| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue Du, Qing Li, Yikai Dou, Min Wang, Yu Wang, Yushun Yan, Huanhuan Fan, Xiao Yang, Xiaohong M. Side effects and cognitive benefits of buspirone: A systematic review and meta-analysis. Heliyon. vol 10. issue 7. 2024-04-11. PMID:38601569. |
buspirone, a 5-hydroxytryptamine 1a (5-ht1a) receptor agonist, has been investigated for its use in various diseases. |
2024-04-11 |
2024-04-13 |
human |
| Manas R Biswal, Ryan J Paulson, Riddhi Vichare, Alfred S Lewi. Buspirone Enhances Cell Survival and Preserves Structural Integrity during Oxidative Injury to the Retinal Pigment Epithelium. Antioxidants (Basel, Switzerland). vol 12. issue 12. 2023-12-23. PMID:38136248. |
the purpose of our study was to determine if buspirone, a partial serotonin 1a (5-ht1a) receptor agonist, protected against oxidative stress-induced changes in the rpe. |
2023-12-23 |
2023-12-25 |
mouse |
| Michael Frazure, In Morimoto, Nathan Fielder, Nicholas Mellen, Kimberly Iceman, Teresa Pitt. Serotonin therapies for opioid-induced dysphagia and respiratory depression: sex differences in a rat electromyography model. bioRxiv : the preprint server for biology. 2023-09-04. PMID:37662371. |
we also evaluated utility of serotonin 5-ht1a agonists (8-oh-dpat and buspirone) to improve swallowing and breathing outcomes following buprenorphine administration. |
2023-09-04 |
2023-09-07 |
rat |
| Michael Frazure, In Morimoto, Nathan Fielder, Nicholas Mellen, Kimberly Iceman, Teresa Pitt. Serotonin therapies for opioid-induced dysphagia and respiratory depression: sex differences in a rat electromyography model. bioRxiv : the preprint server for biology. 2023-09-04. PMID:37662371. |
4) 8-oh-dpat rescued breathing following buprenorphine-induced respiratory arrest, and pre-treatment with the partial 5-ht1a agonist buspirone prevented buprenorphine-induced respiratory arrest in female animals. |
2023-09-04 |
2023-09-07 |
rat |
| Xingmei Jiang, Zhongrui Ma, Zhixiong Li, Ying Ou, Zhenhua Luo, Zhe L. Hematochezia caused by tandospirone in a patient with major depressive disorder and anxious distress: a case report. Frontiers in psychiatry. vol 14. 2023-08-02. PMID:37529069. |
in order to enhance the effectiveness of mdd treatment, 5-ht1a agonists like tandospirone are often prescribed in conjunction with antidepressants. |
2023-08-02 |
2023-08-14 |
Not clear |
| Hanan S Althagafy, Zeina W Sharawi, Ashwaq H Batawi, Hailah M Almohaimeed, Wafa S Al-Thubiani, Emad H M Hassanein, Amal Rate. Buspirone attenuated methotrexate-induced hippocampal toxicity in rats by regulating Nrf2/HO-1, PPAR-γ, NF-κB/nNOS, and ROS/NLRP3/caspase-1 signaling pathways. Journal of biochemical and molecular toxicology. 2023-06-21. PMID:37341015. |
buspirone (bsp), a partial agonist of the 5-ht1a receptor (5-ht1ar), has emerged as an anxiolytic drug. |
2023-06-21 |
2023-08-14 |
rat |
| Olga A Lyubashina, Ivan B Sivachenko, Boris M Sushkevich, Irina I Busygin. Opposing effects of 5-HT1A receptor agonist buspirone on supraspinal abdominal pain transmission in normal and visceral hypersensitive rats. Journal of neuroscience research. 2023-06-18. PMID:37331003. |
opposing effects of 5-ht1a receptor agonist buspirone on supraspinal abdominal pain transmission in normal and visceral hypersensitive rats. |
2023-06-18 |
2023-08-14 |
rat |
| Olga A Lyubashina, Ivan B Sivachenko, Boris M Sushkevich, Irina I Busygin. Opposing effects of 5-HT1A receptor agonist buspirone on supraspinal abdominal pain transmission in normal and visceral hypersensitive rats. Journal of neuroscience research. 2023-06-18. PMID:37331003. |
in this study performed on male wistar rats, we used microelectrode recording of the caudal ventrolateral medulla (cvlm) neuron responses to colorectal distension (crd) and electromyography recording of crd-evoked visceromotor reactions (vmrs) to evaluate post-colitis changes in the effects of 5-ht1a agonist buspirone on supraspinal visceral nociceptive transmission. |
2023-06-18 |
2023-08-14 |
rat |
| Olga A Lyubashina, Ivan B Sivachenko, Boris M Sushkevich, Irina I Busygin. Opposing effects of 5-HT1A receptor agonist buspirone on supraspinal abdominal pain transmission in normal and visceral hypersensitive rats. Journal of neuroscience research. 2023-06-18. PMID:37331003. |
the data obtained indicate a shift from anti- to pronociceptive contribution of 5-ht1a-dependent mechanisms to supraspinal transmission of visceral nociception in intestinal hypersensitivity conditions, arguing for the disutility of buspirone and possibly other 5-ht1a agonists for relieving post-inflammatory abdominal pain. |
2023-06-18 |
2023-08-14 |
rat |
| Yong-Jik Lee, Hyun-Min Kim, Yoo-Na Jang, Yoon-Mi Han, Hong Seog Seo, Tae Woo Jung, Ji Hoon Jeong, Hyun Jung Lee, Kyung Oh Jun. Buspirone Induces Weight Loss and Normalization of Blood Pressure via the Stimulation of PPAR PPAR research. vol 2023. 2023-05-11. PMID:37168052. |
buspirone induces weight loss and normalization of blood pressure via the stimulation of ppar buspirone, as a partial agonist for a 5-hydroxytryptamine (serotonin) receptor 1a (5-ht1a), has been prescribed as an anxiolytic drug for patients. |
2023-05-11 |
2023-08-14 |
Not clear |
| Sandeep Singh, Alexander Botvinnik, Orr Shahar, Gilly Wolf, Corel Yakobi, Michal Saban, Adham Salama, Amit Lotan, Bernard Lerer, Tzuri Lifschyt. Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder. Translational psychiatry. vol 13. issue 1. 2023-05-10. PMID:37164956. |
on this background, we set out to explore (1) the role of serotonin 2a (5-ht2a) and serotonin 1a (5-ht1a) receptors in the effect of psilocybin on marble burying; (2) the effect of staggered versus bolus psilocybin administration and persistence of the effect; (3) the effect of the 5-ht1a partial agonist, buspirone, on marble-burying and the head twitch response (htr) induced by psilocybin, a rodent correlate of psychedelic effects. |
2023-05-10 |
2023-08-14 |
mouse |
| Sandeep Singh, Alexander Botvinnik, Orr Shahar, Gilly Wolf, Corel Yakobi, Michal Saban, Adham Salama, Amit Lotan, Bernard Lerer, Tzuri Lifschyt. Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder. Translational psychiatry. vol 13. issue 1. 2023-05-10. PMID:37164956. |
the 5-ht1a agonist, 8-oh-dpat, reduced marble burying as did the 5-ht1a partial agonist, buspirone. |
2023-05-10 |
2023-08-14 |
mouse |
| Sandeep Singh, Alexander Botvinnik, Orr Shahar, Gilly Wolf, Corel Yakobi, Michal Saban, Adham Salama, Amit Lotan, Bernard Lerer, Tzuri Lifschyt. Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder. Translational psychiatry. vol 13. issue 1. 2023-05-10. PMID:37164956. |
the 5-ht1a antagonist, way100635, attenuated the effect of 8-oh-dpat and buspirone but not the effect of psilocybin. |
2023-05-10 |
2023-08-14 |
mouse |
| Samuel Apeldoorn, Rebecca Chavez, Freshta Haschemi, Kareem Elsherif, David Weinstein, Tyler Torric. Worsening psychosis associated with administrations of buspirone and concerns for intranasal administration: A case report. Frontiers in psychiatry. vol 14. 2023-03-06. PMID:36873224. |
considering its complex mechanism of action, buspirone is suggested to derive its neuropharmacological effects through 5-ht1a receptors. |
2023-03-06 |
2023-08-14 |
Not clear |
| Darshak Shah, Mit Joshi, Jigna Shah, Bhoomika M Pate. Beneficial effects of buspirone in endothelin-1 induced stroke cachexia in rats. Molecular and cellular biochemistry. 2023-01-07. PMID:36609633. |
the present study aimed to evaluate the effect of a 5-ht1a agonist, buspirone on stroke cachexia. |
2023-01-07 |
2023-08-14 |
rat |
| Magdalena Jastrzębska-Więsek, Anna Wesołowska, Marcin Kołaczkowski, Mark A Varney, Adrian Newman-Tancredi, RonanY Depoorter. The selective 5-HT1A receptor agonist, NLX-112, overcomes tetrabenazine-induced catalepsy and depression-like behavior in the rat. Behavioural pharmacology. 2022-06-13. PMID:35695543. |
the prototypical 5-ht1a agonist, (±)8-oh-dpat, and the 5-ht1a partial agonist/dopamine d2 receptor blocker, buspirone, were used as comparators. |
2022-06-13 |
2023-08-14 |
rat |
| Anne R de Kort, Elbert A Joosten, Jacob Patijn, Dick Tibboel, Nynke J van den Hooge. Selective Targeting of Serotonin 5-HT1a and 5-HT3 Receptors Attenuates Acute and Long-Term Hypersensitivity Associated With Neonatal Procedural Pain. Frontiers in pain research (Lausanne, Switzerland). vol 3. 2022-05-16. PMID:35571143. |
the current study aims to attenuate acute and long-term hypersensitivity associated with neonatal procedural pain using ondansetron (a 5-ht3 antagonist) and buspirone (a 5-ht1a agonist) in a well-established rat model of repetitive needle pricking. |
2022-05-16 |
2023-08-13 |
human |
| Urmila Aswar, Hrudaya Shende, Manoj Aswa. Buspirone, a 5-HT1A agonist attenuates social isolation-induced behavior deficits in rats: a comparative study with fluoxetine. Behavioural pharmacology. 2022-04-19. PMID:35438678. |
buspirone, a 5-ht1a agonist attenuates social isolation-induced behavior deficits in rats: a comparative study with fluoxetine. |
2022-04-19 |
2023-08-13 |
rat |
| Cecilia L Bergeria, Hongjun Tan, Denis Antoine, Elise M Weerts, Andrew S Huhn, J Gregory Hobelmann, Kelly E Dun. A double-blind, randomized, placebo-controlled, pilot clinical trial examining buspirone as an adjunctive medication during buprenorphine-assisted supervised opioid withdrawal. Experimental and clinical psychopharmacology. 2022-03-10. PMID:35266779. |
buspirone is a d2 antagonist and 5-ht1a agonist that may decrease opioid withdrawal. |
2022-03-10 |
2023-08-13 |
Not clear |
| Sarah Thomas Broome, Alessandro Castorin. The Anxiolytic Drug Buspirone Prevents Rotenone-Induced Toxicity in a Mouse Model of Parkinson's Disease. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163768. |
the anxiolytic drug buspirone, a serotonin receptor 1a agonist, also functions as a potent d3r antagonist. |
2022-02-15 |
2023-08-13 |
mouse |