| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Changwon Yang, Gwonhwa Song, Whasun Li. Methiothepin mesylate causes apoptosis of human prostate cancer cells by mediating oxidative stress and mitochondrial dysfunction. Free radical biology & medicine. vol 150. 2021-06-18. PMID:32035100. |
we verified apoptotic cell death in prostate cancer cell lines after treatment with methiothepin mesylate (met), an antagonist for serotonin receptor 5-ht |
2021-06-18 |
2023-08-13 |
human |
| Michael W Lewis, Russell T Jones, Margaret T Davi. Exploring the impact of trauma type and extent of exposure on posttraumatic alterations in 5-HT1A expression. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32678079. |
the serotonin 1-a receptor (5-ht1a) is an inhibitory g protein-coupled serotonin receptor encoded by the htr1a gene that plays a role in regulating serotonin release, physiological stress responding, and emotional behavior. |
2021-06-18 |
2023-08-13 |
human |
| Wayne E Pratt, Rafaella Vaca-Tricerri, Alexa C Blanchard, Thomas R Hopkins, Adeolu O Ilesanmi, Zachary Pierce-Messick, Ian A Rosner, Rose Yin. Selective serotonin receptor stimulation of the ventral tegmentum differentially affects appetitive motivation for sugar on a progressive ratio schedule of reinforcement. Behavioural brain research. vol 403. 2021-06-18. PMID:33497748. |
there were no effects of stimulating ventral tegmental serotonin 1b, 2a, or 2b receptors on break point; neither did antagonism of any of the serotonin receptor subtypes significantly affect performance. |
2021-06-18 |
2023-08-13 |
rat |
| Daisuke Tanioka, Sachiko Chikahisa, Noriyuki Shimizu, Tetsuya Shiuchi, Noriaki Sakai, Seiji Nishino, Hiroyoshi Sé. Intracranial mast cells contribute to the control of social behavior in male mice. Behavioural brain research. vol 403. 2021-06-18. PMID:33516739. |
mas-treck male mice also had reduced serotonin content and serotonin receptor expression and increased oxytocin receptor expression in the brain. |
2021-06-18 |
2023-08-13 |
mouse |
| Yvonne Schill, Monika Bijata, Olga Kopach, Volodymyr Cherkas, Dalia Abdel-Galil, Katrin Böhm, Markus H Schwab, Michiyuki Matsuda, Valerie Compan, Subhadip Basu, Krystian Bijata, Jakub Wlodarczyk, Lucie Bard, Nicholas Cole, Alexander Dityatev, Andre Zeug, Dmitri A Rusakov, Evgeni Ponimaski. Serotonin 5-HT Communications biology. vol 3. issue 1. 2021-06-17. PMID:32060357. |
here, we employ high-resolution time-lapse fret imaging in neuroblastoma cells and neuronal dendrites to establish that activation of serotonin receptor 5-ht |
2021-06-17 |
2023-08-13 |
Not clear |
| Chia-Chen Chang, Heidi Connahs, Estella Cai Yu Tan, Y Norma-Rashid, Mrinalini, Daiqin Li, Fook Tim Che. Female spider aggression is associated with genetic underpinnings of the nervous system and immune response to pathogens. Molecular ecology. vol 29. issue 14. 2021-06-04. PMID:32510793. |
individuals that have been treated with serotonin become less aggressive, but individuals treated with a nonselective serotonin receptor antagonist (methiothepin) also reduce aggression. |
2021-06-04 |
2023-08-13 |
spider |
| Ling Shen, Hai-Bo Qiu, Hui-Hong Xu, Kai Wei, Liang Zhao, Cheng-Cheng Zhu, Cheng-Jian Li, Zhi-Jie L. Nicotine withdrawal induces hyperalgesia via downregulation of descending serotonergic pathway in the nucleus raphe magnus. Neuropharmacology. vol 189. 2021-06-04. PMID:33722649. |
intrathecal injection of 5-ht or nrm microinjection of tph-overexpression adeno-associated virus alleviated nicotine withdrawal-induced hyperalgesia, whereas 5-ht receptor pharmacological blockade by methysergide (a 5-ht receptor antagonist) exacerbated hypersensitivity and diminished the difference between the two groups. |
2021-06-04 |
2023-08-13 |
rat |
| Nelly Durand, Méliné Simsir, Laurie Signetti, Fabien Labbal, Robert Ballotti, Isabelle Mus-Vetea. Methiothepin Increases Chemotherapy Efficacy against Resistant Melanoma Cells. Molecules (Basel, Switzerland). vol 26. issue 7. 2021-05-24. PMID:33810240. |
we previously reported that methiothepin, a small molecule known as a nonselective serotonin 5-ht receptor antagonist, inhibited the doxorubicin efflux activity of the hedgehog receptor ptch1 and enhanced the cytotoxic, pro-apoptotic, anti-proliferative, and anti-clonogenic effects of doxorubicin on adrenocortical carcinoma cells. |
2021-05-24 |
2023-08-13 |
Not clear |
| Simli Dey, Dayana Surendran, Oskar Engberg, Ankur Gupta, Sashaina E Fanibunda, Anirban Das, Barun Kumar Maity, Arpan Dey, Vicky Visvakarma, Mamata Kallianpur, Holger A Scheidt, Gilbert Walker, Vidita A Vaidya, Daniel Huster, Sudipta Mait. Altered Membrane Mechanics Provides a Receptor-Independent Pathway for Serotonin Action. Chemistry (Weinheim an der Bergstrasse, Germany). vol 27. issue 27. 2021-05-19. PMID:33502812. |
in the rn46a immortalized serotonergic neuronal cell line, extracellular serotonin enhances transferrin receptor endocytosis, even in the presence of broad-spectrum serotonin receptor and transporter inhibitors. |
2021-05-19 |
2023-08-13 |
Not clear |
| Vasko Kramer, Agnete Dyssegaard, Jonathan Flores, Cristian Soza-Ried, Frank Rösch, Gitte Moos Knudsen, Horacio Amaral, Matthias M Hert. Characterization of the serotonin 2A receptor selective PET tracer (R)-[ European journal of nuclear medicine and molecular imaging. vol 47. issue 2. 2021-05-14. PMID:31606832. |
characterization of the serotonin 2a receptor selective pet tracer (r)-[ the serotonin receptor subtype 2a antagonist (5-ht |
2021-05-14 |
2023-08-13 |
Not clear |
| Tin-Tin Win-Shwe, Chaw Kyi-Tha-Thu, Yuji Fujitani, Shinji Tsukahara, Seishiro Hiran. Perinatal Exposure to Diesel Exhaust-Origin Secondary Organic Aerosol Induces Autism-Like Behavior in Rats. International journal of molecular sciences. vol 22. issue 2. 2021-03-30. PMID:33430368. |
serotonin receptor (5-ht(5b)) and brain-derived neurotrophic factor (bdnf) mrnas were downregulated whereas interleukin 1 β (il-β) and heme oxygenase 1 (ho-1) mrnas were upregulated in the prefrontal cortex of male and female rats exposed to de-soa. |
2021-03-30 |
2023-08-13 |
rat |
| Zhuo Wang, Chen Li, Jiuyang Ding, Yanning Li, Zhihua Zhou, Yanjun Huang, Xiaohan Wang, Haoliang Fan, Jian Huang, Yitong He, Jianwei Li, Jun Chen, Pingming Qi. Basolateral Amygdala Serotonin 2C Receptor Regulates Emotional Disorder-Related Symptoms Induced by Chronic Methamphetamine Administration. Frontiers in pharmacology. vol 12. 2021-02-26. PMID:33628192. |
alterations in both 5-ht and 5-ht receptor levels occurred simultaneously in bla; quantitative polymerase chain reaction, western blotting, and fluorescence analysis revealed that the expression of the 5-ht2c receptor (5-ht |
2021-02-26 |
2023-08-13 |
mouse |
| Aida Iraji, Mahsima Khoshneviszadeh, Omidreza Firuzi, Mehdi Khoshneviszadeh, Najmeh Edrak. Novel small molecule therapeutic agents for Alzheimer disease: Focusing on BACE1 and multi-target directed ligands. Bioorganic chemistry. vol 97. 2021-02-22. PMID:32101780. |
this article also highlights descriptions on the regulator of serotonin receptor (5-ht), metal chelators, anti-aggregants, antioxidants and neuroprotective agents targeting ad. |
2021-02-22 |
2023-08-13 |
Not clear |
| Kazuhiro Mio, Masaki Ishihara, Shoko Fujimura, Daisuke Sasaki, Shunsuke Nozawa, Kohei Ichiyanagi, Ryo Fukaya, Shin-Ichi Adachi, Masahiro Kuramochi, Hiroshi Sekiguchi, Tai Kubo, Yuji C Sasak. X-ray-based living-cell motion analysis of individual serotonin receptors. Biochemical and biophysical research communications. vol 529. issue 2. 2021-02-12. PMID:32703428. |
serotonin receptor subtype 2a (5-ht |
2021-02-12 |
2023-08-13 |
Not clear |
| Sophia Khom, Sarah A Wolfe, Reesha R Patel, Dean Kirson, David M Hedges, Florence P Varodayan, Michal Bajo, Marisa Robert. Alcohol Dependence and Withdrawal Impair Serotonergic Regulation of GABA Transmission in the Rat Central Nucleus of the Amygdala. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 36. 2021-01-01. PMID:32769108. |
the cea receives dense innervation from the dorsal raphe nucleus, the major source of 5-ht, and expresses 5-ht receptor subtypes (e.g., 5-ht2c and 5-ht1a) critically linked to alcohol use disorder. |
2021-01-01 |
2023-08-13 |
rat |
| Jitka Hromádková, Yutaka Suzuki, Sarah Pletts, Jade Pyo, Tao Ma, Yanhong Chen, Michael A Steele, Le Luo Gua. Effect of colostrum feeding strategies on the expression of neuroendocrine genes and active gut mucosa-attached bacterial populations in neonatal calves. Journal of dairy science. vol 103. issue 9. 2020-12-30. PMID:32622610. |
in addition, cf upregulated the expression of htr4 (serotonin receptor) and slc4a4 (serotonin transporter) genes in the ileum and increased the abundance of active lactobacillus spp. |
2020-12-30 |
2023-08-13 |
Not clear |
| Ryota Sakai, Kyoko Komai, Mana Iizuka-Koga, Akihiko Yoshimura, Minako It. Regulatory T Cells: Pathophysiological Roles and Clinical Applications. The Keio journal of medicine. vol 69. issue 1. 2020-12-29. PMID:31353330. |
brain tregs resemble other tissue tregs, but are unique in expressing neural cell-specific genes such as the serotonin receptor (htr7); consequently, brain tregs respond to serotonin. |
2020-12-29 |
2023-08-13 |
Not clear |
| Christian M Gallardo, Camille S Martin, Andrew D Steel. Food Anticipatory Activity on Circadian Time Scales Is Not Dependent on Central Serotonin: Evidence From Tryptophan Hydroxylase-2 and Serotonin Transporter Knockout Mice. Frontiers in molecular neuroscience. vol 13. 2020-12-15. PMID:33041772. |
several studies have implicated serotonin as a negative regulator of faa: (1) aged rats treated with serotonin 5-ht2 and 3 receptor antagonists showed enhanced faa, (2) mice lacking for the 2c serotonin receptor demonstrate enhanced faa, and (3) pharmacologically increased serotonin levels suppressed faa while decreased serotonin levels enhanced faa in mice. |
2020-12-15 |
2023-08-13 |
mouse |
| Manfred Göthert, Heinz Bönisch, Barbara Malinowska, Eberhard Schlicke. Serotonin discovery and stepwise disclosure of 5-HT receptor complexity over four decades. Part II. Some contributions of Manfred Göthert. Pharmacological reports : PR. vol 72. issue 2. 2020-11-27. PMID:32048263. |
serotonin discovery and stepwise disclosure of 5-ht receptor complexity over four decades. |
2020-11-27 |
2023-08-13 |
Not clear |
| Manfred Göthert, Heinz Bönisch, Barbara Malinowska, Eberhard Schlicke. Serotonin discovery and stepwise disclosure of 5-HT receptor complexity over four decades. Part II. Some contributions of Manfred Göthert. Pharmacological reports : PR. vol 72. issue 2. 2020-11-27. PMID:32048263. |
he was not only the witness of the gradual definition of the fourteen 5-ht receptor subtypes but also was involved directly by identifying 5-ht |
2020-11-27 |
2023-08-13 |
Not clear |