| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Małgorzata Łupina, Agnieszka Wąsik, Irena Baranowska-Bosiacka, Maciej Tarnowski, Tymoteusz Słowik, Piotr Listos, Jolanta Kotlińska, Danuta Kosik-Bogacka, Izabela Gutowska, Joanna Listo. Acute and Chronic Exposure to Linagliptin, a Selective Inhibitor of Dipeptidyl Peptidase-4 (DPP-4), Has an Effect on Dopamine, Serotonin and Noradrenaline Level in the Striatum and Hippocampus of Rats. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38474255. |
acute linagliptin exposure increases the serotonin level in both areas, while after chronic linagliptin administration a tendency for the mrna expression of serotoninergic receptors (5-ht1a and 5-ht2a) to increase was observed. |
2024-03-13 |
2024-03-15 |
rat |
| Sampath Madhyastha, Muddanna S Rao, Waleed M Renn. Serotonergic and Adrenergic Neuroreceptor Manipulation Ameliorates Core Symptoms of ADHD through Modulating Dopaminergic Receptors in Spontaneously Hypertensive Rats. International journal of molecular sciences. vol 25. issue 4. 2024-02-24. PMID:38396978. |
after the behavioral tests, rat brains were processed to estimate the density of 5-ht1a, 5-ht2a, da-d1, and da-d2 neuroreceptors in the prefrontal cortex, the striatum, and the substantia nigra. |
2024-02-24 |
2024-02-26 |
rat |
| Sampath Madhyastha, Muddanna S Rao, Waleed M Renn. Serotonergic and Adrenergic Neuroreceptor Manipulation Ameliorates Core Symptoms of ADHD through Modulating Dopaminergic Receptors in Spontaneously Hypertensive Rats. International journal of molecular sciences. vol 25. issue 4. 2024-02-24. PMID:38396978. |
the positive effect was mainly associated with the upregulation of 5-ht2a receptors in all three areas investigated, while 5-ht1a was in the prefrontal cortex and the substantia nigra. |
2024-02-24 |
2024-02-26 |
rat |
| Sampath Madhyastha, Muddanna S Rao, Waleed M Renn. Serotonergic and Adrenergic Neuroreceptor Manipulation Ameliorates Core Symptoms of ADHD through Modulating Dopaminergic Receptors in Spontaneously Hypertensive Rats. International journal of molecular sciences. vol 25. issue 4. 2024-02-24. PMID:38396978. |
in this animal model study, the 5-ht1a agonist or 5-ht2a antagonist monotherapies were able to curtail the adhd symptoms by differential expression of da receptors in different regions of the brain. |
2024-02-24 |
2024-02-26 |
rat |
| Jie Zhou, Jiao-Wen Wu, Bai-Lin Song, Yi Jiang, Qiu-Hong Niu, Lai-Fu Li, Ying-Juan Li. 5-HT1A receptors within the intermediate lateral septum modulate stress vulnerability in male mice. Progress in neuro-psychopharmacology & biological psychiatry. 2024-02-14. PMID:38354893. |
in this study, we assessed the functions of 5-ht1a and 5-ht2a receptors within the lateral septum (ls) in regulating stress vulnerability. |
2024-02-14 |
2024-02-17 |
mouse |
| Adam Wojtas, Agnieszka Bysiek, Agnieszka Wawrzczak-Bargiela, Marzena Maćkowiak, Krystyna Gołembiowsk. Limbic System Response to Psilocybin and Ketamine Administration in Rats: A Neurochemical and Behavioral Study. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203271. |
the changes in d2, 5-ht1a and 5-ht2a receptor density in the nucleus accumbens and hippocampus were observed as a long-lasting effect. |
2024-01-11 |
2024-01-13 |
rat |
| Polona Rus Prelog, Anja Kokalj Palandaci. Hypersexuality during treatment with cariprazine in a patient with schizophrenia? A case report. BMC psychiatry. vol 23. issue 1. 2023-12-11. PMID:38082232. |
it functions as a partial agonist with high affinity for dopamine d2 and d3 and serotonin 5-ht1a receptors, an antagonist for 5-ht2a (moderate affinity) and 5-ht2b (high affinity) receptors. |
2023-12-11 |
2023-12-17 |
Not clear |
| Jasmin Obermanns, Hanna Meiser, Saskia Hoberg, Cynthia Segura Vesterager, Frank Schulz, Georg Juckel, Barbara Emon. Genetic variation of the 5-HT1A rs6295, 5-HT2A rs6311, and CNR1 rs1049353 and an altered endocannabinoid system in depressed patients. Brain and behavior. 2023-11-20. PMID:37984468. |
genetic variation of the 5-ht1a rs6295, 5-ht2a rs6311, and cnr1 rs1049353 and an altered endocannabinoid system in depressed patients. |
2023-11-20 |
2023-11-29 |
Not clear |
| Christophe Moderie, Jacob D King, Nicolas Nuñez, Stefano Comai, Gabriella Gobb. Sleep Quality After Quetiapine Augmentation in Patients With Treatment-Resistant Depression and Personality Disorders. Journal of clinical psychopharmacology. vol 43. issue 6. 2023-11-06. PMID:37930201. |
quetiapine and its active metabolite norquetiapine act mostly on 5-ht2a, 5-ht2c, h1, and d2 as antagonists and on 5-ht1a as partial agonists. |
2023-11-06 |
2023-11-08 |
Not clear |
| Ofelia Limón-Morales, Kenia Morales-Quintero, Marcela Arteaga-Silva, Tania Molina-Jiménez, Marco Cerbón, Herlinda Bonilla-Jaim. Alterations of learning and memory are accompanied by alterations in the expression of 5-HT receptors, glucocorticoid receptor and brain-derived neurotrophic factor in different brain regions of an animal model of depression generated by neonatally male treatment with clomipramine in male rats. Behavioural brain research. 2023-09-15. PMID:37714467. |
in addition, depression is characterized by a decreased functioning of the serotonergic system due to changes in the activity or expression of its receptors including, most significantly, 5-ht1a, 5-ht2a, and 5-ht3 in brain regions that regulate mood, emotions, and memory, such as the prefrontal cortex, hippocampus, and amygdala. |
2023-09-15 |
2023-10-07 |
rat |
| Ofelia Limón-Morales, Kenia Morales-Quintero, Marcela Arteaga-Silva, Tania Molina-Jiménez, Marco Cerbón, Herlinda Bonilla-Jaim. Alterations of learning and memory are accompanied by alterations in the expression of 5-HT receptors, glucocorticoid receptor and brain-derived neurotrophic factor in different brain regions of an animal model of depression generated by neonatally male treatment with clomipramine in male rats. Behavioural brain research. 2023-09-15. PMID:37714467. |
this, study, then, was designed to analyze the long-term effects of early postnatal exposure to cmi on the expression of 5-ht1a, 5-ht2a, and 5-ht3 receptors, as well as bdnf and gr in the following brain regions: pfc, amygdala, hippocampus, and hypothalamus, which could be related to alterations in memory and learning, as evaluated using the novel object recognition (nor) and morris water maze (mwm). |
2023-09-15 |
2023-10-07 |
rat |
| Ofelia Limón-Morales, Kenia Morales-Quintero, Marcela Arteaga-Silva, Tania Molina-Jiménez, Marco Cerbón, Herlinda Bonilla-Jaim. Alterations of learning and memory are accompanied by alterations in the expression of 5-HT receptors, glucocorticoid receptor and brain-derived neurotrophic factor in different brain regions of an animal model of depression generated by neonatally male treatment with clomipramine in male rats. Behavioural brain research. 2023-09-15. PMID:37714467. |
expression of the 5-ht1a receptor increased in the hippocampus, amygdala, and hypothalamus, but decreased in the pfc, while the 5-ht2a and bdnf receptors decreased their expression in the pfc, amygdala, and hippocampus. |
2023-09-15 |
2023-10-07 |
rat |
| Yi Jiang, Jie Zhou, Bai-Lin Song, Yan Wang, Dong-Lin Zhang, Zheng-Tian Zhang, Lai-Fu Li, Ying-Juan Li. 5-HT1A receptor in the central amygdala and 5-HT2A receptor in the basolateral amygdala are involved in social hierarchy in male mice. European journal of pharmacology. 2023-09-02. PMID:37659688. |
5-ht1a receptor in the central amygdala and 5-ht2a receptor in the basolateral amygdala are involved in social hierarchy in male mice. |
2023-09-02 |
2023-09-07 |
mouse |
| Yi Jiang, Jie Zhou, Bai-Lin Song, Yan Wang, Dong-Lin Zhang, Zheng-Tian Zhang, Lai-Fu Li, Ying-Juan Li. 5-HT1A receptor in the central amygdala and 5-HT2A receptor in the basolateral amygdala are involved in social hierarchy in male mice. European journal of pharmacology. 2023-09-02. PMID:37659688. |
quantitative real-time polymerase chain reaction analysis revealed that despite the high expression of 5-ht1a receptor mrna in the central amygdala (cea), 5-ht2a receptor mrna expression was downregulated in the basolateral amygdala (bla) in higher-rank individuals. |
2023-09-02 |
2023-09-07 |
mouse |
| Pukar Khanal, Farshid Zargari, Yadu Nandan Dey, Zahra Nikfarja. Olanzapine manipulates neuroactive signals and may onset metabolic disturbances. Journal of biomolecular structure & dynamics. 2023-07-21. PMID:37477254. |
binding mechanism of olanzapine with d2, 5ht1a, 5ht2a, 5ht2b, 5ht2c, m1, and m2 receptors were created using homology modeling and optimized using md simulations. |
2023-07-21 |
2023-08-14 |
Not clear |
| Sandeep Singh, Alexander Botvinnik, Orr Shahar, Gilly Wolf, Corel Yakobi, Michal Saban, Adham Salama, Amit Lotan, Bernard Lerer, Tzuri Lifschyt. Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder. Translational psychiatry. vol 13. issue 1. 2023-05-10. PMID:37164956. |
on this background, we set out to explore (1) the role of serotonin 2a (5-ht2a) and serotonin 1a (5-ht1a) receptors in the effect of psilocybin on marble burying; (2) the effect of staggered versus bolus psilocybin administration and persistence of the effect; (3) the effect of the 5-ht1a partial agonist, buspirone, on marble-burying and the head twitch response (htr) induced by psilocybin, a rodent correlate of psychedelic effects. |
2023-05-10 |
2023-08-14 |
mouse |
| Sandeep Singh, Alexander Botvinnik, Orr Shahar, Gilly Wolf, Corel Yakobi, Michal Saban, Adham Salama, Amit Lotan, Bernard Lerer, Tzuri Lifschyt. Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder. Translational psychiatry. vol 13. issue 1. 2023-05-10. PMID:37164956. |
these data suggest that neither 5-ht2a nor 5-ht1a receptors are pivotally implicated in the effect of psilocybin on marble burying. |
2023-05-10 |
2023-08-14 |
mouse |
| b' Jelena Nikoli\\xc4\\x87, Katarina Vukojevi\\xc4\\x87, Violeta \\xc5\\xa0olji\\xc4\\x87, Josip Mi\\xc5\\xa1kovi\\xc4\\x87, Martina Orlovi\\xc4\\x87 Vlaho, Mirna Saraga-Babi\\xc4\\x87, Natalija Filipovi\\xc4\\x8. Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36769290.' |
expression patterns of serotonin receptors 5-ht1a, 5-ht2a, and 5-ht3a during human fetal lung development. |
2023-02-11 |
2023-08-14 |
human |
| b' Jelena Nikoli\\xc4\\x87, Katarina Vukojevi\\xc4\\x87, Violeta \\xc5\\xa0olji\\xc4\\x87, Josip Mi\\xc5\\xa1kovi\\xc4\\x87, Martina Orlovi\\xc4\\x87 Vlaho, Mirna Saraga-Babi\\xc4\\x87, Natalija Filipovi\\xc4\\x8. Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36769290.' |
we analyzed the expression of the serotonin receptors 5-ht1a, 5-ht2a, and 5-ht3a at four different stages of fetal lung development from 12 to 40 weeks of gestation, divided into four groups: the pseudoglandular stage (12-16th week of development; |
2023-02-11 |
2023-08-14 |
human |
| Faiq Amin, Mahmoud A A Ibrahim, Syed Rizwan-Ul-Hasan, Saima Khaliq, Gamal A Gabr, Muhammad, Asra Khan, Peter A Sidhom, Prashant Tikmani, Ahmed M Shawky, Saara Ahmad, Syed Hani Abid. Interactions of Apigenin and Safranal with the 5HT1A and 5HT2A Receptors and Behavioral Effects in Depression and Anxiety: A Molecular Docking, Lipid-Mediated Molecular Dynamics, and In Vivo Analysis. Molecules (Basel, Switzerland). vol 27. issue 24. 2022-12-23. PMID:36557792. |
interactions of apigenin and safranal with the 5ht1a and 5ht2a receptors and behavioral effects in depression and anxiety: a molecular docking, lipid-mediated molecular dynamics, and in vivo analysis. |
2022-12-23 |
2023-08-14 |
Not clear |