| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mark S Todtenkopf, Aram Parsegian, Alipi Naydenov, Rachael L Neve, Christine Konradi, William A Carlezo. Brain reward regulated by AMPA receptor subunits in nucleus accumbens shell. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 45. 2006-11-28. PMID:17093088. |
drugs of abuse alter expression of ampa-type glutamate receptor subunits (glurs) in the nucleus accumbens (nac), a key component of brain reward systems. |
2006-11-28 |
2023-08-12 |
rat |
| Elena Butovsky, Ana Juknat, Judith Elbaz, Maytal Shabat-Simon, Raya Eilam, Abraham Zangen, Miriam Altstein, Zvi Voge. Chronic exposure to Delta9-tetrahydrocannabinol downregulates oxytocin and oxytocin-associated neurophysin in specific brain areas. Molecular and cellular neurosciences. vol 31. issue 4. 2006-11-22. PMID:16513365. |
; 7 days) to rats, downregulates the expression of oxytocin-neurophysin (ot-np) mrna and of ot and oxytocin-associated np (npot) immunoreactivity in nucleus accumbens (nac) and ventral tegmental area (vta), brain areas involved in reward and addiction. |
2006-11-22 |
2023-08-12 |
rat |
| Ashley Acheson, Andrew M Farrar, Michele Patak, Kathryn A Hausknecht, Artur K Kieres, Seulgi Choi, Harriet de Wit, Jerry B Richard. Nucleus accumbens lesions decrease sensitivity to rapid changes in the delay to reinforcement. Behavioural brain research. vol 173. issue 2. 2006-11-01. PMID:16884790. |
to investigate the neural mechanisms that mediate delay discounting, the present study examined the effects of excitotoxic lesions of the nucleus accumbens (nac) on discounting of reward value by delay and probability. |
2006-11-01 |
2023-08-12 |
rat |
| Ashley Acheson, Andrew M Farrar, Michele Patak, Kathryn A Hausknecht, Artur K Kieres, Seulgi Choi, Harriet de Wit, Jerry B Richard. Nucleus accumbens lesions decrease sensitivity to rapid changes in the delay to reinforcement. Behavioural brain research. vol 173. issue 2. 2006-11-01. PMID:16884790. |
nac lesions impaired the ability to adapt to frequent between session changes in the delay to reward but did not increase or decrease discounting when the delay was held constant across sessions. |
2006-11-01 |
2023-08-12 |
rat |
| Ashley Acheson, Andrew M Farrar, Michele Patak, Kathryn A Hausknecht, Artur K Kieres, Seulgi Choi, Harriet de Wit, Jerry B Richard. Nucleus accumbens lesions decrease sensitivity to rapid changes in the delay to reinforcement. Behavioural brain research. vol 173. issue 2. 2006-11-01. PMID:16884790. |
nac lesions may disrupt the ability of the animals to predict the timing of delayed rewards when the delay to reward is changed frequently. |
2006-11-01 |
2023-08-12 |
rat |
| Mark R Stefani, Bita Moghadda. Rule learning and reward contingency are associated with dissociable patterns of dopamine activation in the rat prefrontal cortex, nucleus accumbens, and dorsal striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 34. 2006-09-28. PMID:16928870. |
we measured dopamine release in the prefrontal cortex (pfc), nucleus accumbens (nac), and dorsal striatum (ds) of rats exposed to the same maze apparatus under three behavioral conditions: a set-shift task in which reward depended on discrimination learning and extradimensional set-shifting, a yoked condition in which reward was intermittent and not under the control of the subject, and a "reward-retrieval" variant in which reward was certain on every trial. |
2006-09-28 |
2023-08-12 |
human |
| Mark R Stefani, Bita Moghadda. Rule learning and reward contingency are associated with dissociable patterns of dopamine activation in the rat prefrontal cortex, nucleus accumbens, and dorsal striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 34. 2006-09-28. PMID:16928870. |
predictable, noncontingent reward was associated with increased dopamine levels in the nac and ds. |
2006-09-28 |
2023-08-12 |
human |
| Zheng-Xiong Xi, Jeremy G Gilbert, Xiao-Qing Peng, Arlene C Pak, Xia Li, Eliot L Gardne. Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 33. 2006-09-12. PMID:16914679. |
given the importance of dopamine, glutamate, and gaba in cocaine reward and relapse, we studied the effects of am251 [n-(piperidin-1-yl)-5-(4-iodophonyl)-1-(2,4-dichlorophenyl)-4-methyl-1h-pyrazole-3-carboxamide], a novel highly selective cb1 receptor antagonist, on cocaine-primed reinstatement of drug-seeking behavior and on cocaine-induced changes in extracellular da, glutamate, and gaba in the nucleus accumbens (nac) under reinstatement conditions. |
2006-09-12 |
2023-08-12 |
rat |
| Kaushik Misra, Subhash C Pande. The decreased cyclic-AMP dependent-protein kinase A function in the nucleus accumbens: a role in alcohol drinking but not in anxiety-like behaviors in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 7. 2006-09-05. PMID:16192983. |
the nucleus accumbens (nac) brain structures have been implicated in the reward and reinforcing properties of ethanol. |
2006-09-05 |
2023-08-12 |
rat |
| Birgit Abler, Henrik Walter, Susanne Erk, Hannes Kammerer, Manfred Spitze. Prediction error as a linear function of reward probability is coded in human nucleus accumbens. NeuroImage. vol 31. issue 2. 2006-08-14. PMID:16487726. |
first, during the expectation period of the task, the fmri signal in the human nucleus accumbens (nac) increased linearly with the probability of the reward. |
2006-08-14 |
2023-08-12 |
human |
| Birgit Abler, Henrik Walter, Susanne Erk, Hannes Kammerer, Manfred Spitze. Prediction error as a linear function of reward probability is coded in human nucleus accumbens. NeuroImage. vol 31. issue 2. 2006-08-14. PMID:16487726. |
second, during the outcome phase, activity in the nac coded the prediction error as a linear function of reward probabilities. |
2006-08-14 |
2023-08-12 |
human |
| Birgit Abler, Henrik Walter, Susanne Erk, Hannes Kammerer, Manfred Spitze. Prediction error as a linear function of reward probability is coded in human nucleus accumbens. NeuroImage. vol 31. issue 2. 2006-08-14. PMID:16487726. |
third, we found that the nac signal was correlated with individual differences in sensation seeking and novelty seeking, indicating a link between individual fmri activation of the dopamine system in a probabilistic paradigm and personality traits previously suggested to be linked with reward processing. |
2006-08-14 |
2023-08-12 |
human |
| Tao A Zhang, Adam W Hendricson, Richard A Morriset. Dual synaptic sites of D(1)-dopaminergic regulation of ethanol sensitivity of NMDA receptors in nucleus accumbens. Synapse (New York, N.Y.). vol 58. issue 1. 2006-06-28. PMID:16037948. |
these data suggest that d(1)-like receptors modulate both the presynaptic and postsynaptic effects of ethanol on nmda receptor-mediated synaptic transmission in nucleus accumbens (nac) and that these interactions may contribute to ethanol-induced neuroadaptation of the reward pathway. |
2006-06-28 |
2023-08-12 |
Not clear |
| Elyssa B Margolis, Hagar Lock, Vladimir I Chefer, Toni S Shippenberg, Gregory O Hjelmstad, Howard L Field. Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 8. 2006-06-13. PMID:16477003. |
whereas dopamine (da) in the mpfc has been implicated in working memory and attentional processes, da in the nac is required for responding to reward predictive cues. |
2006-06-13 |
2023-08-12 |
Not clear |
| Mohammad-Reza Zarrindast, Bibi-Nasrin Azami, Parvin Rostami, Ameneh Rezayo. Repeated administration of dopaminergic agents in the nucleus accumbens and morphine-induced place preference. Behavioural brain research. vol 169. issue 2. 2006-06-08. PMID:16472879. |
it is concluded that repeated injections of dopamine receptors agents followed by 5 days free of the drugs in the nac can affect morphine reward. |
2006-06-08 |
2023-08-12 |
rat |
| Taku Nagai, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamad. [Role of tissue plasminogen activator in the rewarding effect of morphine]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 41. issue 1. 2006-05-30. PMID:16619846. |
our findings demonstrate a novel function of the tpa-plasmin system in regulating dopamine release in the nac, which is involved in the morphine reward. |
2006-05-30 |
2023-08-12 |
mouse |
| Kenneth Blum, Brian Meshkin, B William Down. DNA based customized nutraceutical "gene therapy" utilizing a genoscore: a hypothesized paradigm shift of a novel approach to the diagnosis, stratification, prognosis and treatment of inflammatory processes in the human. Medical hypotheses. vol 66. issue 5. 2006-05-25. PMID:16403602. |
we also propose that manipulation of neurochemical reward circuitry in the mesolimbic brain region providing dopamine release at the nucleus accumbens (nac), will have both pain and stress relief benefists, which are a cornerstone to the human inflammatory process. |
2006-05-25 |
2023-08-12 |
human |
| Guojun Chen, Josef T Kittler, Stephen J Moss, Zhen Ya. Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 9. 2006-04-11. PMID:16510729. |
the dopamine d3 receptor, which is highly enriched in nucleus accumbens (nac), has been suggested to play an important role in reinforcement and reward. |
2006-04-11 |
2023-08-12 |
Not clear |
| William A Carlezon, Cécile Béguin, Jennifer A DiNieri, Michael H Baumann, Michele R Richards, Mark S Todtenkopf, Richard B Rothman, Zhongze Ma, David Y-W Lee, Bruce M Cohe. Depressive-like effects of the kappa-opioid receptor agonist salvinorin A on behavior and neurochemistry in rats. The Journal of pharmacology and experimental therapeutics. vol 316. issue 1. 2006-03-31. PMID:16223871. |
at a dose that caused the depressive-like effects in both the fst and icss assays, salva decreased extracellular concentrations of dopamine (da) within the nucleus accumbens (nac), a critical component of brain reward circuitry, without affecting extracellular concentrations of serotonin (5-ht). |
2006-03-31 |
2023-08-12 |
rat |
| V Menon, D J Leviti. The rewards of music listening: response and physiological connectivity of the mesolimbic system. NeuroImage. vol 28. issue 1. 2006-01-11. PMID:16023376. |
here, we use functional and effective connectivity analyses to show for the first time that listening to music strongly modulates activity in a network of mesolimbic structures involved in reward processing including the nucleus accumbens (nac) and the ventral tegmental area (vta), as well as the hypothalamus and insula, which are thought to be involved in regulating autonomic and physiological responses to rewarding and emotional stimuli. |
2006-01-11 |
2023-08-12 |
human |