| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Reesha Raja, Emilie Dumontier, Alina Phen, Jean-François Cloutie. Insertion of a neomycin selection cassette in the Amigo1 locus alters gene expression in the olfactory epithelium leading to region-specific defects in olfactory receptor neuron development. Genesis (New York, N.Y. : 2000). vol 62. issue 2. 2024-04-09. PMID:38590146. |
the formation of the olfactory glomerular map is dependent on molecular cues that guide olfactory receptor neuron axons to broad regions of the olfactory bulb and on cell adhesion molecules that promote axonal sorting into specific synaptic units in this structure. |
2024-04-09 |
2024-04-11 |
mouse |
| Koping Chang, Thomas Zaikos, Nicholas Kilner-Pontone, Cheng-Ying H. Mechanisms of COVID-19-associated olfactory dysfunction. Neuropathology and applied neurobiology. vol 50. issue 2. 2024-02-29. PMID:38419211. |
while evidence suggests that infection of sustentacular cells and associated mucosal inflammation may be the culprit of acute, transient smell loss, alterations in other components of the olfactory system (e.g., olfactory receptor neuron dysfunction, olfactory bulb injury and alterations in the olfactory cortex) may lead to persistent, long-term olfactory dysfunction. |
2024-02-29 |
2024-03-02 |
Not clear |
| Mehmet Hakan Ozdener, Barry Rockx, Nancy E Rawso. Primary Culture of the Human Olfactory Neuroepithelium and Utilization for Henipavirus Infection In Vitro. Methods in molecular biology (Clifton, N.J.). vol 2682. 2023-08-23. PMID:37610578. |
the protocol provides a consistent, heterogeneous olfactory epithelial cell population, which demonstrates functional responses to odorant mixtures and exhibits several key features of the olfactory receptor neuron phenotype, encompassing olfactory receptors and signaling pathways. |
2023-08-23 |
2023-09-07 |
human |
| Hideki Sakatani, Masamitsu Kono, Tatsuya Shiga, Hiroki Kuwazoe, Denisa Nanushaj, Ibu Matsuzaki, Shin-Ichi Murata, Masayasu Miyajima, Yuka Okada, Shizuya Saika, Muneki Hotom. The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Olfactory Regeneration. Laboratory investigation; a journal of technical methods and pathology. vol 103. issue 4. 2023-03-04. PMID:36870285. |
the proliferation of orn progenitor cells was reduced in trpv1 ko mice, which delayed orn regeneration and the improvement of olfactory behavior. |
2023-03-04 |
2023-08-14 |
mouse |
| Hari G Lakshmanan, Elayna Miller, AnnElizabeth White-Canale, Lynnette P McCluske. Immune responses in the injured olfactory and gustatory systems: a role in olfactory receptor neuron and taste bud regeneration? Chemical senses. vol 47. 2022-09-24. PMID:36152297. |
immune responses in the injured olfactory and gustatory systems: a role in olfactory receptor neuron and taste bud regeneration? |
2022-09-24 |
2023-08-14 |
Not clear |
| Chao Jiang, Xiaohui Wang, Yizhen Jiang, Zhe Chen, Yongyuan Zhang, Dingjun Hao, Hao Yan. The Anti-inflammation Property of Olfactory Ensheathing Cells in Neural Regeneration After Spinal Cord Injury. Molecular neurobiology. 2022-08-12. PMID:35962300. |
in fact, oecs could support olfactory receptor neuron turnover and axonal extension, which is essential to maintain the function of olfactory nervous system. |
2022-08-12 |
2023-08-14 |
Not clear |
| Sheng-Tien Li, Tai-Horng Young, Tsung-Wei Huan. Regeneration of olfactory neuroepithelium in 3-methylindole-induced anosmic rats treated with intranasal chitosan. Biomaterials. vol 271. 2021-05-25. PMID:33711565. |
consequently, chitosan regenerates the on by regulating olfactory neural homeostasis and reducing orn apoptosis, and serves as a potential therapeutic intervention for olfactory dysfunction in the future. |
2021-05-25 |
2023-08-13 |
rat |
| Noriyuki Nakashima, Kie Nakashima, Akiko Nakashima, Makoto Takan. Olfactory marker protein captures cAMP produced via Gαs-protein-coupled receptor activation. Biochemical and biophysical research communications. vol 529. issue 2. 2021-02-12. PMID:32703433. |
olfactory marker protein (omp) labels the matured stage of olfactory receptor neurons (orn) and has promoted the investigation on the physiology of olfaction. |
2021-02-12 |
2023-08-13 |
Not clear |
| Janez Prešer. Neurostatistical approach to toxicological testing in honeybees. MethodsX. vol 7. 2020-10-09. PMID:33024712. |
investigators in the field of olfactory neurophysiology are faced with similar situation in which olfactory receptor neuron is spontaneously active. |
2020-10-09 |
2023-08-13 |
Not clear |
| David A Clark, Seth R Odell, Joanna M Armstrong, Mariah Turcotte, Donovan Kohler, America Mathis, Deena R Schmidt, Dennis Mathe. Behavior Responses to Chemical and Optogenetic Stimuli in Frontiers in behavioral neuroscience. vol 12. 2020-10-01. PMID:30622461. |
while considerable research has focused on orn responses to odorants, the mechanisms by which olfactory information is encoded in the activities of orns and translated into navigational behavior remain poorly understood. |
2020-10-01 |
2023-08-13 |
Not clear |
| Tsung-Wei Huang, Sheng-Tien Li, Yu-Hsin Wang, Tai-Horng Youn. Regulation of chitosan-mediated differentiation of human olfactory receptor neurons by insulin-like growth factor binding protein-2. Acta biomaterialia. vol 97. 2020-08-17. PMID:31421230. |
this work isolates and cultures human olfactory neuroepithelial cells (honcs) with various gags for 7 days, and find that chitosan promotes orn maturation, expressing olfactory marker protein (omp) and its functional components. |
2020-08-17 |
2023-08-13 |
human |
| Huey Hing, Noah Reger, Jennifer Snyder, Lee G Fradki. Interplay between axonal Wnt5-Vang and dendritic Wnt5-Drl/Ryk signaling controls glomerular patterning in the Drosophila antennal lobe. PLoS genetics. vol 16. issue 5. 2020-07-27. PMID:32357156. |
our work shows that the final patterning of the fly olfactory map is the result of an interplay between orn axons and pn dendrites, wherein converging pre- and postsynaptic processes contribute key wnt5 signaling components, allowing wnt5 to orient the rotation of nascent synapses through a pcp mechanism. |
2020-07-27 |
2023-08-13 |
drosophila_melanogaster |
| Nao Utashiro, Claire R Williams, Jay Z Parrish, Kazuo Emot. Prior activity of olfactory receptor neurons is required for proper sensory processing and behavior in Drosophila larvae. Scientific reports. vol 8. issue 1. 2019-10-21. PMID:29872087. |
these findings together suggest a critical role for prior activity in information processing upon orn activation in drosophila larvae, which in turn contributes to olfactory behavior control. |
2019-10-21 |
2023-08-13 |
drosophila_melanogaster |
| Patricia Duchamp-Viret, Michel Chapu. In Vivo Electrophysiological Recordings of Olfactory Receptor Neuron Units and Electro-olfactograms in Anesthetized Rats. Methods in molecular biology (Clifton, N.J.). vol 1820. 2019-03-20. PMID:29884942. |
this configuration will ensure that when a single orn does not respond to a stimulus it resulted from its qualitative selectivity and not from the olfactory mucosa damaged status. |
2019-03-20 |
2023-08-13 |
rat |
| Jia Wern Pan, Qingyun Li, Scott Barish, Sumie Okuwa, Songhui Zhao, Charles Soeder, Matthew Kanke, Corbin D Jones, Pelin Cayirlioglu Volka. Patterns of transcriptional parallelism and variation in the developing olfactory system of Drosophila species. Scientific reports. vol 7. issue 1. 2019-03-15. PMID:28821769. |
our results suggest that the parallelism observed in the adult olfactory neuroanatomy of ecological specialists extends more broadly to their developmental antennal expression profiles, and to the transcription factor combinations specifying olfactory receptor neuron (orn) fates. |
2019-03-15 |
2023-08-13 |
drosophila_melanogaster |
| Juhi Sardana, Cristina Organisti, Ilona C Grunwald Kado. Eph Receptor Effector Ephexin Mediates Olfactory Dendrite Targeting in Drosophila. Developmental neurobiology. vol 78. issue 9. 2019-02-05. PMID:30019861. |
the olfactory map develops in subsequent steps initially forming a rough and later a precise map of glomeruli in the antennal lobe (al), mainly consisting of olfactory receptor neuron (orn) axons and projection neuron (pn) dendrites. |
2019-02-05 |
2023-08-13 |
drosophila_melanogaster |
| Melissa A Powell, Raiford T Black, Terry L Smith, Thomas M Reeves, Linda L Phillip. Mild Fluid Percussion Injury Induces Diffuse Axonal Damage and Reactive Synaptic Plasticity in the Mouse Olfactory Bulb. Neuroscience. vol 371. 2018-12-11. PMID:29203228. |
ob extracts revealed 3 d postinjury elevation of calpain-cleaved 150-kda αii-spectrin, an indicator of axon damage, in tandem with reduced olfactory marker protein (omp), a protein specific to intact orn axons. |
2018-12-11 |
2023-08-13 |
mouse |
| Melissa A Powell, Raiford T Black, Terry L Smith, Thomas M Reeves, Linda L Phillip. Mild Fluid Percussion Injury Induces Diffuse Axonal Damage and Reactive Synaptic Plasticity in the Mouse Olfactory Bulb. Neuroscience. vol 371. 2018-12-11. PMID:29203228. |
robust 21 d postinjury upregulation of gap-43 was consistent with the time course of orn axon sprouting and synapse regeneration reported after more severe olfactory insult. |
2018-12-11 |
2023-08-13 |
mouse |
| Scott Barish, Qingyun Li, Jia W Pan, Charlie Soeder, Corbin Jones, Pelin C Volka. Transcriptional profiling of olfactory system development identifies distal antenna as a regulator of subset of neuronal fates. Scientific reports. vol 7. 2018-10-22. PMID:28102318. |
despite a number of mutational studies investigating the regulation of orn development, a majority of the transcriptional programs that lead to the different orn classes in the developing olfactory system are unknown. |
2018-10-22 |
2023-08-13 |
drosophila_melanogaster |
| Sheng-Tien Li, Tai-Horng Young, Chih-Feng Lin, Tsung-Wei Huan. Promotion of olfactory receptor neuron differentiation of olfactory neuroepithelial cells by using chitosan solution. American journal of rhinology & allergy. vol 31. issue 5. 2018-05-18. PMID:28859702. |
promotion of olfactory receptor neuron differentiation of olfactory neuroepithelial cells by using chitosan solution. |
2018-05-18 |
2023-08-13 |
Not clear |