| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dušica Briševac, Ralf Scholz, Dan Du, Mohammad Nael Elagabani, Georg Köhr, Hans-Christian Korna. The small GTPase Arf6 is dysregulated in a mouse model for fragile X syndrome. Journal of neurochemistry. vol 157. issue 3. 2021-06-21. PMID:33125726. |
here, we determined the fraction of active, gtp-bound arf6 in cortical neuron cultures and synaptoneurosomes from fmr1 knockout mice, measured actin polymerization in neurons expressing arf6 mutants with variant gtp- or gdp-binding properties, and recorded hippocampal long-term depression induced by metabotropic glutamate receptors (mglur-ltd) in acute brain slices. |
2021-06-21 |
2023-08-13 |
mouse |
| Katie Dyer-Reaves, Anthoni M Goodman, Amy R Nelson, Lori L McMaho. Alpha1-Adrenergic Receptor Mediated Long-Term Depression at CA3-CA1 Synapses Can Be Induced Frontiers in synaptic neuroscience. vol 11. 2021-06-18. PMID:31649525. |
alpha1-adrenergic receptor mediated long-term depression at ca3-ca1 synapses can be induced locus coeruleus (lc) provides the sole source of noradrenergic (na) innervation to hippocampus, and it undergoes significant degeneration early in alzheimer's disease (ad). |
2021-06-18 |
2023-08-13 |
Not clear |
| Carey Wilson, Jake Rogers, Feng Chen, Shanshan Li, Paul A Adlard, Anthony J Hannan, Thibault Renoi. Exercise ameliorates aberrant synaptic plasticity without enhancing adult-born cell survival in the hippocampus of serotonin transporter knockout mice. Brain structure & function. vol 226. issue 6. 2021-06-15. PMID:34052925. |
here, we investigate hippocampal adult-born cell survival and synaptic plasticity (long-term potentiation, ltp, and long-term depression, ltd) in serotonin transporter (5-htt) knockout (ko) mice. |
2021-06-15 |
2023-08-13 |
mouse |
| Min-Gyu Kim, Seungjae Zhang, Hoyong Park, Seung Ju Park, Seyun Kim, ChiHye Chun. Inositol hexakisphosphate kinase-1 is a key mediator of prepulse inhibition and short-term fear memory. Molecular brain. vol 13. issue 1. 2021-06-03. PMID:32381051. |
further, both hippocampal long-term potentiation and long-term depression in ip6k1-knockout mice were similar to those in the wild-type control. |
2021-06-03 |
2023-08-13 |
mouse |
| Wan Yun Ho, Sheeja Navakkode, Fujia Liu, Tuck Wah Soong, Shuo-Chien Lin. Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32887666. |
here, we showed that long-term potentiation at the dentate granule cells and long-term depression at the schaffer collateral/commissural synapses at the area ca1 were reduced in the hippocampus of c9orf72 knockout mice. |
2021-05-31 |
2023-08-13 |
mouse |
| Eun-Sang Hwang, Hyun-Bum Kim, Seok Lee, Min-Jeong Kim, Kwan-Joong Kim, Gaeul Han, Se-Young Han, Eun-A Lee, Jeong-Hee Yoon, Dae-Ok Kim, Sungho Maeng, Ji-Ho Par. Antidepressant-like effects of β-caryophyllene on restraint plus stress-induced depression. Behavioural brain research. vol 380. 2021-05-03. PMID:31862467. |
in organotypic hippocampal slices, bcp reduced the lipopolysaccharide-induced intensification of the long-term depression. |
2021-05-03 |
2023-08-13 |
Not clear |
| Thazin Shwe, Cherry Bo-Htay, Tom Leech, Benjamin Ongnok, Thidarat Jaiwongkum, Sasiwan Kerdphoo, Siripong Palee, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. D-galactose-induced aging does not cause further deterioration in brain pathologies and cognitive decline in the obese condition. Experimental gerontology. vol 138. 2021-04-27. PMID:32522583. |
the results from both d-galactose-treated rats and hfd-fed rats showed that there was an equal increase in advanced glycation end products, and microglial activation, and an impairment in long-term depression, long-term potentiation, and synaptic protein and dendritic spine density in hippocampus, resulting in cognitive decline. |
2021-04-27 |
2023-08-13 |
rat |
| Jonathan E Draffin, Carla Sánchez-Castillo, Alba Fernández-Rodrigo, Xavier Sánchez-Sáez, Jesús Ávila, Florence F Wagner, José A Esteba. GSK3α, not GSK3β, drives hippocampal NMDAR-dependent LTD via tau-mediated spine anchoring. The EMBO journal. vol 40. issue 2. 2021-04-19. PMID:33197065. |
we now directly address this question for nmda receptor-dependent long-term depression (ltd) in the hippocampus. |
2021-04-19 |
2023-08-13 |
mouse |
| Pietro Micheli, Rui Ribeiro, Alejandro Giorgett. A Mechanistic Model of NMDA and AMPA Receptor-Mediated Synaptic Transmission in Individual Hippocampal CA3-CA1 Synapses: A Computational Multiscale Approach. International journal of molecular sciences. vol 22. issue 4. 2021-04-19. PMID:33546429. |
inside hippocampal circuits, neuroplasticity events that individual cells may undergo during synaptic transmissions occur in the form of long-term potentiation (ltp) and long-term depression (ltd). |
2021-04-19 |
2023-08-13 |
Not clear |
| Yuqian Shen, Zi Chao Zhang, Shanshan Cheng, An Liu, Jian Zuo, Shuting Xia, Xian Liu, Wenhua Liu, Zhengping Jia, Wei Xie, Junhai Ha. PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation. Molecular cell. vol 81. issue 7. 2021-04-14. PMID:33662272. |
moreover, we show that pqbp1 regulates hippocampal metabotropic glutamate receptor-dependent long-term depression (mglur-ltd) and mglur-ltd-associated behaviors by suppressing eef2k-mediated phosphorylation. |
2021-04-14 |
2023-08-13 |
Not clear |
| Soomaayeh Heysieattalab, Ka-Hung Lee, Yan Liu, Yubin Wang, Michael R Foy, Xiaoning Bi, Michel Baudr. Impaired cerebellar plasticity and eye-blink conditioning in calpain-1 knock-out mice. Neurobiology of learning and memory. vol 170. 2021-04-12. PMID:30735788. |
our recent studies indicate that calpain-1 is required for hippocampal synaptic plasticity, including long-term depression (ltd) and long-term potentiation (ltp) in field ca1. |
2021-04-12 |
2023-08-13 |
mouse |
| Koyam Morales-Weil, Macarena Moreno, Juan Ahumada, Jorge Arriagada, Pablo Fuentealba, Christian Bonansco, Marco Fuenzalid. Priming of GABAergic Long-term Potentiation by Muscarinic Receptors. Neuroscience. vol 428. 2021-04-07. PMID:31917346. |
we have previously shown that co-activation of endocannabinoids (cb1r) and muscarinic receptor (machr) in hippocampal interneurons can induce activity-dependent gabaergic long-term depression in ca1 pyramidal neurons. |
2021-04-07 |
2023-08-13 |
rat |
| Ichrak Drissi, Chloé Deschamps, Rachel Alary, Alexandre Robert, Véronique Dubreuil, Anne Le Mouël, Myriame Mohammed, Délara Sabéran-Djoneidi, Valérie Mezger, Mickael Naassila, Olivier Pierrefich. Role of heat shock transcription factor 2 in the NMDA-dependent neuroplasticity induced by chronic ethanol intake in mouse hippocampus. Addiction biology. vol 26. issue 2. 2021-03-25. PMID:32720424. |
ethanol consumption impairs learning and memory through disturbances of nmda-type glutamate receptor-dependent synaptic plasticity (long-term depression [ltd] and long-term potentiation [ltp]) in the hippocampus. |
2021-03-25 |
2023-08-13 |
mouse |
| Scott D Sawchuk, Hannah M O Reid, Katie J Neale, James Shin, Brian R Christi. Effects of Ethanol on Synaptic Plasticity and NMDA Currents in the Juvenile Rat Dentate Gyrus. Brain plasticity (Amsterdam, Netherlands). vol 6. issue 1. 2021-03-10. PMID:33680851. |
we examined how acute ethanol (etoh) exposure affects long term depression (ltd) in the dentate gyrus (dg) of the hippocampus in juvenile rats. |
2021-03-10 |
2023-08-13 |
rat |
| Elena Coccia, Laura Planells-Ferrer, Raquel Badillos-Rodríguez, Marta Pascual, Miguel F Segura, Rita Fernández-Hernández, Joaquin López-Soriano, Eloi Garí, Eduardo Soriano, Bruna Barneda-Zahonero, Rana S Moubarak, M Jose Pérez-García, Joan X Comell. SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L. Cell death & disease. vol 11. issue 2. 2021-02-16. PMID:32015347. |
this interaction also modulates non-apoptotic functions of caspases, such as the endocytosis of ampa receptor (ampar) in hippocampal long-term depression (ltd). |
2021-02-16 |
2023-08-13 |
Not clear |
| Donovan M Ashby, Stan B Floresco, Anthony G Phillips, Alexander McGirr, Jeremy K Seamans, Yu Tian Wan. LTD is involved in the formation and maintenance of rat hippocampal CA1 place-cell fields. Nature communications. vol 12. issue 1. 2021-01-14. PMID:33397954. |
hippocampal synaptic plasticity includes both long-term potentiation (ltp) and long-term depression (ltd) of synaptic strength, and has been implicated in shaping place field representations that form upon initial exposure to a novel environment. |
2021-01-14 |
2023-08-13 |
rat |
| Luis E B Bettio, Jonathan S Thacker, Shaefali P Rodgers, Patricia S Brocardo, Brian R Christie, Joana Gil-Mohape. Interplay between hormones and exercise on hippocampal plasticity across the lifespan. Biochimica et biophysica acta. Molecular basis of disease. vol 1866. issue 8. 2021-01-04. PMID:32376385. |
while structural changes are achieved through modulation of hippocampal neurogenesis as well as alterations in dendritic morphology and spine remodeling, functional (i.e., synaptic) changes can be noted through the strengthening (i.e., long-term potentiation) or weakening (i.e., long-term depression) of the synapses. |
2021-01-04 |
2023-08-13 |
Not clear |
| Xavier Yerna, Olivier Schakman, Ikram Ratbi, Anna Kreis, Sophie Lepannetier, Marie de Clippele, Younès Achouri, Nicolas Tajeddine, Fadel Tissir, Roberta Gualdani, Philippe Gaill. Role of the TRPC1 Channel in Hippocampal Long-Term Depression and in Spatial Memory Extinction. International journal of molecular sciences. vol 21. issue 5. 2020-12-08. PMID:32138218. |
role of the trpc1 channel in hippocampal long-term depression and in spatial memory extinction. |
2020-12-08 |
2023-08-13 |
Not clear |
| L T Stewart, K Abiraman, J C Chatham, L L McMaho. Increased O-GlcNAcylation rapidly decreases GABA Scientific reports. vol 10. issue 1. 2020-11-24. PMID:32366857. |
an acute increase in o-glcnacylation can affect neuronal communication by inducing long-term depression (ltd) of excitatory transmission at hippocampal ca3-ca1 synapses, as well as suppressing hyperexcitable circuits in vitro and in vivo. |
2020-11-24 |
2023-08-13 |
Not clear |
| Katisha R Gopaul, Muhammad Irfan, Omid Miry, Linnea R Vose, Alexander Moghadam, Galadu Subah, Tomas Hökfelt, Christina Bark, Patric K Stanto. Developmental Time Course of SNAP-25 Isoforms Regulate Hippocampal Long-Term Synaptic Plasticity and Hippocampus-Dependent Learning. International journal of molecular sciences. vol 21. issue 4. 2020-11-19. PMID:32093363. |
we show here that the isoform snap-25a, which is expressed first developmentally in rodent brain, contributes to developmental regulation of the expression of both long-term depression (ltd) and long-term potentiation (ltp) at schaffer collateral-ca1 synapses in the hippocampus. |
2020-11-19 |
2023-08-13 |
mouse |