| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katarzyna Kaczanowska, Gisela Andrea Camacho Hernandez, Larissa Bendiks, Larissa Kohs, Jose Manuel Cornejo-Bravo, Michal Harel, M G Finn, Palmer Taylo. Substituted 2-Aminopyrimidines Selective for α7-Nicotinic Acetylcholine Receptor Activation and Association with Acetylcholine Binding Proteins. Journal of the American Chemical Society. vol 139. issue 10. 2018-06-04. PMID:28221788. |
to examine receptor interactions of this structural family on ligand-gated ion channels, we employed hek cells transfected with cdnas encoding three requisite receptor subtypes: α7-nachr, α4β2-nachr, and a serotonin receptor (5-ht |
2018-06-04 |
2023-08-13 |
Not clear |
| Felicia Russ. [Full functional recovery in depression treatment. Clinical cases treated with vortioxetina]. Rivista di psichiatria. vol 52. issue 3. 2018-05-30. PMID:28692076. |
a novel antidepressant, with a multimodal mechanism of action that combines the classical inhibition of serotonin transporter (sert) with the modulation of serotonin receptor activity, is vortioxetine. |
2018-05-30 |
2023-08-13 |
Not clear |
| D Sarrouilhe, C Dejea. [Autism spectrum disorders and bisphenol A: Is serotonin the lacking link in the chain?] L'Encephale. vol 43. issue 4. 2018-05-23. PMID:27623126. |
finally, decreased serotonin transporter and serotonin receptor binding have been reported in both children and adults with autism. |
2018-05-23 |
2023-08-13 |
mouse |
| Bin Tian, Xue-Long Wang, Ya Huang, Li-Hua Chen, Ruo-Xiao Cheng, Feng-Ming Zhou, Ran Guo, Jun-Cheng Li, Tong Li. Peripheral and spinal 5-HT receptors participate in cholestatic itch and antinociception induced by bile duct ligation in rats. Scientific reports. vol 6. 2018-05-08. PMID:27824106. |
although 5-ht has been implicated in cholestatic itch and antinociception, two common phenomena in patients with cholestatic disease, the roles of 5-ht receptor subtypes are unclear. |
2018-05-08 |
2023-08-13 |
rat |
| Yan-Hai Li, Lei Han, Kenneth Lap Kei Wu, Ying-Shing Cha. Activation of 5-HT Neuropharmacology. vol 123. 2018-04-17. PMID:28483393. |
we therefore aim to determine the action of 5-ht on the ltd of type b mvn neurons and elucidate the relevant 5-ht receptor subtypes responsible for its action. |
2018-04-17 |
2023-08-13 |
Not clear |
| Guoxun Zheng, Weiwei Xue, Fengyuan Yang, Yang Zhang, Yuzong Chen, Xiaojun Yao, Feng Zh. Revealing vilazodone's binding mechanism underlying its partial agonism to the 5-HT Physical chemistry chemical physics : PCCP. vol 19. issue 42. 2018-02-09. PMID:29057413. |
various types of drugs, including selective serotonin reuptake inhibitors (ssris), serotonin-norepinephrine reuptake inhibitors (snris), and serotonin receptor partial agonist/reuptake inhibitors (sparis), have been approved and become the primary or first-line medications prescribed for mdd. |
2018-02-09 |
2023-08-13 |
Not clear |
| Daniel Hoye. 5-HT Receptor Nomenclature: Naming Names, Does It Matter? A Tribute to Maurice Rapport. ACS chemical neuroscience. vol 8. issue 5. 2018-02-07. PMID:28269984. |
this is a short personal history on how advances in biochemistry, molecular biology, biophysics, imaging and medicinal chemistry, some lateral thinking, and a decent amount of collaborative spirit within the 5-ht receptor nomenclature committee and the 5-ht community at large have helped to better define the pharmacology of the 5-ht receptor family. |
2018-02-07 |
2023-08-13 |
human |
| T Shiina, K Naitou, H Nakamori, Y Suzuki, K Horii, Y Sano, H Shimaoka, Y Shimiz. Serotonin-induced contractile responses of esophageal smooth muscle in the house musk shrew (Suncus murinus). Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 28. issue 11. 2018-02-05. PMID:27194102. |
therefore, the aims of this study were to determine characteristics of contractile responses induced by serotonin and to identify 5-ht receptor subtypes responsible for regulating motility in the suncus esophagus. |
2018-02-05 |
2023-08-13 |
Not clear |
| K Bannister, S Lockwood, L Goncalves, R Patel, A H Dickenso. An investigation into the inhibitory function of serotonin in diffuse noxious inhibitory controls in the neuropathic rat. European journal of pain (London, England). vol 21. issue 4. 2018-01-31. PMID:27891703. |
here, we manipulate spinal 5-ht content in spinal nerve ligated (snl) animals and investigate which 5-ht receptor mediated actions predominate. |
2018-01-31 |
2023-08-13 |
rat |
| Katherine M Serafine, Kenner C Rice, Charles P Franc. Characterization of the discriminative stimulus effects of lorcaserin in rats. Journal of the experimental analysis of behavior. vol 106. issue 2. 2018-01-29. PMID:27640338. |
lorcaserin is approved by the food and drug administration for treating obesity and is under consideration for treating substance use disorders; it has agonist properties at serotonin (5-ht)2c receptors and might also have agonist properties at other 5-ht receptor subtypes. |
2018-01-29 |
2023-08-13 |
rat |
| A Komorowski, G M James, C Philippe, G Gryglewski, A Bauer, M Hienert, M Spies, A Kautzky, T Vanicek, A Hahn, T Traub-Weidinger, D Winkler, W Wadsak, M Mitterhauser, M Hacker, S Kasper, R Lanzenberge. Association of Protein Distribution and Gene Expression Revealed by PET and Post-Mortem Quantification in the Serotonergic System of the Human Brain. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 1. 2018-01-15. PMID:27909009. |
pet binding values and gene expression intensities were correlated for the main inhibitory (5-ht1a) and excitatory (5-ht2a) serotonin receptor, the serotonin transporter (sert) as well as monoamine oxidase-a (mao-a), using spearman's correlation coefficients (rs) in a voxel-wise and region-wise analysis. |
2018-01-15 |
2023-08-13 |
human |
| Junfeng Yao, Xiaoliang Wang, Huangxiang Yan, Xia Cai, Min Wang, Yingying Tu, Changsuo Yan. Enhanced Expression of Serotonin Receptor 5-Hydroxytryptamine 2C is Associated with Increased Feather Damage in Dongxiang Blue-Shelled Layers. Behavior genetics. vol 47. issue 3. 2018-01-02. PMID:28275879. |
enhanced expression of serotonin receptor 5-hydroxytryptamine 2c is associated with increased feather damage in dongxiang blue-shelled layers. |
2018-01-02 |
2023-08-13 |
chicken |
| Estelle Louiset, Céline Duparc, Sébastien Lenglet, Celso E Gomez-Sanchez, Hervé Lefebvr. Role of cAMP/PKA pathway and T-type calcium channels in the mechanism of action of serotonin in human adrenocortical cells. Molecular and cellular endocrinology. vol 441. 2017-11-21. PMID:27743992. |
in human adrenal, serotonin (5-ht), produced by mast cells located in zona glomerulosa, stimulates production of corticosteroids through a paracrine mechanism involving the 5-ht receptor type 4 (5-ht |
2017-11-21 |
2023-08-13 |
human |
| Filip Tylš, Tomáš Páleníček, Lukáš Kadeřábek, Michaela Lipski, Anna Kubešová, Jiří Horáče. Sex differences and serotonergic mechanisms in the behavioural effects of psilocin. Behavioural pharmacology. vol 27. issue 4. 2017-11-20. PMID:26461483. |
the contribution of serotonin receptors in the behavioural action was tested in male rats with selective serotonin receptor antagonists: 5-ht1a receptor antagonist (way100635 1 mg/kg), 5-ht2a receptor antagonist (mdl100907 0.5 mg/kg), 5-ht2b receptor antagonist (sb215505 1 mg/kg) and 5-ht2c receptor antagonist (sb242084 1 mg/kg). |
2017-11-20 |
2023-08-13 |
rat |
| Matthias M Herth, Ida Nymann Petersen, Hanne Demant Hansen, Martin Hansen, Anders Ettrup, Anders A Jensen, Szabolcs Lehel, Agnete Dyssegaard, Nic Gillings, Gitte M Knudsen, Jesper L Kristense. Synthesis and evaluation of (18)F-labeled 5-HT2A receptor agonists as PET ligands. Nuclear medicine and biology. vol 43. issue 8. 2017-11-20. PMID:27209485. |
the serotonin 2a receptor (5-ht2ar) is the most abundant excitatory 5-ht receptor in the human brain and implicated in various brain disorders such as schizophrenia, depression, and alzheimer's disease. |
2017-11-20 |
2023-08-13 |
human |
| Kangjian Xiang, Xuefei Zhao, Youjun Li, Liang Zheng, Jue Wang, Yan-Hai L. Selective 5-HT7 Receptor Activation May Enhance Synaptic Plasticity Through N-methyl-D-aspartate (NMDA) Receptor Activity in the Visual Cortex. Current neurovascular research. vol 13. issue 4. 2017-10-19. PMID:27558200. |
serotonin (5-hydroxytryptamine, 5-ht) is an important neurotransmitter that modulates n-methyl-d-aspartate (nmda) receptor activity by binding to several different 5-ht receptor subtypes. |
2017-10-19 |
2023-08-13 |
rat |
| Susan Schenk, Dane Aronse. Contribution of Impulsivity and Serotonin Receptor Neuroadaptations to the Development of an MDMA ('Ecstasy') Substance Use Disorder. Current topics in behavioral neurosciences. vol 34. 2017-10-17. PMID:26718587. |
data from both the human and laboratory animal literature are synthesized to support the idea that (1) mdma becomes a less efficacious serotonin releaser and a more efficacious dopamine releaser with the development of behaviour consistent with an sud and (2) that upregulated serotonin receptor mechanisms contribute to the development of the mdma sud via dysregulated inhibitory control associated with the trait of impulsivity. |
2017-10-17 |
2023-08-13 |
human |
| Dina Ripken, Nikkie van der Wielen, Heleen M Wortelboer, Jocelijn Meijerink, Renger F Witkamp, Henk F J Hendrik. Nutrient-induced glucagon like peptide-1 release is modulated by serotonin. The Journal of nutritional biochemistry. vol 32. 2017-10-09. PMID:27142747. |
the central hypothesis for the current study was that nutrient-induced glp-1 release from eecs is modulated by serotonin through a process involving serotonin receptor interaction. |
2017-10-09 |
2023-08-13 |
Not clear |
| D J David, A M Gardie. [The pharmacological basis of the serotonin system: Application to antidepressant response]. L'Encephale. vol 42. issue 3. 2017-09-20. PMID:27112704. |
however, antidepressant activity of sert inhibitors is not directly mediated by the sert inhibition, but a consequence of postsynaptic 5-ht receptor activation following the increase in 5-ht levels in the synaptic cleft. |
2017-09-20 |
2023-08-13 |
Not clear |
| Thomas E Finger, Dianna L Bartel, Nicole Shultz, Noah B Goodson, Charles A Gree. 5HTR3A-driven GFP labels immature olfactory sensory neurons. The Journal of comparative neurology. vol 525. issue 7. 2017-09-15. PMID:28152579. |
the ionotropic serotonin receptor, 5-ht |
2017-09-15 |
2023-08-13 |
Not clear |