| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miki Kishitake, Korehito Yamanouch. Effects of highly or relatively selective 5-HT1A receptor agonists on lordosis in female rats. Zoological science. vol 20. issue 9. 2004-01-05. PMID:14578574. |
the injected agents were the selective 5-ht1a receptor agonist, buspirone (bus), the highly selective 5-ht1a receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin ((+/-)8-oh-dpat), and the 5-ht1a and 5-ht7 receptor agonist, (r)-8-hydroxy-2-(di-n-propylamino)tetralin ((+)8-oh-dpat). |
2004-01-05 |
2023-08-12 |
rat |
| N P Bondar', N N Kudriavtsev. [Effect of buspirone on aggressive and anxiety behavior of male mice with various aggressive experience]. Eksperimental'naia i klinicheskaia farmakologiia. vol 66. issue 4. 2003-12-29. PMID:14558344. |
the effect of the 5-ht1a receptor agonist buspirone on the aggressive and anxious behavior of c57bl/6j male mice with different experience of aggression was studied. |
2003-12-29 |
2023-08-12 |
mouse |
| N P Bondar', N N Kudriavtsev. [Effect of buspirone on aggressive and anxiety behavior of male mice with various aggressive experience]. Eksperimental'naia i klinicheskaia farmakologiia. vol 66. issue 4. 2003-12-29. PMID:14558344. |
it is suggested that the antiaggressive effect of buspirone in the former case is related to the anxiogenic action, while a long experience of aggression reduced the pharmacological sensitivity of 5-ht1a receptors to buspirone in the latter case. |
2003-12-29 |
2023-08-12 |
mouse |
| Petrus J Pauwels, Francis C Colpaer. Ca2+ responses in Chinese hamster ovary-K1 cells demonstrate an atypical pattern of ligand-induced 5-HT1A receptor activation. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12970382. |
in contrast, the prototypical 5-ht1a receptor agonists buspirone, ipsapirone, and 8-(hydroxy-2-(di-n-propylamino)tetralin, and also flesinoxan and eptapirone, were virtually inactive (< or =5). |
2003-12-10 |
2023-08-12 |
human |
| Petrus J Pauwels, Francis C Colpaer. Ca2+ responses in Chinese hamster ovary-K1 cells demonstrate an atypical pattern of ligand-induced 5-HT1A receptor activation. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12970382. |
therefore, some of these 5-ht1a ligands (i.e., f 13640) may in a selective way induce responses that may be not at all be achieved with other ligands (i.e., buspirone). |
2003-12-10 |
2023-08-12 |
human |
| Kimberly Bell, David Shokrian, Carl Potenzieri, Patricia M Whitaker-Azmiti. Harm avoidance, anxiety, and response to novelty in the adolescent S-100beta transgenic mouse: role of serotonin and relevance to Down syndrome. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 10. 2003-12-05. PMID:12888777. |
however, in the hole-board test for exploratory behavior, the s-100beta animals were found to be less responsive to the inhibiting effects of the serotonin receptor 5-ht1a agonist, buspirone. |
2003-12-05 |
2023-08-12 |
mouse |
| Donatella Marazziti, Lionella Palego, Annalisa Giromella, Maria Rosa Mazzoni, Franco Borsini, Norbert Mayer, Antonio Giuseppe Naccarato, Antonio Lucacchini, Giovanni Battista Cassan. Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain. The international journal of neuropsychopharmacology. vol 5. issue 2. 2003-11-21. PMID:12135537. |
in animals, two 5-ht1a agonists, flibanserin and buspirone, have shown different pharmacological properties, depending on the brain region. |
2003-11-21 |
2023-08-12 |
human |
| Donatella Marazziti, Lionella Palego, Annalisa Giromella, Maria Rosa Mazzoni, Franco Borsini, Norbert Mayer, Antonio Giuseppe Naccarato, Antonio Lucacchini, Giovanni Battista Cassan. Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain. The international journal of neuropsychopharmacology. vol 5. issue 2. 2003-11-21. PMID:12135537. |
agonist effects were sensitive to the 5-ht1a antagonists way-100135 and pindobind 5-ht1a in the cortex and raphe nuclei, whereas buspirone antagonized flibanserin in the hippocampus. |
2003-11-21 |
2023-08-12 |
human |
| Y K Gupta, S S Sharm. Involvement of 5-HT1A and 5-HT2 receptor in cisplatin induced emesis in dogs. Indian journal of physiology and pharmacology. vol 46. issue 4. 2003-08-07. PMID:12683222. |
buspirone, 5-ht1a receptor partial agonist significantly reduced the emetic episodes though it had no significant effect on emetic latency. |
2003-08-07 |
2023-08-12 |
Not clear |
| Y K Gupta, S S Sharm. Involvement of 5-HT1A and 5-HT2 receptor in cisplatin induced emesis in dogs. Indian journal of physiology and pharmacology. vol 46. issue 4. 2003-08-07. PMID:12683222. |
the antiemetic activity of buspirone may be attributable to its agonistic activity at 5-ht1a receptor and antagonistic activity at dopamine receptors. |
2003-08-07 |
2023-08-12 |
Not clear |
| David H Overstreet, Randall C Commissaris, Richard De La Garza, Sandra E File, Darin J Knapp, Lewis S Seide. Involvement of 5-HT1A receptors in animal tests of anxiety and depression: evidence from genetic models. Stress (Amsterdam, Netherlands). vol 6. issue 2. 2003-08-06. PMID:12775329. |
clinical studies have suggested the involvement of 5-ht1a receptors in anxiety and depressive disorders because partial 5-ht1a receptor agonists such as buspirone are therapeutic. |
2003-08-06 |
2023-08-12 |
mouse |
| Pierre Blier, Nick M War. Is there a role for 5-HT1A agonists in the treatment of depression? Biological psychiatry. vol 53. issue 3. 2003-07-03. PMID:12559651. |
the azapirones are full agonists at 5-ht1a autoreceptors and are generally, but not exclusively, partial agonists at postsynaptic 5-ht1a receptors. |
2003-07-03 |
2023-08-12 |
human |
| Pierre Blier, Nick M War. Is there a role for 5-HT1A agonists in the treatment of depression? Biological psychiatry. vol 53. issue 3. 2003-07-03. PMID:12559651. |
some of these drugs, including gepirone and other 5-ht1a agonists such as buspirone, have been reported to exert anxiolytic and antidepressive activity in double-blind, placebo-controlled, and comparative trials. |
2003-07-03 |
2023-08-12 |
human |
| Yang Dong Teng, Marian Bingaman, Angelo M Taveira-DaSilva, Peter P Pace, Richard A Gillis, Jean R Wrathal. Serotonin 1A receptor agonists reverse respiratory abnormalities in spinal cord-injured rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 10. 2003-06-25. PMID:12764106. |
identical results were obtained with another 5-ht1a receptor agonist, buspirone (1.5 mg/kg, i.p. |
2003-06-25 |
2023-08-12 |
rat |
| R C B Silva, N R Santos, M L Brandã. Influence of housing conditions on the effects of serotonergic drugs on feeding behavior in non-deprived rats. Neuropsychobiology. vol 47. issue 2. 2003-05-29. PMID:12707493. |
we have therefore examined the effects of fluoxetine, a selective 5-ht reuptake inhibitor, and gepirone, a 5-ht1a agonist, on body weight in isolated and in group-housed rats during 3 weeks of daily treatment. |
2003-05-29 |
2023-08-12 |
rat |
| R C B Silva, N R Santos, M L Brandã. Influence of housing conditions on the effects of serotonergic drugs on feeding behavior in non-deprived rats. Neuropsychobiology. vol 47. issue 2. 2003-05-29. PMID:12707493. |
from the data obtained in this study, it is suggested that increased 5-ht transmission produced by fluoxetine during chronic administration seems to be crucial for the appetite-regulating action of 5-ht, and this hypophagic effect does not seem to be dependent on the activation of 5-ht1a receptors since it was not shared by gepirone. |
2003-05-29 |
2023-08-12 |
rat |
| Zdzisław Chilmonczyk, Krzysztof J Krajewski, Jacek Cybulsk. Rigid analogues of buspirone and gepirone, 5-HT1A receptors partial agonists. Farmaco (Societa chimica italiana : 1989). vol 57. issue 11. 2003-05-15. PMID:12484540. |
rigid analogues of buspirone and gepirone, 5-ht1a receptors partial agonists. |
2003-05-15 |
2023-08-12 |
Not clear |
| Zdzisław Chilmonczyk, Krzysztof J Krajewski, Jacek Cybulsk. Rigid analogues of buspirone and gepirone, 5-HT1A receptors partial agonists. Farmaco (Societa chimica italiana : 1989). vol 57. issue 11. 2003-05-15. PMID:12484540. |
rigid analogues of buspirone and gepirone, 5-ht1a receptors partial agonists, were obtained. |
2003-05-15 |
2023-08-12 |
Not clear |
| Zdzisław Chilmonczyk, Krzysztof J Krajewski, Jacek Cybulsk. Rigid analogues of buspirone and gepirone, 5-HT1A receptors partial agonists. Farmaco (Societa chimica italiana : 1989). vol 57. issue 11. 2003-05-15. PMID:12484540. |
their structural features resembled to a large extent the arrangement of the respective structural elements found in the solid state of buspirone and in the theoretical structure of nan-190 (5-ht1a postsynaptic antagonist) rigid analogue exhibiting high affinity to the receptor. |
2003-05-15 |
2023-08-12 |
Not clear |
| Peter J Winsauer, Marcus S Delatte, Michael W Stevenson, Joseph M Moerschbaeche. Effects of triazolam, 8-OH-DPAT, and buspirone on repeated acquisition in squirrel monkeys. Experimental and clinical psychopharmacology. vol 10. issue 4. 2003-05-15. PMID:12498336. |
the nonserotonergic benzodiazepine, triazolam, was compared with two 5-ht1a receptor agonists, 8-oh-dpat and buspirone, in squirrel monkeys responding under a repeated-acquisition procedure. |
2003-05-15 |
2023-08-12 |
human |