Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Enrica Montalban, Albert Giralt, Lieng Taing, Yuki Nakamura, Assunta Pelosi, Mallory Brown, Benoit de Pins, Emmanuel Valjent, Miquel Martin, Angus C Nairn, Paul Greengard, Marc Flajolet, Denis Herv, Nicolas Gambardella, Jean-Pierre Roussarie, Jean-Antoine Giraul. Operant training for highly palatable food alters translating mRNA in nucleus accumbens D2 neurons and reveals a modulatory role of bioRxiv : the preprint server for biology. 2023-03-22. PMID:36945487. |
these effects involve the reward system and dopamine neurons, which modulate neurons in the nucleus accumbens (nac). |
2023-03-22 |
2023-08-14 |
Not clear |
Kyle D Ketchesin, Darius D Becker-Krail, Xiangning Xue, Rashaun S Wilson, TuKiet T Lam, Kenneth R Williams, Angus C Nairn, George C Tseng, Ryan W Loga. Differential Effects of Cocaine and Morphine on the Diurnal Regulation of the Mouse Nucleus Accumbens Proteome. bioRxiv : the preprint server for biology. 2023-03-13. PMID:36909659. |
repeated use of substances such as psychostimulants and opioids may lead to significant alterations in molecular rhythms in the nucleus accumbens (nac), a brain region central to reward and motivation. |
2023-03-13 |
2023-08-14 |
mouse |
Yajie Jiang, Manshu Zou, Yeqing Wang, Yuhong Wan. Nucleus Accumbens in the Pathogenesis of Major Depressive Disorder: A Brief Review. Brain research bulletin. 2023-03-08. PMID:36889362. |
nac,a region critical for reward and motivation,dysregulation of its activity seems to be a hallmark of this mood disorder. |
2023-03-08 |
2023-08-14 |
Not clear |
Marek Lapka, Chrysostomos Charalambous, Anna Khryakova, Alina Certilina, Jiri Novotny, Lucie Hejnova, Magdalena Sustkova-Fiserov. Ghrelin/GHS-R1A antagonism in memory test and its effects on central molecular signaling involved in addiction in rats. Pharmacology, biochemistry, and behavior. 2023-03-04. PMID:36870422. |
these results imply, that the ghs-r1a antagonist/jmv2959 might reduce/prevent some of the memory-linked molecular changes elicited by methamphetamine addiction within brain structures associated with memory (hipp), reward (nac), and motivation (mpfc), which may contribute to the previously observed significant jmv2959-induced reduction of the methamphetamine self-administration and drug-seeking behavior in the same animals. |
2023-03-04 |
2023-08-14 |
rat |
Eric Y Choi, Daniela Franco, Catherine A Stapf, Madeleine Gordin, Amanda Chow, Kara K Cover, Ramesh Chandra, Mary Kay Lob. Inducible CRISPR Epigenome Systems Mimic Cocaine Induced Bidirectional Regulation of Nab2 and Egr3. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-02-27. PMID:36849419. |
the nucleus accumbens (nac) is a major brain hub mediating reward behavior. |
2023-02-27 |
2023-08-14 |
Not clear |
Hillary A Wadsworth, Elizabeth Q Anderson, Benjamin M Williams, Joakim W Ronström, Janna K Moen, Anna M Lee, J Michael McIntosh, Jie Wu, Jordan T Yorgason, Scott C Steffense. Role of α6-Nicotinic Receptors in Alcohol-Induced GABAergic Synaptic Transmission and Plasticity to Cholinergic Interneurons in the Nucleus Accumbens. Molecular neurobiology. 2023-02-21. PMID:36802012. |
the prevailing view is that enhancement of dopamine (da) transmission in the mesolimbic system, consisting of da neurons in the ventral tegmental area (vta) that project to the nucleus accumbens (nac), underlies the reward properties of ethanol (etoh) and nicotine (nic). |
2023-02-21 |
2023-08-14 |
mouse |
Gaowei Chen, Shishi Lai, Guo Bao, Jincan Ke, Xiaogao Meng, Shanshan Lu, Xiaocong Wu, Hua Xu, Fengyi Wu, Yu Xu, Fang Xu, Guo-Qiang Bi, Guangdun Peng, Kuikui Zhou, Yingjie Zh. Distinct reward processing by subregions of the nucleus accumbens. Cell reports. vol 42. issue 2. 2023-02-08. PMID:36753418. |
the nucleus accumbens (nac) plays an important role in motivation and reward processing. |
2023-02-08 |
2023-08-14 |
Not clear |
Gaowei Chen, Shishi Lai, Guo Bao, Jincan Ke, Xiaogao Meng, Shanshan Lu, Xiaocong Wu, Hua Xu, Fengyi Wu, Yu Xu, Fang Xu, Guo-Qiang Bi, Guangdun Peng, Kuikui Zhou, Yingjie Zh. Distinct reward processing by subregions of the nucleus accumbens. Cell reports. vol 42. issue 2. 2023-02-08. PMID:36753418. |
however, how reward is encoded in individual nac neurons remains unclear. |
2023-02-08 |
2023-08-14 |
Not clear |
Gaowei Chen, Shishi Lai, Guo Bao, Jincan Ke, Xiaogao Meng, Shanshan Lu, Xiaocong Wu, Hua Xu, Fengyi Wu, Yu Xu, Fang Xu, Guo-Qiang Bi, Guangdun Peng, Kuikui Zhou, Yingjie Zh. Distinct reward processing by subregions of the nucleus accumbens. Cell reports. vol 42. issue 2. 2023-02-08. PMID:36753418. |
using in vivo single-cell resolution calcium imaging, we find diverse patterns of reward encoding in the medial and lateral shell subdivision of the nac (nacmed and naclat, respectively). |
2023-02-08 |
2023-08-14 |
Not clear |
Qiang Lyu, Hecun Zou, Li Luo, Wei Liu, Xiang He, Fei-Fei Shan. The Role of eIF5A1 in LPS-Induced Neuronal Remodeling of the Nucleus Accumbens in the Depression. Journal of integrative neuroscience. vol 22. issue 1. 2023-02-01. PMID:36722231. |
the nucleus accumbens (nac) is a key region in the brain that integrates reward signals. |
2023-02-01 |
2023-08-14 |
Not clear |
Julianna Cavallaro, Jenna Yeisley, Başak Akdoǧan, Joseph Floeder, Peter D Balsam, Eduardo F Gall. Dopamine D2 receptors in nucleus accumbens cholinergic interneurons increase impulsive choice. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36711450. |
here, we show that d2r upregulation in cins of the mouse nac increases impulsive choice as measured in a delay discounting task without affecting reward magnitude sensitivity or interval timing. |
2023-01-30 |
2023-08-14 |
mouse |
Yu-Chen Chan, Tai-Li Cho. Effective connectivity of the amygdala during the consumption of erotic, sexual humor, and monetary rewards with a DCM-PEB approach. PloS one. vol 17. issue 12. 2022-12-29. PMID:36580445. |
the amygdala, nac, and lofc are major dopaminergic targets with known roles in the reward circuitry. |
2022-12-29 |
2023-08-14 |
Not clear |
Hong Zhou, Jiayu Zhu, Jie Jia, Wei Xiang, Hualing Peng, Yuejin Zhang, Bo Liu, Yangling Mu, Yisheng L. The antidepressant effect of nucleus accumbens deep brain stimulation is mediated by parvalbumin-positive interneurons in the dorsal dentate gyrus. Neurobiology of stress. vol 21. 2022-12-19. PMID:36532368. |
the nucleus accumbens (nac) is a crucial region in the reward circuit and is related to anhedonia, the pivotal symptom of major depression disorder (mdd). |
2022-12-19 |
2023-08-14 |
mouse |
He Chen, Limei Chen, Zhirong Yuan, Jiajie Yuan, Yitong Li, Yuesi Xu, Jieyi Wu, Lu Zhang, Guohua Wang, Juan L. Glutamate receptor-interacting protein 1 in D1- and D2-dopamine receptor-expressing medium spiny neurons differentially regulates cocaine acquisition, reinstatement, and associated spine plasticity. Frontiers in cellular neuroscience. vol 16. 2022-11-21. PMID:36406750. |
in the nac, d1-medium spiny neurons (msns) encode cocaine reward, whereas d2-msns encode aversive responses in drug addiction. |
2022-11-21 |
2023-08-14 |
Not clear |
Wanqi Che. Neural circuits provide insights into reward and aversion. Frontiers in neural circuits. vol 16. 2022-11-17. PMID:36389177. |
the aim of this paper is to summarize the latest findings on the mechanisms of the neural circuits associated with reward and aversion in a review of previous studies with a focus on the ventral tegmental area (vta), nucleus accumbens (nac), and basal forebrain (bf). |
2022-11-17 |
2023-08-14 |
Not clear |
Xuansong Mao, Kolter B Grigsby, Taylor J Kelty, Nathan R Kerr, Thomas E Childs, Frank W Boot. Transcriptomic analysis reveals novel molecular signaling networks in response to nucleus accumbens AP-1 inhibition in rats selectively bred for low voluntary wheel running behavior. Neuroscience. 2022-11-17. PMID:36395916. |
transcriptome analysis of the nucleus accumbens (nac; a brain region critical for pa reward and motivation) was performed to further determine molecular responses to intra-nac ap-1 inhibition in these rat lines. |
2022-11-17 |
2023-08-14 |
rat |
Hasan Alhaddad, Woonyen Wong, Magid Abou-Gharbia, Wayne Childers, Edward Melenski, Richard L Bell, Youssef Sar. Effects of a Novel Beta Lactam Compound, MC-100093, on the Expression of Glutamate Transporters/Receptors and Ethanol Drinking Behavior of Alcohol-Preferring Rats. The Journal of pharmacology and experimental therapeutics. vol 383. issue 3. 2022-11-17. PMID:36153003. |
chronic ethanol exposure affects the glutamatergic system in several brain reward regions including the nucleus accumbens (nac). |
2022-11-17 |
2023-11-20 |
rat |
Jinlan Zhao, Lihong Ye, Zuyi Liu, Yongfei Cui, Di Deng, Shasha Bai, Lei Yang, Yafei Shi, Zhongqiu Liu, Rong Zhan. Protective Effects of Resveratrol on Adolescent Social Isolation-Induced Anxiety-Like Behaviors via Modulating Nucleus Accumbens Spine Plasticity and Mitochondrial Function in Female Rats. Nutrients. vol 14. issue 21. 2022-11-11. PMID:36364807. |
the nucleus accumbens (nac) is an important reward center implicated in psychiatric disorders. |
2022-11-11 |
2023-08-14 |
rat |
William C Griffin, Marcelo F Lopez, John J Woodward, Howard C Becke. Alcohol Dependence and the Ventral Hippocampal Influence on Alcohol Drinking in Male Mice. Alcohol (Fayetteville, N.Y.). 2022-11-03. PMID:36328184. |
facilitated by its connectivity with other parts of the brain such as the nucleus accumbens (nac), the ventral hippocampus (vhc) supports many behaviors, including those related to reward seeking and addiction. |
2022-11-03 |
2023-08-14 |
mouse |
Kuikui Zhou, Hua Xu, Shanshan Lu, Shaolei Jiang, Guoqiang Hou, Xiaofei Deng, Miao He, Yingjie Zh. Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice. Nature communications. vol 13. issue 1. 2022-10-21. PMID:36271048. |
the nucleus accumbens (nac) is critical in mediating reward seeking and is also involved in negative emotion processing, but the cellular and circuitry mechanisms underlying such opposing behaviors remain elusive. |
2022-10-21 |
2023-08-14 |
mouse |