| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karen-Amanda Irvine, Xiao-You Shi, Adam R Ferguson, David Clar. DREADD-mediated activation of the periaqueductal gray restores nociceptive descending inhibition after traumatic brain injury in rats. Journal of neurotrauma. 2024-04-08. PMID:38588130. |
to define the serotonergic receptor(s) required for the cno-stimulated effects in tbi rats we administered 5-ht7 (sb-269970) and 5-ht1a (way-100635) receptor antagonists but observed no effects. |
2024-04-08 |
2024-04-11 |
rat |
| Aineng Peng, Jianbo Chai, Haiyuan Wu, Bing Bai, Huihui Yang, Weizhi He, Yonghou Zha. New Therapeutic Targets and Drugs for Schizophrenia Beyond Dopamine D2 Receptor Antagonists. Neuropsychiatric disease and treatment. vol 20. 2024-03-25. PMID:38525480. |
from the third generation of antipsychotics onwards, the therapeutic targets for antipsychotic schizophrenia expanded beyond d2 receptor blockade to explore d2 receptor partial agonism and the antipsychotic effects of new targets such as d3, 5-ht1a, 5-ht7, and mglu2/3 receptors. |
2024-03-25 |
2024-03-27 |
Not clear |
| Berta Buey, Ana Forcén, Laura Grasa, Elena Layunta, Jose Emilio Mesonero, Eva Latorr. Gut Microbiota-Derived Short-Chain Fatty Acids: Novel Regulators of Intestinal Serotonin Transporter. Life (Basel, Switzerland). vol 13. issue 5. 2023-05-27. PMID:37240731. |
our results show that the microbiota-derived scfas regulate intestinal serotonergic system, both individually and in combination, modulating the function and expression of sert and the 5-ht1a, 5-ht2b, and 5-ht7 receptors expression. |
2023-05-27 |
2023-08-14 |
Not clear |
| Nuh Mehmet Bozkurt, Gokhan Una. Vortioxetine Improved Negative and Cognitive Symptoms of Schizophrenia in Subchronic MK-801 Induced Schizophrenia Model in Rats. Behavioural brain research. 2023-03-01. PMID:36858318. |
vortioxetine is a new multimodal antidepressant with 5-ht1a agonism, 5-ht1b partial agonism, 5-ht3, 5-ht7, and 5-ht1d antagonism, and serotonin reuptake inhibition. |
2023-03-01 |
2023-08-14 |
rat |
| Cheng-Jie Li, Li-Ge Zhang, Lu-Bing Liu, Meng-Qi An, Li-Guo Dong, Han-Ying Gu, Yong-Ping Dai, Fen Wang, Cheng-Jie Mao, Chun-Feng Li. Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson's Disease. Molecular neurobiology. 2022-09-28. PMID:36168076. |
several 5-ht receptor subtypes have been confirmed to be associated with nociception in the spinal cord, such as 5-ht1a receptor, 5-ht1b receptor, 5-ht2 receptor, 5-ht3 receptor, and 5-ht7 receptor. |
2022-09-28 |
2023-08-14 |
rat |
| Kouji Fukuyama, Eishi Motomura, Takashi Shiroyama, Motohiro Okad. Impact of 5-HT7 receptor inverse agonism of lurasidone on monoaminergic tripartite synaptic transmission and pathophysiology of lower risk of weight gain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 148. 2022-02-26. PMID:35219120. |
therefore, to explore mechanisms underlying antidepressive mood-stabilising and antipsychotic effects of lurasidone, we determined concentration-dependent effects of acute and subchronic lurasidone administrations on astroglial l-glutamate release, and expression of connexin43, erk, akt, adenosine monophosphate activated protein kinase (ampk), 5-ht1a (5-ht1ar) and 5-ht7 (5-ht7r) receptors in cultured astrocytes using ultra-high-pressure liquid-chromatography with mass-spectrometry and capillary-immunoblotting systems. |
2022-02-26 |
2023-08-13 |
Not clear |
| Lila Wollman, Andrew Hill, Brady Hasse, Christina Young, Giovanni Hernandez-De La Pena, Richard B Levine, Ralph F Fregos. Influence of developmental nicotine exposure on serotonergic control of breathing-related motor output. Developmental neurobiology. 2022-01-11. PMID:35016263. |
we applied 5ht alone, or together with antagonists of 5ht1a, 5ht2a or 5ht7 receptor subtypes. |
2022-01-11 |
2023-08-13 |
rat |
| Daniela Adamo, Elena Calabria, Noemi Coppola, Giuseppe Pecoraro, Michele Davide Mignogn. Vortioxetine as a new frontier in the treatment of chronic neuropathic pain: a review and update. Therapeutic advances in psychopharmacology. vol 11. 2021-09-10. PMID:34497709. |
this drug inhibits the serotonin transporter with a high affinity, antagonises the 5-ht3, 5-ht1d and 5ht7 serotonin receptors, and activates the 5-ht1a and 5-ht1b receptors. |
2021-09-10 |
2023-08-13 |
Not clear |
| Miguel A Núñez-Ochoa, Gustavo A Chiprés-Tinajero, Laura Medina-Cej. Evaluation of the hippocampal immunoreactivity of the serotonin 5-HT1A, 5-HT2 and 5-HT7 receptors in a pilocarpine temporal lobe epilepsy rat model with fast ripples. Neuroreport. vol 32. issue 4. 2021-06-18. PMID:33470771. |
evaluation of the hippocampal immunoreactivity of the serotonin 5-ht1a, 5-ht2 and 5-ht7 receptors in a pilocarpine temporal lobe epilepsy rat model with fast ripples. |
2021-06-18 |
2023-08-13 |
rat |
| Miguel A Núñez-Ochoa, Gustavo A Chiprés-Tinajero, Laura Medina-Cej. Evaluation of the hippocampal immunoreactivity of the serotonin 5-HT1A, 5-HT2 and 5-HT7 receptors in a pilocarpine temporal lobe epilepsy rat model with fast ripples. Neuroreport. vol 32. issue 4. 2021-06-18. PMID:33470771. |
therefore, to gather more details about the state of the serotoninergic system in the hippocampus under an epileptogenic process, we studied the immunoreactivity of three 5-ht receptors (5-ht1a, 5-ht2 and 5-ht7) as well as the extracellular levels of 5-ht in the hippocampal tissue of epileptic rats with fr. |
2021-06-18 |
2023-08-13 |
rat |
| Dasiel O Borroto-Escuela, Xiang Li, Alexander O Tarakanov, David Savelli, Manuel Narváez, Kirill Shumilov, Yuniesky Andrade-Talavera, Antonio Jimenez-Beristain, Bartosz Pomierny, Zaida Díaz-Cabiale, Riccardo Cuppini, Patrizia Ambrogini, Maria Lindskog, Kjell Fux. Existence of Brain 5-HT1A-5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor-Receptor Interactions Regulating 5-HT1A Receptor Recognition. ACS omega. vol 2. issue 8. 2020-10-01. PMID:28920103. |
there are many 5-ht subtypes involved; some need to be blocked (e.g., 5-ht2a, 5-ht3, and 5-ht7), whereas others need to be activated (e.g., postjunctional 5-ht1a and 5-ht4). |
2020-10-01 |
2023-08-13 |
Not clear |
| Motohiro Okada, Kouji Fukuyama, Ruri Okubo, Takashi Shiroyama, Yuto Ued. Lurasidone Sub-Chronically Activates Serotonergic Transmission via Desensitization of 5-HT1A and 5-HT7 Receptors in Dorsal Raphe Nucleus. Pharmaceuticals (Basel, Switzerland). vol 12. issue 4. 2020-09-30. PMID:31590422. |
lurasidone sub-chronically activates serotonergic transmission via desensitization of 5-ht1a and 5-ht7 receptors in dorsal raphe nucleus. |
2020-09-30 |
2023-08-13 |
Not clear |
| Majid Jafari-Sabet, Sepehr Nemati, Mansour Tora. Cross state-dependency of learning between 5-HT1A and/or 5-HT7 receptor agonists and muscimol in the mouse dorsal hippocampus. Journal of psychopharmacology (Oxford, England). vol 33. issue 6. 2020-06-23. PMID:30789290. |
cross state-dependency of learning between 5-ht1a and/or 5-ht7 receptor agonists and muscimol in the mouse dorsal hippocampus. |
2020-06-23 |
2023-08-13 |
mouse |
| E M Kondaurova, D V Bazovkina, V S Naumenk. [5-HT1A/5-HT7 receptor interplay: Chronic activation of 5-HT7 receptors decreases the functional activity of 5-HT1A receptor and its сontent in the mouse brain]. Molekuliarnaia biologiia. vol 51. issue 1. 2019-04-30. PMID:28251979. |
serotonin receptors 5-ht1a and 5-ht7 are involved in the development of various psychopathologies. |
2019-04-30 |
2023-08-13 |
mouse |
| Anna Rita Zuena, Daniela Maftei, Giovanni Sebastiano Alemà, Francesca Dal Moro, Roberta Lattanzi, Paola Casolini, Ferdinando Nicolett. Multimodal antidepressant vortioxetine causes analgesia in a mouse model of chronic neuropathic pain. Molecular pain. vol 14. 2019-02-20. PMID:30289053. |
vortioxetine is a multimodal antidepressant that potently antagonizes 5-ht3 serotonin receptors, inhibits the high-affinity serotonin transporter, activates 5-ht1a and 5-ht1b receptors, and antagonizes 5-ht1d and 5-ht7 receptors. |
2019-02-20 |
2023-08-13 |
mouse |
| Lauren Hatherall, Connie Sánchez, David A Morila. Chronic Vortioxetine Treatment Reduces Exaggerated Expression of Conditioned Fear Memory and Restores Active Coping Behavior in Chronically Stressed Rats. The international journal of neuropsychopharmacology. vol 20. issue 4. 2018-05-18. PMID:27927740. |
vortioxetine, a novel multimodal antidepressant, is a serotonin transporter inhibitor; 5-ht3, 5-ht7, and 5-ht1d receptor antagonist; 5-ht1b partial agonist; and 5-ht1a agonist. |
2018-05-18 |
2023-08-13 |
rat |
| Anna Czopek, Agnieszka Zagorska, Marcin Kolaczkowski, Adam Bucki, Beata Gryzlo, Joanna Rychtyk, Maciej Pawlowsk, Agata Siwek, Grzegorz Satala, Andrzej Bojarski, Monika Kubacka, Barbara Filipe. NEW SPIROHYDANTOIN DERIVATIVES - SYNTHESIS, PHARMACOLOGICAL EVALUATION, AND MOLECULAR MODELING STUDY. Acta poloniae pharmaceutica. vol 73. issue 6. 2018-05-03. PMID:29634109. |
a binding mode of representative molecule 19, which behaved as a 5-ht1a agonist and weak 5-ht7 antagonist in the site of 5-ht 1a/7, was also analyzed in computational stud- ies. |
2018-05-03 |
2023-08-13 |
Not clear |
| Laura Orsolini, Carmine Tomasetti, Alessandro Valchera, Felice Iasevoli, Elisabetta Filomena Buonaguro, Michele Fornaro, Annastasia L C Fiengo, Giovanni Martinotti, Federica Vellante, Ilaria Matarazzo, Roberta Vecchiotti, Giampaolo Perna, Marco Di Nicola, Alessandro Carano, Andrea Di Bartolomeis, Massimo De Giannantonio, Domenico De Berardi. Current and Future Perspectives on the Major Depressive Disorder: Focus on the New Multimodal Antidepressant Vortioxetine. CNS & neurological disorders drug targets. vol 16. issue 1. 2018-02-09. PMID:27781949. |
vortioxetine (vrx) is a multimodal antidepressant that acts as serotonin (5ht) transporter inhibitor as well as 5ht3a and 5ht7 receptors antagonist, 5ht1a and 5ht1b receptors partial agonist. |
2018-02-09 |
2023-08-13 |
Not clear |
| Alfredo Menese. Neural activity, memory, and dementias: serotonergic markers. Behavioural pharmacology. vol 28. issue 2 and 3-Spec Issue. 2018-01-11. PMID:27926574. |
in addition, at least, 5-ht1a, 5-ht4, 5-ht6, and 5-ht7 receptors as well as serotonin transporter seem to be useful neural markers and therapeutic targets. |
2018-01-11 |
2023-08-13 |
Not clear |
| Andrew D Krystal, Gary Zammi. The sleep effects of lurasidone: a placebo-controlled cross-over study using a 4-h phase-advance model of transient insomnia. Human psychopharmacology. vol 31. issue 3. 2017-12-15. PMID:27108672. |
lurasidone, an atypical antipsychotic, is a potent 5-ht7 antagonist and d2 , 5-ht2a antagonist, and 5-ht1a partial agonist. |
2017-12-15 |
2023-08-13 |
human |