavior. |
2021-09-02 |
2023-08-13 |
Not clear |
| Sachie Sasaki-Hamada, Ayumu Fujiwara, Show Satoh, Takashi Iwai, Jun-Ichiro Ok. GLP-2 restores impairments in spatial working memory and hippocampal LTD via the MEK/ERK pathway in juvenile-onset diabetes rats. Behavioural brain research. vol 406. 2021-09-02. PMID:33716118. |
the results obtained demonstrated that glp-2 restored impairments in spatial working memory and hippocampal long-term depression (ltd) in jdm rats, and that the mek1/2 inhibitor, u0126, inhibited this recovery. |
2021-09-02 |
2023-08-13 |
rat |
| Alexander V Maltsev, Pavel M Balaba. PP1/PP2A phosphatase inhibition-induced metaplasticity in protein synthesis blocker-treated hippocampal slices: LTP and LTD, or There and Back again. Biochemical and biophysical research communications. vol 558. 2021-08-23. PMID:33901925. |
long-term potentiation (ltp) and long-term depression (ltd) are key forms of synaptic plasticity in the hippocampus. |
2021-08-23 |
2023-08-13 |
Not clear |
| Lara Costa, Alessandra Tempio, Enza Lacivita, Marcello Leopoldo, Lucia Cirann. Serotonin 5-HT7 receptors require cyclin-dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome. The European journal of neuroscience. 2021-08-18. PMID:33949019. |
electrophysiology studies in fmr1 knockout (ko) mice, a murine model of fragile x syndrome, have demonstrated alterations of synaptic plasticity, with exaggerated long-term depression induced by activation of metabotropic glutamate receptors (mglur-ltd) in fmr1 ko hippocampus. |
2021-08-18 |
2023-08-13 |
mouse |
| Pierre Sauton, Chloé Deschamps, Virginie Jeanblanc, Olivier Pierrefiche, Jérôme Jeanblanc, Mickael Naassil. Interstrain differences in voluntary binge-like drinking behavior and in two acute ethanol injections-induced synaptic plasticity deficits in rats. Addiction biology. vol 26. issue 4. 2021-08-16. PMID:33331070. |
because we found different propensity to bd between strains, we also sought to test interstrain differences using another procedure of two acute ethanol exposures known to alter long-term depression of hippocampal synaptic plasticity. |
2021-08-16 |
2023-08-13 |
rat |
| Pierre Sauton, Chloé Deschamps, Virginie Jeanblanc, Olivier Pierrefiche, Jérôme Jeanblanc, Mickael Naassil. Interstrain differences in voluntary binge-like drinking behavior and in two acute ethanol injections-induced synaptic plasticity deficits in rats. Addiction biology. vol 26. issue 4. 2021-08-16. PMID:33331070. |
when we tested the acute effects of ethanol, long-term depression in hippocampus was abolished specifically in long-evans rats with no impact in the two other strains. |
2021-08-16 |
2023-08-13 |
rat |
| Kevin Rabiant, Johan Antol, Mickael Naassila, Olivier Pierrefich. Sex difference in the vulnerability to hippocampus plasticity impairment after binge-like ethanol exposure in adolescent rat: Is estrogen the key? Addiction biology. vol 26. issue 4. 2021-08-16. PMID:33511744. |
long-term depression (ltd) in hippocampus slice of pubertal female rats was recorded 24 h after two ethanol binges (3 g/kg, i.p., 9 h apart). |
2021-08-16 |
2023-08-13 |
rat |
| Jesús David Urbano-Gámez, Juan José Casañas, Itziar Benito, María Luz Montesino. Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down's syndrome mouse model. Molecular brain. vol 14. issue 1. 2021-08-12. PMID:34034796. |
here we characterize the proteome of hippocampal synaptoneurosomes (sns) from these mice, and found a predicted alteration of synaptic plasticity pathways, including long term depression (ltd). |
2021-08-12 |
2023-08-13 |
mouse |
| Sachie Sasaki-Hamada, Yuki Hojyo, Ryo Mizumoto, Hajime Koyama, Shoko Yanagisawa, Jun-Ichiro Ok. Cognitive and hippocampal synaptic profiles in monosodium glutamate-induced obese mice. Neuroscience research. vol 170. 2021-08-04. PMID:32949668. |
hippocampal synaptic plasticity, including long-term potentiation (ltp) and long-term depression (ltd), and excitatory synaptic transmission at schaffer collateral-ca1 (sc-ca1) synapses were compared between msg-treated mice and age-matched control mice. |
2021-08-04 |
2023-08-13 |
mouse |
| Anna Brachet, Argentina Lario, Alba Fernández-Rodrigo, Frank F Heisler, Yolanda Gutiérrez, Clara Lobo, Matthias Kneussel, José A Esteba. A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression. Cell reports. vol 36. issue 5. 2021-08-04. PMID:34348158. |
the synaptic removal of ampa-type glutamate receptors (ampars) is a core mechanism for hippocampal long-term depression (ltd). |
2021-08-04 |
2023-08-13 |
Not clear |
| Thu-Huong Hoang, Juliane Böge, Denise Manahan-Vaugha. Hippocampal subfield-specific Homer1a expression is triggered by learning-facilitated long-term potentiation and long-term depression at medial perforant path synapses. Hippocampus. vol 31. issue 8. 2021-07-22. PMID:33964041. |
hippocampal subfield-specific homer1a expression is triggered by learning-facilitated long-term potentiation and long-term depression at medial perforant path synapses. |
2021-07-22 |
2023-08-13 |
rat |
| Chun-An Chen, Wei Wang, Steen E Pedersen, Ayush Raman, Michelle L Seymour, Fernanda R Ruiz, Anping Xia, Meike E van der Heijden, Li Wang, Jiani Yin, Joanna Lopez, Megan E Rech, Richard A Lewis, Samuel M Wu, Zhandong Liu, Fred A Pereira, Robia G Pautler, Huda Y Zoghbi, Christian P Schaa. Nr2f1 heterozygous knockout mice recapitulate neurological phenotypes of Bosch-Boonstra-Schaaf optic atrophy syndrome and show impaired hippocampal synaptic plasticity. Human molecular genetics. vol 29. issue 5. 2021-07-05. PMID:31600777. |
the mice showed altered fear memory, and further electrophysiological investigation in hippocampal slices revealed significantly reduced long-term potentiation and long-term depression. |
2021-07-05 |
2023-08-13 |
mouse |
| Hiroki Yasuda, Hikaru Yamamoto, Kenji Hanamura, Mona Mehruba, Toshio Kawamata, Hiromi Morisaki, Masaaki Miyamoto, Shinji Takada, Tomoaki Shirao, Yoshitaka Ono, Hideyuki Muka. PKN1 promotes synapse maturation by inhibiting mGluR-dependent silencing through neuronal glutamate transporter activation. Communications biology. vol 3. issue 1. 2021-06-25. PMID:33244074. |
knocking out pkn1a, the dominant pkn1 subtype in the brain, unmasked abnormal input-nonspecific mglur-dependent long-term depression (mglur-ltd) and ampa receptor (ampar) silencing in the developing hippocampus. |
2021-06-25 |
2023-08-13 |
mouse |