| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peipei Lin, Chuang Wang, Bing Xu, Siyun Gao, Jiejie Guo, Xin Zhao, Huihui Huang, Junfang Zhang, Xiaowei Chen, Qinwen Wang, Wenhua Zho. The VGF-derived peptide TLQP62 produces antidepressant-like effects in mice via the BDNF/TrkB/CREB signaling pathway. Pharmacology, biochemistry, and behavior. vol 120. 2014-12-09. PMID:24631486. |
in contrast, none of these effects were diminished by pretreatment with the non-specific 5-ht receptor antagonist metergoline, the selective 5-ht1a receptor antagonist nan-190, the 5-ht synthase inhibitor parachlorophenylalanine, the selective α1-adrenoceptor antagonist prazosin, the β receptor antagonist propranolol, or the d2 receptor antagonist raclopride. |
2014-12-09 |
2023-08-12 |
mouse |
| Theodore A Slotkin, Jennifer Card, Frederic J Seidle. Nicotine administration in adolescence reprograms the subsequent response to nicotine treatment and withdrawal in adulthood: sex-selective effects on cerebrocortical serotonergic function. Brain research bulletin. vol 102. 2014-12-03. PMID:24487013. |
combined with earlier work showing persistent dysregulation of serotonin receptor expression and receptor coupling, the present results indicate that adolescent nicotine exposure reprograms future responses of 5ht systems to nicotine, changes that may contribute to life-long vulnerability to relapse and re-addiction. |
2014-12-03 |
2023-08-12 |
rat |
| Donatella Marazziti, Stefano Baroni, Lionella Palego, Laura Betti, Gino Giannaccini, Maura Castagna, Antonio G Naccarato, Antonio Luccachini, Mario Catena-Dell'Osso, Liliana Dell'Oss. Clozapine effects on adenylyl cyclase activity and serotonin type 1A receptors in human brain post-mortem. Journal of psychopharmacology (Oxford, England). vol 28. issue 4. 2014-11-24. PMID:24429224. |
in particular, much interest is focused on the understanding of clozapine activity on serotonin (5-ht) neurotransmission, particularly on 5-ht receptor of type 1a (5-ht(1a)) that seems to play a pivotal role in the control of the 5-ht system. |
2014-11-24 |
2023-08-12 |
human |
| Aaron M Marshall, Laura L Hernandez, Nelson D Horsema. Serotonin and serotonin transport in the regulation of lactation. Journal of mammary gland biology and neoplasia. vol 19. issue 1. 2014-11-11. PMID:24136337. |
in the mammary gland, two actions of 5-ht through two different 5-ht receptor subtypes have been described: negative feedback on milk synthesis and secretion, and stimulation of parathyroid hormone related-protein, a calcium-mobilizing hormone. |
2014-11-11 |
2023-08-12 |
Not clear |
| Sushil Chandra Regmi, Su-Young Park, Sae Kwang Ku, Jung-Ae Ki. Serotonin regulates innate immune responses of colon epithelial cells through Nox2-derived reactive oxygen species. Free radical biology & medicine. vol 69. 2014-11-08. PMID:24524998. |
in colon epithelial cells (ccd 841, ht-29, caco-2), direct application of 5-ht induced production of reactive oxygen species (ros) and monocyte-epithelial adhesion, an initial event of inflammation, which were blocked not only by 5-ht receptor antagonists (tropisetron, rs39604, and sb269970), antioxidants (ascorbic acid, apocynin), and various inhibitors of nadph oxidase (dpi), creb (kg-501), and nf-κb (pdtc), but also by transfection with nox2 sirna. |
2014-11-08 |
2023-08-12 |
mouse |
| Hua-Li Wu, Si-Lin Pang, Qiong-Zhen Liu, Qian Wang, Min-Xuan Cai, Jing Shan. 5-HT1A/1B receptors as targets for optimizing pigmentary responses in C57BL/6 mouse skin to stress. PloS one. vol 9. issue 2. 2014-10-28. PMID:24586946. |
the down-regulation of tyrosinase (tyr) and tyrosinase-related proteins (trp1 and trp2) expression in stressed skin was accompanied by reduced levels of 5-ht and decreased expression of 5-ht receptor (5-htr) system. |
2014-10-28 |
2023-08-12 |
mouse |
| Rutger van der Schier, Margot Roozekrans, Monique van Velzen, Albert Dahan, Marieke Niester. Opioid-induced respiratory depression: reversal by non-opioid drugs. F1000prime reports. vol 6. 2014-10-24. PMID:25343036. |
(c) while animal studies show that serotonin receptor agonists increase respiratory drive via activation of serotonin receptors in brainstem respiratory centers, human studies are without success. |
2014-10-24 |
2023-08-13 |
human |
| Man Luo, Xiang Simon Wang, Bryan L Roth, Alexander Golbraikh, Alexander Tropsh. Application of quantitative structure-activity relationship models of 5-HT1A receptor binding to virtual screening identifies novel and potent 5-HT1A ligands. Journal of chemical information and modeling. vol 54. issue 2. 2014-10-23. PMID:24410373. |
the 5-hydroxytryptamine 1a (5-ht1a) serotonin receptor has been an attractive target for treating mood and anxiety disorders such as schizophrenia. |
2014-10-23 |
2023-08-12 |
Not clear |
| Zana R Majeed, Audra Stacy, Robin L Coope. Pharmacological and genetic identification of serotonin receptor subtypes on Drosophila larval heart and aorta. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. vol 184. issue 2. 2014-09-29. PMID:24370737. |
in this study, various 5-ht agonists and antagonists were employed to determine which 5-ht receptor subtypes are responsible for the positive chronotropic effect by 5-ht. |
2014-09-29 |
2023-08-12 |
drosophila_melanogaster |
| Hitoshi Watanabe, Ryo Saito, Tatsuya Nakano, Hideyuki Takahashi, Yu Takahashi, Keisuke Sumiyoshi, Katsuyoshi Sato, Xiangning Chen, Natsumi Okada, Shunsuke Iwasaki, Dian W Harjanti, Natsumi Sekiguchi, Hiroaki Sano, Haruki Kitazawa, Michael T Rose, Shyuichi Ohwada, Kouichi Watanabe, Hisashi As. Effect of peripheral 5-HT on glucose and lipid metabolism in wether sheep. PloS one. vol 9. issue 2. 2014-09-26. PMID:24505376. |
therefore, in this study, we investigated the effect of 5-ht on the circulating concentrations of metabolites and insulin using five 5-ht receptor (5htr) antagonists in sheep. |
2014-09-26 |
2023-08-12 |
mouse |
| Pantaleo Di Pilato, Mauro Niso, Walter Adriani, Emilia Romano, Domenica Travaglini, Francesco Berardi, Nicola A Colabufo, Roberto Perrone, Giovanni Laviola, Enza Lacivita, Marcello Leopold. Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. Reviews in the neurosciences. vol 25. issue 3. 2014-09-25. PMID:24622785. |
the serotonin 7 (5-ht7) receptor was the last serotonin receptor subtype to be discovered in 1993. |
2014-09-25 |
2023-08-12 |
rat |
| Rammohan Shukla, Akiya Watakabe, Tetsuo Yamamor. mRNA expression profile of serotonin receptor subtypes and distribution of serotonergic terminations in marmoset brain. Frontiers in neural circuits. vol 8. 2014-09-24. PMID:24904298. |
to better understand serotonin function in the primate brain, we examined the mrna expression patterns of all the 13 members of the serotonin receptor (5htr) family, by in situ hybridization (ish) and the distribution of serotonergic terminations by serotonin transporter (sert) protein immunohistochemical analysis. |
2014-09-24 |
2023-08-13 |
mouse |
| Jesper Bornø Jensen, Kristian Gaarn du Jardin, Dekun Song, David Budac, Gennady Smagin, Connie Sanchez, Alan Lars Pehrso. Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: evidence for direct 5-HT receptor modulation. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 1. 2014-09-12. PMID:24284262. |
vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-ht depletion in rats: evidence for direct 5-ht receptor modulation. |
2014-09-12 |
2023-08-12 |
rat |
| Jesper Bornø Jensen, Kristian Gaarn du Jardin, Dekun Song, David Budac, Gennady Smagin, Connie Sanchez, Alan Lars Pehrso. Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: evidence for direct 5-HT receptor modulation. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 1. 2014-09-12. PMID:24284262. |
we hypothesized that vortioxetine's 5-ht receptor mechanisms are involved in its memory effects, and therefore investigated these effects in 5-ht depleted rats. |
2014-09-12 |
2023-08-12 |
rat |
| Lili Xu, Shanglin Zhou, Kunqian Yu, Bo Gao, Hualiang Jiang, Xuechu Zhen, Wei F. Molecular modeling of the 3D structure of 5-HT(1A)R: discovery of novel 5-HT(1A)R agonists via dynamic pharmacophore-based virtual screening. Journal of chemical information and modeling. vol 53. issue 12. 2014-08-26. PMID:24245825. |
the serotonin receptor subtype 1a (5-ht(1a)r) has been implicated in several neurological conditions, and potent 5-ht(1a)r agonists have therapeutic potential for the treatment of depression, anxiety, schizophrenia, and parkinson's disease. |
2014-08-26 |
2023-08-12 |
Not clear |
| Ferdinando Fiorino, Beatrice Severino, Elisa Magli, Antonio Ciano, Giuseppe Caliendo, Vincenzo Santagada, Francesco Frecentese, Elisa Perissutt. 5-HT(1A) receptor: an old target as a new attractive tool in drug discovery from central nervous system to cancer. Journal of medicinal chemistry. vol 57. issue 11. 2014-08-20. PMID:24295064. |
the serotonin receptor subtype 5-ht(1a) was one of the first serotonin receptor subtypes pharmacologically characterized. |
2014-08-20 |
2023-08-12 |
Not clear |
| Marie-Jeanne Perrot-Minnot, Emilie Dion, Frank Cézill. Modulatory effects of the serotonergic and histaminergic systems on reaction to light in the crustacean Gammarus pulex. Neuropharmacology. vol 75. 2014-08-19. PMID:23851256. |
using several mammalian 5-ht receptor antagonists and agonists, we provide evidence for a role of serotonin receptors in the 5-ht-dependent regulation of g. pulex photic behaviour, possibly involving 5-htr2 subtype. |
2014-08-19 |
2023-08-12 |
Not clear |
| Kara A Clissold, Eugene Choi, Wayne E Prat. Serotonin 1A, 1B, and 7 receptors of the rat medial nucleus accumbens differentially regulate feeding, water intake, and locomotor activity. Pharmacology, biochemistry, and behavior. vol 112. 2014-07-16. PMID:24125784. |
these data suggest that the food intake, water intake, and locomotor effects seen after medial nucleus accumbens injections of 5-ct are due to actions on separate serotonin receptor subtypes, and contribute to growing evidence for selective roles of individual serotonin receptors within the nucleus accumbens on motivated behavior. |
2014-07-16 |
2023-08-12 |
rat |
| Adrian Oblak, Terrell T Gibbs, Gene J Blat. Reduced serotonin receptor subtypes in a limbic and a neocortical region in autism. Autism research : official journal of the International Society for Autism Research. vol 6. issue 6. 2014-07-03. PMID:23894004. |
although information is known regarding peripheral 5-ht in autism, there is emerging evidence that 5-ht systems in the central nervous system, including various 5-ht receptor subtypes and transporters, are affected in autism. |
2014-07-03 |
2023-08-12 |
Not clear |
| Adrian Oblak, Terrell T Gibbs, Gene J Blat. Reduced serotonin receptor subtypes in a limbic and a neocortical region in autism. Autism research : official journal of the International Society for Autism Research. vol 6. issue 6. 2014-07-03. PMID:23894004. |
this study provides potential substrates for decreased 5-ht modulation/innervation in the autism brain, and implicate two 5-ht receptor subtypes as potential neuromarkers for novel or existing pharmacotherapies. |
2014-07-03 |
2023-08-12 |
Not clear |