| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hajer El Oussini, Hanna Bayer, Jelena Scekic-Zahirovic, Pauline Vercruysse, Jérôme Sinniger, Sylvie Dirrig-Grosch, Stéphane Dieterlé, Andoni Echaniz-Laguna, Yves Larmet, Kathrin Müller, Jochen H Weishaupt, Dietmar R Thal, Wouter van Rheenen, Kristel van Eijk, Roland Lawson, Laurent Monassier, Luc Maroteaux, Anne Roumier, Philip C Wong, Leonard H van den Berg, Albert C Ludolph, Jan H Veldink, Anke Witting, Luc Dupui. Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis. Acta neuropathologica. vol 131. issue 3. 2016-11-08. PMID:26744351. |
here we observed that the serotonin 2b receptor (5-ht2b), a serotonin receptor expressed in microglia, is upregulated in the spinal cord of three different transgenic mouse models of als. |
2016-11-08 |
2023-08-13 |
mouse |
| Knud Larsen, Jamal Momeni, Leila Farajzadeh, Christian Bendixe. Differential A-to-I RNA editing of the serotonin-2C receptor G-protein-coupled, HTR2C, in porcine brain tissues. Biochimie. vol 121. 2016-10-25. PMID:26707647. |
the htr2c gene encodes the 5-hydroxytryptamine (serotonin) receptor 2c, g-protein-coupled protein which functions as a serotonin receptor. |
2016-10-25 |
2023-08-13 |
human |
| Hyo Jung Kim, Sang Won Shin, Eun-Kee Song, Na-Ri Lee, Jun Suk Kim, Jin Seok Ahn, Hwan-Jung Yun, Yo-Han Cho, Keon Uk Park, Si-Young Kim, Joung Soon Jang, Sang-We Kim, Hyun Woo Lee, Se Ryeon Lee, Yang Soo Kim, Soon Nam Lee, Yoon Ho Ko, Hwa Jung Kim, Jin-Hyoung Kan. Ramosetron Versus Ondansetron in Combination With Aprepitant and Dexamethasone for the Prevention of Highly Emetogenic Chemotherapy-Induced Nausea and Vomiting: A Multicenter, Randomized Phase III Trial, KCSG PC10-21. The oncologist. vol 20. issue 12. 2016-09-21. PMID:26512046. |
a combination of serotonin receptor (5-hydroxytryptamine receptor type 3) antagonists, nk-1 receptor antagonist, and steroid improves the complete response (cr) of chemotherapy-induced nausea and vomiting (cinv) in cancer patients. |
2016-09-21 |
2023-08-13 |
Not clear |
| Hua Sui, Hanchen Xu, Qing Ji, Xuan Liu, Lihong Zhou, Haiyan Song, Xiqiu Zhou, Yangxian Xu, Zhesheng Chen, Jianfeng Cai, Guang Ji, Qi L. 5-hydroxytryptamine receptor (5-HT1DR) promotes colorectal cancer metastasis by regulating Axin1/β-catenin/MMP-7 signaling pathway. Oncotarget. vol 6. issue 28. 2016-07-19. PMID:26214021. |
overexpression of 5-hydroxytryptamine (5-ht) in human cancer contributes to tumor metastasis, but the role of 5-ht receptor family in cancer has not been thoroughly explored. |
2016-07-19 |
2023-08-13 |
mouse |
| Alan L Pehrson, Theepica Jeyarajah, Connie Sanche. Regional distribution of serotonergic receptors: a systems neuroscience perspective on the downstream effects of the multimodal-acting antidepressant vortioxetine on excitatory and inhibitory neurotransmission. CNS spectrums. vol 21. issue 2. 2016-07-19. PMID:26250622. |
in this article, we attempt to develop a conceptual framework in which the effects of 5-ht, selective serotonin reuptake inhibitors (ssris), and vortioxetine on gaba and glutamate neurotransmission can be understood in the pfc and striatum-2 regions with roles in cognition and substantially different 5-ht receptor expression patterns. |
2016-07-19 |
2023-08-13 |
Not clear |
| Alan L Pehrson, Theepica Jeyarajah, Connie Sanche. Regional distribution of serotonergic receptors: a systems neuroscience perspective on the downstream effects of the multimodal-acting antidepressant vortioxetine on excitatory and inhibitory neurotransmission. CNS spectrums. vol 21. issue 2. 2016-07-19. PMID:26250622. |
thus, we review the anatomy of the neuronal microcircuitry in the pfc and striatum, anatomical data on 5-ht receptor expression within these microcircuits, and electrophysiological evidence on the effects of 5-ht on the behavior of each cell type. |
2016-07-19 |
2023-08-13 |
Not clear |
| Elena Dale, Alan L Pehrson, Theepica Jeyarajah, Yan Li, Steven C Leiser, Gennady Smagin, Christina K Olsen, Connie Sanche. Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function. CNS spectrums. vol 21. issue 2. 2016-07-19. PMID:26346726. |
furthermore, hippocampal cells often co-express multiple 5-ht receptor subtypes that can have either complementary or opposing effects on cell function, adding to the complexity of 5-ht neurotransmission. |
2016-07-19 |
2023-08-13 |
Not clear |
| Hitoshi Watanabe, Tatsuya Nakano, Ryo Saito, Daisuke Akasaka, Kazuki Saito, Hideki Ogasawara, Takeshi Minashima, Kohtaro Miyazawa, Takashi Kanaya, Ikuro Takakura, Nao Inoue, Ikuo Ikeda, Xiangning Chen, Masato Miyake, Haruki Kitazawa, Hitoshi Shirakawa, Kan Sato, Kohji Tahara, Yuya Nagasawa, Michael T Rose, Shyuichi Ohwada, Kouichi Watanabe, Hisashi As. Serotonin Improves High Fat Diet Induced Obesity in Mice. PloS one. vol 11. issue 1. 2016-07-08. PMID:26766570. |
the elevation of these gene mrna expressions by 5-ht injection was inhibited by treatment with 5-ht receptor (5htr) 2a or 7 antagonists. |
2016-07-08 |
2023-08-13 |
mouse |
| Michael S Virk, Yotam Sagi, Lucian Medrihan, Jenny Leung, Michael G Kaplitt, Paul Greengar. Opposing roles for serotonin in cholinergic neurons of the ventral and dorsal striatum. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 3. 2016-06-14. PMID:26733685. |
here we show that, in mice, 5-ht depolarizes cholinergic interneurons (chis) of the dst whereas hyperpolarizing chis from the vst by acting on different 5-ht receptor isoforms. |
2016-06-14 |
2023-08-13 |
mouse |
| Agnieszka Nikiforu. Targeting the Serotonin 5-HT7 Receptor in the Search for Treatments for CNS Disorders: Rationale and Progress to Date. CNS drugs. vol 29. issue 4. 2016-06-13. PMID:25721336. |
the 5-ht7 (5-hydroxytryptamine 7, serotonin 7) receptor is one of the most recently identified members of the serotonin receptor family. |
2016-06-13 |
2023-08-13 |
mouse |
| Carla Letizia Busceti, Paola Di Pietro, Barbara Riozzi, Anna Traficante, Francesca Biagioni, Robert Nisticò, Francesco Fornai, Giuseppe Battaglia, Ferdinando Nicoletti, Valeria Brun. 5-HT(2C) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice. Pharmacological research. vol 99. 2016-06-13. PMID:26145279. |
5-ht(2c) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice. |
2016-06-13 |
2023-08-13 |
mouse |
| Tanimul Alam, Hiroki Maruyama, Chun Li, Strahil Iv Pastuhov, Paola Nix, Michael Bastiani, Naoki Hisamoto, Kunihiro Matsumot. Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans. Nature communications. vol 7. 2016-06-07. PMID:26790951. |
here we show that in caenorhabditis elegans, axotomy induces ectopic expression of serotonin (5-ht) in axotomized non-serotonergic neurons via hif-1, a hypoxia-inducible transcription factor, and that 5-ht subsequently promotes axon regeneration by autocrine signalling through the ser-7 5-ht receptor. |
2016-06-07 |
2023-08-13 |
caenorhabditis_elegans |
| Sjoerd J Finnema, Christer Halldin, Benny Bang-Andersen, Christoffer Bundgaard, Lars Fard. Serotonin transporter occupancy by escitalopram and citalopram in the non-human primate brain: a [(11)C]MADAM PET study. Psychopharmacology. vol 232. issue 21-22. 2016-06-02. PMID:25980484. |
a number of serotonin receptor positron emission tomography (pet) radioligands have been shown to be sensitive to changes in extracellular serotonin concentration, in a generalization of the well-known dopamine competition model. |
2016-06-02 |
2023-08-13 |
human |
| Sjoerd J Finnema, Christer Halldin, Benny Bang-Andersen, Christoffer Bundgaard, Lars Fard. Serotonin transporter occupancy by escitalopram and citalopram in the non-human primate brain: a [(11)C]MADAM PET study. Psychopharmacology. vol 232. issue 21-22. 2016-06-02. PMID:25980484. |
high doses of selective serotonin reuptake inhibitors (ssris) decrease serotonin receptor availability in monkey brain, consistent with increased serotonin concentrations. |
2016-06-02 |
2023-08-13 |
human |
| Sjoerd J Finnema, Christer Halldin, Benny Bang-Andersen, Christoffer Bundgaard, Lars Fard. Serotonin transporter occupancy by escitalopram and citalopram in the non-human primate brain: a [(11)C]MADAM PET study. Psychopharmacology. vol 232. issue 21-22. 2016-06-02. PMID:25980484. |
however, two recent studies on healthy human subjects, using a single, lower and clinically relevant ssri dose, showed increased cortical serotonin receptor radioligand binding, suggesting potential decreases in serotonin concentration in projection regions when initiating treatment. |
2016-06-02 |
2023-08-13 |
human |
| R A Abzalov, R R Abzalov, A M Valeev, N I Abzalov, A A Gulyako. Role of 5-HT(2B) Serotonin Receptor Agonist in the Regulation of Pumping Function of the Heart. Bulletin of experimental biology and medicine. vol 159. issue 3. 2016-05-23. PMID:26201901. |
role of 5-ht(2b) serotonin receptor agonist in the regulation of pumping function of the heart. |
2016-05-23 |
2023-08-13 |
rat |
| Guadalupe Mengod, José M Palacios, Roser Corté. Cartography of 5-HT1A and 5-HT2A Receptor Subtypes in Prefrontal Cortex and Its Projections. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25739427. |
5-ht receptors were first visualized using radioligand autoradiography in the late 1980s and early 1990s and showed, in contrast to 5-ht innervation, a differential distribution of binding sites associated with different 5-ht receptor subtypes. |
2016-04-19 |
2023-08-13 |
Not clear |
| Steven C Leiser, Yan Li, Alan L Pehrson, Elena Dale, Gennady Smagin, Connie Sanche. Serotonergic Regulation of Prefrontal Cortical Circuitries Involved in Cognitive Processing: A Review of Individual 5-HT Receptor Mechanisms and Concerted Effects of 5-HT Receptors Exemplified by the Multimodal Antidepressant Vortioxetine. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25746856. |
serotonergic regulation of prefrontal cortical circuitries involved in cognitive processing: a review of individual 5-ht receptor mechanisms and concerted effects of 5-ht receptors exemplified by the multimodal antidepressant vortioxetine. |
2016-04-19 |
2023-08-13 |
Not clear |
| Nadia Khan, Ahsana Dar Farooq, Bassem Sade. Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists. Drug design, development and therapy. vol 9. 2016-04-18. PMID:26185418. |
interestingly, the synergistic effect observed for aa with 5-ht was, also, blocked by the 5-ht receptor blockers cyproheptadine (ic50=22.0 ± 7 μmol/l), ketanserin (ic50=152 ± 23 μmol/l), phospholipase c (plc) inhibitor (u73122; ic50=6.1 ± 0.8 μmol/l), and mitogen activated protein kinase (mapk) inhibitor (pd98059; ic50=3.8 ± 0.5 μmol/l). |
2016-04-18 |
2023-08-13 |
human |
| Bo-Mi Song, Serge Faumont, Shawn Lockery, Leon Aver. Recognition of familiar food activates feeding via an endocrine serotonin signal in Caenorhabditis elegans. eLife. vol 2. 2016-04-11. PMID:23390589. |
the released serotonin activates the feeding response mainly by acting humorally and directly activates ser-7, a type 7 serotonin receptor, in mc motor neurons in the feeding organ. |
2016-04-11 |
2023-08-12 |
caenorhabditis_elegans |