| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brandon Taraku, Joana R Loureiro, Ashish K Sahib, Artemis Zavaliangos-Petropulu, Noor Al-Sharif, Amber Leaver, Benjamin Wade, Shantanu Joshi, Roger P Woods, Randall Espinoza, Katherine L Nar. Ketamine treatment modulates habenular and nucleus accumbens static and dynamic functional connectivity in major depression. medRxiv : the preprint server for health sciences. 2023-12-18. PMID:38106178. |
dysfunctional reward processing in major depressive disorder (mdd) involves functional circuitry of the habenula (hb) and nucleus accumbens (nac). |
2023-12-18 |
2023-12-21 |
human |
| Brandon Taraku, Joana R Loureiro, Ashish K Sahib, Artemis Zavaliangos-Petropulu, Noor Al-Sharif, Amber Leaver, Benjamin Wade, Shantanu Joshi, Roger P Woods, Randall Espinoza, Katherine L Nar. Ketamine treatment modulates habenular and nucleus accumbens static and dynamic functional connectivity in major depression. medRxiv : the preprint server for health sciences. 2023-12-18. PMID:38106178. |
to clarify how ketamine perturbs reward circuitry in mdd, we examined how serial ketamine infusions (ski) modulate static and dynamic functional connectivity (fc) in hb and nac networks. |
2023-12-18 |
2023-12-21 |
human |
| Caroline S Johnson, Andrew D Chapp, Erin B Lind, Mark J Thomas, Paul G Mermelstei. Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell. Biology of sex differences. vol 14. issue 1. 2023-12-12. PMID:38082417. |
the nucleus accumbens (nac) is an important region in motivation and reward. |
2023-12-12 |
2023-12-17 |
mouse |
| Caroline S Johnson, Andrew D Chapp, Erin B Lind, Mark J Thomas, Paul G Mermelstei. Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell. Biology of sex differences. vol 14. issue 1. 2023-12-12. PMID:38082417. |
glutamatergic inputs from the infralimbic cortex (ilc) to the shell region of the nac (nacsh) have been implicated in driving the motivation to seek reward through repeated action-based behavior. |
2023-12-12 |
2023-12-17 |
mouse |
| Miguel Á Luján, Dan P Covey, Reana Young-Morrison, LanYuan Zhang, Andrew Kim, Fiorella Morgado, Sachin Patel, Caroline E Bass, Carlos Paladini, Joseph F Chee. Mobilization of endocannabinoids by midbrain dopamine neurons is required for the encoding of reward prediction. Nature communications. vol 14. issue 1. 2023-11-24. PMID:37985770. |
moreover, dopamine recording in the nac reveals that deletion of dglα impairs the transfer of accumbal dopamine signaling from a reward to its earliest predictors. |
2023-11-24 |
2023-11-28 |
mouse |
| Rifka C Derman, Elizabeth C Bryda, Carrie R Ferrari. Role of Nucleus Accumbens D1-type Medium Spiny Neurons in the Expression and Extinction of Sign-tracking. Behavioural brain research. 2023-11-20. PMID:37984521. |
after sign-tracking was established, all rats were administered clozapine-n-oxide (cno) prior to three additional conditioning sessions to assess the effects of nac d1-msns inhibition on sign-tracking in the presence of reward. |
2023-11-20 |
2023-11-29 |
rat |
| Xiaohui Bai, Kun Zhang, Chaopeng Ou, Yanyu Mu, Dongmei Chi, Jianxing Zhang, Jingxiu Huang, Xile Li, Yingjun Zhang, Wan Huang, Handong Ouyan. AKAP150 from nucleus accumbens dopamine D1 and D2 receptor-expressing medium spiny neurons regulates morphine withdrawal. iScience. vol 26. issue 11. 2023-11-13. PMID:37953959. |
dopamine d1 receptor-expressing medium spiny neurons (d1r-msns) and dopamine d2 receptor-expressing msns (d2r-msns) in nucleus accumbens (nac) have been demonstrated to show different effects on reward and memory of abstinence. |
2023-11-13 |
2023-11-20 |
Not clear |
| Michał Sobstyl, Marek Prokopienko, Tadeusz Pietra. The ventral capsule and ventral striatum-Stereotactic targets for the management of treatment-resistant depression. A systematic literature review. Frontiers in psychiatry. vol 14. 2023-11-06. PMID:37928918. |
the main nucleus of the reward circuit is the nucleus accumbens (nac). |
2023-11-06 |
2023-11-08 |
Not clear |
| Caleb J Browne, Philipp Mews, Xianxiao Zhou, Leanne M Holt, Molly Estill, Rita Futamura, Anne Schaefer, Paul J Kenny, Yasmin L Hurd, Li Shen, Bin Zhang, Eric J Nestle. Shared and divergent transcriptomic regulation in nucleus accumbens D1 and D2 medium spiny neurons by cocaine and morphine. bioRxiv : the preprint server for biology. 2023-10-02. PMID:37781621. |
substance use disorders (suds) induce widespread molecular dysregulation in the nucleus accumbens (nac), a brain region pivotal for coordinating motivation and reward. |
2023-10-02 |
2023-10-07 |
Not clear |
| Sarah M Barry, Gabriella M Barry, Dalia Martinez, Rachel D Penrod, Christopher W Cowa. The activity-regulated cytoskeleton-associated protein, Arc, functions in the nucleus accumbens shell to limit multiple triggers of cocaine-seeking behaviour. Addiction biology. vol 28. issue 10. 2023-09-27. PMID:37753560. |
the activity-regulated cytoskeleton-associated protein (arc) is induced by cocaine in the nucleus accumbens (nac), an important brain reward region, but arc's nac function in sud-related behaviour remains unclear. |
2023-09-27 |
2023-10-07 |
rat |
| Mary Ann Raghanti, Elaine N Miller, Danielle N Jones, Heather N Smith, Emily L Munger, Melissa K Edler, Kimberley A Phillips, William D Hopkins, Patrick R Hof, Chet C Sherwood, C Owen Lovejo. Hedonic eating, obesity, and addiction result from increased neuropeptide Y in the nucleus accumbens during human brain evolution. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 38. 2023-09-11. PMID:37695892. |
within the nac, npy plays a role in reward and is involved in emotional behavior and in increasing alcohol and drug addiction and fat intake. |
2023-09-11 |
2023-10-07 |
human |
| Stephanie Puig, Xiangning Xue, Ryan Salisbury, Micah A Shelton, Sam-Moon Kim, Mariah A Hildebrand, Jill R Glausier, Zachary Freyberg, George C Tseng, Anastasia K Yocum, David A Lewis, Marianne L Seney, Matthew L MacDonald, Ryan W Loga. Circadian rhythm disruptions associated with opioid use disorder in synaptic proteomes of human dorsolateral prefrontal cortex and nucleus accumbens. Molecular psychiatry. 2023-09-06. PMID:37674018. |
previous work indicated molecular rhythm disruptions in the human brain associated with oud, highlighting synaptic alterations in the dorsolateral prefrontal cortex (dlpfc) and nucleus accumbens (nac)-key brain regions involved in cognition and reward, and heavily implicated in the pathophysiology of oud. |
2023-09-06 |
2023-10-07 |
human |
| Pingping Zhao, Xing Chen, Arash Bellafard, Avaneesh Murugesan, Jonathan Quan, Daniel Aharoni, Peyman Golshan. Accelerated social representational drift in the nucleus accumbens in a model of autism. bioRxiv : the preprint server for biology. 2023-08-14. PMID:37577515. |
how the nucleus accumbens (nac), as a key hub of reward circuitry, encodes social interaction and whether these representations are altered in asd remain poorly understood. |
2023-08-14 |
2023-08-16 |
Not clear |
| Enrica Montalban, Albert Giralt, Lieng Taing, Yuki Nakamura, Assunta Pelosi, Mallory Brown, Benoit de Pins, Emmanuel Valjent, Miquel Martin, Angus C Nairn, Paul Greengard, Marc Flajolet, Denis Hervé, Nicolas Gambardella, Jean-Pierre Roussarie, Jean-Antoine Giraul. Operant training for highly palatable food alters translating mRNA in nucleus accumbens D2 neurons and reveals a modulatory role of Neurochondrin. Biological psychiatry. 2023-08-14. PMID:37579933. |
these effects involve the reward system and dopamine neurons, which modulate neurons in the nucleus accumbens (nac). |
2023-08-14 |
2023-09-07 |
Not clear |
| Anushree N Karkhanis, Alyssa M West, Sara R Jone. Kappa opioid receptor agonist U50,488 inhibits dopamine more in caudal than rostral nucleus accumbens core. Basic & clinical pharmacology & toxicology. 2023-08-04. PMID:37539456. |
the nucleus accumbens core (nac core) is involved in regulating stress and shaping reward seeking behaviors. |
2023-08-04 |
2023-08-14 |
mouse |
| Anushree N Karkhanis, Alyssa M West, Sara R Jone. Kappa opioid receptor agonist U50,488 inhibits dopamine more in caudal than rostral nucleus accumbens core. Basic & clinical pharmacology & toxicology. 2023-08-04. PMID:37539456. |
given the importance of nac core, particularly the interaction between kors and dopamine, in regulating reward seeking behaviors we examined the impact of kor activation on dopamine release and uptake along the rostro-caudal axis in the nac core of male and female mice. |
2023-08-04 |
2023-08-14 |
mouse |
| Samah Shahen-Zoabi, Reem Smoum, Alexey Bingor, Etty Grad, Alina Nemirovski, Tawfeeq Shekh-Ahmad, Raphael Mechoulam, Rami Yak. N-oleoyl glycine and N-oleoyl alanine attenuate alcohol self-administration and preference in mice. Translational psychiatry. vol 13. issue 1. 2023-07-31. PMID:37524707. |
we first measured the ecbs and ecb-ls levels in different brain reward system regions following chronic alcohol self-administration using lc-ms. we have found that following chronic intermittent alcohol consumption, n-oleoyl glycine (olgly) levels were significantly elevated in the prefrontal cortex (pfc), and n-oleoyl alanine (olala) was significantly elevated in the pfc, nucleus accumbens (nac) and ventral tegmental area (vta) in a region-specific manner. |
2023-07-31 |
2023-08-14 |
mouse |
| Juan Enriquez-Traba, Hector E Yarur-Castillo, Rodolfo J Flores, Tenley Weil, Snehashis Roy, Ted B Usdin, Christina T LaGamma, Miguel Arenivar, Huikun Wang, Valerie S Tsai, Amy E Moritz, David R Sibley, Rosario Moratalla, Zachary Z Freyberg, Hugo A Tejed. Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors. bioRxiv : the preprint server for biology. 2023-07-10. PMID:37425766. |
dopamine release in striatal circuits, including the nucleus accumbens (nac), tracks separable features of reward such as motivation and reinforcement. |
2023-07-10 |
2023-08-14 |
Not clear |
| Juan Enriquez-Traba, Hector E Yarur-Castillo, Rodolfo J Flores, Tenley Weil, Snehashis Roy, Ted B Usdin, Christina T LaGamma, Miguel Arenivar, Huikun Wang, Valerie S Tsai, Amy E Moritz, David R Sibley, Rosario Moratalla, Zachary Z Freyberg, Hugo A Tejed. Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors. bioRxiv : the preprint server for biology. 2023-07-10. PMID:37425766. |
paralleling dissociable roles in reward function, we report non-overlapping physiological actions of d3r and d1r signaling in nac neurons. |
2023-07-10 |
2023-08-14 |
Not clear |
| Daniela Neuhofer, Peter Kaliva. Differential modulation of GABAergic and glutamatergic neurons in the ventral pallidum by GABA and neuropeptides. eNeuro. 2023-07-06. PMID:37414552. |
the ventral pallidum (vp) is an integral locus in the reward circuitry and a major target of gabaergic innervation of both d1-medium spiny neurons (msns) and d2-msns from the nucleus accumbens (nac). |
2023-07-06 |
2023-08-14 |
mouse |