| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanzhi Yu, Zhilin Huang, Chunfang Dai, Yehong Du, Huili Han, Yu Tian Wang, Zhifang Don. Facilitated AMPAR endocytosis causally contributes to the maternal sleep deprivation-induced impairments of synaptic plasticity and cognition in the offspring rats. Neuropharmacology. vol 133. 2018-11-13. PMID:29378210. |
here, we report that the msd induced ltp impairment at the ca1 hippocampus of the offspring rats is associated with increased long-term depression (ltd) and reduced expression of postsynaptic glua2-containing α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptors (ampars). |
2018-11-13 |
2023-08-13 |
rat |
| Kelly A Hamilton, Yue Wang, Sophia M Raefsky, Sean Berkowitz, Ryan Spangler, Caitlin N Suire, Simonetta Camandola, Robert H Lipsky, Mark P Mattso. Mice lacking the transcriptional regulator Bhlhe40 have enhanced neuronal excitability and impaired synaptic plasticity in the hippocampus. PloS one. vol 13. issue 5. 2018-07-30. PMID:29715265. |
however, significant reductions in long term potentiation and long term depression at ca1 synapses were observed in bhlhe40 ko mice, indicating impaired hippocampal synaptic plasticity. |
2018-07-30 |
2023-08-13 |
mouse |
| Benoît Silvestre de Ferron, Catherine Vilpoux, Myriam Kervern, Alexandre Robert, Johan Antol, Mickael Naassila, Olivier Pierrefich. Increase of KCC2 in hippocampal synaptic plasticity disturbances after perinatal ethanol exposure. Addiction biology. vol 22. issue 6. 2018-07-16. PMID:27778437. |
learning and memory are mediated in the hippocampus by long-term potentiation (ltp) and long term depression (ltd), two forms of synaptic plasticity. |
2018-07-16 |
2023-08-13 |
rat |
| Cristina Pinar, Christine J Fontaine, Juan Triviño-Paredes, Carina P Lottenberg, Joana Gil-Mohapel, Brian R Christi. Revisiting the flip side: Long-term depression of synaptic efficacy in the hippocampus. Neuroscience and biobehavioral reviews. vol 80. 2018-07-03. PMID:28624435. |
revisiting the flip side: long-term depression of synaptic efficacy in the hippocampus. |
2018-07-03 |
2023-08-13 |
Not clear |
| Qi Ma, Hongyu Ruan, Lisheng Peng, Mingjie Zhang, Michaela U Gack, Wei-Dong Ya. Proteasome-independent polyubiquitin linkage regulates synapse scaffolding, efficacy, and plasticity. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 41. 2018-06-26. PMID:28973854. |
silencing cyld in hippocampal neurons abolishes nmda-induced chemical long-term depression. |
2018-06-26 |
2023-08-13 |
Not clear |
| Niels Hanse. The Longevity of Hippocampus-Dependent Memory Is Orchestrated by the Locus Coeruleus-Noradrenergic System. Neural plasticity. vol 2017. 2018-04-23. PMID:28695015. |
memory storage can be modified by the activation of the locus coeruleus and subsequent facilitation of hippocampal long-term plasticity in the forms of long-term depression and long-term potentiation. |
2018-04-23 |
2023-08-13 |
Not clear |
| Jia-Yi Li, Jia Liu, Nimshitha Pavathuparambil Abdul Manaph, Larisa Bobrovskaya, Xin-Fu Zho. ProBDNF inhibits proliferation, migration and differentiation of mouse neural stem cells. Brain research. vol 1668. 2018-03-28. PMID:28528122. |
probdnf, a precursor of brain-derived neurotrophic factor (bdnf), is an important regulator of neurodegeneration, hippocampal long-term depression, and synaptic plasticity. |
2018-03-28 |
2023-08-13 |
mouse |
| Andrey D Ivanov, Aleksey V Zaitse. NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy. Synapse (New York, N.Y.). vol 71. issue 8. 2018-03-06. PMID:28432779. |
nmdar-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy. |
2018-03-06 |
2023-08-13 |
Not clear |
| Koichi Uegaki, Haruko Kumanogoh, Toshiyuki Mizui, Takatsugu Hirokawa, Yasuyuki Ishikawa, Masami Kojim. BDNF Binds Its Pro-Peptide with High Affinity and the Common Val66Met Polymorphism Attenuates the Interaction. International journal of molecular sciences. vol 18. issue 5. 2018-02-22. PMID:28498321. |
lastly, we performed electrophysiological experiments, which indicated that the bdnf pro-peptide, when pre-incubated with bdnf, attenuated the ability of bdnf to inhibit hippocampal long-term depression (ltd), suggesting a possibility that the bdnf pro-peptide may interact directly with bdnf and thereby inhibit its availability. |
2018-02-22 |
2023-08-13 |
human |
| Fabrice D Heitz, Mélissa Farinelli, Safa Mohanna, Martin Kahn, Kerstin Duning, Marco C Frey, Hermann Pavenstädt, Isabelle M Mansu. The memory gene KIBRA is a bidirectional regulator of synaptic and structural plasticity in the adult brain. Neurobiology of learning and memory. vol 135. 2018-02-09. PMID:27498008. |
here, we show that a selective overexpression of kibra in neurons increases hippocampal long-term potentiation (ltp) but prevents the induction of long-term depression (ltd), and impairs spatial long-term memory in adult mice. |
2018-02-09 |
2023-08-13 |
mouse |
| S Y Yau, C A Bostrom, J Chiu, C J Fontaine, S Sawchuk, A Meconi, R C Wortman, E Truesdell, A Truesdell, C Chiu, B N Hryciw, B D Eadie, M Ghilan, B R Christi. Impaired bidirectional NMDA receptor dependent synaptic plasticity in the dentate gyrus of adult female Fmr1 heterozygous knockout mice. Neurobiology of disease. vol 96. 2018-02-09. PMID:27659109. |
we, and others, have recently reported that there is significant impairment in n-methyl-d-aspartate receptor (nmdar)-dependent long-term potentiation (ltp) and long-term depression (ltd) in the hippocampal dentate gyrus (dg) of male fmr1 knock out mice. |
2018-02-09 |
2023-08-13 |
mouse |
| Stephan Jansen, Christine Gottschling, Andreas Faissner, Denise Manahan-Vaugha. Intrinsic cellular and molecular properties of in vivo hippocampal synaptic plasticity are altered in the absence of key synaptic matrix molecules. Hippocampus. vol 27. issue 8. 2018-02-02. PMID:28512860. |
in the hippocampus, both long-term potentiation (ltp) and long-term depression (ltd) are triggered by synaptic ca |
2018-02-02 |
2023-08-13 |
Not clear |
| Yuniesky Andrade-Talavera, Paloma Duque-Feria, Ole Paulsen, Antonio Rodríguez-Moren. Presynaptic Spike Timing-Dependent Long-Term Depression in the Mouse Hippocampus. Cerebral cortex (New York, N.Y. : 1991). vol 26. issue 8. 2018-01-10. PMID:27282393. |
presynaptic spike timing-dependent long-term depression in the mouse hippocampus. |
2018-01-10 |
2023-08-13 |
mouse |
| Yuniesky Andrade-Talavera, Paloma Duque-Feria, Ole Paulsen, Antonio Rodríguez-Moren. Presynaptic Spike Timing-Dependent Long-Term Depression in the Mouse Hippocampus. Cerebral cortex (New York, N.Y. : 1991). vol 26. issue 8. 2018-01-10. PMID:27282393. |
in the present work, we investigated the requirements for induction of hippocampal spike timing-dependent long-term potentiation (t-ltp) and spike timing-dependent long-term depression (t-ltd) and the mechanisms of these 2 forms of plasticity at ca3-ca1 synapses in young (p12-p18) mouse hippocampus. |
2018-01-10 |
2023-08-13 |
mouse |
| Ana Contreras, Danila Del Rio, Ana Martínez, Carmen Gil, Lidia Morales, Mariano Ruiz-Gayo, Nuria Del Olm. Inhibition of hippocampal long-term potentiation by high-fat diets: is it related to an effect of palmitic acid involving glycogen synthase kinase-3? Neuroreport. vol 28. issue 6. 2018-01-10. PMID:28328738. |
high-fat diets (hfd) impair hippocampal-dependent learning and memory and produce important changes in synaptic transmission by enhancing glutamate uptake, decreasing synaptic efficacy, and inhibiting plasticity mechanisms such as n-methyl-d-aspartate-mediated long-term depression (ltd) within the hippocampus. |
2018-01-10 |
2023-08-13 |
mouse |
| Aude Marzo, Soledad Galli, Douglas Lopes, Faye McLeod, Marina Podpolny, Margarita Segovia-Roldan, Lorenza Ciani, Silvia Purro, Francesca Cacucci, Alasdair Gibb, Patricia C Salina. Reversal of Synapse Degeneration by Restoring Wnt Signaling in the Adult Hippocampus. Current biology : CB. vol 26. issue 19. 2017-12-26. PMID:27593374. |
using a transgenic mouse model that inducibly expresses dkk1 in the hippocampus, we demonstrate that dkk1 triggers synapse loss, impairs long-term potentiation, enhances long-term depression, and induces learning and memory deficits. |
2017-12-26 |
2023-08-13 |
mouse |
| Daniel R Romano, Matthew C Pharris, Neal M Patel, Tamara L Kinzer-Urse. Competitive tuning: Competition's role in setting the frequency-dependence of Ca2+-dependent proteins. PLoS computational biology. vol 13. issue 11. 2017-12-18. PMID:29107982. |
in hippocampal neurons, calcium ion (ca2+) flux through n-methyl-d-aspartate (nmda) receptors activates ca2+/calmodulin signal transduction networks that either increase or decrease the strength of the neuronal synapse, phenomena known as long-term potentiation (ltp) or long-term depression (ltd), respectively. |
2017-12-18 |
2023-08-13 |
Not clear |
| Ying Wang, Xia Zhan. FAAH inhibition produces antidepressant-like efforts of mice to acute stress via synaptic long-term depression. Behavioural brain research. vol 324. 2017-12-13. PMID:28193523. |
here we find that a systemic administration of the faah inhibitor pf3845 or an intra-ca1 application of aea elicits an in vivo long-term depression (ltd) at excitatory glutamatergic ca3-ca1 synapses of the hippocampus. |
2017-12-13 |
2023-08-13 |
mouse |
| Kari A Johnson, David M Lovinge. Presynaptic Plasticity Found in Translation. Neuron. vol 92. issue 2. 2017-10-26. PMID:27764658. |
(2016) demonstrate that activation of presynaptic cb1 receptors by retrograde endocannabinoid signaling stimulates protein synthesis in axon terminals to induce long-term depression of hippocampal inhibitory transmission. |
2017-10-26 |
2023-08-13 |
Not clear |
| Crystal Bostrom, Suk-Yu Yau, Namat Majaess, Mariana Vetrici, Joana Gil-Mohapel, Brian R Christi. Hippocampal dysfunction and cognitive impairment in Fragile-X Syndrome. Neuroscience and biobehavioral reviews. vol 68. 2017-10-24. PMID:27345143. |
this review provides an overview of the neuropathology of fragile-x syndrome, highlighting how structural and synaptic deficits in hippocampal subregions, including the ca1 exhibiting exaggerated metabotropic glutamate receptor dependent long-term depression and the dentate gyrus displaying hypofunction of n-methyl-d-aspartate receptors, contribute to cognitive impairments associated with this neurodevelopmental disorder. |
2017-10-24 |
2023-08-13 |
Not clear |